13 results about "Biological specimen" patented technology

An electrochemical method for detecting hydrogen peroxide includes providing an electrochemical sensor comprising: a container holding an electrolyte; a coated electrode positioned in the container; and a counter electrode spaced apart from the coated electrode in the container, where the coated electrode includes a conductive substrate and a coating comprising a topological insulator on the conductive substrate. A voltage is applied to the coated electrode and the counter electrode, and a biological specimen is added to the electrolyte to form an analyte solution. Current density is measured. An increase in the current density upon forming the analyte solution indicates presence of hydrogen peroxide in the biological specimen.

Disclosed herein are detectable moieties and detectable conjugates comprising one or more detectable moieties. In some embodiments, the disclosed detectable moieties have a narrow wavelength and are suitable for multiplexing. Also disclosed are methods of labeling one or more targets within a biological specimen using any of the detectable conjugates and / or detectable moieties described herein.

The system can include: a set of incubation modules, a fluid module, a gas module, a sensor module, and a processing system. The method can include incubating a set of biological specimens using the system. The system and / or method can function to incubate (e.g., gestate) a set of biological specimens (e.g., embryos) from a one-cell stage through full development or any range therebetween. The set of biological specimens can optionally be used for therapeutics

The present disclosure relates to a method of controlling an incubator including controlling an environmental condition of an incubation chamber for a first time period, wherein a pH value of media surrounding a biological specimen in a culture dish in the incubation chamber is affected by the environmental condition. The method includes controlling the environmental condition of the incubation chamber for a second time period, wherein the pH value of media surrounding the biological specimen in the culture dish during the second time period is different than the pH value during the first time period.

This invention discloses a high-quality insect crystal specimen model and its preparation method, belonging to the field of biological specimen preparation technology. This invention employs a compound insecticidal solution for rapid insecticidal action, enhances insect biological characteristics through enhanced color enhancement, improves the AB glue formula to improve the refractive index of the resin colloid, and improves the transparency of the crystal specimen. The synergistic effect of ultrasound and oscillation ensures good dispersion of nano-additives in the glue solution, significantly improving transparency and weather resistance. A negative pressure pouring process ensures the cured colloid possesses excellent sensory properties, achieving an overall high-transparency texture. A progressive polishing process is used for fine processing and stress relief, ensuring the finished product has good sensory characteristics and weather resistance. This invention systematically enhances the wing biological characteristics of various winged insect crystal specimen models, solves the problems of air bubble elimination and long-term weather resistance in model making, significantly improves specimen quality and added value, and is suitable for long-term preservation and outdoor exhibition.

This utility model discloses a multifunctional support device for fixing and extracting cryopreserved tissues in a liquid nitrogen tank, relating to the field of biological specimen preservation technology. It mainly consists of a liquid nitrogen tank, limiting guide rails, an outer frame, a tray, and a lifting rod. The liquid nitrogen tank has an insulating layer to reduce liquid nitrogen evaporation; the limiting guide rails are arranged in a rectangular vertical "L" shape to ensure the stability of the outer frame's sliding; the outer frame has partitions dividing the storage chamber, and a locking plate combined with a spring can fix the tray; the lifting rod and sleeve engage through a J-shaped slot and locking protrusion for easy extraction of the outer frame. Furthermore, the outer frame and the outside of the liquid nitrogen tank are respectively equipped with a first and a second electronic tag for convenient sample information management. This device is easy to operate, effectively protects samples, and improves the practicality and safety of liquid nitrogen tanks in biological specimen preservation.

A modular incubator system includes a base module including a base housing, one or more control components supported by the base housing, and one or more connectors coupled to the base housing; a first incubation chamber module located externally to the base housing, coupled to a first connector of the one or more connectors, and comprising a first incubation chamber configured to house a first culture dish containing a first biological specimen; and a second incubation chamber module located externally to the base housing, coupled to the first connector or a second connector of the one or more connectors, and comprising a second incubation chamber configured to house a second culture dish containing a second biological specimen, wherein the first and second incubation chamber modules are movable with respect to each other and with respect to the base housing. Methods include arranging the chamber modules with respect to each other.

The present application incorporates high-hardness boron carbide into pure polytetrafluoroethylene coating to improve the overall hardness. Studies have shown that as the mass fraction of boron carbide doping gradually increases, the biocompatibility of the composite coating is slightly improved and then continuously reduced; the coating hardness is continuously improved as a whole, however, excessive doping amount will greatly deteriorate the biocompatibility, which is not suitable for clinical tumor tissue contact use. Therefore, the doping amount of boron carbide in the composite coating should be controlled at 3.1% to 10.7%.

The application discloses a detection method and a kit based on a one-needle puncture sample. The detection method based on the one-needle puncture sample comprises the following steps: performing single-nucleus extraction treatment on all the one-needle puncture samples to obtain single-nucleus samples; taking a part of the single-nucleus samples for single-nucleus acid detection; directly using the remaining single-nucleus samples for whole-transcriptome detection and / or whole-genome detection; or, freezing the remaining single-nucleus samples for the whole-transcriptome detection and / or the whole-genome detection. The detection method based on the one-needle puncture sample can realize the detection of two omics simultaneously on the same one-needle puncture tissue, maximizes the utilization rate of the puncture tissue which is a kind of biological sample with a very small sample amount; moreover, the detection method avoids the increase of patient trauma caused by multiple puncture sampling, and avoids the serious heterogeneity problem of two omics data, thereby reducing the difficulty of later multi-omics analysis.

Provided is a picking device (1) comprising: a housing tray (2) in which a housing recess capable of housing a first liquid containing a biological specimen is formed in a tray surface (10); a hollow picking section (3) which is disposed above the housing tray and which acquires the biological specimen through an opening that opens at a distal end part; a first illumination optical system (4) which irradiates the housing tray with a first observation light (OL1) from above through the opening from the inside of the picking section; an observation optical system (6) which is disposed below the housing tray and which observes the first observation light transmitted through the housing tray; and a control unit (7) which controls at least the relative positional relationship between the picking section and the housing tray. The control unit controls the positional relationship of the picking section with respect to the housing recess on the basis of the state of convergence of the first observation light observed by the observation optical system.

The invention discloses a biological specimen-based special-type interstitial lung disease association analysis method, which comprises the following steps of: acquiring multi-dimensional omics and pathological characteristic data through a biological specimen omics data mining platform, and realizing characteristic differentiation grouping through a lung interstitial characteristic deep clustering identification algorithm, inputting the grouped data into an interstitial lung disease subtype typing prediction model, completing preliminary typing in combination with clinical phenotypes, capturing a pathological feature dynamic change rule by using a specimen pathological feature time sequence evolution model, integrating clustering, typing and time sequence evolution results through a platform feature fusion module to construct a feature set, and carrying out classification on the feature set; and establishing a parameter mapping relation of each dimension through a correlation analysis module. According to the method, feature input optimization, sequential sequence analysis and multi-dimensional feature efficient fusion are realized, the pertinence and reliability of correlation analysis are comprehensively improved, and technical support is provided for precise diagnosis and treatment of diseases.

The present disclosure provides systems and methods which facilitate the prediction of an estimated time in which one or more fluids will optimally be diffused into a biological specimen, e.g., a tissue sample derived from a human subject. In some embodiments, the present disclosure provides systems and methods which facilitate the prediction of an estimated time until a biological specimen will optimally be fixed with one or more fixatives. In other embodiments, the prediction of a future time at which the biological specimen will be optimally fixed is based on time-of-flight data acquired at a particular point in time during the fixation of the biological specimen that has been deemed sufficiently accurate to predict the time at which the biological specimen will be optimally diffused with fixative.

The application relates to the technical field of biological detection, and particularly discloses a pretreatment method and a detection method for synchronously analyzing polycyclic aromatic hydrocarbons (PAHs) and hydroxyl polycyclic aromatic hydrocarbons (OH-PAHs) in a biological sample. The pretreatment method comprises the following steps: S100, treating the biological sample by using an alkaline hydrolysis method to obtain supernatant containing PPAHs and lower solution; treating the lower solution by using an acid hydrolysis method to obtain supernatant containing OH-PAHs; S200, treating the supernatant containing PPAHs to obtain a to-be-detected solution containing PPAHs; and S300, treating the supernatant containing OH-PAHs to obtain a to-be-detected solution containing OH-PAHs. The detection method comprises the pretreatment method. The application provides a method which is universal for multiple biological samples, can realize synchronous determination of PPAHs and OH-PAHs, and greatly reduces the sample amount and pretreatment cost.