522results about "Laboratory apparatus" patented technology

A device for addressing an electrode array of 2ⁿ lines of an electro-fluidic device, each line having N electrodes (n≦N). The device includes, on each line, n selection electrodes, all of the line selection electrodes being connected to 2n line selection conductors, 2ⁿ⁻¹ line selection electrodes of 2ⁿ⁻¹ lines being connected to each line selection conductor, and selection devices for selecting one or more line selection conductors.

A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component and the clotting and adhesive proteins component are harvested simultaneously from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.

A sensor dispensing instrument adapted to handle a sensor pack containing a plurality of sensors and to perform a test using one of the sensors. The sensor dispensing instrument includes an outer housing and a disk drive mechanism contained therein for rotating the sensor pack and ejecting one of the sensors from the sensor pack and through a sensor opening on the housing. The disk drive mechanism of the sensor dispensing instrument is operated by pressing a button which activates a motor. The motor moves a disk drive pusher in a first direction to rotate the sensor pack, and then moves the disk drive pusher in a second direction to eject a sensor from the sensor cavity and through the sensor opening.

The invention relates to a hand-held analytical device for analyzing a sample, in particular a biological fluid, for a medically significant component, comprising a housing comprising a loading opening for receiving a replaceable cartridge having multiple chambers that may contain analytical consumables, in particular test strips, and each chamber comprising an opening on at least one face of the cartridge and each opening may be sealed by a sealing foil, a removal facility for removing one of the analytical consumables from the cartridge. The removal facility can be used to remove one of the consumables from one of the chambers of the cartridge, in the process of which the opening sealed by the sealing foil is opened. A drive allows the cartridge to be moved in order to position one chamber in a removal position in which a consumable can be removed from the chamber by the removal facility. The invention provides for the hand-held analytical device to comprise a testing facility that can generate a signal containing information regarding whether the opening of one of the chambers is sealed by sealing foil.

This invention describes a device consisting of a micro channel plate, filter, and porous holder for filter, which is substituted by a pure agar block during method performance, and supportive structural elements. The device is intended for rapid detection and/or identification of microorganisms. Microorganisms are trapped by filtration in long (diameter/length=1/10-1/100), cylindrical, parallel, micro-channels that are open from both sides and attached to a filter from one side. A micro channel plate houses a multiplicity of micro channels (possible diameter of each channel=1-30 μm, length 100-1000 μm, and number on centimeter²−100,000-1,000,000). The micro channel plate with cells trapped on the surface of the filter is attached to an agar block impregnated by artificial substrate(s) so that the molecules of the artificial substrates will fill all micro channels. Trapped cells produce colored or fluorescent molecules from artificial substrates. These molecules are collected in the very small volume of a micro channel. The extremely small volume of a micro channel (1/25 million part of milliliter) allows it to collect a detectable concentration of color or fluorescent substances in a very short time (several minutes). Even one cell from a filtrated sample can be detected by the enzyme—artificial substrate method and/or identified by enzyme immunoassay.

The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location.

A label comprises a first area having a first barcode printed thereon and a second area having a second barcode printed thereon. The first barcode is of a first format, the second barcode is of a second format and each barcode encodes at least a subset of identical information. The subset of identical information encoded in the first barcode and the second barcode may include information identifying the patient, the type of sample, or date or time of sampling, or any combination thereof.

An ingestible device is provided. The ingestible device comprises a sink mechanism, for generating net influx of at least one constituent-of-interest present in a gastrointestinal tract of an individual, and a confining mechanism for confining the sink mechanism in a predetermined confinement.

This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.

The present invention is directed novel lateral flow devices for analyzing liquid samples. The devices contain chemical test strips and are useful for testing liquids for physical properties, such as pH, specific gravity, contamination or adulteration, the presence of proteins or blood, and the like. The test strips contain a bibulous material, a filter element, a reagent pad, and in some embodiments also contain a hydrophobic member and a cover. Any fluid can be tested, for example, urine or other body fluids, environmental samples, biological samples, clinical samples, or food and beverage samples.

The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ sequencing of nucleic acids as well as new methods for fluorescent in situ sequencing (FISSEQ) in a new process referred to herein as “expansion sequencing” (ExSEQ).

Automated methods and devices that facilitate iterative staining of biological samples from imaging applications are provided. The methods include the steps of providing a small volume flow cell containing a biological sample, applying a stain to the biological sample, combining at least two precursor reagents to form an activated destaining agent and wherein the activated destaining agent decomposition rate is greater than or similar to the destaining reaction rate, and flowing the destaining agent over the biological sample at a flow rate that is greater than the decomposition rate of the activated destaining agent. The process of staining, combining and flowing may be iteratively repeated. Also disclosed herein are devices for iterative staining of biological samples comprising a flow cell, in fluid communication with a premixer, wherein the volume capacity of the premixer is smaller than about five times the volume capacity of the flow cell.

A mixing system has a single-use container (1) with flexible walls and a mixing device. The mixing device has at least one encapsulated drive (5) and a mixer shaft (3). The drive (5) can be disposed of after use together with the mixer shaft (3) and the single-use container (1). The mixing system can be used in biotechnology and the pharmaceutical industry for mixing liquids, dissolving solids or cultivating cells and microorganisms.

A device for optical examination of biological materials using radiation of a selected wavelength includes a substrate having a first surface and a second surface opposite to the first surface. The first surface includes a dense array of micro-optical elements arranged to provide increased intensity radiation or evanescent radiation. The first surface is in close proximity to the biological material being examined.

This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.

The invention concerns a device for synthesis of radiopharmaceutical products based on chemical reagents contained in bottles, said device comprising several reaction compartments, transfer means between said bottles and said reaction compartments as well as mechanical means acting on said transfer means and enabling to monitor and control mechanically the transfer of chemical reagents. The invention is characterized in that it comprises: a fixed module including at least the mechanical means; a removable and disposable module, essentially in the shape of a support, whereon are arranged the transfer means between said bottles and said reaction compartments, said removable and disposable module not including any mechanical means; and means for securing said removable and disposable module to said fixed module.

A syringe for a fluid comprises a cylinder, a piston portion arranged in the cylinder and slidable on its inside, and an operating means connected to the piston portion for sliding thereof. The operating means projects from a first end of the cylinder and the cylinder has at a second end an inlet and outlet part for said fluid. Moreover a sealing means is connected in a contamination-free manner to the cylinder in the area of the first end thereof and extends into the cylinder to isolate, sealed against contamination, the inside of the cylinder from the environment.

A fluid path system includes a vial containing a frozen pharmaceutical product therein. A dissolution fluid path is also included in the fluid path system, the dissolution fluid path having an output end in fluid communication with the vial and an input end attached to a pressure vessel containing a dissolution medium. A delivery fluid path is also included in the system having a first end hermetically attached to the vial to transport therefrom a mixture of dissolved pharmaceutical product and dissolution medium and a second end connected to a receiving vessel to receive the mixture. A dissolution fluid path valve is positioned between the pressure vessel and the dissolution fluid path to control flow of the dissolution medium, and a delivery fluid path valve is also included in the fluid path system to control flow of the mixture from the delivery fluid path to the receiving vessel.

A container security device comprises a sensor and a local memory configured to store input from the sensor, wherein the device is configured to detect a breach of a container. A container security method comprises the steps of detecting a change in a measurement value inside a container, and indicating a breach if a change in measurement value exceeds a threshold. A method of determining if a container was breached comprises the steps of downloading a log of gathered information, and checking the gathered information for any abnormalities, wherein the gathered information includes at least one sensor measurement taken from the inside of a container. A device for maintaining security of a navigation receiver unit comprises an enclosure, comprising a sensor, a processor, a local memory configured to store input from the sensor, and a navigation receiver unit, wherein the device is configured to detect a breach of the enclosure.