165 results about "Fertility" patented technology

The invention provides a compound of formula (I), or salt thereof,wherein:A, B, C, D, W, X, Y and Z are each independently selected from H and OH; for use in a method of enhancing or improving fertility in a male or female subject, for example, a human male subject. The invention also provides a method of enhancing or improving fertility in a subject (for example a male subject) comprising administering a compound of formula (I) to the subject, and compositions that find use in such methods.

The invention provides a breeding method for constructing XX / XY sex determination all-female sterile fish and application. The method comprises the following steps: knocking out a catalytic enzyme coding gene of a fish sex steroid hormone synthesis pathway by using a gene editing technology to block the fish sex steroid hormone synthesis pathway, screening to obtain an effectively mutated homozygote XX sex genetic type pseudo male fish, and hybridizing the pseudo male fish with improved allotetraploid crucian and carp female fish to obtain the fish sex steroid hormone synthesis pathway. Therefore, an allotriploid population is obtained, and the population completely develops into female fishes and is sterile, so that the effect of obtaining all-female and sterile populations is achieved at the same time. The method provided by the invention has very strong applicability, and can be widely applied to aquaculture of fishes to obtain female unisexual groups of the fishes so as to improve the aquaculture yield, realize effective control on female fertility and protect ecological safety; the method has a wide application prospect in the fields of genetic breeding and ecological safety of aquaculture fishes.

The invention relates to the technical field of demand prediction, in particular to a method and a system for predicting a growth resource demand, and a storage medium. The method comprises the following steps: obtaining real-time number of people waiting for delivery and real-time fertility resource data, carrying out space-time alignment, constructing a number-of-delivery-resource curve, collecting historical number of people waiting for delivery and fertility resource consumption data to identify a historical association relationship, analyzing the historical change influence degree based on the association relationship, and determining the number of people waiting for delivery. The method comprises the following steps: simulating a growth resource circulation condition in combination with a current resource curve, deducing a resource change trend according to real-time resources and a simulation result, reversely predicting the number change of people to be born through the resource change trend and a historical change influence degree, and calculating required matched resources in combination with historical associated data, thereby completing accurate prediction of growth resource demands. According to the method, structured and standardized resource prediction output is realized, and the adaptability of the system to high-frequency input, periodic fluctuation and structural variation is enhanced.

The invention discloses an SNP (Single Nucleotide Polymorphism) molecular marker related to the fertility rate of pigeons at 52 weeks old as well as application and a breeding method of the SNP molecular marker, the molecular marker is located at the 5476830th basic group of the 15th chromosome of a pigeon reference genome colLiv2, C / T polymorphism exists, and based on genotype discovery of the specific SNP molecular marker, the specific SNP molecular marker can be used for identifying the fertility rate of pigeons at 52 weeks old. The fertilization rate of the pigeons with the 52-week age is remarkably higher than that of C / T genotype individuals and T / T genotype individuals, in breeding, the C / T genotype individuals and the T / T genotype individuals are eliminated, and the C / C genotype individuals are reserved, so that early selection of the fertilization rate of the pigeons with the 52-week age can be realized, the breeding accuracy is improved, the breeding progress is accelerated, the breeding cost is saved, and the breeding effect is improved.

The invention relates to a male gamete killer gene S19g-A1 of a rice interspecific hybrid sterile S19 seat and application of the male gamete killer gene S19g-A1. The invention provides a rice hybrid sterility related protein S19g-A1. The amino acid sequence of the rice hybrid sterility related protein S19g-A1 is as shown in SEQ ID NO. 2. According to the invention, a key gene S19g-A1 of a rice interspecific hybrid sterile S19 site is researched and identified, function knockout is carried out on African rice S19g-A1, and pollen fertility of a mutant hybrid F1 obtained by carrying out distant hybridization on an obtained African rice s19g-a1 mutant returns to normal. Based on a gene editing technology, the invention develops a method for rapidly creating a hybrid affinity line capable of overcoming sterility of African rice hybrid, effectively eliminates S19 locus mediated interspecific hybrid reproductive disorder, breaks through the bottleneck of rice interspecific hybrid advantage utilization, provides target gene resources for distant hybrid advantage utilization and crop yield improvement, and has a wide application prospect. Good application prospects are realized.

The invention discloses a gene of a rice indica-japonica intersubspecific hybrid sterile locus HS12 and application thereof, and belongs to the field of plant genetic engineering. The locus is positioned at the tail end of a long arm of a chromosome 12, is positioned between molecular markers Sy55 and Sy8, and comprises four fertility related genes iTx1, iTx2, iAd1 and jAd2. By functional knockout or inhibition of expression of the gene iTx1 and / or iTx2, iAd1 and / or jAd2 are / is transferred, a wide-compatibility rice material can be created, meanwhile, a molecular marker for detecting HS12 is further provided and used for filial generation detection and auxiliary breeding, indica-japonica hybrid sterility can be effectively overcome, and the setting rate of offspring is increased.

The invention relates to the technical field of plant breeding, in particular to a method for constructing a dominant male sterile line based on CIF1 gene overexpression. The brand-new dominant male sterility gene CIF1 is found, it is verified that the gene has functions in monocotyledonous and dicotyledonous plants, and dominant male sterility resources are enriched; besides, a method capable of manually controlling the fertility recovery of the dominant sterile line is found, a reproductive breeding line for large-scale propagation is obtained, male sterile filial generations can be obtained by hybridizing the breeding line with normal plants, and a new application way is provided for large-scale application of dominant sterility.

The invention provides a double-cropping rice field annual rotation fertility dynamic monitoring system based on the Internet of Things, and relates to the technical field of fertility monitoring, and the system comprises a sensing collection module which is used for collecting soil fertility under the annual scale, and synchronously recording double-cropping rice growth indexes and rotation management information; the data processing module is used for preprocessing the multi-dimensional original monitoring data flow and generating a structured data packet; the trend prediction module is used for predicting fertility change through a Prophet algorithm; and the scheme optimization module is used for constructing a fertility regulation and control model and generating an optimized fertility regulation and control scheme. According to the method, the Prophet algorithm is used for feature extraction and model training, so that accurate pre-judgment and early warning of fertility change are realized; the fertility regulation and control rule base is constructed based on the prediction result and the rotation tillage characteristics, personalized regulation and control schemes are generated according to the risk levels of different field parcels, the scheme effect is optimized through historical scene verification, and the pertinence and the implementation effect of fertility regulation and control are effectively improved.

This invention belongs to the field of molecular genetics and discloses a method and application for controlling fish fertility using in vivo gene editing technology. The applicant, for the first time, cloned a carp-specific U6 promoter and used this promoter to construct the U6 gene. MOVIE gRNA transgenic vectors and water The Cas9 vector allows for the establishment of an in vivo editing system. This strategy enables the heritability of sterility, a reproductive control trait, through hybridization of fertile parents to produce sterile offspring. The operation is highly efficient, simple, and environmentally friendly. Furthermore, since high-copy-rate short, scattered repetitive sequences exist in all fish species, this strategy has broad applicability across species.

The invention relates to the technical field of animal husbandry, in particular to a synchronous oestrus-timing insemination method suitable for cattle, which comprises the following steps: firstly, performing intramuscular injection of PG (cloprostenol sodium) at different time points after calving to promote uterine recovery and luteolysis and lay a synchronous oestrus foundation; the method comprises the key steps that GnRH (gonadotropin release hormone) is given through intramuscular injection on the 43rd day, the 53rd day, the 60th day and the 69th day, pituitary is promoted to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), collection and screening of follicles are guided, follicle maturation is promoted, the oestrus uncovering rate and the oestrus conception rate are increased, a melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day, and the melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day. The synthesis of ovarian hormones is promoted by regulating the hypothalamus-pituitary-gonad axis, the secretion of follicle cell factors and maturation promoting factors is promoted, the development of granular cells is promoted, and the maturation of oocytes is promoted. According to the method, the pregnancy rate of a double-synchronization-timing insemination scheme which is most widely used in a large-scale dairy cow breeding pasture at present can be remarkably increased, and feasible technical support is provided for success of increasing the breeding efficiency of cows.

The present invention discloses an SNP molecular marker affecting the litter interval trait. This SNP molecular marker is a C>A base mutation at the position of 29,375,835 bp on chromosome 7 of the international pig genome Ensemble Sscrofa11.1 version. The gene fragment of this SNP molecular marker locus is as shown in SEQ ID NO:1. The mutation site in the nucleotide sequence of SEQ ID NO:1 is the 161st base M, and M is selected from base C or A. This molecular marker is applied to the breeding of sow litter interval traits, the cultivation of high-fertility sow lines, and the improvement of the genetic traits of sow population fecundity. It can greatly shorten the litter interval, thereby significantly shortening the production process, reducing the risk of sow dystocia, reducing the harm to sows and improving the survival rate of piglets, improving the reproductive performance of sows / populations, and improving production efficiency.

The invention discloses application of spermidine in preparation of a preparation for improving fertility of female mammals, and belongs to the technical field of reproductive biology. According to the invention, spermidine with different concentrations is introduced into mice, and the effect of spermidine on ovarian hormone secretion, ovarian reserve level and follicle number of female mammals is determined in a diet intake manner, so that the fertility of female animals is improved; it is found that spermidine can effectively improve the ovarian function, increase the secretion level of E2, P4, LH and AMH hormones closely related to the ovarian function, reduce the number of atresia follicles of the ovarian and increase the litter birth number of female mice by 1-2, and the spermidine has good animal breeding and livestock raising application prospects.

The invention discloses an application of an overexpression level transfer gene GlpQ in improving the fertility of male silkworms, and the nucleotide sequence of the GlpQ is shown as SEQ ID NO.3. After the GlpQ1 gene is overexpressed, the reproductive activity of the male silkworms is obviously enhanced, the number of female silkworms capable of mating with each male silkworm on average is obviously increased, and the reproductive activity of the male silkworms is obviously improved. Correspondingly, the number of female silkworms capable of being fertilized by the male silkworms is also obviously increased, the testis development process can be promoted, the gene may act on the testis outer membrane to promote the increase of the testis volume and act on the seminal vesicle to promote sperm formation, and therefore the gene can be used for the fertility of the male silkworms.

The invention provides an application of NUCB1 in reproductive capacity diagnosis and assisted reproductive evaluation, and particularly provides an application of an NUCB1 gene, mRNA, cDNA, protein or a detection reagent thereof. The invention finds for the first time that (1) the reproductive capacity of a mouse with NUCB1 gene deletion is lost or obviously reduced no matter whether the mouse is male or female; (2) during assisted reproduction, the superovulation capacity of the female rats is obviously reduced; therefore, the NUCB1 gene or the protein thereof can be (i) used as a marker for detecting and diagnosing reproductive capacity and (ii) used as a marker for judging female superovulation potential during assisted reproduction.

Disclosed are systems, devices, and methods for detecting characteristics of an unhatched egg. A set of images of an unhatched egg are obtained, where each of the spectral images is obtained in a particular wavelength range. The set of images is processed to extract image features, where the image features includes an image texture feature. The extracted image features are processed to classify the unhatched egg according to at least one characteristic. The at least one characteristic may include fertility and / or gender.

This invention discloses a method for constructing a fast-growing, sterile zebrafish model, belonging to the field of fish animal model preparation technology. This invention is the first to discover the role of the CK gene in regulating fish growth rate and fertility: fish with simultaneous knockout of ck1 and ck2 genes exhibit rapid growth and gonadal abortion. Using the method provided by this invention, a fast-growing, sterile zebrafish model was successfully constructed. These zebrafish exhibited gonadal dysplasia and sterility, but also rapid growth. Compared to wild-type zebrafish, the 4-month-old double mutant zebrafish showed significantly increased body length and weight. The disclosed gene function and zebrafish model construction method can be used for breeding fast-growing, sterile fish varieties and studying related mechanisms, which is of great significance for improving the economic benefits of aquaculture and protecting ecological security.

The invention discloses a multifunctional double-layer pig breeding device, and relates to the technical field of livestock breeding, the multifunctional double-layer pig breeding device comprises a base, the top of the base is fixedly provided with a support frame, the top of the base is fixedly provided with a guardrail, the front part of the guardrail is rotatably provided with a protective door, and the top of the base is fixedly provided with a feeding box; an automatic feeding device is arranged at the top of the feeding box, and a pushing device is arranged at the top of the automatic feeding device; by ensuring that feed is not deficient, sufficient nutrition needed by livestock can be provided, the livestock can be helped to obtain sufficient energy, protein, vitamins and mineral substances, healthy growth is promoted, meanwhile, the sufficient nutrition is crucial to the reproductive capacity of the livestock, especially the fertility of female livestock, and the livestock can be prevented from being damaged. Good feeding management can increase the pregnancy rate of female animals and the survival rate of fetuses and ensure the health of newborn animals.

The invention discloses a method for evaluating damage of ionizing radiation to male sperm quality, which belongs to the technical field of reproductive biology, and comprises the following steps: establishing a dose-effect database model between ionizing radiation dose and male sperm quality based on a logistic regression model, determining a mapping relation between sperm quality rating and fertility recovery average time; collecting a to-be-detected semen sample exposed by ionizing radiation, comparing the to-be-detected semen sample with the dose-effect database model, evaluating the male sperm quality rating, and predicting the fertility recovery time based on the male sperm quality rating and the mapping relation.

The present invention relates to methods of rejuvenating aged oocytes using young somatic cells through the generation of chimeric follicles. The chimeric follicles defined herein may be used to treat infertility or improve fertility in female subjects.

A method for providing assistance in determining the fertility of a female subject according to the present invention comprises a step for generating information for determining the fertility of the female subject by using the proportion of cells in which an X chromosome has been lost in somatic cells collected from the female subject.

The present invention belongs to the field of molecular biology technology and relates to a SNP marker of the FRMD4A gene associated with the teat number trait of Large White pigs, a detection method thereof, and an application thereof. The SNP marker is located on the nucleotide sequence of the FRMD4A gene on pig chromosome 10. The site of the SNP marker is the g.48019215 nucleotide site on pig chromosome 10 in the International Porcine Genome Version 11.1 reference sequence, and has a C / T polymorphism. The SNP marker is significantly associated with the teat number trait. The SNP marker provided by the present invention is associated with the teat number trait of pigs. By identifying the SNP marker, pig strains with a high teat number can be screened. The resulting high-fertility strains with a high teat number have important economic benefits and social value.

The presently disclosed subject matter relates to a system and method for evaluating a. level of fertility of a given animal. The system and method include a processing circuitry configured to: obtain: (i) information relating to estrus events occurring in said given animal during a first period following a calving event, and (ii) information relating to rumination behavior exhibited by said animal during a second period following said calving event; and, based on said information relating to estrus events and said information relating to rumination behavior, evaluate the level of fertility of said given animal.

The present invention relates to the use of vitamin D3, 25-OH-D3 and / or 25-OH-D3 and canthaxanthin to improve fertility in birds, preferably poultry, more preferably laying hens. The invention also relates to a method for improving the fertility of birds. The method comprises a feeding regimen and a feed adaptive to the age of the birds.

The present application relates to the field of agricultural technology, in particular to a plant temperature-sensitive male sterility gene mutant tms17 and application thereof.The nucleotide sequence of the plant temperature-sensitive male sterility gene mutant tms17 comprises the nucleotide sequence shown in SEQ ID NO.1 in the sequence listing.The present application screens a new temperature-sensitive male sterile line tms17 by chemical mutagen ethyl methyl sulfone (EMS) mutagenesis of japonica rice variety ZH11, which is completely sterile at high temperature and fertility is restored at low temperature, and the mechanism of temperature-sensitive fertility restoration is disclosed, which provides a new germplasm resource with application potential for rice two-line hybrid breeding.

Embodiments of the invention comprise a test strip configured to detect one or more metabolites of progesterone in urine, and optionally further detect one or more additional metabolites or hormones in urine within the same test strip. Embodiments of the invention are methods of utilizing such a test strip in association with avoidance of pregnancy, detection of menopause, and in association with fertility planning purposes. Embodiments of the invention are associated with the incorporation of a test strip within a testing kit, optionally further comprising a digital reader.

The present invention is directed to methods and uses of a series of compounds and compositions comprising the same for treating diseases, disorders and / or conditions related to fertility and preserving same and conditions related to same. In some aspects, the compounds and or compositions as herein described promote, improve, recover or restore fertility in a subject in need thereof, including in male and / or female subjects. Such methods / uses include promoting, enhancing or improving fertility-associated cell or tissue yield as part of an in vitro fertilization protocol.

Disclosed are methods and products for improving the quality of sperm, methods for treating subjects to improve sperm quality or improve fertility, and use of sperm with improved quality in assisted reproductive technologies, including exposing the sperm to BGP-15 and / or a derivative thereof, such as BGP-15, propanolol, bimoclomol, arimoclomal, NG94, iroxanadine, and / or a pharmaceutically acceptable derivative, prodrug, solvate, salt, tautomer, stereoisomer, and / or racemate thereof.

The invention discloses a gene BnA09GDSL for regulating and controlling male sterility of brassica napus and application of the gene BnA09GDSL. According to the invention, a novel gene BnA09GDSL for regulating and controlling the male sterility of the brassica napus is identified, a PC3301-BnA09GDSL overexpression vector and a CRISPR-BnA09GDSL gene editing vector are constructed, the gene BnA09GDSL is overexpressed in a male sterility line Bngms1, and the plant fertility is recovered; meanwhile, a CRISPR-BnA09GDSL transgenic plant is obtained, and the transgenic plant has a male sterility phenotype. The BnA09GDSL gene obtained by cloning can regulate and control the fertility of the brassica napus, so that cross breeding is facilitated, and the BnA09GDSL gene has important application value in the field of male sterility breeding of the brassica napus.

The present application belongs to the technical field of genetic propagation, and particularly relates to application of targeted Rbm24a control of fish fertility. Specifically, the present application finds that Rbm24a is a new fish germ plasm component, which plays the function of a germ plasm organizer. Loss of function of the maternal protein will lead to the failure of primordial germ cells to form and exhibit a sterile phenotype, but does not affect the development of other tissues and organs, so that rbm24a is a new target gene for controlling fish fertility. Further, the present application also develops a strategy of inducing degradation of maternal Rbm24a protein by treatment with plant growth hormone, thereby achieving control of fish fertility, and also can produce sterile offspring by inducing degradation of Rbm24a through zGrad. The method is convenient, safe and thorough in controlling fish fertility, and therefore has good practical application value.

Provided herein are methods and compositions comprising pulsatile follicle stimulating hormone (FSH). The pulsatile FSH may be used in methods of treating infertility, restoring normal hormonal levels, stimulating secretion of a sex steroid, treating or preventing fatty tissue accumulation, treating or preventing loss of bone density, preventing ovarian inflammation, and / or promoting metabolic health.