74results about "Laboratory apparatus" patented technology

Using a biosensor including a flow path into which blood containing a target is introduced, an upstream electrode pair disposed in the flow path and having a reagent reacting with the target disposed on either of the electrodes, and a downstream electrode pair disposed at a downstream side of the flow path; the method includes a first detection step of detecting a first introduction of blood as far as the upstream electrode pair; a second detection step of detecting a second introduction of blood as far as the downstream electrode pair; a time measurement step of measuring a time difference from the first introduction to the second introduction; and a measurement step of acquiring the value related to the target based on the time difference by using any two electrodes among the upstream and downstream electrode pair after the second introduction is detected.

A system for plant-mediated synthesis and characterization of vanadium pentoxide (V2O5) nanoparticles, comprising a structurally integrated device configured to perform extraction, reaction, calcination and performance evaluation within a closed automated control loop, wherein the system includes: a basic chassis made of heat-insulated stainless steel, which houses a microcontroller-based central control unit; a bioextract preparation unit fluidically connected to a reactive mixing chamber, the bioextract preparation unit comprising a Soxhlet extractor with a borosilicate condenser, a thermostatically controlled heating jacket and a digital thermocouple to maintain extraction temperatures between 60°C and 70°C; a precursor feed vessel containing an ammonium metavanadate solution with a molarity between 0.1 M and 0.3 M, wherein this vessel is connected to the reaction mixing chamber via an electromagnetically actuated inlet valve and a precision peristaltic pump; a reaction mixing chamber with an inductive heating coil, a magnetic stirrer plate and a temperature and pH monitoring device configured to maintain a uniform reaction temperature of 70±2°C during the precursor-extract interaction; a calcination module consisting of a muffle furnace lined with refractory ceramic material and containing embedded nichrome heating elements controlled by a PID-controlled temperature controller to achieve a heating rate between 5 °C and 10 °C per minute up to a setpoint of 445±5 °C for combustion synthesis; an optical characterization module with integrated UV-VIS spectrometer, Fourier transform infrared analyzer and photoluminescence detector, each optically isolated and electronically connected to the control unit; and a photocatalytic and antibacterial test chamber fluidically connected to the output of the calcination module, the chamber comprising a UV irradiation array, an optical absorption sensor and a temperature-controlled bacterial incubation plate, the central control unit includes a programmable logic controller (PLC) configured to synchronize the operation of all submodules via feedback control loops, which receive data from temperature, pH and optical sensors, thereby automating the synthesis, analysis and testing of V2O5 nanoparticles.

Certain aspects relate to systems and usage techniques for modular lateral flow assay reader devices that can receive a number of different modules having a barcode scanning input device and optional network connectivity capabilities. A barcode scanning module can provide a simple input method that reduces errors compared to manual data entry. A network connectivity module can enable transmission of test results over a public network for standardizing, tracking and electronically connecting test results from assay reader devices located throughout a network. Such devices can programmatically implement a simplified workflow whereby pressing a single button readies the device for imaging, analyzing, and data storage / transmission and, in some implementations, configures the device to operate in one of a plurality of device operation modes.

The present invention relates to a SAW sensor module comprising a cartridge with a sensor chip made of piezoelectric material and at least one SAW sensor formed thereon, and at least one control and readout device for the at least one SAW sensor.According to the invention, the control and readout device has a circuit board on the front of which device coupling electrodes are formed, which are connected to a device connection formed on the circuit board by means of electrical conductors passing through the circuit board, and the cartridge has cartridge coupling electrodes which are capacitively coupled on the one hand to the device coupling electrodes and on the other hand to sensor electrodes of the at least one SAW sensor, wherein at least one magnetic element is formed on the circuit board and the cartridge has at least one metallic and / or magnetic alignment element which aligns itself with the at least one magnetic element.

The present invention relates to a laboratory operation system and method based on experimental process modularization, wherein, according to an execution order of a plurality of job objects generated from a plurality of job scripts in which are recorded the names of a plurality of modules selected by a user from among a plurality of modules, the modules being obtained by grouping a plurality of unit processes performed in a laboratory and modularizing same into respective experimental processes, experimental processes of the plurality of modules are performed for each job object, on the basis of process conditions of the experimental processes of the plurality of modules presented by each job object, thereby enabling the user to have a desired experiment performed automatically without user intervention simply by discriminately selecting some of the plurality of modules.

Presented herein are compositions, systems, and methods related to optical substrates that simultaneous (1) enhance a fluorescence signal emitted by a fluorophore and (2) enhance “contrast” signal that comprises scattered signal intensity over substrate reflectivity at a non-fluorescent wavelength. In certain embodiments, the optical substrate comprises a thin, transparent, dielectric layer. In alternative embodiments, the optical substrate comprises a stack of thin, transparent dielectric layers, for example, that is designed for both specific scattering enhancement and fluorescence enhancement.

Disclosed herein is a method of biosensing nucleic acid analytes in samples, potentially complex biological samples, and the use of such methods in diagnostic applications. Also disclosed herein are diagnostic methods which use a voltametric biosensing device comprising a porous substrate comprising a plurality of channels, wherein at least a portion of the plurality of channels comprise moieties e.g., capture probes, which may be capable of binding with one or more nucleic acid analytes in complex biological samples.

A sensing device for detecting analytes within a package or container is disclosed. The sensing device can include a substrate, one or more electrodes, and an array of sensors disposed on the substrate. The array of sensors can include a plurality of carbon-based sensors coupled to the one or more electrodes. Each sensor can be configured to react with a unique set of analytes in response to an electromagnetic signal received from an external device. In some cases, a first sensor can be functionalized with a first material configured to detect the presence of each analyte of a first set of analytes, and a second sensor can be functionalized with a second material configured to detect the presence of each analyte of a second set of analytes. The second set of analytes can be a subset of the first set of analytes, and the second material can be different than the first material.

The invention relates to a SAW sensor module comprising a cartridge having a sensor chip made of a piezoelectric material and at least one SAW sensor formed thereon, and at least one control and reading device for the at least one SAW sensor. According to the invention, the control and reading device has a device circuit board, on a device circuit board front side of which a device coupling electrode is formed, which is connected to a device connection formed on the device circuit board via an electrical conductor passing through the device circuit board, the device circuit board has a device coupling electrode, and the cartridge has a cartridge coupling electrode which is capacitively coupled to the device coupling electrode on the one hand and to a sensor electrode of the at least one SAW sensor on the other hand, at least one magnetic element being formed on the device circuit board, and the box body is provided with at least one metal and / or magnetic alignment element which is aligned with the at least one magnetic element.

The utility model relates to the technical field of laboratories, and provides a laboratory for outdoor operation, which comprises a bin body and an operation table, the outer side of the bin body is provided with a storage cavity, the bin body is provided with a working window, and the working window is communicated with the storage cavity; the operation table is stored in the storage cavity and comprises a table plate; the table plate can be connected to the edge of the working window to form a workbench. According to the laboratory for outdoor operation, the storage cavity is formed in the outer side of the bin body, the operation table can be directly taken out from the storage cavity, the operation table is connected to the edge of the working window, and then an experiment can be conducted outside the bin body. The operation table is taken out from the storage cavity on the outer side of the bin body without entering the bin body, and operation can be carried out on the workbench after the operation table is installed; and after the operation is completed, the storage cavity can store the operation table and also can store other experimental equipment, so that the experimental equipment is convenient to take and place.

Disclosed herein is a method of biosensing a nucleic acid analyte in a sample, potentially a complex biological sample, and the use of such methods in diagnostic applications. Also disclosed herein are diagnostic methods using voltammetric biosensing devices comprising a porous substrate comprising a plurality of channels wherein at least a portion of the plurality of channels comprises a moiety, such as a capture probe, capable of binding to one or more nucleic acid analytes in a complex biological sample.

The invention relates to a closure cap (2) for a flask-type medical device, comprising: - an elastomeric stopper intended to be inserted into the neck of the flask after it has been filled with a pharmaceutical or chemical product; - a plastic locking cuff surrounding the stopper and intended to be locked under a collar of the flask when the stopper is inserted into the neck; and - a magnetic material (24) secured to or fully or partially integrated into the stopper or the locking cuff.

A liquid injection method of injecting a liquid from a liquid injector to a liquid cartridge including a liquid ejection head that ejects the liquid, a channel that is connected to the liquid ejection head and is capable of supplying the liquid to the liquid ejection head, and an opening portion that is connected to the channel and is provided to be wider than the channel, wherein the channel is a groove, and the liquid is injected from the liquid injector into the liquid cartridge including the channel in which an aspect ratio obtained by dividing a depth of the channel by a width of the channel is six or more. The method includes directly injecting the liquid into the channel.

A system for electrical stimulation of samples, the system including: a plate lid having a plurality of pairs of electrodes, the plate lid being configured to removably couple with a culture plate having a plurality of wells, such that each well of the culture plate receives a pair of the electrodes, the pair of electrodes being at least partially in contact with a sample in the corresponding well; and a connector head having one or more pairs of electrical connectors configured to electrically connect to an electrical stimulator.

The present disclosure provides a container testing equipment, specifically related to the field of analysis and testing, which includes: a conveying mechanism, and a rejection mechanism, a testing mechanism, and a driving mechanism provided on the conveying mechanism; the conveying mechanism for conveying containers to be tested; the rejection mechanism includes a container pushing device and a container holding device disposed opposite each other on both sides of the conveying mechanism, and the container pushing device is used to push the containers to be tested on the conveying mechanism into the container holding device when the working circuit is on. The present disclosure improves the efficiency and accuracy of container testing and greatly reduces the possibility of damage to the analyzing instrument due to over-high containers.

The present disclosure refer to a method for classifying an identification tag on a sample tube containing a sample to be processed in an automated laboratory system having a plurality of laboratory devices (4), the method comprising providing a sample tube (5) having an identification tag (9) and containing a sample (6) to be analyzed . Each of the plurality of laboratory devices (4) is assigned a tag reader device (10) configured to read the identification tag (9) for recognizing identification tag information. The method further comprises, in a classifying device (2): providing a classifying module (8) configured to predict whether the identification tag information can be recognized from measured tag data detected by the tag reader device (10) assigned to the laboratory device and being indicative of characteristics of the identification tag (9); reading the identification tag (9) on the sample tube (5) by a classifying reader device (7), thereby, providing the measured tag data for the identification tag (9) indicative of tag characteristics of the identification tag (9) on the sample tube (5); determining the tag characteristics for the identification tag (9) from the measured tag data; in the classifying module (8), receiving the tag characteristics, and predicting whether the tag reader device (10) of at least one of the plurality of laboratory devices (4) can read the identification tag (9); and providing classification data being (i) first classification data indicative of predicting, by the classifying module (8), the identification tag (9) being readable by the tag reader device (10) of at least one of the plurality of laboratory devices (4); and (ii) second classification data which are different from the first classification data and indicative of predicting, by the classifying module (8), the identification tag (9) being not readable by the tag reader device (10) of at least one of the plurality of laboratory devices (4). Further, an automated laboratory system (1) for processing a sample tube containing a sample for at least one of pre-analytics and sample analysis is provided.

A plate assembly includes a first sample holder for receiving a plurality of samples, wherein the first sample holder is a transparent foil sheet and includes a plurality of cuvettes configured to receive a sample. A sample fixing plate for positioning the samples is placed in the cuvettes, wherein the sample fixing plate includes a plurality of inserts to be inserted into the cuvettes such that per cuvette a chamber is formed between the first sample holder and the inserted sample fixing plate. The chamber ensures the structural integrity of a single sample. At least one slot is formed next to each insert to allow the transmission of light emitted by the light-sheet microscope. The sample fixing plate also includes at least two opposite magnets and a sample holder frame for receiving the sample holder and the sample fixing plate fitted to each other. The sample holder frame has a planar flat sheet, which includes at least one receiving element configured to receive the first sample holder and the sample fixing plate inserted therein, wherein the bottom of the receiving element is made of transparent material. The sample holder frame includes a planar flat edge extending around the circumference of the sheet where the dimensions of said edge enable a scanning unit of a lightsheet microscope to operate continuously.

A carrier for a sample holder includes a frame defining a holding space to receive the sample holder. The frame is configured to enclose the sample holder at least partially on a plurality of sides. The frame is configured to enable visual inspection of at least a sample area of the sample holder. The frame includes at least one handling structure configured to be engaged by a handling device.

The present disclosure provides methods that combine RNA fluorescent in situ sequencing (FISSEQ) with other molecular detection modalities, forming an integrated panomic detection platform. In various embodiments, the present disclosure provides systems and methods to prepare a biological sample to preserve the spatial relationships of biomolecules of interest within the biological sample for FISSEQ detection.

Cartridge for manufacturing a population of cells suitable for formulation as a cellular therapeutic are disclosed herein, along with systems for operating the cartridges and performing methods to generate the population of cells suitable for formulation as a cellular therapeutic. The population of cells suitable for formulation as a cellular therapeutic can be T-cells, including CAR T-cells. The systems and methods can be largely automated.

Analyzers and methods for making and using analyzers are described such as a method in which multiple absorption readings of a liquid assay are obtained by a photodetector using multiple light sources having at least three separate and independent wavelength ranges and with each of the absorption readings taken at a separate instant of time. Using at least one processor and calibration information of the liquid assay, an amount of at least two analytes within the liquid assay using the multiple absorption readings is determined.

Packaging for preservation of biological material, wherein, in use, the packaging is filled with one or more samples of biological material and placed in an apparatus for preserving the biological material such that a heat exchange fluid flows around the packaging, the packaging including: a substantially planar substrate including a leading edge that faces the flow of heat transfer fluid in use, a trailing edge opposing the leading edge, and opposing end edges; one or more wells defined in the substrate, each well being configured to receive a sample of biological material and including: a substantially planar base, a sidewall, a leading portion of the well and an opposing trailing portion of the well; and a sealing layer that is applied to the substrate in use, to enclose the one or more wells and respective samples of biological material contained within the one or more wells.

One aspect of the invention is to provide systems and methods for improving the accuracy of an assay comprising at least one or more parameters each having a random error.

A system for the environmentally friendly synthesis, adsorption testing and characterization of nickel oxide nanoparticles, comprising: a plant extract processing plant configured to extract a phytochemical-rich solution from gooseberry biomass by controlled Soxhlet reflux and continuous water circulation; a pre-reaction and mixing chamber which is operationally connected to the extract preparation unit and is configured to receive metered volumes of the extract and an aqueous nickel nitrate hexahydrate solution, the chamber comprising a temperature-controlled stirrer, a pH probe and a peristaltic feed pump to maintain the homogeneity of the solution and the pH within a predefined range; a microprocessor-controlled calcination and combustion unit connected downstream of the reaction chamber and configured to thermally decompose the reaction mixture into nickel oxide nanoparticles under programmed temperature cycles between 300 °C and 700 °C; a nanoparticle collector and drying system configured to separate, transport and dry the synthesized nanoparticles under inert air circulation at controlled temperature; an adsorption test module with two reaction chambers for simultaneous testing of the adsorption of amaranth dye and hexavalent chromium, each reaction chamber comprising an integrated UV-Vis probe, magnetic stirrer, heating plate and microvalve-controlled reagent inlets for pH modulation; a characterization interface configured to transmit optical and surface data from the nanoparticles via dedicated optical and mechanical coupling ports to analytical instruments such as UV-Vis spectrophotometers, FTIR spectrometers, XRD analyzers, and SEM imaging systems; and a central control and processing unit consisting of a microcontroller configured to receive sensor data from temperature, pH and optical transducers, execute synthesis and adsorption control techniques, calculate adsorption kinetics and output real-time process parameters as well as adsorption efficiency.

A method for surface modification is provided. [Solution] A method is provided for forming a phosphorus-containing layer on a metallic surface, which is a metal surface or a metal oxide surface, the method comprising treating the metallic surface with a phosphoryl halide in the gas phase, wherein the phosphoryl halide forms the phosphorus-containing layer on the metallic surface. In some embodiments, a method is provided for forming a stable surface coating on an oxide surface.

The present disclosure provides methods that combine RNA fluorescent in situ sequencing (FISSEQ) with other molecular detection modalities, forming an integrated panomic detection platform. In various embodiments, the present disclosure provides systems and methods to prepare a biological sample to preserve the spatial relationships of biomolecules of interest within the biological sample for FISSEQ detection.

A position tracking system (112) is disclosed for tracking the relative position between at least two connection modules (114). The position tracking system (112) includes at least one target (118) associated with a first module of the at least two connection modules (114), where the at least one target (118) can be disposed on and / or within the first module of the at least two connection modules (114), and the at least two connection modules (114) are mechanically interacting entities and / or components configured to enable the transfer of an object from one module to the other. The position tracking system (112) also includes at least one position sensor (120) associated with a second module of the at least two connection modules (114), where the position sensor (120) is configured to generate at least one sensor signal according to the relative position between the at least one position sensor (120) and the at least one target (118), and the at least one position sensor (120) can be disposed on and / or within the second module of the at least two connection modules (114). The position tracking system (112) further includes at least one processing unit (122) configured to track the relative position between the connection modules (114) from the at least one sensor signal within at least one plane (124), and at least one additional sensor (140) configured to generate an additional sensor signal according to at least one additional parameter, where the additional sensor (140) is selected from the group consisting of a temperature sensor (142) and / or a humidity sensor, and the processing unit (122) is further configured to consider the at least one additional sensor signal when determining the relative position between the connection modules (114).A monitoring system (110) for monitoring at least two connection modules (114), a method for tracking a relative position between at least two connection modules (114) by using at least one position tracking system (112), and a method for monitoring at least two connection modules (114) by using at least one monitoring system (110) are further disclosed.

The present disclosure generally relates to methods for treating cellulosic or synthetic materials by using bio-based coatings and / or compositions containing blends of glycerides and / or fatty acid salts to provide new and / or improved properties, such as water and oil / grease resistance (also referred to as oleophobic and hydrophobic barrier properties), separately or in combination, and to products obtained by these methods.

Analyzers and methods for making and using analyzers are described such as a method in which multiple absorption readings of a liquid assay are obtained by a photodetector using multiple light sources having at least three separate and independent wavelength ranges and with each of the absorption readings taken at a separate instant of time. Using at least one processor and calibration information of the liquid assay, an amount of at least two analytes within the liquid assay using the multiple absorption readings is determined.