177 results about "Biological specimen" patented technology

A system and method facilitates transfers of specimen containers (e.g., vials with caps) between storage cassettes and carrier cassettes. The storage cassettes are designed to be stored in cryogenic refrigerators while the carrier cassettes are designed to be temporarily stored in a portable carrier. Identification information is read from wireless transponders carried by the specimen containers. Visual mappings of the positions of the specimen container in the cassettes is provided. Presence and position of the specimen containers in the cassettes is verified, and alerts of inconsistencies provided along with corrective commands. Inventories of specimen container and even specific specimen holders are provided.

The invention relates to the technical field of biological sample information management, and discloses an intelligent management system for vector biological sample information, and the system comprises a daily sample management module which is used for managing the inspection information and disposal information of a vector biological sample; the sample library management module is used for carrying out storage management on the vector biological samples; the specimen museum management module is used for managing information, storage conditions and calling conditions of the vector biological specimens; the data statistics and analysis module is used for completing statistical analysis and report generation of the vector biological sample data; and the intelligent reminding and early warning module is used for controlling regular reminding and storage environment abnormity early warning in the sample library management module. According to the system and the method, the whole-process intelligent management of the vector biological sample information can be realized, the collection, storage, analysis and calling efficiency of the sample information is remarkably improved, and a scientific basis is provided for vector biological prevention and control through multi-dimensional data statistics and trend analysis.

There is provided an optical measurement device including a spectral optical system that disperses fluorescence emitted from a biological specimen, and an image sensor that receives the fluorescence dispersed by the spectral optical system and generates fluorescence information. The image sensor is divided into a plurality of regions that receive different wavelength components of the fluorescence and generate fluorescence information for each of the wavelength components.

The present disclosure provides systems and methods for the generation of a virtually stained image of an unstained biological specimen based on an acquired image of the unstained biological specimen, where the virtually stained image manifests the appearance of the unstained biological specimen as if it were chemically stained with a morphological stain.

An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, a pipettor carried by the tool head, the pipettor having a pipette tip engaging member configured to releasably engage pipette tips, and a supplemental container holder configured for holding a supplemental container, the tool head configured to automatically position the pipette tip engaging member into a position in which an engaged pipette tip is inserted into a sample container held in the sample container holder, and into a position in which an engaged pipette tip is inserted into a supplemental container held in the supplemental container holder, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.

The present disclosure relates to techniques for transforming digital pathology images obtained by different slide scanners into a common format for image analysis. Particularly, aspects of the present disclosure are directed to obtaining a source image of a biological specimen, the source image is generated from a first type of scanner, inputting into a generator model a randomly generated noise vector and a latent feature vector from the source image as input data, generating, by the generator model, a new image based on the input data, inputting into a discriminator model the new image, generating, by the discriminator model, a probability for the new image being authentic or fake, determining whether the new image is authentic or fake based on the generated probability, and outputting the new image when the image is authentic.

An electron paramagnetic resonant (EPR) instrument able to determine chemical properties of a sample using paramagnetic resonance is provided. In one embodiment, the instrument is able to measure the paramagnetic concentration of a wide variety of practical substances, ranging from food and beverages to biological specimens and solid-state electronic materials. The disclosed device can be portable and perform a measurement faster than commonly used techniques to quantify this parameter, including methods that use vibrating sample magnetometers and currently available electron paramagnetic resonance spectrometers.

The utility model provides a biological specimen storage device, which relates to the technical field of specimen storage and comprises a storage box, a plurality of storage cavities are arranged at the top end of the storage box, an adjusting cavity is arranged at the bottom end of each storage cavity in the storage box, and support frames are arranged on two sides of the lower part of each storage cavity in the adjusting cavity. Through arrangement of a storage cavity, specimens can be stored, two flat plates can be driven to move oppositely through operation of two symmetrical first telescopic rods, so that the planar specimens placed in the storage cavity can be clamped and fixed, and two sets of arc-shaped clamping plates can be driven to move oppositely through operation of two symmetrical second telescopic rods; in addition, the device can drive a screw rod to rotate through operation of a motor, so that all the supporting frames ascend and descend under limiting cooperation of a limiting column and a supporting plate, and therefore the clamped specimens can be driven to move upwards and move out.

The invention relates to a stirring rod for extracting a biological sample. The stirring rod sequentially comprises an assembling part, a body part and a tail end part along an extending direction, the assembling part is used for being connected to a rotating assembling head of a biological sample extraction mechanism in a sleeved mode. The body part is formed by integrally extending from the assembling part along the extending direction, and is provided with a peripheral surface and at least one first convex rib structure convexly extending from the peripheral surface; and the tail end part is integrally connected to the body part, is provided with a conical surface which is adjacent to the body part and gradually contracts along the extension direction, is provided with an end surface far away from the body part, and comprises at least one tail end stirring structure which convexly extends from the end surface along the extension direction.

There is provided a biological specimen separation instrument with which a biological specimen can be stably separated into a predetermined component. The biological specimen separation instrument includes an accommodation instrument (1) for accommodating a collected biological specimen, a filter (128) for filtering a predetermined component in the collected biological specimen, and a holding instrument (100) for accommodating the predetermined component filtered by the filter (128), where the holding instrument (100) is configured to be inserted into the accommodation instrument (1), in which the filter (128) is provided on a tip side of the holding instrument (100) in a direction of insertion into the accommodation instrument (1), a sealing member (130) is provided in an outer circumference on the tip side of the holding instrument (100) in the direction of insertion to allow movement in the accommodation instrument (1), in a state of being liquid-tightly brought into contact with an interior wall of the accommodation instrument (1), and the sealing member (130) has a Shore A hardness of 20 or more and 90 or less and has a residual siloxane concentration of 1 wt % or less.

To provide improved devices for use as tissue sample carrier in biopsy procedures in general.SOLUTION: A fluidic device 1 comprises a flow chamber 2 for accommodating a biological specimen on a carrier portion 3, and at least one flow channel 4a, 4b, 4c, 4d fluidly connected to the flow chamber 2. The fluidic device 1 has a layered structure comprising a bottom plate 5, a cover plate 6 and an insert 7 therebetween. The insert 7 comprises the carrier portion 3, and a frame portion surrounding the carrier portion 3, and is elastomeric to enable a biological specimen to be clamped inside an incision in the carrier portion 3.SELECTED DRAWING: Figure 1

To provide a technique for supporting selection of a binding molecule and a labeled molecule to be used in detecting and / or analyzing a target molecule. An information processing apparatus, including:a processing unit configured to calculate, based on a signal derived from a sample including a biological specimen, when using a plurality of different binding molecules labeled by different labeled molecules, reactivity between a target molecule and each of the plurality of different binding molecules,whereinthe signal includes:a first signal group acquired when each of a plurality of different binding molecules having been labeled by a labeled molecule of a same type is reacted with a target molecule, anda second signal group acquired when each of binding molecules of a same type having been labeled by different labeled molecules is reacted with a target molecule.

The utility model relates to the technical field of specimen sampling, and discloses a fecal microorganism specimen collecting device which comprises a main body shaft and a containing part arranged on the side face of the main body shaft. A bucket is arranged at the bottom end of the main body shaft, an adjusting rotating shaft is arranged at the joint of the main body shaft and the bucket, an adjusting rod is arranged on the inner side of the adjusting rotating shaft, a collecting scraper is arranged at the left end of the adjusting rod, and a handle is arranged at the right end of the adjusting rod; and the storage part comprises a positioning shell, a storage rotating shaft is fixedly installed on the left side of the positioning shell and arranged at the bottom end of a main body shaft, and the main body shaft is rotationally installed on the inner side of the storage rotating shaft. According to the fecal microorganism specimen collecting device, an operator can accurately control the amount of collected fecal microorganism specimens through the collecting scraping plate on the adjusting rod, it is ensured that the sample amount collected every time is consistent, and the accuracy and reliability of subsequent experiments or analysis are improved.

A modular incubator system includes a base module including a base housing, one or more control components supported by the base housing, and one or more connectors coupled to the base housing; a first incubation chamber module located externally to the base housing, coupled to a first connector of the one or more connectors, and comprising a first incubation chamber configured to house a first culture dish containing a first biological specimen; and a second incubation chamber module located externally to the base housing, coupled to the first connector or a second connector of the one or more connectors, and comprising a second incubation chamber configured to house a second culture dish containing a second biological specimen, wherein the first and second incubation chamber modules are movable with respect to each other and with respect to the base housing. Methods include arranging the chamber modules with respect to each other.

The invention discloses a clinical microbiological examination specimen transfer box, and relates to the technical field of microbiological specimen transfer, the clinical microbiological examination specimen transfer box comprises a transfer box shell, a layered preservation mechanism is arranged in the transfer box shell, the layered preservation mechanism comprises a first motor arranged in the transfer box shell, and the output end of the first motor is provided with a first threaded rod; the side, close to the first motor, of the first threaded rod is in threaded connection with a first temporary storage plate, the side edge of the first temporary storage plate is fixedly connected with a first rack plate, the side edge of the first rack plate is in meshed connection with a first gear, and the side, away from the first rack plate, of the first gear is in meshed connection with a third rack plate. According to the microbiological specimen temporary storage device, different types of microbiological specimens can be respectively stored on the temporary storage plates with different heights, so that the risk of confusion possibly caused when all the specimens are stored on the same horizontal plane is effectively avoided, particularly in a busy medical environment, medical staff can quickly and accurately take the required specimens, and inspection errors caused by negligence are reduced.

Closure devices and kits allow closure of an open-ended container and provide a visible indication of closure torque. The closure device will include an outer cap defining a torque indicator window, an inner cap nested within the outer cap and a torque indicator disc positionally fixed to an upper surface of the inner cap and having at least two different indicia regions angularly adjacent to one another. The outer and inner caps are in mechanical interference fit with one another such that turning movement applied to the closure device allows the outer and inner caps to be turned as a unit and threadably coupled onto a threaded container until the inner cap is frictionally engaged with an edge of the container. Thereafter, continued turning movement of the outer cap relative to the inner cap causes angular displacement of the indicator window relative to the torque indicator to thereby provide a visible indication through the indicator window of an indicia region indicative of sufficient closure torque.

The biological specimen recovery device comprises a handle, a sheathing canal, a containing bag, an opening device and a locking mechanism. The sheathing canal comprises an inner sheathing canal and an outer sheathing canal; the locking mechanism is arranged on the inner sheath tube and / or the outer sheath tube, when the locking mechanism is in a locking state, the outer sheath tube and the opening device do not move relatively, the movement of the outer sheath tube drives the opening device to move, and then the bag opening of the bag body is driven to move. Due to the fact that action linkage can be achieved between the outer sheath tube and the opening device through the locking mechanism, the action of the opening device can be controlled through the action of the outer sheath tube to drive the bag opening to move, and therefore the surgical requirements of the surgical robot can be well met.

To provide an improved device and method for acquiring an aliquot from a liquid-based biological sample such as a Papanicolaou smear test sample, while minimizing the risk of secondary contamination.SOLUTION: An automated system for processing a sample contained in a liquid sample container includes an automated tool head configured to rotate about a first axis, and to translate along a second axis different than the first axis, an analytic element positioner having an analytic element holder configured to releasably hold an analytic element, and a specimen transfer device mounted on the tool head, where the tool head is configured to automatically position a working end of the specimen transfer device to obtain a specimen from a sample container held in the sample container holder, and to transfer the obtained specimen to an analytic element held by the analytic element holder, respectively, through one or both of rotation of the tool head about the first axis and translation of the tool head along the second axis.SELECTED DRAWING: Figure 10

The present invention relates to a kind of hydrogel and application thereof for protecting biological specimens in pathological preparation, and belong to the field of medical hydrogel materials. The hydrogel of the present invention includes: the first precursor liquid contains a polymer that can be chemically cross-linked with formaldehyde, and contains a catalyst for catalyzing the chemical cross-linking reaction of formaldehyde, and the second precursor liquid is a formaldehyde solution; the functional group species contained in the polymer structure in the first precursor liquid is one or more of amino, hydroxyl, and sulfhydryl, and the number of functional groups contained in each molecule is greater than or equal to two; the concentration range of the second precursor liquid is 4% 20%. The hydrogel for protecting biological specimens in pathological preparation of the present invention utilizes the formalin soaking step in the specimen processing process to further cross-link liquid glue, so that it is solidified into a protective layer on the surface of biological tissue, with simple operation, the advantage of rapid gelation, and can reduce the damage of various physical and chemical factors to biological samples in conventional pathological preparation.

The invention discloses a medical examination laboratory microbial specimen efficient inactivation and waste liquid treatment device, and relates to the field of medical examination, the medical examination laboratory microbial specimen efficient inactivation and waste liquid treatment device comprises an inactivation tank, the top of the inactivation tank is movably provided with a tank cover, and the top center of the tank cover is provided with a microbial specimen inlet; a liquid injection pipe fixedly connected to the microorganism sample inlet is arranged below the tank cover, a plurality of groups of flow dividing pipes are fixedly connected to two sides of the liquid injection pipe, and a sealing assembly is arranged at the joint of the tank cover and the inactivation tank. According to the efficient inactivation and waste liquid treatment device for the microbial specimens in the medical examination laboratory, the joint of the inactivation tank and the tank cover can be sealed in the reaction process, the situation that the reaction effect is affected due to heat leakage is effectively avoided, connection between the liquid inlet pipe and the liquid outlet pipe can be simpler and faster, and therefore the assembly efficiency of the device and the waste liquid pipe is improved; and the sealing performance of the joint of the liquid inlet pipe and the liquid outlet pipe can be effectively enhanced, and the problem of waste liquid leakage caused by deformation of a conventional sealing gasket is avoided.

[Problem] To easily measure intestinal metabolites. [Solution] This quantification method for quantifying a substance contained in a biological specimen includes a step A for preparing a mixed specimen in which a prescribed amount of the aforementioned substance is mixed with a liquid containing an extract obtained by extracting two or more substances including the aforementioned substance from the specimen, a step B for drying and derivatizing the extract and the mixed specimen by the same method to obtain a derivatized substance group, and a step C for detecting the derivatized substance group obtained in step B by using a mass spectrometer.

An electrochemical method for detecting hydrogen peroxide includes providing an electrochemical sensor comprising: a container holding an electrolyte; a coated electrode positioned in the container; and a counter electrode spaced apart from the coated electrode in the container, where the coated electrode includes a conductive substrate and a coating comprising a topological insulator on the conductive substrate. A voltage is applied to the coated electrode and the counter electrode, and a biological specimen is added to the electrolyte to form an analyte solution. Current density is measured. An increase in the current density upon forming the analyte solution indicates presence of hydrogen peroxide in the biological specimen.

A multi-stage extraction device for biological specimens comprises a device body, a first magnetic rod telescopic module and a second magnetic rod telescopic module. The equipment body comprises a base, a plurality of first stirring sleeve group joints, a plurality of second stirring sleeve group joints and a driving motor; the first stirring sleeve assembly joint and the second stirring sleeve assembly joint are rotatably arranged on the base and are used for assembling a plurality of stirring sleeves; and the driving motor is used for driving the first stirring sleeve group joint and the second stirring sleeve group joint to rotate. The first magnetic rod telescopic module is used for controlling the plurality of first magnetic rods to correspondingly penetrate through the first stirring sleeve group joints respectively; and the second magnetic rod telescopic module is used for controlling a plurality of second magnetic rods to correspondingly penetrate through the second stirring sleeve group joints respectively. Wherein the first magnetic rod telescopic module and the second magnetic rod telescopic module operate independently from each other.

A biological specimen of a subject is handled and tracked for a procedure involving that specimen. Prior to initiation of the procedure, a first procedure data structure (PDS) is generated. The first PDS binds an identifier corresponding to the subject with an indicator of a procedure to be performed on the specimen and identifiers of a specimen container and a specimen holder that physically contacts the biological specimen, as well as a scheduled time for the procedure. A schedule of a plurality of PDSs including the first PDS, is displayed on a display device of a graphical user interface. Following initiation of the procedure, the first PDS is updated based on user input, and after the procedure, at least a portion of the first PDS, as updated, is stored in a database in conjunction with other PDSs respectively associated with other completed procedures.

The disclosure relates to photocleavable crosslinkers that are suitable for preparing photodegradable hydrogels and to methods for volumetric imaging of biological specimens by photochemical sectioning and imaging of photodegradable hydrogels. A photocleavable crosslinker according to the disclosure can include one or more water-soluble hydrocarbon linkers, two or more reactive functional groups such as ethylenically unsaturated groups, and one or more photocleavable groups. A crosslinked hydrogel can be formed between the photocleavable crosslinker and other hydrogel monomers. The crosslinked hydrogel can be used as a matrix immobilize a biological or other sample material in a hydrogel composite. The hydrogel composite and the sample material therein can be volumetric imaged by sequentially and repeatedly optically imaging an image layer of the hydrogel composite and then photochemically sectioning a depolymerization layer of the hydrogel composite.

Disclosed herein are detectable moieties and detectable conjugates comprising one or more detectable moieties. In some embodiments, the disclosed detectable moieties have a narrow wavelength and are suitable for multiplexing. Also disclosed are methods of labeling one or more targets within a biological specimen using any of the detectable conjugates and / or detectable moieties described herein.

A method to assess presence of tumor tissue in a biological specimen resected during surgery / biopsy using the Field Cycling Relaxometry technique, system for carrying out the method of corresponding computer program product for controlling the system.

A method of analyzing images of a biological specimen using a computational model is described, the method including processing a cell image of the biological specimen and a phase contrast image of the biological specimen using the computational model to generate output data. The cell image is a composite of a first brightfield image of the biological specimen at a first focal plane and a second brightfield image of the biological specimen at a second focal plane. The method further includes performing a comparison of the output data and reference data, and improving the computational model based on the comparison of the output data and the reference data. The method further includes thereafter processing additional image pairs according to the computational model to further improve the computational model based on a comparison of additional output data generated by the computational model and additional reference data.

To provide an automatic sampler for a liquid chromatography provided with a dilution tank and a dilution pipeline which enhance haemolysis / dilution efficiency in a compact and inexpensive manner.SOLUTION: An automatic sampler for a liquid chromatography is provided with an automatic sampler part which contains an aspirator and an ejector for a biological specimen of an analysis object and cleaning fluid, and a dilution unit. The dilution unit is provided with a dilution block containing a dilution tank, a pump which sucks and discharges a blend of the biological specimen of the analysis object and the cleaning fluid, and a dilution device which fluidly connects the dilution tank and the pump.SELECTED DRAWING: Figure 1