82 results about "Biological specimen" patented technology

To provide a technique for supporting selection of a binding molecule and a labeled molecule to be used in detecting and / or analyzing a target molecule. An information processing apparatus, including:a processing unit configured to calculate, based on a signal derived from a sample including a biological specimen, when using a plurality of different binding molecules labeled by different labeled molecules, reactivity between a target molecule and each of the plurality of different binding molecules,whereinthe signal includes:a first signal group acquired when each of a plurality of different binding molecules having been labeled by a labeled molecule of a same type is reacted with a target molecule, anda second signal group acquired when each of binding molecules of a same type having been labeled by different labeled molecules is reacted with a target molecule.

To provide an improved device and method for acquiring an aliquot from a liquid-based biological sample such as a Papanicolaou smear test sample, while minimizing the risk of secondary contamination.SOLUTION: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably hold an analytic element, and a specimen transfer device mounted on the tool head, where the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.SELECTED DRAWING: Figure 10

The invention discloses a medical examination laboratory microbial specimen efficient inactivation and waste liquid treatment device, and relates to the field of medical examination, the medical examination laboratory microbial specimen efficient inactivation and waste liquid treatment device comprises an inactivation tank, the top of the inactivation tank is movably provided with a tank cover, and the top center of the tank cover is provided with a microbial specimen inlet; a liquid injection pipe fixedly connected to the microorganism sample inlet is arranged below the tank cover, a plurality of groups of flow dividing pipes are fixedly connected to two sides of the liquid injection pipe, and a sealing assembly is arranged at the joint of the tank cover and the inactivation tank. According to the efficient inactivation and waste liquid treatment device for the microbial specimens in the medical examination laboratory, the joint of the inactivation tank and the tank cover can be sealed in the reaction process, the situation that the reaction effect is affected due to heat leakage is effectively avoided, connection between the liquid inlet pipe and the liquid outlet pipe can be simpler and faster, and therefore the assembly efficiency of the device and the waste liquid pipe is improved; and the sealing performance of the joint of the liquid inlet pipe and the liquid outlet pipe can be effectively enhanced, and the problem of waste liquid leakage caused by deformation of a conventional sealing gasket is avoided.

An electrochemical method for detecting hydrogen peroxide includes providing an electrochemical sensor comprising: a container holding an electrolyte; a coated electrode positioned in the container; and a counter electrode spaced apart from the coated electrode in the container, where the coated electrode includes a conductive substrate and a coating comprising a topological insulator on the conductive substrate. A voltage is applied to the coated electrode and the counter electrode, and a biological specimen is added to the electrolyte to form an analyte solution. Current density is measured. An increase in the current density upon forming the analyte solution indicates presence of hydrogen peroxide in the biological specimen.

The disclosure relates to photocleavable crosslinkers that are suitable for preparing photodegradable hydrogels and to methods for volumetric imaging of biological specimens by photochemical sectioning and imaging of photodegradable hydrogels. A photocleavable crosslinker according to the disclosure can include one or more water-soluble hydrocarbon linkers, two or more reactive functional groups such as ethylenically unsaturated groups, and one or more photocleavable groups. A crosslinked hydrogel can be formed between the photocleavable crosslinker and other hydrogel monomers. The crosslinked hydrogel can be used as a matrix immobilize a biological or other sample material in a hydrogel composite. The hydrogel composite and the sample material therein can be volumetric imaged by sequentially and repeatedly optically imaging an image layer of the hydrogel composite and then photochemically sectioning a depolymerization layer of the hydrogel composite.

Disclosed herein are detectable moieties and detectable conjugates comprising one or more detectable moieties. In some embodiments, the disclosed detectable moieties have a narrow wavelength and are suitable for multiplexing. Also disclosed are methods of labeling one or more targets within a biological specimen using any of the detectable conjugates and / or detectable moieties described herein.

A method of analyzing images of a biological specimen using a computational model is described, the method including processing a cell image of the biological specimen and a phase contrast image of the biological specimen using the computational model to generate output data. The cell image is a composite of a first brightfield image of the biological specimen at a first focal plane and a second brightfield image of the biological specimen at a second focal plane. The method further includes performing a comparison of the output data and reference data, and improving the computational model based on the comparison of the output data and the reference data. The method further includes thereafter processing additional image pairs according to the computational model to further improve the computational model based on a comparison of additional output data generated by the computational model and additional reference data.

To provide a cryopreservation device with an integrated tracking device chamber.SOLUTION: Provided is an RFID tag as the tracking device which can be placed in the cryopreservation device as part of the procedure for vitrification of a biological specimen. The cryopreservation device maintains its integrity and keeps the RFID tag securely in the chamber at both ambient conditions when the specimen is collected and under liquid nitrogen where the specimen is stored. The cryopreservation device with an integrated tracking device chamber allows for each individual biological sample to have its own tracking device for monitoring during cryogenic storage.SELECTED DRAWING: Figure 2a

The invention discloses a biological specimen interactive keyboard system of modular hardware and a working method thereof, the system is composed of three modules: a specimen integrated keyboard module adopts a special keycap to package an entity biological specimen, and the specimen is used as a physical interface capable of triggering interaction; the multi-modal image acquisition module is fixed above the keyboard through a mechanical bracket, integrates visible light and infrared imaging units, and accurately acquires the characteristics of a specimen; the local processing and interaction control module serves as an off-line intelligent center, a local resource library and a special processing circuit are arranged in the local processing and interaction control module, feature matching and information output are achieved, all the modules cooperatively work through physical connection (such as a USB interface and an HDMI interface), and an independent hardware assembly line is formed. The system has the advantages of high integration, off-line operation, natural and smooth interaction and high reliability, and is suitable for teaching, scientific research, exhibition and other scenes.

The system can include: a set of incubation modules, a fluid module, a gas module, a sensor module, and a processing system. The method can include incubating a set of biological specimens using the system. The system and / or method can function to incubate (e.g., gestate) a set of biological specimens (e.g., embryos) from a one-cell stage through full development or any range therebetween. The set of biological specimens can optionally be used for therapeutics

The present invention provides an automated system and method for collecting biological samples from liquid sample containers and distributing those samples onto analytical elements such as sample slides, as well as an automated system and method for obtaining aliquots of samples for additional testing. [Solution] An automated system for processing a sample contained in a liquid sample container comprises an automated tool head configured to rotate around a first axis and move along a second axis different from the first axis; an analytical element positioner having an analytical element holder configured to hold an analytical element in a releasable manner; and a sample transfer device mounted on the tool head. The tool head is configured to automatically position the working end of the sample transfer device by either or both rotation of the tool head around the first axis and / or movement of the tool head along the second axis to acquire a sample from a sample container held in a sample container holder and transfer the acquired sample to an analytical element held in an analytical element holder.

The present disclosure relates to a method of controlling an incubator including controlling an environmental condition of an incubation chamber for a first time period, wherein a pH value of media surrounding a biological specimen in a culture dish in the incubation chamber is affected by the environmental condition. The method includes controlling the environmental condition of the incubation chamber for a second time period, wherein the pH value of media surrounding the biological specimen in the culture dish during the second time period is different than the pH value during the first time period.

The invention discloses application of an anti-PCCB antibody in preparation of a sicca syndrome (SS) diagnostic product. The diagnostic product comprises a reagent for detecting the anti-PCCB antibody. It is found that the anti-PCCB antibody in serum and plasma of an SS patient is significantly increased, the sensitivity of the antibody as a biomarker for diagnosing SS is 32.89%, the specificity is 91.82%, and the antibody has significant diagnostic value. The positive rate of the anti-PCCB antibody is 23.08% in patients with negative SS of the anti-SSA antibody, and the positive rate of the anti-PCCB antibody is 34.65% in patients with negative SS of the anti-SSB antibody. In addition, the combination of the anti-PCCB antibody and the anti-SSA antibody / anti-SSB antibody also has a good diagnostic value. The invention also provides a PCCB polypeptide, which can effectively identify the anti-PCCB antibody in a biological specimen of a SS patient, provides more choices for SS diagnosis, and fills the blank of anti-SSA antibody and anti-SSB antibody diagnosis.

The invention relates to the technical field of biological specimen preparation, and discloses a macro fungus three-dimensional dry specimen and a preparation method thereof.The preparation method comprises the steps that lewis acid is adsorbed to fungus cell walls in advance, and catalytic anchor points of interfacial polymerization are constructed; carrying out vacuum infiltration on the fungi by using a composite impregnation liquid containing an organic silicon-acrylate blended monomer and an inert diluent; and finally, at normal temperature, introducing a gaseous catalyst in a pressure pulse manner to initiate in-situ polymerization and curing of the monomer. Macroscopic shrinkage is effectively inhibited through catalytic anchor point guided interface priority polymerization; polymerization heat is taken away by volatilization of the inert diluent, so that natural pigments are protected; and through the forced convection transportation of the pressure pulse, the rapid and uniform permeation of the catalyst to the sample core is realized. The specimen prepared by the method has the characteristics of low volume shrinkage rate, high color retention degree, uniform internal and external curing and excellent mechanical strength, and realizes high-fidelity and permanent preservation of the original form and color of the macro fungi.

The utility model relates to a biological specimen material pool which comprises a pool body, the pool body is provided with a containing cavity, and a pool opening is formed in the upper portion of the pool body. The drain pipe is communicated below the tank body; the tank cover is hinged above the tank body; the driving structure is arranged on the pool body and connected with the pool body, and the driving structure drives the pool cover to cover the pool opening or the pool cover is turned over relative to the pool body to open the pool opening; the blending tank is provided with a first liquid inlet and a second liquid inlet, the first liquid inlet is used for adding a formaldehyde solution into the blending tank, and the second liquid inlet is used for adding water into the blending tank; a communicating pipe is arranged at the bottom of the blending tank, the communicating pipe is communicated with the accommodating cavity of the tank body, and a switch valve is arranged on the communicating pipe; the stirring mechanism is arranged in the blending tank; and after the materials are uniformly blended, the materials enter the accommodating cavity of the tank body through the communicating pipe.

Provided herein are systems, methods, and cryoprotective solutions for reversible cryopreservation of biological specimens, whole organs, and whole organisms. Exemplary methods include loading a cryoprotective agent into the biological specimen, cooling the biological specimen to a cryogenic temperature for preservation, storing the biological specimen at a preservation temperature state to preserve the biological specimen, rewarming the biological specimen by increasing a temperature of the biological specimen above the preservation temperature state, and unloading the cryoprotective agent from the biological specimen. The cooling is performed at a first rate to reduce ice formation, substantially homogeneously to reduce propensity for cracking of the preserved biological specimen, and at a first pressure to prevent or reduce ice expansion within the preserved biological specimen. The rewarming is performed at a second rate to reduce ice formation, substantially homogeneously to reduce propensity for cracking, and at a second pressure to prevent or reduce ice expansion.

An improved vitrification method is provided that vitrifies biological materials by rapid drying while preserving proteins and nucleic acids. [Solution] A method for preserving a biological sample includes the steps of preparing a biological sample containing at least one cell, contacting the biological sample with a vitrification medium containing a vitrification agent and a dissolution agent to form a vitrification mixture, and vitrifying the vitrification mixture to produce a storage-stable sample.

This invention discloses a high-quality insect crystal specimen model and its preparation method, belonging to the field of biological specimen preparation technology. This invention employs a compound insecticidal solution for rapid insecticidal action, enhances insect biological characteristics through enhanced color enhancement, improves the AB glue formula to improve the refractive index of the resin colloid, and improves the transparency of the crystal specimen. The synergistic effect of ultrasound and oscillation ensures good dispersion of nano-additives in the glue solution, significantly improving transparency and weather resistance. A negative pressure pouring process ensures the cured colloid possesses excellent sensory properties, achieving an overall high-transparency texture. A progressive polishing process is used for fine processing and stress relief, ensuring the finished product has good sensory characteristics and weather resistance. This invention systematically enhances the wing biological characteristics of various winged insect crystal specimen models, solves the problems of air bubble elimination and long-term weather resistance in model making, significantly improves specimen quality and added value, and is suitable for long-term preservation and outdoor exhibition.

A sample container for culturing a biological sample, an apparatus for its operation, and a microscope are provided. [Solution] The present invention relates to a sample container (1) for culturing a biological sample (9), comprising: a cavity (2) for accommodating a medium (8); at least one access opening (10) for delivering the medium (8) into the cavity (2); and a sample space (3) arranged within the cavity (2) for accommodating the sample (9), the sample space (3) being separated from the rest of the cavity (2) by at least one side wall (4), the at least one side wall (4) having a hole (6) by which the medium (8) present in the cavity (2) can communicate with the sample space (3). The sample container (1) is characterized in that at least one side wall (4) stands on a bottom (5) of the sample space (3), and that the bottom (5) is transparent to wavelengths in at least one wavelength range of visible light, thereby allowing illumination of the sample space (3) and / or detection of detection radiation leaving the sample space (3) through the bottom (5) of the cavity (2). The invention further relates to an apparatus (12) for operating the sample container (1) and to a microscope (17).

The present invention relates to the compositions, methods, and associated devices (1) for the cryopreservation of biological specimens that enables to freeze and thaw the entire specimen by straightforwardly protecting its three-dimensional architecture. The invention comprises compositions including reagents to protect the specimen and preserve the physiological conditions. The methods comprise fewer steps excluding the need for other solutions used in conventional methods. The methods also eliminate stressful steps for biological specimens in conventional methods including harvesting, pipetting, centrifuging, and transferring. With this invention, the entire content of the specimen can be frozen, stored long-term in a single cell culture vessel with one of the associated devices (1) described here, and then thawed while still in the device (1). The biological specimens frozen by that method render high post-thawing viability. Moreover, the invention reduces cryoprotectant-related toxic events, human errors, and contamination risk.

The present invention provides a sterilization system, composition, and method for sterilizing biological specimens using nitric oxide generated in the solution in which the specimens are placed. In some embodiments, the nitric oxide is released from a nitric oxide precursor material that can be formed in situ from a suitable reagent. Advantageously, the sterilization can be carried out at ambient temperature and pressure, using nitric oxide as the sterilizing agent, thereby preserving the biochemical and / or biomechanical properties of the sterilized tissue. Furthermore, this sterilization process does not require specialized equipment, and the sterilization solution can be disposed of after use without adversely impacting the environment.

This utility model discloses a multifunctional support device for fixing and extracting cryopreserved tissues in a liquid nitrogen tank, relating to the field of biological specimen preservation technology. It mainly consists of a liquid nitrogen tank, limiting guide rails, an outer frame, a tray, and a lifting rod. The liquid nitrogen tank has an insulating layer to reduce liquid nitrogen evaporation; the limiting guide rails are arranged in a rectangular vertical "L" shape to ensure the stability of the outer frame's sliding; the outer frame has partitions dividing the storage chamber, and a locking plate combined with a spring can fix the tray; the lifting rod and sleeve engage through a J-shaped slot and locking protrusion for easy extraction of the outer frame. Furthermore, the outer frame and the outside of the liquid nitrogen tank are respectively equipped with a first and a second electronic tag for convenient sample information management. This device is easy to operate, effectively protects samples, and improves the practicality and safety of liquid nitrogen tanks in biological specimen preservation.

The utility model relates to the technical field of biological specimens, and provides a biological specimen transport case which comprises a case body, a transverse plate is arranged on the inner side of the case body, a supporting plate is fixed to the top face of the transverse plate, fixing plates are symmetrically fixed to the top face of the supporting plate, a fixing clamp is fixed to one side wall of the upper end of each fixing plate, and clamping plates are symmetrically arranged above the supporting plate. The clamping plates are located on the two sides of the fixed plate, movable plates are fixed to one side walls of the clamping plates, the lower ends of the movable plates are located on the inner sides of the movable grooves, threaded holes are formed in the lower ends of the movable plates, and the movable grooves are symmetrically formed in the top face of the supporting plate. A test tube is preliminarily fixed through the deformable fixing clamp, then the test tube is clamped through cooperation of the clamping plate and the fixing plate for final fixing, and the distance between the clamping plate and the fixing plate can be adjusted by rotating the screw rod, so that specimens with different sizes are fixed, and the test tube fixing device has very high universality and is convenient to use. And continuous low temperature can be kept through refrigeration of the refrigeration sheet, so that long-distance transportation of the specimens is facilitated.

A modular incubator system includes a base module including a base housing, one or more control components supported by the base housing, and one or more connectors coupled to the base housing; a first incubation chamber module located externally to the base housing, coupled to a first connector of the one or more connectors, and comprising a first incubation chamber configured to house a first culture dish containing a first biological specimen; and a second incubation chamber module located externally to the base housing, coupled to the first connector or a second connector of the one or more connectors, and comprising a second incubation chamber configured to house a second culture dish containing a second biological specimen, wherein the first and second incubation chamber modules are movable with respect to each other and with respect to the base housing. Methods include arranging the chamber modules with respect to each other.

The utility model relates to the technical field of biological specimen preservation, in particular to a temperature control device of a biological living specimen transfer box, which is provided with an outer box body for placing the biological living specimen transfer box. An active temperature control unit and an emergency temperature control unit are arranged in an inner cavity of the outer box body, passive temperature control units used for sealing are arranged on the outer surface and the joint face of the outer box body, and a waterproof touch screen, an audible and visual alarm and an emergency knob used for manually switching a standby mode during power failure are further arranged on the front face of the outer box body. The temperature control precision of the biological living specimen transfer box can be improved; energy consumption is reduced, and the service life of the transfer box is prolonged; self-adaptive temperature adjustment is achieved, and different environment temperature changes are adapted; preparing an emergency temperature control device to deal with emergencies; and the requirement that a constant temperature environment needs to be kept in the transferring process of the biological living specimens is met.

Disclosed is a method for preserving high molecular weight DNA in biological tissue, comprising contacting for a period of time at a temperature the biological tissue with an aqueous solution comprising a compound having the structure:

Instruments and methods of obtaining a three-dimensional image of a biological specimen are described herein. The methods include capturing a first image of a first frame of the specimen using a sensor array. The first frame is an in-focus area of the specimen at a first depth level of the specimen. The specimen is then moved relative to the sensor array in a scanning direction by a predetermined number of rows of pixels. A second image of a second frame of the specimen is captured using the sensor array. The second frame is an in-focus area of the specimen at a second depth level of the specimen. The second depth level is spaced apart from the first depth level in a direction perpendicular to the scanning direction. The first image and the second image are processed to obtain the three-dimensional image of the specimen.

An exemplary embodiment of the present disclosure provides a method of identifying one or more components in a biological material, the method comprising: providing a biological specimen, the biological specimen comprising one or more components; imaging at least a portion of the biological specimen to generate data indicative of a topography of the at least a portion of the biological specimen; and determining, using a machine learning algorithm, based at least in part on the data indicative of a topography of the at least a portion of the biological specimen, an identity of the one or more components of the biological specimen.

The present application incorporates high-hardness boron carbide into pure polytetrafluoroethylene coating to improve the overall hardness. Studies have shown that as the mass fraction of boron carbide doping gradually increases, the biocompatibility of the composite coating is slightly improved and then continuously reduced; the coating hardness is continuously improved as a whole, however, excessive doping amount will greatly deteriorate the biocompatibility, which is not suitable for clinical tumor tissue contact use. Therefore, the doping amount of boron carbide in the composite coating should be controlled at 3.1% to 10.7%.