1295 results about "Primary cell" patented technology

Methods for developing engineered T-cells for immunotherapy that are both non-alloreactive and resistant to immunosuppressive drugs. The present invention relates to methods for modifying T-cells by inactivating both genes encoding target for an immunosuppressive agent and T-cell receptor, in particular genes encoding CD52 and TCR. This method involves the use of specific rare cutting endonucleases, in particular TALE-nucleases (TAL effector endonuclease) and polynucleotides encoding such polypeptides, to precisely target a selection of key genes in T-cells, which are available from donors or from culture of primary cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer and viral infections.

Improved assemblies, systems, and methods provide an implantable pulse generator for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The implantable pulse generator is sized and configured to be implanted subcutaneously in a tissue region. The implantable pulse generator includes an electrically conductive laser welded titanium case. Control circuitry is located within the case, and includes a primary cell or rechargeable power source, a receive coil for receiving an RF magnetic field to recharge the rechargeable power source, and a microcontroller for control of the implantable pulse generator. Improved assemblies, systems, and methods also provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system provides at least one electrically conductive surface, a lead connected to the electrically conductive surface, and an implantable pulse generator electrically connected to the lead.

A cardiac event microrecorder comprising a hermetically sealed housing is shaped and dimensioned to facilitate the subcutaneous implantation of the microrecorder in a human patient by injection through the lumen of a hypodermic needle. The housing comprises a tubular central section of an electrically insulating material, the central section having spaced apart extremities. An electrically conductive sense electrode is secured to and seals each extremity. The housing may have an interior enclosing (1) electrical circuitry for processing, storing and telemetering data representing physiologic information detected by the sense electrodes; (2) a primary cell or rechargeable battery for electrically powering the electrical circuitry; and (3) an inductively couplable charger where a rechargeable battery is used. Also disclosed are a method of subcutaneously implanting a cardiac event recorder in a patient's thoracic region, and a handheld mapping device for determining an optimum location and orientation for the cardiac event microrecorder to be implanted.

The invention provides a channel detection notification method, a channel detection notification system and base stations used when an LTE system works at an unauthorized frequency band. The channel detection notification method includes the steps that the primary cell base station receives RRM measuring results, reported by a terminal, of multiple base stations at the unauthorized frequency band; according to the RRM measuring results of the base stations, the secondary cell base station is selected for the terminal; if it is determined that downlink traffic reaches a set first traffic threshold value, the secondary cell base station is informed to conduct downlink channel detection; if it is determined that uplink traffic reaches a set second traffic threshold value, the secondary cell base station and/or the terminal are/is informed to conduct uplink channel detection. According to the channel detection notification method, channel detection work conducted when the LTE system works at the unauthorized frequency band is managed by the primary cell base station in a united mode, the time delay generated when the secondary cell base station and/or the terminal carry/carries out channel detection can be effectively shortened, accuracy at which channel detection time is judged can be improved, and the resource utilization rate is increased when the LTE system works at the unauthorized frequency band.

Improved assemblies, systems, and methods provide a stimulation system for prosthetic or therapeutic stimulation of muscles, nerves, or central nervous system tissue, or any combination. The stimulation system may include both external and internal components, with an implantable pulse generator sized and configured to be implanted subcutaneously in a tissue region. The implantable pulse generator includes a welded titanium case. Circuitry and hardware adapted for wireless telemetry is located within the case, and includes a primary cell or rechargeable power source, a microcontroller for control of the implantable pulse generator, and a power receiving coil for receiving an RF magnetic field to recharge the rechargeable power source, the power receiving coil having a maximum outside dimension.

An electrochemical cell, particularly an electrochemical cell having a container with a positive polarity. In one embodiment, the cell is a primary cell that includes an electrode assembly having a lithium negative electrode and a positive electrode, preferably comprising iron disulfide. The cell is provided with a spiral wound electrode assembly with a portion of the positive electrode contacting the container. The positive electrode current collector contacts the container in one embodiment. The negative electrode includes an electrically conductive member that electrically contacts a cover of the cell and provides the cover with a negative polarity. In a preferred embodiment, the electrically conductive member makes pressure contact with a portion of the cell cover. A method of manufacturing such a cell is also provided.

Cross-carrier scheduling by sending resource assignment of resources for a Secondary Component carrier, SCC, on the data portion (i.e. on the Physical Downlink Shared Channel, PDSCH) of the PDCCH sent on the Primary Component Carrier, PCC, to the UE. Problem: for reliable Physical Downlink Control Channel, PDCCH, operation, cross-carrier scheduling may be used from the primary cell (primary complement carrier, PCC) to allocate resources for the supplementary complement carrier, SuppCC. However, PDCCH congestion or blocking at the PDCCH may occur. Solution: sending the allocation of resources for the secondary CC, SuppCC, at the data portion (i.e. at the PDSCH part) of the primary complement carrier, PCC. Additional embodiments: blind decoding control information (PDCCH) based on downlink control information, DCI, format type. Search space reconfiguration. Determining physical resource blocks, PRB, allocated to a supplementary component carrier. Reading PDCCH on a supplementary component carrier. Configuring PDCCH. Aggregation level mode change: change an aggregation level mode from a first to a second order.

An apparatus, method and computer program product comprise controlling cellular network based communication in a primary cell on a frequency band related to the cellular network and by using an uplink and downlink configuration specific to the primary cell; controlling communication in a secondary cell on a frequency band related to a television white space channel and by using an uplink and downlink configuration specific to the secondary cell; measuring radio interference on a temporarily set uplink related carrier on the secondary cell based on information on the temporarily set uplink related carrier received on a downlink related carrier on the primary cell; and reporting results of radio interference measurement via the primary cell.

A data transmission method and an apparatus to communicate data on multiple carriers in the mobile communication system are provided. A random access method of a terminal in a mobile communication system including primary and secondary cells operating on multiple carriers according to the present invention includes communicating data after random access in the primary cell, receiving, when the random access is triggered in the secondary cell, information for use in the secondary cell random access from the primary cell, transmitting a preamble in the secondary cell based on the received information, monitoring the primary cell to receive a Random Access Response for the secondary cell, and applying, when the Random Access Response for the secondary cell is received, the information carried in the Random Access Response to the secondary cell in which the preamble has been transmitted.

Methods, systems, and devices are described for dynamic cell mode indication and reporting channel and interference feedback for dormant cells in a carrier aggregation environment. Indicators of cell mode for one or more secondary cells are sent using a transmission mechanism and may configure active or dormant sub-periods within the indicated periods. Indicators of cell mode for a secondary cell may be transmitted on a carrier of the primary cell, or the indicators may be transmitted on carriers of the secondary cell. Dormancy may also be indicated by the presence or absence of a cell mode indicator for predetermined time periods. When CSI measurements occur for a carrier of a dormant cell, the UE may report CSI for the dormant periods, suppress CSI reporting for the dormant periods, adjust a reporting frequency for the dormant periods, or report some types of CSI and not others for the dormant periods.

Systems and methods for managing communication in an unlicensed band of frequencies to supplement communication in a licensed band of frequencies in unlicensed spectrum are disclosed. The management may comprise, for example, monitoring utilization of resources currently available to a first Radio Access Technology (RAT) via at least one of a Primary Cell (PCell) operating in the licensed band, a set of one or more Secondary Cells (SCells) operating in the unlicensed band, or a combination thereof. Based on the utilization, a first SCell among the set of SCells may be configured or de-configured with respect to operation in the unlicensed band.

The present disclosure relates to communication schemes for combining 5G communication systems with IoT technology to support higher data transmission rate as post-4G systems and systems for the same. The present disclosure may be used in intelligent services (e.g., smart home, smart building, smart city, smart car, or connected car, health-care, digital education, retail business, security and safety-related services, etc.) based on the 5G communication technology and IoT-related techniques. According to an embodiment of the present disclosure, a method for transmitting control information in a wireless communication system comprises generating a header including a plurality of MAC subheaders and a medium access control (MAC) control information including a control field indicating whether there are included information related to a power headroom for a primary cell (PCell) and information regarding secondary cells (SCells) reportable to an extended power headroom and transmitting a payload including the MAC control information and the header, wherein the control field indicating activation or deactivation of at least one of the SCells.

The present invention discloses processing methods and processing systems for multi-carrier handover, wherein one of the processing methods comprises: a source base station, determining, according to a obtained supported-carrier-aggregation relationship among cells in an adjacent base station, a target Primary Cell (Pcell) and target Secondary Cell (Scell) (s), and notifying a target base station to which the target Pcell and the target Scell (s) belong; the target base station configuring the target Pcell, the target Scell (s) and a corresponding handover command, and sending the handover command to the source base station; and the source base station forwarding the handover command to a user equipment which, according to the handover command, accomplishes a handover process. The present invention achieves the handover in the multi-carrier system.

RRC signaling is used to configure a user device for N secondary cells SCells on license-exempt channels w; in a frequency hopping channel set W={wi} where i=1,2,...N. Then cross-carrier scheduling is sent on a primary cell PCell to schedule a frequency hopping FH resource block hi on the ith license-exempt channel wi. Based on measurements of at least some of the license-exempt channels wi received from at least the user device, parameters for the frequency hopping are adapted. The FH resource block contains M physical resource blocks, scheduled for the SCell during a FH time interval Tu*L+j by a resource grant sent on a PDCCH of the PCell. In an embodiment the RRC signaling is sent by a micro access node/HeNB on the PCell, the cross carrier scheduling is sent also by the micro access node/HeNB on the PCell, and the PCell lies within an LTE licensed frequency band.

The invention discloses a cell configuration method for changing a primary cell, which are used for realizing the change of the primary cell in a carrier aggregation system. The method comprises the steps that a user equipment (UE) acquires the configuration information of the primary cell and a secondary cell through a primary cell change command; and through the acquired configuration information of the primary cell and the secondary cell and in combination with the reserved configuration information of an original primary cell and an original secondary cell, the UE acquires the configuration information of a target primary cell and a target secondary cell and switches the original primary cell and the original secondary cell to the target primary cell and the target secondary cell. The invention additionally discloses the device for realizing the method.

Embodiments of the invention include methods and compositions for producing standards for noninvasive prenatal genetic diagnostics and for the detection and monitoring of cancer. The compositions can include a plurality of different nucleosomal DNA fragments derived from either primary cells or cell lines and can include one or more synthetic oligonucleotides. The amount of the different nucleosomal DNA fragments can be varied so as to simulate naturally occurring cell free DNA samples obtained from the blood of the pregnant woman or naturally occurring cell free DNA samples obtained from the blood of cancer patients.

Methods for performing change of primary cell during carrier aggregation operation are described. A mobile station (MS) receives a message to change a primary cell and to perform a random access communication with a new primary cell. Upon receiving a random access response message from the new primary cell, the MS starts transmitting a control channel to the new primary cell. In one embodiment, the MS releases the configuration of an uplink control channel and transmits uplink control information through an uplink shared channel. Upon completion of the primary cell change procedure, the MS starts transmission of an uplink control channel to the new primary cell.