113results about "Laboratory apparatus" patented technology

To provide a novel technique for detaching adherent cells from a solid phase.SOLUTION: A cell manipulation method includes: a step of culturing cells in a liquid; a step of disposing a flow path through which a gas is able to be introduced in the liquid; a step of forming an air bubble at an end portion of the flow path; and a step of attaching the cells to the air bubble.SELECTED DRAWING: Figure 10

The invention essentially relates to a microtome system (200) for cutting sections from a specimen (122), the microtome system (200) comprising: a knife (112) having a knife edge (114), a knife holder (110), a specimen holder (120), an illumination (230), a first actor (260.1), a detector (240), and a controller (250); the knife holder (110) and the specimen holder (120) are moveable relative to one another; the knife holder (110) or the specimen holder (120) is mounted rotatably about a first axis (z'); the first actor is configured to cause a rotation of the knife holder (110) or specimen holder (120) about the first axis); the illumination is configured to illuminate a gap (235) between a front face (124) of the specimen (122) in order to generate a light gap (236), the detector (240) is configured to detect a geometric feature of the light gap (236), the controller is configured to automatically align the knife edge with the front face by controlling the first actor depending on the geometric feature, and / or provide indications to a user depending on the geometric feature on how to manually control the first actor in order to align the knife edge with the front face.

The disclosure provides processes for temperature and pressure controlled cryopreservation of samples by using isochoric systems.

Using a biosensor including a flow path into which blood containing a target is introduced, an upstream electrode pair disposed in the flow path and having a reagent reacting with the target disposed on either of the electrodes, and a downstream electrode pair disposed at a downstream side of the flow path; the method includes a first detection step of detecting a first introduction of blood as far as the upstream electrode pair; a second detection step of detecting a second introduction of blood as far as the downstream electrode pair; a time measurement step of measuring a time difference from the first introduction to the second introduction; and a measurement step of acquiring the value related to the target based on the time difference by using any two electrodes among the upstream and downstream electrode pair after the second introduction is detected.

A system for plant-mediated synthesis and characterization of vanadium pentoxide (V2O5) nanoparticles, comprising a structurally integrated device configured to perform extraction, reaction, calcination and performance evaluation within a closed automated control loop, wherein the system includes: a basic chassis made of heat-insulated stainless steel, which houses a microcontroller-based central control unit; a bioextract preparation unit fluidically connected to a reactive mixing chamber, the bioextract preparation unit comprising a Soxhlet extractor with a borosilicate condenser, a thermostatically controlled heating jacket and a digital thermocouple to maintain extraction temperatures between 60°C and 70°C; a precursor feed vessel containing an ammonium metavanadate solution with a molarity between 0.1 M and 0.3 M, wherein this vessel is connected to the reaction mixing chamber via an electromagnetically actuated inlet valve and a precision peristaltic pump; a reaction mixing chamber with an inductive heating coil, a magnetic stirrer plate and a temperature and pH monitoring device configured to maintain a uniform reaction temperature of 70±2°C during the precursor-extract interaction; a calcination module consisting of a muffle furnace lined with refractory ceramic material and containing embedded nichrome heating elements controlled by a PID-controlled temperature controller to achieve a heating rate between 5 °C and 10 °C per minute up to a setpoint of 445±5 °C for combustion synthesis; an optical characterization module with integrated UV-VIS spectrometer, Fourier transform infrared analyzer and photoluminescence detector, each optically isolated and electronically connected to the control unit; and a photocatalytic and antibacterial test chamber fluidically connected to the output of the calcination module, the chamber comprising a UV irradiation array, an optical absorption sensor and a temperature-controlled bacterial incubation plate, the central control unit includes a programmable logic controller (PLC) configured to synchronize the operation of all submodules via feedback control loops, which receive data from temperature, pH and optical sensors, thereby automating the synthesis, analysis and testing of V2O5 nanoparticles.

An expectorated blood spatter generator includes: a compressed air ejection unit configured to eject compressed air through an air nozzle; and a blood ejection unit having one end connected to the air nozzle and ejecting blood through a blood nozzle by pressure of compressed air being ejected.

Certain aspects relate to systems and usage techniques for modular lateral flow assay reader devices that can receive a number of different modules having a barcode scanning input device and optional network connectivity capabilities. A barcode scanning module can provide a simple input method that reduces errors compared to manual data entry. A network connectivity module can enable transmission of test results over a public network for standardizing, tracking and electronically connecting test results from assay reader devices located throughout a network. Such devices can programmatically implement a simplified workflow whereby pressing a single button readies the device for imaging, analyzing, and data storage / transmission and, in some implementations, configures the device to operate in one of a plurality of device operation modes.

A sensing device for detecting analytes within a package or container is disclosed. The sensing device may include a substrate, one or more electrodes, and a sensor array disposed on the substrate. The sensor array may include a plurality of carbon-based sensors coupled to the one or more electrodes. Each of the sensors may be configured to react with a unique group of analytes in response to an electromagnetic signal received from an external device. In some cases, a first sensor may be functionalized with a first material configured to detect the presence of each analyte in the first group of analytes, and a second sensor may be functionalized with a second material configured to detect the presence of each analyte in the second group of analytes. The second group of analytes may be a subset of the first group of analytes, and the second material may be different from the first material.

The present invention provides a method for sequencing a nucleic acid using an immersion reaction protocol. The immersion reaction protocol comprises sequentially immersing a solid support having nucleic acid molecules immobilized thereon in different reaction containers to realize nucleic acid sequencing.

The present invention relates to a SAW sensor module comprising a cartridge with a sensor chip made of piezoelectric material and at least one SAW sensor formed thereon, and at least one control and readout device for the at least one SAW sensor.According to the invention, the control and readout device has a circuit board on the front of which device coupling electrodes are formed, which are connected to a device connection formed on the circuit board by means of electrical conductors passing through the circuit board, and the cartridge has cartridge coupling electrodes which are capacitively coupled on the one hand to the device coupling electrodes and on the other hand to sensor electrodes of the at least one SAW sensor, wherein at least one magnetic element is formed on the circuit board and the cartridge has at least one metallic and / or magnetic alignment element which aligns itself with the at least one magnetic element.

The present invention relates to a microfluidic chip for cell culture, comprising: an X-direction channel having at least a part extending in an X-direction; a Y-direction channel extending in a vertical direction across the X-direction channel; a Y-positive region channel formed to be in contact with the Y-direction channel in a Y-positive direction; a Y-negative region channel formed to be in contact with the Y-direction channel in a Y-negative direction; a Z-positive region channel formed to be in contact with the Y-direction channel in a Z direction; and a Y-positive direction reservoir surrounding the Y-positive region channel and in contact with the X-direction channel.

The present invention relates to a laboratory operation system and method based on experimental process modularization, wherein, according to an execution order of a plurality of job objects generated from a plurality of job scripts in which are recorded the names of a plurality of modules selected by a user from among a plurality of modules, the modules being obtained by grouping a plurality of unit processes performed in a laboratory and modularizing same into respective experimental processes, experimental processes of the plurality of modules are performed for each job object, on the basis of process conditions of the experimental processes of the plurality of modules presented by each job object, thereby enabling the user to have a desired experiment performed automatically without user intervention simply by discriminately selecting some of the plurality of modules.

Presented herein are compositions, systems, and methods related to optical substrates that simultaneous (1) enhance a fluorescence signal emitted by a fluorophore and (2) enhance “contrast” signal that comprises scattered signal intensity over substrate reflectivity at a non-fluorescent wavelength. In certain embodiments, the optical substrate comprises a thin, transparent, dielectric layer. In alternative embodiments, the optical substrate comprises a stack of thin, transparent dielectric layers, for example, that is designed for both specific scattering enhancement and fluorescence enhancement.

Disclosed herein is a method of biosensing nucleic acid analytes in samples, potentially complex biological samples, and the use of such methods in diagnostic applications. Also disclosed herein are diagnostic methods which use a voltametric biosensing device comprising a porous substrate comprising a plurality of channels, wherein at least a portion of the plurality of channels comprise moieties e.g., capture probes, which may be capable of binding with one or more nucleic acid analytes in complex biological samples.

A sensing device for detecting analytes within a package or container is disclosed. The sensing device can include a substrate, one or more electrodes, and an array of sensors disposed on the substrate. The array of sensors can include a plurality of carbon-based sensors coupled to the one or more electrodes. Each sensor can be configured to react with a unique set of analytes in response to an electromagnetic signal received from an external device. In some cases, a first sensor can be functionalized with a first material configured to detect the presence of each analyte of a first set of analytes, and a second sensor can be functionalized with a second material configured to detect the presence of each analyte of a second set of analytes. The second set of analytes can be a subset of the first set of analytes, and the second material can be different than the first material.

The invention relates to a SAW sensor module comprising a cartridge having a sensor chip made of a piezoelectric material and at least one SAW sensor formed thereon, and at least one control and reading device for the at least one SAW sensor. According to the invention, the control and reading device has a device circuit board, on a device circuit board front side of which a device coupling electrode is formed, which is connected to a device connection formed on the device circuit board via an electrical conductor passing through the device circuit board, the device circuit board has a device coupling electrode, and the cartridge has a cartridge coupling electrode which is capacitively coupled to the device coupling electrode on the one hand and to a sensor electrode of the at least one SAW sensor on the other hand, at least one magnetic element being formed on the device circuit board, and the box body is provided with at least one metal and / or magnetic alignment element which is aligned with the at least one magnetic element.

The utility model relates to the technical field of laboratories, and provides a laboratory for outdoor operation, which comprises a bin body and an operation table, the outer side of the bin body is provided with a storage cavity, the bin body is provided with a working window, and the working window is communicated with the storage cavity; the operation table is stored in the storage cavity and comprises a table plate; the table plate can be connected to the edge of the working window to form a workbench. According to the laboratory for outdoor operation, the storage cavity is formed in the outer side of the bin body, the operation table can be directly taken out from the storage cavity, the operation table is connected to the edge of the working window, and then an experiment can be conducted outside the bin body. The operation table is taken out from the storage cavity on the outer side of the bin body without entering the bin body, and operation can be carried out on the workbench after the operation table is installed; and after the operation is completed, the storage cavity can store the operation table and also can store other experimental equipment, so that the experimental equipment is convenient to take and place.

Disclosed herein is a method of biosensing a nucleic acid analyte in a sample, potentially a complex biological sample, and the use of such methods in diagnostic applications. Also disclosed herein are diagnostic methods using voltammetric biosensing devices comprising a porous substrate comprising a plurality of channels wherein at least a portion of the plurality of channels comprises a moiety, such as a capture probe, capable of binding to one or more nucleic acid analytes in a complex biological sample.

Apparatuses and methods for recovering solid tissue and dislodged cells (“D-cells”) from a biopsy are disclosed herein. In an embodiment, a biopsy container apparatus includes a sample collection container, a basket sieve, and a buffer container. The sample collection container includes a reagent chamber. The basket sieve is configured for removable attachment at least partially within the sample collection container and includes a sieve surface configured to pass the D-cells from the biopsy but not the solid tissue from the biopsy. The buffer container is configured for removable attachment to the sample collection container and includes a buffer chamber.

The present invention provides for methods of using kits and methods for attaching cells to a biosensor surface (5) of a biosensor (4) comprising: providing a cell suspension in a liquid receiving unit (1), wherein the cell suspension forms a surface (7) to the exterior of the liquid receiving unit (1); contacting the biosensor surface (5) with the surface (7) of the cell suspension in the liquid receiving unit (1); and allowing the cells to settle on the biosensor surface (5) by gravity, and allowing the cells to adhere to the biosensor surface (5).

The invention relates to a closure cap (2) for a flask-type medical device, comprising: - an elastomeric stopper intended to be inserted into the neck of the flask after it has been filled with a pharmaceutical or chemical product; - a plastic locking cuff surrounding the stopper and intended to be locked under a collar of the flask when the stopper is inserted into the neck; and - a magnetic material (24) secured to or fully or partially integrated into the stopper or the locking cuff.

To reduce discomfort of a user accompanying an odor of a urine specimen stored in a specimen container.SOLUTION: A specimen processing method processes a urine specimen 90 stored in a specimen container 80 having an opening 81 by a specimen processing device, and includes the steps of: sealing the opening 81 of the specimen container 80 containing the urine specimen 90 by a sealing body; penetrating a sealing body 71 by a suction pipe 32 of the specimen processing device to suck the urine specimen 90 in the specimen container 80; and performing specimen processing relative to the sucked urine specimen 90.SELECTED DRAWING: Figure 7

A liquid injection method of injecting a liquid from a liquid injector to a liquid cartridge including a liquid ejection head that ejects the liquid, a channel that is connected to the liquid ejection head and is capable of supplying the liquid to the liquid ejection head, and an opening portion that is connected to the channel and is provided to be wider than the channel, wherein the channel is a groove, and the liquid is injected from the liquid injector into the liquid cartridge including the channel in which an aspect ratio obtained by dividing a depth of the channel by a width of the channel is six or more. The method includes directly injecting the liquid into the channel.

A system for electrical stimulation of samples, the system including: a plate lid having a plurality of pairs of electrodes, the plate lid being configured to removably couple with a culture plate having a plurality of wells, such that each well of the culture plate receives a pair of the electrodes, the pair of electrodes being at least partially in contact with a sample in the corresponding well; and a connector head having one or more pairs of electrical connectors configured to electrically connect to an electrical stimulator.

A flow cell includes a support and a heteropolymer attached to the support. The heteropolymer includes an acrylamide monomer including an attachment group to react with a functional group attached to a primer, and a monomer including a stimuli-responsive functional group. The monomer including the stimuli-responsive functional group may be pH-responsive, temperature-responsive, saccharide-responsive, nucleophile-responsive, and / or salt-responsive.

The present disclosure provides a container testing equipment, specifically related to the field of analysis and testing, which includes: a conveying mechanism, and a rejection mechanism, a testing mechanism, and a driving mechanism provided on the conveying mechanism; the conveying mechanism for conveying containers to be tested; the rejection mechanism includes a container pushing device and a container holding device disposed opposite each other on both sides of the conveying mechanism, and the container pushing device is used to push the containers to be tested on the conveying mechanism into the container holding device when the working circuit is on. The present disclosure improves the efficiency and accuracy of container testing and greatly reduces the possibility of damage to the analyzing instrument due to over-high containers.

The present disclosure refer to a method for classifying an identification tag on a sample tube containing a sample to be processed in an automated laboratory system having a plurality of laboratory devices (4), the method comprising providing a sample tube (5) having an identification tag (9) and containing a sample (6) to be analyzed . Each of the plurality of laboratory devices (4) is assigned a tag reader device (10) configured to read the identification tag (9) for recognizing identification tag information. The method further comprises, in a classifying device (2): providing a classifying module (8) configured to predict whether the identification tag information can be recognized from measured tag data detected by the tag reader device (10) assigned to the laboratory device and being indicative of characteristics of the identification tag (9); reading the identification tag (9) on the sample tube (5) by a classifying reader device (7), thereby, providing the measured tag data for the identification tag (9) indicative of tag characteristics of the identification tag (9) on the sample tube (5); determining the tag characteristics for the identification tag (9) from the measured tag data; in the classifying module (8), receiving the tag characteristics, and predicting whether the tag reader device (10) of at least one of the plurality of laboratory devices (4) can read the identification tag (9); and providing classification data being (i) first classification data indicative of predicting, by the classifying module (8), the identification tag (9) being readable by the tag reader device (10) of at least one of the plurality of laboratory devices (4); and (ii) second classification data which are different from the first classification data and indicative of predicting, by the classifying module (8), the identification tag (9) being not readable by the tag reader device (10) of at least one of the plurality of laboratory devices (4). Further, an automated laboratory system (1) for processing a sample tube containing a sample for at least one of pre-analytics and sample analysis is provided.

A plate assembly includes a first sample holder for receiving a plurality of samples, wherein the first sample holder is a transparent foil sheet and includes a plurality of cuvettes configured to receive a sample. A sample fixing plate for positioning the samples is placed in the cuvettes, wherein the sample fixing plate includes a plurality of inserts to be inserted into the cuvettes such that per cuvette a chamber is formed between the first sample holder and the inserted sample fixing plate. The chamber ensures the structural integrity of a single sample. At least one slot is formed next to each insert to allow the transmission of light emitted by the light-sheet microscope. The sample fixing plate also includes at least two opposite magnets and a sample holder frame for receiving the sample holder and the sample fixing plate fitted to each other. The sample holder frame has a planar flat sheet, which includes at least one receiving element configured to receive the first sample holder and the sample fixing plate inserted therein, wherein the bottom of the receiving element is made of transparent material. The sample holder frame includes a planar flat edge extending around the circumference of the sheet where the dimensions of said edge enable a scanning unit of a lightsheet microscope to operate continuously.

One aspect of the present invention is to provide a system and method for improving measurement accuracy, which includes at least one or more parameters each having a random error.