14 results about "Subcutaneous implantation" patented technology

The invention discloses an antihypertensive material for subcutaneous implantation and a preparation method of the antihypertensive material, and belongs to the technical field of biomedical materials. The antihypertensive material comprises a carrier material and a drug mixture loaded on the carrier material according to a mass ratio of (10-15): (5-8), and the carrier material comprises the following raw materials: polylactic acid-glycolic acid copolymer, citric acid-chitosan ester, genipin and a silicon dioxide active material. The silicon dioxide active material is obtained by compounding mesoporous silicon dioxide nanoparticles and a collagen coating on the surface of the mesoporous silicon dioxide nanoparticles. According to the antihypertensive material disclosed by the invention, a degradable skeleton is provided by the polylactic acid-glycolic acid copolymer, citric acid-chitosan ester is used as a toughening agent and an antibacterial material, genipin is used as a cross-linking agent, and a mesoporous structure of a silicon dioxide active material is used for loading a medicine; the problems that an existing subcutaneous implant material is high in burst release rate, poor in mechanical property, insufficient in biocompatibility and the like are solved.

The invention relates to the technical field of animal husbandry, in particular to a synchronous oestrus-timing insemination method suitable for cattle, which comprises the following steps: firstly, performing intramuscular injection of PG (cloprostenol sodium) at different time points after calving to promote uterine recovery and luteolysis and lay a synchronous oestrus foundation; the method comprises the key steps that GnRH (gonadotropin release hormone) is given through intramuscular injection on the 43rd day, the 53rd day, the 60th day and the 69th day, pituitary is promoted to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), collection and screening of follicles are guided, follicle maturation is promoted, the oestrus uncovering rate and the oestrus conception rate are increased, a melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day, and the melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day. The synthesis of ovarian hormones is promoted by regulating the hypothalamus-pituitary-gonad axis, the secretion of follicle cell factors and maturation promoting factors is promoted, the development of granular cells is promoted, and the maturation of oocytes is promoted. According to the method, the pregnancy rate of a double-synchronization-timing insemination scheme which is most widely used in a large-scale dairy cow breeding pasture at present can be remarkably increased, and feasible technical support is provided for success of increasing the breeding efficiency of cows.

Techniques disclosed herein relate to adjustable glucose sensor initialization sequences. In some embodiments, the techniques may involve determining an initial amplitude of one or more voltage pulses of a sequence of voltage pulses applied to a working electrode of the glucose sensor that is at least partially inserted subcutaneously in a patient. The techniques may further involve determining a slope of one or more parameters of the glucose sensor. The techniques may further involve determining an updated amplitude of the one or more voltage pulses based on the slope of the one or more parameters. The techniques may further involve executing an initialization sequence using the one or more voltage pulses having the updated amplitude to the working electrode of the glucose sensor.

An exemplary implantable device and an exemplary method for using the same can be provided. Such exemplary implantable device can comprise a mechanically flexible structure configured for a subdermal implantation, cell reservoirs (i) encased within the mechanically flexible structure, and (ii) configured to house engineered cells for secreting therapeutic peptides therein, integrated circuit (IC) chips including sensing and actuating arrays configured to provide temporal-controlled and dose-controlled release of the peptides, and wireless communication components configured to facilitate a wireless data transmission and a wireless charging of the implantable medical device.

Tri -partite devices, kits, and methods (e.g., pull techniques) for subcutaneous implantation of a therapeutic pellet within pre-determined sites in a subject in need thereof are provided. The tri-partite devices are atraumatic devices comprising a cannula barrel, a unitary medication loading system, and a detachable and retractable obturator with or without a coated tip.

The invention relates to the field of medicine, namely to biosensor analytical devices (biosensors) and can be used for continuous minimally invasive determination of blood glucose content. An electrode system for a device for quantitative analysis of blood glucose content comprises a reference electrode (6), an auxiliary electrode (5) and a working electrode (1) a surface of which is modified by a composite material containing a matrix (2) with chitosan covalently linked to an electron transport mediator, and inclusions of the glucose oxidase enzyme (3) placed in said matrix (2), wherein the matrix (2) of the composite material is chitosan-based, the surface of the working electrode (1) with the composite material is covered with a protective diffusion membrane (4), and the electrode system is designed for subcutaneous placement. The technical effect of the invention is to provide minimally invasive continuous determination of blood glucose concentrations within the range of 1.5 to 48 mM.

A system comprises one or more implantable monitoring devices configured to continuously sense a plurality of physiological signals of a subject and collect parameter data of the subject based on the sensed physiological signals. At least one monitoring device of the one or more monitoring devices comprises a housing configured for subcutaneous implantation in the subject and a plurality of electrodes positioned on the housing. The at least one monitoring device is configured to continuously sense at least one physiological signal of the plurality of physiological signals via the plurality of electrodes. The system further comprises processing circuitry configured to determine a mental state of the subject based on at least one of the sensed physiological signals or the parameter data.

A hair implant includes: (a) a hair strand anchor including: an anchor body; at least one hair chamber disposed within the anchor body; and at least one tunnel through the anchor body, where the tunnel is free of a hair; and (b) at least one hair strand having a portion thereof retained in the at least one of the hair chamber; wherein the tunnel is configured to support collagen ligature growth after subcutaneous implantation by receiving and retaining collagen ligatures that anchor the hair implant to a hair implant recipient. Also disclosed is a hair implant including an anchor with first and second anchor bodies and at least one bridge connecting the anchor bodies and bridging at least one void between the anchor bodies, wherein the bridge supports and retains collagen ligature growth. One-piece implants are also disclosed, as are anchors, hair restoration and manufacturing methods.

The invention relates to a method for testing the biological efficiency of a pure magnesium material, which comprises the following steps of: selecting a pure magnesium plate with the thickness of 0.2-0.3 mm, preparing a magnesium patch with the thickness of 0.3 mm, a 3mm * 3mm grid and the porosity of 40%, and testing the in-vitro biocompatibility, the in-vivo biomechanics and the in-vivo biological activity of the magnesium patch. The method comprises the following steps: co-culturing a magnesium patch leaching solution and human dermal fibroblasts in vitro, evaluating cytotoxicity through CCK8, detecting cell morphology through Calcein-AM / PI double staining, and detecting cell cycle and apoptosis through a flow cytometer; in order to evaluate the in-vivo biomechanics of the magnesium patch, a rat subcutaneous implantation test is carried out, and the biodegradability of the degradable magnesium patch is explored; in order to evaluate the in-vivo biological effect of the magnesium patch, a rat abdominal wall defect model is established, the magnesium patch is used for repairing, and TMT protein quantitative detection, differential protein correlation analysis, PCR and western blot are carried out.

Disclosed herein is a system for optical stimulation of a target region in a living body. The system includes one or more probes subcutaneously placed adjacent to the target region connected to a microdevice subcutaneously placed in the living body. Each probe includes a biocompatible elastic strip, a flexible-length wire inside the elastic strip, and a plurality of light emitting elements mounted along the wire. The microdevice includes a processing unit connected to one or more light drivers coupled to the plurality of light emitting elements delivering light thereto. The processing unit includes a memory and a processor executing instructions stored in the memory to perform a method of optically stimulating cells of the target region by delivering a light beam with a predetermined set of characteristics to at least one light emitting element utilizing at least one light driver.

To provide an administering device capable of administering a medical instrument to a host while its manipulation is simple.SOLUTION: An administering device (1000) for administering a medical instrument (800) to a host comprises a housing, an auxiliary mechanism, and a drive mechanism. The housing comprises a first holding part, a proximal end close to the host in manipulation, and a distal end far from the host in manipulation. The auxiliary mechanism comprises: a motion body held by the first holding part releasably and arranged movably relative to the housing in release; a housing part; and a puncture member. The drive mechanism is arranged to act on the motion body toward the proximal end. When the motion body is released by the first holding part, the motion body is driven by the drive mechanism toward the proximal end to arrange the medical instrument housed in the housing part under the skin of the host via the puncture member.SELECTED DRAWING: Figure 1

The present invention provides a multi-layer hybrid coating with a biomimetic cell membrane structure and a preparation method thereof. For the first time, by mimicking the cell membrane structure, the hydrophobicity and bioactivity are organically combined in the same coating, solving the problems of poor tissue integration and osteogenesis performance of traditional organic hydrophobic coatings. Moreover, a transition layer mainly composed of MgF2 is used to enhance the interfacial bonding force between the coating and the magnesium substrate, improving the mechanical stability of the coating and the reliability during long-term use. And through the verification of subcutaneous implantation experiments in rats, it is proved that the coating has excellent in vivo corrosion resistance and biocompatibility, can effectively inhibit the in vivo corrosion of magnesium-based materials, and has good tissue binding potential. In summary, the multi-layer hybrid coating with a biomimetic cell membrane structure and the preparation method thereof proposed by the present invention can not only inhibit the biological corrosion of magnesium, but also have the potential to promote bone bonding and generation, especially in the fields of orthopedics and dental restoration, etc., and has broad application prospects.

A vagus nerve stimulation system for mammals includes signal generating, conditioning, and control electronics, stimulation monitoring electronics, and a collar coupling apparatus configured for coupling energy emitters anatomically proximal to the cervical branch of the vagus nerve. Collar coupling apparatus includes multiple, position-stabilizing anti-rotation bodies, at least one position verification indicator, and a movable car housing energy emitter circuits or an inductive energy transducer. Two energy modalities are available via electrodes for electrical stimulation and induction-powered haptic emitters for vibrational stimulation. In an advanced configuration, a stimulation transducer produces inductive energy transmitted to an energy receiver-emitter package percutaneously introduced in the subcutaneous layer proximal to the vagus nerve target. Subcutaneous energy receiver-emitters include electrical and haptic variants, both having magnetic compositions which enable spatial position matching with external transducers using Hall sensor technology. In the haptic receiver-emitter variant, a magnetic composition produces haptic stimulation via electromagnetic induction from the external transducer. A further configuration includes an RFID tag in the subcutaneously deposited energy receiver-emitter package. A modularized configuration offers selectable, interchangeable energy emitter packages for electric and haptic stimulation. Stimulation control electronics are comprised within an external computerized device having a GUI for user parameterization of stimulation. A closed loop stimulation variant operates according to algorithmic programming incorporating cardiorespiratory sensor feedback and divisional monitoring of autonomic nervous system indicia and sensor actigraphy.

1. The name of the design product: infiltration catheter assembly. 2. The use of the design product: for postoperative subcutaneous implantation, delivery of local anesthetic infiltration analgesia. 3. The design features of the design product: in the overall shape of the product. 4. The picture or photo that best indicates the design features: perspective view.