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117 results about "Follicle" patented technology

In botany, a follicle is a dry unilocular fruit formed from one carpel, containing two or more seeds. It is usually defined as dehiscing by a suture in order to release seeds, for example in Consolida (some of the larkspurs), peony and milkweed (Asclepias).

Preparation method of rhizoma polygonati and radix angelicae sinensis fermented product and application of rhizoma polygonati and radix angelicae sinensis fermented product in female health

The invention provides a strain of lactobacillus plantarum YS-AG23 with high antioxidant activity, and a rhizoma polygonati and radix angelicae sinensis fermented product obtained by fermenting rhizoma polygonati and radix angelicae sinensis with the strain of lactobacillus plantarum YS-AG23. In a D-galactose induced premature ovarian failure mouse model, the fermentation product can regulate up the levels of antioxidant and stress protection genes SOD2 and HO-1 and an anti-aging gene SIRT1 by regulating down the expression of a key gene AGER of an inflammation and oxidative stress pathway, so that the oxidative stress and inflammatory response of model mouse ovarian tissues are remarkably reduced; meanwhile, the serum hormone level can be specifically adjusted, the serum estradiol (E2) level can be increased, the follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels can be reduced to be close to the normal range, the expression of anti-mullerian hormone (AMH) and hormone regulatory gene LHR of ovarian reserve markers can be up-regulated, the proliferative activity and estrogen secretion function of follicular granulosa cells can be improved, and the effect of preventing ovarian reserve is achieved. The wet weight of atrophic uterus and ovary of the model mouse is remarkably increased, uterine and ovary atrophy is effectively reversed, and the ovarian reserve function of the D-galactose induced premature ovarian failure model mouse is recovered. Besides, in an H2O2-induced human dermal fibroblast aging model, the yeast can improve the activity of aging cells in a concentration-dependent manner and reduce the level of reactive oxygen species (ROS) in the cells; in addition, by up-regulating the expression of a collagen synthesis key gene COL1A1 and down-regulating the expression of a cell senescence marker gene p16, skin cell senescence caused by oxidative stress can be effectively improved. In conclusion, the polygonatum sibiricum and angelica sinensis leavening can synchronously improve premature ovarian failure and skin cell senescence caused by oxidative stress by accurately regulating and controlling oxidative stress, inflammatory response and tissue function related genes, and has wide application potential.
Owner:HUNAN NUTRITION TREE BIOTECHNOLOGY CO LTD

Traditional Chinese medicine composition for repairing and / or activating residual ovarian function of senescence ovary and preparation method and application thereof

The invention discloses a traditional Chinese medicine composition for repairing and / or activating residual ovarian functions of an aging ovary, and a preparation method and application thereof, and relates to the technical field of biology. The traditional Chinese medicine composition is prepared from the following components: radix astragali, radix angelicae sinensis, radix ophiopogonis, radix polygonati officinalis, semen cuscutae, radix morindae officinalis, fructus rubi, rhizoma dioscoreae and folium mori. The invention further provides application of the traditional Chinese medicine composition in repairing and / or activating the residual ovarian function of the senescent ovary and improving the quality of the senescent oocyte, the traditional Chinese medicine composition can increase the volume and weight of the senescent ovary, increase the number of follicles of all levels in the senescent ovary, reduce apoptosis of granular cells in the ovary and improve the survival rate of the senescent ovary. The abnormal rate of oocytes, oxidative stress of the oocytes and DNA damage are reduced, development and maturation of residual follicles are promoted and maintained, and the traditional Chinese medicine composition has a wide application prospect.
Owner:GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Multi-factor risk assessment method for ovarian hyperstimulation

The invention discloses a multi-factor risk assessment method for ovarian hyperstimulation, and relates to the technical field of intelligent medical treatment, and the method comprises the steps: based on a multi-source baseline data packet, calculating the trend of follicle volume along with time through ovarian reaction simulation to obtain a follicle reaction curve, calculating the probability of vascular injury through puncture path bleeding simulation, and calculating the risk of ovarian hyperstimulation according to the probability of vascular injury. Obtaining a bleeding probability, and fusing the follicle reaction curve and the bleeding probability to form a patient characterization risk vector; associating the intervention suggestions in the structured strategy list with the ovarian overstimulation risk score and the bleeding risk score to generate a risk change description, and forming a risk assessment report according to the risk change description; according to the method, the patient characterization risk vector fusing the follicle dynamic response and the puncture bleeding risk is constructed, so that the safety and individuation level of assisted reproduction treatment are effectively enhanced.
Owner:THE SEVENTH MEDICAL CENTER OF PLA GENERAL HOSPITAL

Intelligent precise positioning system for hair follicles in micro-needle art hair transplantation

The invention discloses an intelligent precise positioning system for hair follicles in micro-needle art hair transplantation, and relates to the technical field of image processing of hair follicles in hair transplantation. According to the system, a to-be-transplanted hair area is determined through an obtained hair follicle three-dimensional network image, a two-dimensional coordinate system taking a to-be-measured target area as a reference is established to carry out preliminary planting density planning, then hair follicle density gradient division is carried out according to the determined to-be-transplanted hair area, and the coordinate position of each hair follicle is marked; a visual hair follicle planting point location distribution map is formed, a reference point location is provided for positioning of the microneedle, finally, skin deformation quantity and microneedle positioning coordinate deviation are monitored in real time in a spatial feature coordinate system, microneedle puncture positioning is adjusted, accurate positioning alignment of the microneedle and a target hair follicle is achieved, and the accuracy of the positioning of the microneedle and the target hair follicle is improved. The problem that in the prior art, when a microneedle carries out planting operation according to feedback information, in the link that position image coordinates of a to-be-planted area are converted to a mechanical arm coordinate system, the intelligent positioning accuracy of hair follicles is not high is solved.
Owner:BARLEY HAIR TRANSPLANT MEDICAL (SHENZHEN) GRP CO LTD

Frog follicle crude extract, VMO1 protein, and their extraction methods and uses

The present invention belongs to the field of natural compounds, and specifically relates to a crude extract of frog follicles, the VMO1 protein, and their extraction methods and uses. The specific technical solution is as follows: A crude extract, wherein the crude extract is from frog follicles and does not contain egg grains. The preparation method includes: extracting the follicles of frogs, removing the egg grains under a sterile environment, adding a buffer solution, performing ultrasonic treatment and centrifugation, taking the supernatant, and filtering to obtain the crude extract. The crude extract obtained by the present invention has good maintained activity and can be further developed for subsequent uses. The crude extract obtained by the present invention can significantly reduce the surface tension, and at the same time has good antioxidant activity and good antibacterial ability, such as the ability to inhibit Pseudomonas aeruginosa. Since products derived from natural products have good biocompatibility, therefore, based on the above activities and functions, the crude extract provided by the present invention has good application prospects in multiple fields such as the field of cosmetics water retention, the field of food preservation, and the field of pharmaceuticals.
Owner:CHENGDU INSTITUTE OF BIOLOGY CHINESE ACADEMY OF SCIENCES

Application of traditional Chinese medicine composition in preparation of medicine for preventing and / or treating ovarian dysfunction

The invention provides application of a traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating ovarian dysfunction, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials in parts by weight: 8-10 parts of American ginseng, 2-4 parts of pseudo-ginseng, 55-65 parts of kudzuvine root, 42-48 parts of coptis chinensis, 42-48 parts of scutellaria baicalensis, 14-16 parts of stiff silkworm, 14-16 parts of rhizoma zingiberis, 42-48 parts of bitter gourd and 55-65 parts of rhizoma anemarrhenae. The traditional Chinese medicine composition has the effects of increasing the number of follicles and corpus luteum, restoring the duration of an estrus cycle and restoring the levels of serum hormones and sex hormone receptors. The traditional Chinese medicine composition provided by the invention provides a new means for preventing and treating ovarian dysfunction.
Owner:NINGXIA MEDICAL UNIV +1

Traditional Chinese medicine composition, traditional Chinese medicine extract and pharmaceutical preparation for treating hypoovarian reserve function and application of traditional Chinese medicine composition, traditional Chinese medicine extract and pharmaceutical preparation

The invention discloses a traditional Chinese medicine composition, a traditional Chinese medicine extract, a pharmaceutical preparation and application for treating hypoovarian reserve function. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 12 to 18 parts of radix astragali seu hedysari, 9 to 15 parts of radix angelicae sinensis, 9 to 15 parts of fructus ligustri lucidi, 9 to 15 parts of fructus mori, 9 to 15 parts of semen cuscutae, 6 to 12 parts of cornu cervi degelatinatum, 7 to 13 parts of tortoise shell and 7 to 13 parts of radix cyathulae. The traditional Chinese medicine composition, the traditional Chinese medicine extract and the pharmaceutical preparation are low in cost and high in safety, and can remarkably improve the ovarian function of an elderly patient suffering from hypoovarian reserve function, increase the number of sinus follicles and improve the follicle quality.
Owner:SHANGHAI HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Special compound feed for weaning sows as well as preparation method and use method of special compound feed

The invention relates to the technical field of pig feeds, and particularly discloses a special compound feed for weaning sows, the feed comprises a functional additive, the functional additive comprises the following raw materials in parts by weight: 1-3 parts of a plant extract compound, 2-5 parts of conjugated linoleic acid, 0.0003-0.0005 part of selenomethionine, 0.15-0.35 part of vitamin E, and 0.15-0.3 part of vitamin C; the plant extract compound is prepared from the following components: astragalus polysaccharide, icariin, epigallocatechin gallate and a carrier, and the mass ratio of the astragalus polysaccharide to the icariin to the epigallocatechin gallate is 1 to (1 to 4) to (0.2 to 0.8). The special compound feed for the weaned sows is used for feeding the weaned sows through a scientific and reasonable formula, can promote follicular development of the sows after weaning, improve the oestrus rate and reduce the proportion of non-oestrus sows, and can solve the problem of slow ovarian function recovery of the sows in summer high-temperature seasons.
Owner:GUANGXI SHANGDA TECH

Synchronous oestrus-timed insemination method suitable for cows

The invention relates to the technical field of animal husbandry, in particular to a synchronous oestrus-timing insemination method suitable for cattle, which comprises the following steps: firstly, performing intramuscular injection of PG (cloprostenol sodium) at different time points after calving to promote uterine recovery and luteolysis and lay a synchronous oestrus foundation; the method comprises the key steps that GnRH (gonadotropin release hormone) is given through intramuscular injection on the 43rd day, the 53rd day, the 60th day and the 69th day, pituitary is promoted to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), collection and screening of follicles are guided, follicle maturation is promoted, the oestrus uncovering rate and the oestrus conception rate are increased, a melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day, and the melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day. The synthesis of ovarian hormones is promoted by regulating the hypothalamus-pituitary-gonad axis, the secretion of follicle cell factors and maturation promoting factors is promoted, the development of granular cells is promoted, and the maturation of oocytes is promoted. According to the method, the pregnancy rate of a double-synchronization-timing insemination scheme which is most widely used in a large-scale dairy cow breeding pasture at present can be remarkably increased, and feasible technical support is provided for success of increasing the breeding efficiency of cows.
Owner:张靖

Follicle hatching device for seed breeding

The utility model discloses a follicle hatching device for fry cultivation, relates to the technical field of follicle hatching, and aims to solve the technical problem that a current follicle hatching device easily causes adhesion of fish follicles to cause hatching failure. The follicle hatching device comprises a culture box, a shunt tube is arranged at the top of the culture box, and a mounting plate is arranged in the culture box; a plurality of groups of hatching barrels are movably arranged on the mounting plate. By designing the structures of the hatching barrel, the mounting pipe, the flow dividing pipe, the connecting hose, the first water pump, the second water pump and the like, after a water source is discharged into the hatching barrel from the center of the bottom in the hatching barrel through the mounting pipe, the water source in the hatching barrel is in a surging-shaped flow generation state at the moment, so that follicles can upwards surge according to water flow, and follicles in the hatching barrel can be more effectively hatched. The follicles can be dispersed, the fish follicles can be prevented from being adhered together, the environment in a parent body can be simulated through proper gushing, and development and incubation of the fish follicles can be better promoted.
Owner:WUXI YUCHEN TECHNOLOGY CO LTD

Application of paeonol in preparation of product for improving liver function and ovarian function of laying hens in later laying period

PendingCN121986872ADigestive systemFood processingSerum glutamate pyruvate transaminaseAnimal science
The invention discloses application of paeonol in preparation of a product for improving liver functions and ovarian functions of laying hens in the later egg laying period, belongs to the technical field of feed additives, and particularly relates to application of paeonol in preparation of a product for improving liver functions and ovarian functions of laying hens in the later egg laying period. It is found that paeonol can significantly reduce the activity of glutamic-pyruvic transaminase in the liver, significantly reduce the content of cholesterol and the content of triglyceride in serum, significantly reduce hepatic cell fatty degeneration and lipid droplet aggregation in a hepatic tissue pathological section, relieve liver injury and lipid metabolism disorder, and significantly improve the liver function. The paeonol can effectively improve the fatty liver hemorrhagic syndrome of the laying hens in the later egg laying period, and the paeonol can recover the storage capacity of ovary by improving the survival rate of follicles, improve the egg laying performance of the laying hens and improve the egg laying rate.
Owner:HENAN AGRICULTURAL UNIVERSITY

Method for promoting ovulation of sexual maturity zebrafish by using Gap27

The invention discloses a method for promoting ovulation of sexual maturity zebrafish by using Gap27, and relates to the technical field of artificial breeding of fish, a gap connecting protein inhibitor Gap27 is applied to ovulation induction of zebrafish, an intercellular communication network in follicles is accurately intervened, the problem of asynchronous ovulation is solved, and in the final stage of maturation of oocytes, ovulation of sexual maturity zebrafish is promoted. Close substance and information exchange is carried out among follicular granule cells through a gap connecting channel formed by connecting protein Cx43, and Gap27 is used as a specific peptide fragment, can simulate an extracellular ring structure of Cx43, and competitively binds with Cx43 on an adjacent cell membrane, so that formation and functions of the gap connecting channel are physically blocked, and the follicular granule cells are separated from each other. When ovarian tissues of sexually mature female fish are exposed in a Gap27 solution, the transmission of inhibitory signals from granular cells to oocytes can be effectively interrupted, the rupture of nuclear membranes of the cells is promoted, and the final maturation process is completed.
Owner:NINGDE NORMAL UNIV

Application of spermidine in preparation of preparation for improving fertility of female mammals

The invention discloses application of spermidine in preparation of a preparation for improving fertility of female mammals, and belongs to the technical field of reproductive biology. According to the invention, spermidine with different concentrations is introduced into mice, and the effect of spermidine on ovarian hormone secretion, ovarian reserve level and follicle number of female mammals is determined in a diet intake manner, so that the fertility of female animals is improved; it is found that spermidine can effectively improve the ovarian function, increase the secretion level of E2, P4, LH and AMH hormones closely related to the ovarian function, reduce the number of atresia follicles of the ovarian and increase the litter birth number of female mice by 1-2, and the spermidine has good animal breeding and livestock raising application prospects.
Owner:SICHUAN AGRI UNIV

Effect of REV-ERBalpha agonist SR9009 in delaying ovarian aging

The invention relates to an effect of an REV-ERBalpha agonist SR9009 in the aspect of delaying ovarian senescence, and aims at the problem of fertility decline caused by cliff-type decline of ovarian functions of women over 35 years old, the SR9009 is applied to activate an REV-ERBalpha circadian rhythm signal channel in ovarian tissues, inhibit excessive autophagy of granular cells and maintain a primordial follicle dormancy state, so that the agonist SR9009 can be used for delaying ovarian senescence. Therefore, the original follicle depletion speed is delayed, follicle storage is maintained, and the ovary reproductive function cycle is prolonged. The effect is verified by a mammal model: REV-ERBalpha protein expression in an ovary of an aging individual is reduced, rhythmicity expression is disordered, autophagy of granulosa cells can be effectively inhibited in the ovary of the aging individual intervened by the SR9009, and the number of residual primordial follicles and the number of total follicles are obviously greater than those of an untreated control group. The invention provides an innovative treatment strategy of targeted rhythm regulation and control for clinical intervention of ovarian aging.
Owner:AFFILIATDE CANCER HOSPITAL & INST OF GUANGZHOU MEDICAL UNIV

An agent for activating and increasing follicles and its application

This invention relates to the field of ovarian tissue in vitro culture technology, and discloses a formulation for activating and increasing follicles and its application. The formulation consists of a PI3K / Akt / mTOR pathway activator and / or a PTEN inhibitor SF1670. The PI3K / Akt / mTOR pathway activator is a 5-15 μM statin, and the PTEN inhibitor is a 20-50 μM SF1670. Using this formulation can achieve the follicle activation and increase effect of existing technologies, contributing to the development and selection of in vitro follicle activators in clinical practice. Furthermore, the use of this formulation opens up a new technological application area for statins.
Owner:MULTIPOTENT STEM CELL REGENERATIVE MEDICINE TECH (GUANGZHOU) CO LTD

Follicle flushing liquid constant temperature device

The utility model provides a follicle flushing liquid constant-temperature device which comprises a constant-temperature box, a box body cover plate is rotationally connected to the constant-temperature box, a fixing opening is fixedly connected to the box body cover plate, the fixing opening is connected with a flushing assembly, an extrusion assembly is arranged in the constant-temperature box, and the extrusion assembly is connected with a constant-temperature assembly. The extrusion assembly achieves the stable and continuous flushing effect and controls the flushing force, the constant-temperature assembly achieves uniform dispersion of heat, so that flushing liquid can be continuously heated, the temperature sensor achieves temperature regulation and control, the constant-temperature state of the flushing liquid is achieved, and the flushing assembly guarantees sterility of medical supplies in contact with the flushing liquid. And control over the flushing flow can be achieved through the arranged flow adjusting valve.
Owner:WEIFANG MATERNAL & CHILD HEALTH HOSPITAL (WEIFANG MATERNAL & CHILD HEALTH & FAMILY PLANNING SERVICE CENT)

A two-dimensional metal polyphenol complex nanomaterial which can be enriched in ovaries, a preparation method and application thereof

PendingCN122440792A
The present application relates to a kind of two-dimensional metal polyphenol complex nanomaterials that can be enriched in ovary, preparation method and application thereof, the nanomaterial can be enriched in ovary, including two-dimensional metal polyphenol complex as substrate, and follicle-stimulating hormone polypeptide grafted to the surface of the substrate;Wherein, the surface of the two-dimensional metal polyphenol complex grafts-COOH functional group and forms 2D MPC-COOH intermediate, the follicle-stimulating hormone polypeptide is covalently grafted with the-COOH on the surface of 2D MPC-COOH intermediate and obtains the two-dimensional metal polyphenol complex nanomaterial.The technical effect of the present application is that the preparation method of nanomaterial is simple, and nanoparticle dispersibility is good, and biosafety is high, and nanomaterial can physically absorb BRD7 target protein through its special structure, block BRD7 into cell nucleus, and then realize the safe down-regulation of KAT7 path and the effective reversal of granulosa cell stress aging.
Owner:TONGJI UNIV +1

Use of parabacteroides johnsonii in ovarian aging

The application relates to the field of biotechnology, and particularly relates to an application of Bacteroides ovatus in ovarian aging; the application comprises: taking low-abundance Bacteroides ovatus as a biomarker of ovarian aging; the application comprises using Bacteroides ovatus in a medicine for delaying ovarian aging; the application further comprises using a fermentation product of Bacteroides ovatus in the medicine for delaying ovarian aging; it is found through experiments that there is a significant difference in Bacteroides ovatus in mice with different degrees of ovarian aging, and it is found through subsequent experiments that Bacteroides ovatus has the effects of significantly increasing the number of oocytes, up-regulating anti-Mullerian hormone, up-regulating the level of estradiol and down-regulating the level of follicle-stimulating hormone, which indicates that Bacteroides ovatus can be used in the medicine for delaying ovarian aging.
Owner:HUAZHONG AGRI UNIV

Method for activating follicles by means of using small-molecule compound, and preparation thereof

Disclosed are a method and culture medium for performing an in vivo treatment on ovaries of mammals including humans or performing in vitro culturing on ex vivo ovaries or ovarian tissue by means of using 4-vinylcyclohexene diepoxide. The method or culture medium provided facilitates the retention and enhancement of the developmental and reproductive potential of mammalian ovaries or ovarian tissue, and is particularly capable of promoting follicle maturation and increasing the number of ovulations.
Owner:TSINGTAO A-SMART MEDICAL TECH CO LTD

A superovulation method based on synergistic effect of multiple hormones

PendingCN122342379ABurmese catObstetrics
The application discloses a superovulation method based on synergistic effect of composite hormones, which comprises the following steps: injecting PMSG and FSH to induce estrus, and injecting hCG to promote synchronous ovulation. The application adopts synergistic regulation of PMSG (long-acting follicle-stimulating hormone) and FSH (short-acting follicle-stimulating hormone), PMSG completes follicle recruitment, and FSH finely regulates the development stage, thereby avoiding overgrowth of follicles. In the examples, the Burmese cat, the British short cat and the farm cat do not appear OHSS symptoms (such as ovarian enlargement and ascites), and the ovarian state is normal.
Owner:YANGZHOU UNIV

Composition for improving premature ovarian failure and preparation method thereof

The invention belongs to the technical field of functional foods and health foods, and particularly relates to a composition for improving premature ovarian failure and a preparation method thereof. The composition comprises the following components in parts by weight: 5-15 parts of orange osmanthus pollen, 4-12 parts of flaxseed concentrated powder, 2-8 parts of black-bone chicken peptide, 4-20 parts of rehmannia powder, 2-10 parts of cistanche powder and 1-5 parts of lemon concentrated powder. The composition for improving premature ovarian failure prepared by the invention can reduce the content of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in the serum of a premature ovarian failure rat induced by cyclophosphamide and increase the content of estradiol (E2), thereby achieving the effect of improving premature ovarian failure.
Owner:江苏菌钥生命科技发展有限公司

Living sow egg collecting instrument system

The invention discloses a live sow egg collecting instrument system, and belongs to the technical field of livestock breeding detection. A living sow egg collecting instrument system comprises a host, an ultrasonic probe, a negative pressure pump, an egg collecting tube, an egg collecting needle and an operation system. The host is a control center of the system, integrates an ultrasonic signal processing module, a negative pressure adjusting module and a data recording module, and is used for receiving signals transmitted by the ultrasonic probe, adjusting the pressure of the negative pressure pump and recording key data in the egg collecting process. The ultrasonic probe is electrically connected with the host, is used for transmitting and receiving ultrasonic signals and is inserted into the dome part of the vagina of the sow, and after the operation system is started, the probe is in contact with ultrasonic images of ovaries and follicles of the sow and displays the ultrasonic images on a host screen; the problems that in the prior art, the utilization rate of improved variety resources is low, the egg collecting accuracy and efficiency are insufficient, the egg quality is not guaranteed, and data management is disordered cannot be effectively solved.
Owner:ZHENGZHOU BOXIANGLAI ELECTRONIC TECH CO LTD

Sensors

A sensor comprising a whisker shaft and a follicle is provided. The shaft has a root end and a tip end and the shaft tapers from the root end to the tip end so that the root end is wider and the tip end is narrower. The root end is pivotably mounted in the follicle.
Owner:BRISTOL MARITIME ROBOTICS LTD

A preparation of Polygonatum sibiricum vesicles for treating premature ovarian failure, its preparation method and application

This invention discloses a Polygonatum sibiricum vesicle preparation for treating premature ovarian failure, its preparation method, and its application. The preparation method includes: cleaning Polygonatum sibiricum, juicing, filtering to remove residue, and collecting the juice; subjecting the juice to gradient centrifugation to remove residual plant tissue, plant cells, and plant cell debris; then using an extraction reagent for stepwise precipitation, collecting the precipitate, and resuspending it to obtain the final product. The Polygonatum sibiricum vesicle preparation prepared by this invention can be efficiently taken up by ovarian granulosa cells. It effectively treats premature ovarian failure by activating the Nrf2 signaling pathway, upregulating antioxidant enzyme expression, scavenging reactive oxygen species, restoring mitochondrial membrane potential, inhibiting apoptosis, and restoring the expression levels of estrogen, follicle-stimulating hormone, and anti-Müllerian hormone. The preparation method of this invention is standardized, biocompatible, and safe, and has broad clinical application prospects.
Owner:SOUTHEAST UNIV

Micro-needle art hair transplantation follicle intelligent precise positioning system

The application discloses a micro-needle artistic hair transplantation follicle intelligent precise positioning system and relates to the technical field of hair transplantation follicle image processing. The system determines a hair transplantation area through obtained three-dimensional network imaging of follicles, establishes a two-dimensional coordinate system taking the target area to be measured as a reference to preliminarily plan the planting density, further divides the follicle density gradient according to the determined hair transplantation area, marks the coordinate positions of the follicles, forms a visual follicle planting point distribution map, provides reference points for the positioning of the micro-needle, and finally monitors the skin deformation and the deviation of the micro-needle positioning coordinates in the spatial feature coordinate system in real time, adjusts the micro-needle puncture positioning, realizes the precise positioning alignment of the micro-needle and the target follicle, and solves the problem of low accuracy of the intelligent positioning of the hair transplantation follicle in the process of converting the position image coordinates of the hair transplantation area to the mechanical arm coordinate system when the micro-needle carries out the planting operation according to the feedback information.
Owner:BARLEY HAIR TRANSPLANT MEDICAL (SHENZHEN) GRP CO LTD

Construction method and detection method of chicken follicle ultrasonic image automatic detection model based on deep learning

The invention relates to the technical field of biological breeding and artificial intelligence image recognition, in particular to a chicken follicle ultrasonic image automatic detection model construction method and system based on deep learning. Aiming at the problems of unclear follicle boundary identification, easy missing detection of small-size follicles, easy identification of adjacent follicles as a single target in an ultrasonic image and the like when a conventional target detection model is adopted to process a chicken follicle ultrasonic image under the condition that targeted structure optimization is not performed in the prior art, the model is improved, and the follicle boundary identification accuracy is improved. Therefore, the improved model can more accurately identify the follicle center echo region and the edge structure thereof, the adjacent follicles can be respectively labeled, and the positioning result of the follicles in the ultrasonic image is clearer and more stable.
Owner:CHINA AGRI UNIV

Composition for prevention, improvement, or treatment of poor ovarian responders caused by aging, comprising butylphthalide or acceptable salt thereof as active ingredient

PCT designated stage expiredWO2025127804A1Organic active ingredientsSexual disorderMaturation oocytePhysiology
The present invention relates to a composition for prevention, improvement, or treatment of poor ovarian responders caused by aging, comprising butylphthalide or an acceptable salt thereof as an active ingredient, for which a statistically significant increase in the number and quality of mature oocytes was confirmed in 38- to 40-week-old mice (40 years old or older in humans) fed butylphthalide. Not only does the number of mature oocytes produced in the ovaries decrease in women as a result of aging, but also healthy mature oocytes (MII oocytes) decrease as a result thereof, thereby gradually reducing the possibility of pregnancy, but the active ingredient of the present invention may increase the number and quality of mature oocytes and thus has the effect of increasing the chances of pregnancy for older women. In addition, the present invention may inhibit a decrease in the number of primordial follicles caused by aging and thus has the effect of enabling the inhibition of diminished ovarian reserve caused by aging.
Owner:KOREA INST OF ORIENTAL MEDICINE +1

Strategy for treating premature ovarian failure based on extracellular vesicles derived from embryonic stem cells

PendingCN120459141AUnknown materialsEmbryonic cellsOvarian morphologyPremature aging
The premature ovarian failure is caused by ovarian function decline and is one of important factors affecting physical and psychological health of women. The invention relates to a technology for reversing premature ovarian failure by using embryonic stem cells (ESCs)-derived extracellular vesicles (ESC-EVs). The ESCs in the early development stage have self-renewal capacity and multidirectional differentiation potential, and have great application prospects in degenerative disease treatment and regenerative medicine. The ESC-EVs is formed by wrapping tiny vesicles with a phospholipid bilayer, carries nucleic acid, protein and other components secreted by the embryonic stem cells, and has a regeneration promoting effect similar to that of the embryonic stem cells; the problems of immunological rejection, ethical restriction, safety and the like are avoided, and compared with stem cells, the extracellular vesicles are more stable and easier to store, so that more and more extracellular vesicles are applied to the field of regenerative medicine. The invention relates to a new technology for treating premature ovarian failure by using embryonic stem cell-derived extracellular vesicles, which can improve the ovarian morphology and ovarian microenvironment, increase the number of primary follicles, anterior sinus follicles and sinus follicles, reduce the number of atresia follicles, reduce the expression of oxidative stress and senescence-related proteins, promote the recovery of ovarian functions and estrus cycle, and improve the curative effect of premature ovarian failure. The technical invention expands the application of the embryonic stem cell source exosome in the field of reproduction.
Owner:NANKAI UNIV

Method and system for auxiliary diagnosis of polyovarian syndrome based on image recognition

The invention relates to the technical field of ovarian ultrasound image enhancement, in particular to a polyovarian syndrome auxiliary diagnosis method and system based on image recognition. The method comprises the following steps: segmenting an ovary ultrasound image of a patient, analyzing the pixel gray level and distance distribution of an ovary region, evaluating the image recognition degree, clustering, and recognizing a potential follicle region. Any region is selected as a reference region, and the sinus degree is calculated according to the boundary gray level change and the internal gradient of the region; evaluating the follicle arrangement degree in combination with the position distribution and the neighbor distance; and calculating the change degree of the multi-capsule sample through the area proportion. And integrating the three indexes of follicle areas of all patients to mark to-be-enhanced levels, thereby enhancing the image and assisting in diagnosis of the polycystic ovarian syndrome. According to the method, targeted image enhancement can be carried out on all potential follicle regions, the omission ratio is reduced, and thus a relatively accurate diagnosis result is obtained.
Owner:XIAN GAOXIN HOSPITAL CO LTD