131 results about "Biological specimen" patented technology

The present disclosure provides systems and methods for the generation of a virtually stained image of an unstained biological specimen based on an acquired image of the unstained biological specimen, where the virtually stained image manifests the appearance of the unstained biological specimen as if it were chemically stained with a morphological stain.

The utility model provides a biological specimen storage device, which relates to the technical field of specimen storage and comprises a storage box, a plurality of storage cavities are arranged at the top end of the storage box, an adjusting cavity is arranged at the bottom end of each storage cavity in the storage box, and support frames are arranged on two sides of the lower part of each storage cavity in the adjusting cavity. Through arrangement of a storage cavity, specimens can be stored, two flat plates can be driven to move oppositely through operation of two symmetrical first telescopic rods, so that the planar specimens placed in the storage cavity can be clamped and fixed, and two sets of arc-shaped clamping plates can be driven to move oppositely through operation of two symmetrical second telescopic rods; in addition, the device can drive a screw rod to rotate through operation of a motor, so that all the supporting frames ascend and descend under limiting cooperation of a limiting column and a supporting plate, and therefore the clamped specimens can be driven to move upwards and move out.

To provide a technique for supporting selection of a binding molecule and a labeled molecule to be used in detecting and / or analyzing a target molecule. An information processing apparatus, including:a processing unit configured to calculate, based on a signal derived from a sample including a biological specimen, when using a plurality of different binding molecules labeled by different labeled molecules, reactivity between a target molecule and each of the plurality of different binding molecules,whereinthe signal includes:a first signal group acquired when each of a plurality of different binding molecules having been labeled by a labeled molecule of a same type is reacted with a target molecule, anda second signal group acquired when each of binding molecules of a same type having been labeled by different labeled molecules is reacted with a target molecule.

A modular incubator system includes a base module including a base housing, one or more control components supported by the base housing, and one or more connectors coupled to the base housing; a first incubation chamber module located externally to the base housing, coupled to a first connector of the one or more connectors, and comprising a first incubation chamber configured to house a first culture dish containing a first biological specimen; and a second incubation chamber module located externally to the base housing, coupled to the first connector or a second connector of the one or more connectors, and comprising a second incubation chamber configured to house a second culture dish containing a second biological specimen, wherein the first and second incubation chamber modules are movable with respect to each other and with respect to the base housing. Methods include arranging the chamber modules with respect to each other.

The invention discloses a clinical microbiological examination specimen transfer box, and relates to the technical field of microbiological specimen transfer, the clinical microbiological examination specimen transfer box comprises a transfer box shell, a layered preservation mechanism is arranged in the transfer box shell, the layered preservation mechanism comprises a first motor arranged in the transfer box shell, and the output end of the first motor is provided with a first threaded rod; the side, close to the first motor, of the first threaded rod is in threaded connection with a first temporary storage plate, the side edge of the first temporary storage plate is fixedly connected with a first rack plate, the side edge of the first rack plate is in meshed connection with a first gear, and the side, away from the first rack plate, of the first gear is in meshed connection with a third rack plate. According to the microbiological specimen temporary storage device, different types of microbiological specimens can be respectively stored on the temporary storage plates with different heights, so that the risk of confusion possibly caused when all the specimens are stored on the same horizontal plane is effectively avoided, particularly in a busy medical environment, medical staff can quickly and accurately take the required specimens, and inspection errors caused by negligence are reduced.

Closure devices and kits allow closure of an open-ended container and provide a visible indication of closure torque. The closure device will include an outer cap defining a torque indicator window, an inner cap nested within the outer cap and a torque indicator disc positionally fixed to an upper surface of the inner cap and having at least two different indicia regions angularly adjacent to one another. The outer and inner caps are in mechanical interference fit with one another such that turning movement applied to the closure device allows the outer and inner caps to be turned as a unit and threadably coupled onto a threaded container until the inner cap is frictionally engaged with an edge of the container. Thereafter, continued turning movement of the outer cap relative to the inner cap causes angular displacement of the indicator window relative to the torque indicator to thereby provide a visible indication through the indicator window of an indicia region indicative of sufficient closure torque.

The biological specimen recovery device comprises a handle, a sheathing canal, a containing bag, an opening device and a locking mechanism. The sheathing canal comprises an inner sheathing canal and an outer sheathing canal; the locking mechanism is arranged on the inner sheath tube and / or the outer sheath tube, when the locking mechanism is in a locking state, the outer sheath tube and the opening device do not move relatively, the movement of the outer sheath tube drives the opening device to move, and then the bag opening of the bag body is driven to move. Due to the fact that action linkage can be achieved between the outer sheath tube and the opening device through the locking mechanism, the action of the opening device can be controlled through the action of the outer sheath tube to drive the bag opening to move, and therefore the surgical requirements of the surgical robot can be well met.

To provide an improved device and method for acquiring an aliquot from a liquid-based biological sample such as a Papanicolaou smear test sample, while minimizing the risk of secondary contamination.SOLUTION: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably hold an analytic element, and a specimen transfer device mounted on the tool head, where the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.SELECTED DRAWING: Figure 10

The present invention relates to a kind of hydrogel and application thereof for protecting biological specimens in pathological preparation, and belong to the field of medical hydrogel materials. The hydrogel of the present invention includes: the first precursor liquid contains a polymer that can be chemically cross-linked with formaldehyde, and contains a catalyst for catalyzing the chemical cross-linking reaction of formaldehyde, and the second precursor liquid is a formaldehyde solution; the functional group species contained in the polymer structure in the first precursor liquid is one or more of amino, hydroxyl, and sulfhydryl, and the number of functional groups contained in each molecule is greater than or equal to two; the concentration range of the second precursor liquid is 4% 20%. The hydrogel for protecting biological specimens in pathological preparation of the present invention utilizes the formalin soaking step in the specimen processing process to further cross-link liquid glue, so that it is solidified into a protective layer on the surface of biological tissue, with simple operation, the advantage of rapid gelation, and can reduce the damage of various physical and chemical factors to biological samples in conventional pathological preparation.

The invention discloses a medical examination laboratory microbial specimen efficient inactivation and waste liquid treatment device, and relates to the field of medical examination, the medical examination laboratory microbial specimen efficient inactivation and waste liquid treatment device comprises an inactivation tank, the top of the inactivation tank is movably provided with a tank cover, and the top center of the tank cover is provided with a microbial specimen inlet; a liquid injection pipe fixedly connected to the microorganism sample inlet is arranged below the tank cover, a plurality of groups of flow dividing pipes are fixedly connected to two sides of the liquid injection pipe, and a sealing assembly is arranged at the joint of the tank cover and the inactivation tank. According to the efficient inactivation and waste liquid treatment device for the microbial specimens in the medical examination laboratory, the joint of the inactivation tank and the tank cover can be sealed in the reaction process, the situation that the reaction effect is affected due to heat leakage is effectively avoided, connection between the liquid inlet pipe and the liquid outlet pipe can be simpler and faster, and therefore the assembly efficiency of the device and the waste liquid pipe is improved; and the sealing performance of the joint of the liquid inlet pipe and the liquid outlet pipe can be effectively enhanced, and the problem of waste liquid leakage caused by deformation of a conventional sealing gasket is avoided.

An electrochemical method for detecting hydrogen peroxide includes providing an electrochemical sensor comprising: a container holding an electrolyte; a coated electrode positioned in the container; and a counter electrode spaced apart from the coated electrode in the container, where the coated electrode includes a conductive substrate and a coating comprising a topological insulator on the conductive substrate. A voltage is applied to the coated electrode and the counter electrode, and a biological specimen is added to the electrolyte to form an analyte solution. Current density is measured. An increase in the current density upon forming the analyte solution indicates presence of hydrogen peroxide in the biological specimen.

The disclosure relates to photocleavable crosslinkers that are suitable for preparing photodegradable hydrogels and to methods for volumetric imaging of biological specimens by photochemical sectioning and imaging of photodegradable hydrogels. A photocleavable crosslinker according to the disclosure can include one or more water-soluble hydrocarbon linkers, two or more reactive functional groups such as ethylenically unsaturated groups, and one or more photocleavable groups. A crosslinked hydrogel can be formed between the photocleavable crosslinker and other hydrogel monomers. The crosslinked hydrogel can be used as a matrix immobilize a biological or other sample material in a hydrogel composite. The hydrogel composite and the sample material therein can be volumetric imaged by sequentially and repeatedly optically imaging an image layer of the hydrogel composite and then photochemically sectioning a depolymerization layer of the hydrogel composite.

Disclosed herein are detectable moieties and detectable conjugates comprising one or more detectable moieties. In some embodiments, the disclosed detectable moieties have a narrow wavelength and are suitable for multiplexing. Also disclosed are methods of labeling one or more targets within a biological specimen using any of the detectable conjugates and / or detectable moieties described herein.

A method to assess presence of tumor tissue in a biological specimen resected during surgery / biopsy using the Field Cycling Relaxometry technique, system for carrying out the method of corresponding computer program product for controlling the system.

A method of analyzing images of a biological specimen using a computational model is described, the method including processing a cell image of the biological specimen and a phase contrast image of the biological specimen using the computational model to generate output data. The cell image is a composite of a first brightfield image of the biological specimen at a first focal plane and a second brightfield image of the biological specimen at a second focal plane. The method further includes performing a comparison of the output data and reference data, and improving the computational model based on the comparison of the output data and the reference data. The method further includes thereafter processing additional image pairs according to the computational model to further improve the computational model based on a comparison of additional output data generated by the computational model and additional reference data.

The present teachings generally include techniques for characterizing the health of an animal (e.g., gastrointestinal health) using image analysis (e.g., of a sample of an exudate such as mucus) as a complement, alternative, or a replacement to traditional laboratory analyses of biological specimens. The present teachings may further include techniques for personalizing a health and wellness plan (including, but not limited to, a dietary supplement such as a customized formula based on a health assessment), where such a plan may be based on one or more of the health characterization techniques described herein. The present teachings may also or instead include techniques or plans for continuous care for an animal, e.g., by executing health characterization and heath planning techniques in a cyclical fashion. A personalized supplement system (e.g., using a personalized supplement, personalized dosing device, and personalized packaging) may also or instead be created using the present teachings.

To provide a cryopreservation device with an integrated tracking device chamber.SOLUTION: Provided is an RFID tag as the tracking device which can be placed in the cryopreservation device as part of the procedure for vitrification of a biological specimen. The cryopreservation device maintains its integrity and keeps the RFID tag securely in the chamber at both ambient conditions when the specimen is collected and under liquid nitrogen where the specimen is stored. The cryopreservation device with an integrated tracking device chamber allows for each individual biological sample to have its own tracking device for monitoring during cryogenic storage.SELECTED DRAWING: Figure 2a

The invention discloses a biological specimen interactive keyboard system of modular hardware and a working method thereof, the system is composed of three modules: a specimen integrated keyboard module adopts a special keycap to package an entity biological specimen, and the specimen is used as a physical interface capable of triggering interaction; the multi-modal image acquisition module is fixed above the keyboard through a mechanical bracket, integrates visible light and infrared imaging units, and accurately acquires the characteristics of a specimen; the local processing and interaction control module serves as an off-line intelligent center, a local resource library and a special processing circuit are arranged in the local processing and interaction control module, feature matching and information output are achieved, all the modules cooperatively work through physical connection (such as a USB interface and an HDMI interface), and an independent hardware assembly line is formed. The system has the advantages of high integration, off-line operation, natural and smooth interaction and high reliability, and is suitable for teaching, scientific research, exhibition and other scenes.

1. Name of the product under this design: Microscope (XSP‑1408AW). 2. Purpose of this design: For observing objects, tiny objects, and biological specimens, and for observing specimens with one eye. 3. The key design feature of this product is its shape. 4. The picture or photo that best illustrates the key points of the design: main view.

A system and method for displaying multiple simultaneous views of the same region of a biological tissue sample. A processor executes logic instructions to perform operations such as receiving multiple images of the biological tissue sample, transforming the multiple images to a common reference frame based on metadata associated with each image, and arranging the multiple images into a display pattern for simultaneously viewing different aspects of the imaged biological tissue sample on a display screen. The multiple images are generated by preprocessing the images of the biological tissue sample. Each image shows a view pattern of the same region of the biological tissue sample, and each image includes metadata describing the spatial orientation of the image (such as translation, rotation, and magnification) to bring the multiple images into a common view.

The system can include: a set of incubation modules, a fluid module, a gas module, a sensor module, and a processing system. The method can include incubating a set of biological specimens using the system. The system and / or method can function to incubate (e.g., gestate) a set of biological specimens (e.g., embryos) from a one-cell stage through full development or any range therebetween. The set of biological specimens can optionally be used for therapeutics

The present invention provides an automated system and method for collecting biological samples from liquid sample containers and distributing those samples onto analytical elements such as sample slides, as well as an automated system and method for obtaining aliquots of samples for additional testing. [Solution] An automated system for processing a sample contained in a liquid sample container comprises an automated tool head configured to rotate around a first axis and move along a second axis different from the first axis; an analytical element positioner having an analytical element holder configured to hold an analytical element in a releasable manner; and a sample transfer device mounted on the tool head. The tool head is configured to automatically position the working end of the sample transfer device by either or both rotation of the tool head around the first axis and / or movement of the tool head along the second axis to acquire a sample from a sample container held in a sample container holder and transfer the acquired sample to an analytical element held in an analytical element holder.

The present disclosure relates to a method of controlling an incubator including controlling an environmental condition of an incubation chamber for a first time period, wherein a pH value of media surrounding a biological specimen in a culture dish in the incubation chamber is affected by the environmental condition. The method includes controlling the environmental condition of the incubation chamber for a second time period, wherein the pH value of media surrounding the biological specimen in the culture dish during the second time period is different than the pH value during the first time period.

The invention discloses application of an anti-PCCB antibody in preparation of a sicca syndrome (SS) diagnostic product. The diagnostic product comprises a reagent for detecting the anti-PCCB antibody. It is found that the anti-PCCB antibody in serum and plasma of an SS patient is significantly increased, the sensitivity of the antibody as a biomarker for diagnosing SS is 32.89%, the specificity is 91.82%, and the antibody has significant diagnostic value. The positive rate of the anti-PCCB antibody is 23.08% in patients with negative SS of the anti-SSA antibody, and the positive rate of the anti-PCCB antibody is 34.65% in patients with negative SS of the anti-SSB antibody. In addition, the combination of the anti-PCCB antibody and the anti-SSA antibody / anti-SSB antibody also has a good diagnostic value. The invention also provides a PCCB polypeptide, which can effectively identify the anti-PCCB antibody in a biological specimen of a SS patient, provides more choices for SS diagnosis, and fills the blank of anti-SSA antibody and anti-SSB antibody diagnosis.

The invention relates to the technical field of biological specimen preparation, and discloses a macro fungus three-dimensional dry specimen and a preparation method thereof.The preparation method comprises the steps that lewis acid is adsorbed to fungus cell walls in advance, and catalytic anchor points of interfacial polymerization are constructed; carrying out vacuum infiltration on the fungi by using a composite impregnation liquid containing an organic silicon-acrylate blended monomer and an inert diluent; and finally, at normal temperature, introducing a gaseous catalyst in a pressure pulse manner to initiate in-situ polymerization and curing of the monomer. Macroscopic shrinkage is effectively inhibited through catalytic anchor point guided interface priority polymerization; polymerization heat is taken away by volatilization of the inert diluent, so that natural pigments are protected; and through the forced convection transportation of the pressure pulse, the rapid and uniform permeation of the catalyst to the sample core is realized. The specimen prepared by the method has the characteristics of low volume shrinkage rate, high color retention degree, uniform internal and external curing and excellent mechanical strength, and realizes high-fidelity and permanent preservation of the original form and color of the macro fungi.

The utility model relates to a biological specimen material pool which comprises a pool body, the pool body is provided with a containing cavity, and a pool opening is formed in the upper portion of the pool body. The drain pipe is communicated below the tank body; the tank cover is hinged above the tank body; the driving structure is arranged on the pool body and connected with the pool body, and the driving structure drives the pool cover to cover the pool opening or the pool cover is turned over relative to the pool body to open the pool opening; the blending tank is provided with a first liquid inlet and a second liquid inlet, the first liquid inlet is used for adding a formaldehyde solution into the blending tank, and the second liquid inlet is used for adding water into the blending tank; a communicating pipe is arranged at the bottom of the blending tank, the communicating pipe is communicated with the accommodating cavity of the tank body, and a switch valve is arranged on the communicating pipe; the stirring mechanism is arranged in the blending tank; and after the materials are uniformly blended, the materials enter the accommodating cavity of the tank body through the communicating pipe.

1. The name of this design product: Fluorescence microscope. 2. Purpose of this design product: used for observing fluorescent biological specimens. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1. 5. Other situations that require explanation Other explanations: Part A is marked with transparent material.

Provided herein are systems, methods, and cryoprotective solutions for reversible cryopreservation of biological specimens, whole organs, and whole organisms. Exemplary methods include loading a cryoprotective agent into the biological specimen, cooling the biological specimen to a cryogenic temperature for preservation, storing the biological specimen at a preservation temperature state to preserve the biological specimen, rewarming the biological specimen by increasing a temperature of the biological specimen above the preservation temperature state, and unloading the cryoprotective agent from the biological specimen. The cooling is performed at a first rate to reduce ice formation, substantially homogeneously to reduce propensity for cracking of the preserved biological specimen, and at a first pressure to prevent or reduce ice expansion within the preserved biological specimen. The rewarming is performed at a second rate to reduce ice formation, substantially homogeneously to reduce propensity for cracking, and at a second pressure to prevent or reduce ice expansion.

A computer-implemented method for processing an image, comprising: receiving at least one image of an unsectioned sample; and processing at least the image using a neural network arrangement configured to perform digital staining to obtain a digitally stained histological image of the unsectioned sample. The image of the unsectioned sample is obtained by an imaging system having an excitation light source that provides light to cause the emission of light from one or more substances, such as one or more photoluminescent substances, in the unsectioned sample to image the unsectioned sample.The digitally stained histological image generally corresponds to, or is substantially equivalent to, an image of the non-sectioned specimen that has been chemically stained using one or more chemical stains. The non-sectioned specimen may be an unstained biological specimen with endogenous fluorophores, and the image may be an autofluorescence image of the unstained biological specimen.