7 results about "Stress induced" patented technology

The invention relates to the technical field of biomedicine, in particular to an ELS-induced depression-like behavior rat whole-brain tissue lipid space metabolism analysis method which comprises the following steps: firstly, constructing an ELS-induced depression-like behavior rat model, and determining a depression model group by adopting a depression-like behavior test; then, taking a conventionally fed rat as a control group, respectively carrying out 2D scanning on the control group and the depression model group based on a mass spectrum space omics technology, constructing a 2D brain lipid map, and carrying out whole-brain 3D reconstruction to obtain brain tissue lipid mass spectrum imaging data; and finally, carrying out metabolic heterogeneity analysis on brain tissue lipid mass spectrum imaging data. The method provided by the invention aims to provide technical and data atlas support for research on a lipid metabolism disorder molecular mechanism of occurrence and development of early-stage negative stress induced depression from an animal model level, and meanwhile, the application range of a mass spectrum space omics technology is expanded.

The invention relates to the technical field of medicine and biology, and particularly discloses a stress-inducible virus and application thereof.The stress-inducible virus comprises a stress-inducible adenovirus or a stress-inducible lentivirus, the nucleotide sequence of the stress-inducible adenovirus or the stress-inducible lentivirus is shown as SEQ ID NO: 1, and the nucleotide sequence of the stress-inducible adenovirus or the stress-inducible lentivirus is shown as SEQ ID NO: 2. The preparation method comprises the following steps: constructing a virus vector, wherein the virus vector has a nucleotide sequence as shown in SEQ ID NO: 1; and virus packaging: transfecting HEK293T cells by adopting shuttle plasmids containing SEQ ID NO: 1 and skeleton plasmids containing viral genome sequences, and collecting a virus stock solution to obtain the stress induced virus. The invention also discloses application of the stress-induced virus in preparation of medicines for preventing and treating oral tumors. Controllable release of the foreign protein under a specific signal is realized. The therapeutic protein produced by the invention can maximize the curative effect of drugs such as CD47 targeted protein and the like, and meanwhile, the toxic and side effects of the drugs on other tissues of the whole body are reduced.

The invention discloses application of allyl isothiocyanate in preparation of drugs or health-care foods for improving mental disorder, and belongs to the technical field of medicines. Allyl isothiocyanate shows rapid, convenient and efficient intervention potential for depression, emotional disorder, social difficulty, biphasic emotional fluctuation, anxiety and autism spectrum symptoms when used as a functional component of a medicine or health food. Specific experiments verify that in a depression model constructed by adopting social contusion stress, the component can obviously reverse typical depression-like behaviors such as social avoidance tendency and behavioral despair states shown by mice. In a chronic unpredictable stress induced model, allyl isothiocyanate effectively relieves anxiety and depression symptoms of mice and recovers pleasant sensation experience ability of the mice. In a drug-induced bipolar affective disorder model, the component obviously stabilizes the manic attack and depression alternating behavior of mice. In an autism model mouse, the allyl isothiocyanate effectively relieves the repetitive engraving behavior of the autism model mouse.

The invention discloses a test system for noise disturbance degree in a high-speed train tunnel based on electroencephalogram signals. The test system comprises a noise acquisition and separation module, a dynamic noise simulation module and a multi-modal evaluation module, wherein the noise acquisition and separation module is used for separating aerodynamic noise, wheeltrack noise and cavity resonance noise in a tunnel environment in real time; the dynamic noise simulation module is used for generating an adjustable sound field based on the parameterized noise database and supporting noise switching and dynamic reverberation control; the multi-modal evaluation module is used for calculating a dynamic annoyance index DFI according to the physiological signals, the behavior data and subjective feedback and outputting a quantitative evaluation result; according to the method, the subconsciousness stress intensity caused by noise is quantified through EEG (electroencephalogram), eye movement tracking and other multi-dimensional physiological signals, the memory deviation defect of a subjective questionnaire is made up, and total factor evaluation of tunnel noise dynamic characteristics is achieved.

The application belongs to an animal model, and aims to solve the technical problems that the evaluation method of the current Skinner box experimental data lacks a systematic experimental paradigm and evaluation means, and lacks related parameters, and provides an experimental animal learning and memory disorder model, a construction method and application. The traditional chronic social frustration model experiment process is optimized, the learning and memory disorder model of the mouse is stably induced, and the obtained experimental animal learning and memory disorder phenotype is obvious, and the diversity of stress-related disorder animal models is enriched. The learning and memory ability of the animal is evaluated by the Skinner box, the learning and memory related evaluation means is expanded, and new data support is provided for the construction and evaluation of the acute violent stress induced learning and memory disorder animal model.

The application relates to an intraocular pressure measuring device and system, comprising a wearing assembly; a mounting shell movably arranged on the wearing assembly; a pressure measuring assembly detachably mounted in the mounting shell, the pressure measuring assembly comprising a pressure sensing piece, a displacement sensing piece, a contact piece, a barrel and a driving piece, the driving piece, the pressure sensing piece and the displacement sensing piece being mounted in the barrel, and the pressure sensing piece being connected with the contact piece; the contact piece is used for contacting and applying pressure to the eye of a subject, the pressure sensing piece is used for monitoring pressure information of the surface of the eye, and the displacement sensing piece is used for measuring the moving distance of the pressure sensing piece. The contact piece in the pressure measuring assembly acts on the eye of the subject, closed-eye measurement is realized, the discomfort of the subject in the measurement process is reduced, and corneal damage and stress reaction are avoided, and the application is especially suitable for children or corneal patients.

This invention provides a labor pain feedback gripping device, belonging to the field of medical device technology. It includes a gripping body; a soft area is provided on the gripping body, and a pressure sensing module is disposed within the soft area to detect the pressure applied to the soft area; a control center is used to assess the pain level based on the pressure detected by the pressure sensing module, and outputs the assessment result through a feedback output module. This invention provides an intelligent device integrating real-time monitoring, assessment, and feedback functions for labor pain, offering effective support for pain management during labor for medical personnel.