1843results about "Burettes/pipettes" patented technology

A bodily-fluid transfer device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

According to an embodiment of the present invention, provided is a dropper cap which can be detached from a container part accommodating contents and which suctions or discharges the contents. The dropper cap comprises; an inner cap which can be detached from the container part; and an outer cap coupled to the inner cap so as to encompass at least a part of the inner cap, wherein the inner cap and the outer cap can be formed from a metal material.

The invention discloses an exosome enrichment microfluidic device based on a synergistic effect. The exosome enrichment microfluidic device comprises a continuous phase injection device, a dispersed phase injection device, a laser, a microfluidic enrichment module, a continuous phase infusion tube, a dispersed phase infusion tube, a continuous phase variable-diameter connecting tube, a dispersed phase variable-diameter connecting tube and a liquid outlet tube. According to the device disclosed by the invention, through a synergistic driving mechanism of a thermophoresis effect, natural convection and thermal capillary convection, the exosome is directionally migrated and efficiently enriched on the surface of the dispersed phase liquid drop, the dispersed phase liquid drop is used as a targeted interface carrier for exosome enrichment, the exosome is stably adsorbed by utilizing interface force, and the enrichment specificity and efficiency are improved.

A microfluidic chip liquid inlet device disclosed by the present invention comprises a bottom plate and supporting legs, a liquid inlet structure is arranged above the bottom plate, the liquid inlet structure comprises a liquid inlet mechanism, a liquid injection mechanism and a feeding mechanism, and the liquid inlet mechanism comprises a first motor, a rotating rod, a mounting plate, a rotating rod and a first bearing plate. The output end of the first motor is connected with the bottom of the rotating rod, the top of the rotating rod is connected with the bottom of the mounting plate, and the bottom of the mounting plate is connected with the top of the rotating rod. According to the invention, micro-fluidic chips with different sizes can be rapidly and conveniently clamped and fixed, and a plurality of micro-fluidic chips can be subjected to liquid feeding work at the same time, so that the problem that the plurality of micro-fluidic chips cannot be rapidly and conveniently used at the same time is solved; and moreover, the problem that the micro-fluidic chips with different sizes cannot be quickly and conveniently clamped and fixed is solved, and the working efficiency of the liquid inlet device is improved.

A high-throughput automated chemical synthesis workstation, relating to the technical field of chemical synthesis. The workstation comprises a base. The base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-throughput chemical reaction module, a pipette tip box, a cover plate, and a liquid storage tank, wherein the negative pressure suction filter and the magnetic stirring reactor can be replaced with other testing instruments; a screw is lap-jointed on the cover plate; a moving device is also mounted on the base, and a tightening assembly, a gripper assembly, and a pipetting assembly are mounted on the moving device; and pipetting is performed by the pipetting assembly, the gripper assembly drives the cover plate to move to the high-throughput chemical reaction module for sealing, and after tightening is performed by the tightening assembly, the gripper assembly drives the sealed module to move to the reactor, thereby achieving real-time observation during remote operation.

The present disclosure provides flow cell devices, systems, and methods for facilitating and performing DNA sequencing analysis with reduced system complexity and cost, significant cost of goods (COGS) savings and reduced contamination levels.

The technology relates in part to a segmented pipette tip adapter that includes a plurality of plate segments and a junction between adjacent plate segments. Each of the plate segments often includes a proximal surface, a distal surface, edges, one or more nozzles disposed on the proximal surface, and one or more tubular projections disposed on the distal surface. Each of the nozzles often includes a nozzle bore, each of the tubular projections often includes a tubular projection bore, each of the plate segments often includes a plate bore disposed at each of the nozzles, and each nozzle bore often is aligned with a tubular projection bore and a plate bore. Each junction often is between adjacent edges of a pair of adjacent plate segments.

The invention provides a liquid drop continuous generation device which comprises a first flow channel and a second flow channel, the first flow channel and the second flow channel comprise first positions which are tightly attached to each other, and each first position comprises a through hole communicating with the first flow channel and the second flow channel; the first flow channel and the second flow channel are used for introducing a first liquid and a second liquid respectively; the special ultrasonic device can act on the first liquid in the first flow channel, when the special ultrasonic device is driven in a first power period, an acoustic beam current facing the through hole is generated in the first liquid, the acoustic beam current enters the second liquid through the through hole, and liquid drops formed by the first liquid are formed in the second liquid. The invention also correspondingly provides a method for continuously generating liquid drops. The liquid drop generation mode is more flexible, the controllability is higher, and the cost is lower.

The invention relates to a high-precision micro-pipetting device and a control method thereof, and the pipetting device, the high-precision micro-pipetting device comprises a control module, a positive pressure system, a negative pressure system, a three-way solenoid valve and a pipetting head, the control module controls the switching of the three-way solenoid valve to enable a micro-control solenoid valve to be communicated with the positive pressure system or the negative pressure system, and the control module controls the opening time of the micro-control solenoid valve; a proportional valve, a pressure sensor and a flow sensor are arranged between the three-way electromagnetic valve and the micro-control electromagnetic valve, the proportional valve is used for adjusting the pressure and the flow of a gas circuit, and the control module conducts PID control on the proportional valve according to measurement data of the pressure sensor and the flow sensor. The positive / negative pressure value and the gas flow rate of the gas circuit are adjusted through the proportional valve, so that the positive / negative pressure at the liquid suction head can be changed, the suction and discharge of samples with different viscosities can be realized, the switching time of the liquid suction head is controlled through the micro-control electromagnetic valve, and the sample amount of each time of pipetting can be accurately controlled.

The invention discloses a self-adaptive pipetting system and method based on multi-mode sensing fusion. The system comprises a PLC (Programmable Logic Controller), a fusion multi-mode sensing module, a high-throughput execution module, a self-adaptive protocol matching module and a man-machine interaction module. According to the invention, through multi-channel cooperation and continuous transmission, the experiment efficiency is greatly improved; multi-modal sensing data are fused, and real-time closed-loop control and dynamic compensation are performed by adopting algorithms such as fuzzy PID (Proportion Integration Differentiation) and the like, so that the pipetting volume precision reaches + / -1%, and the repeatability is improved by 20-30%; a protocol feature library and an intelligent matching algorithm are built in, and experimental parameters can be automatically analyzed, matched and optimized; equipment state and process parameters are monitored in real time, faults and pollution risks are automatically early warned, and the operation safety and reliability are remarkably improved in combination with automatic anti-pollution design; a PLC is deeply fused with a sensing module and a decision module, a sensing-decision-execution intelligent closed loop is constructed, and an accurate and reliable integrated solution is provided for automatic pipetting.

The invention discloses a high-flux automatic chemical synthesis workstation, which relates to the technical field of chemical synthesis, and comprises a base, the base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-flux chemical reaction module, a gun head box, a cover plate and a liquid storage tank, and the negative pressure suction filter and the magnetic stirring reactor can be replaced by other detection instruments. The cover plate is in lap joint with a screw, the base is further provided with a moving device, the moving device is provided with a button assembly, a clamping jaw assembly and a pipetting assembly, the pipetting assembly is used for pipetting, and the clamping jaw assembly drives the cover plate to the high-flux chemical reaction module for sealing. The sealing module is driven to the reactor through the clamping jaw assembly after being fastened through the fastening assembly, and real-time observation can be carried out during remote operation. By means of the technical scheme, it is guaranteed that high-throughput chemical synthesis experiments including pipetting, reaction system sealing, reaction starting, gradient dilution and suction filtration are completed in one work station.

The utility model relates to the technical field of water conservancy projects, and discloses a water conservancy project water quality detection device which comprises a working table, a rotating table is arranged on the upper side of the working table, an L-shaped connecting plate is fixedly connected to the upper surface of the working table, and a water quality detector body is arranged on the surface of the L-shaped connecting plate. The water quality detector body comprises a detection probe arranged on the lower surface of a transverse plate of an L-shaped connecting plate, a positioning groove is formed in the surface of a rotating table, a detection cup can be conveniently placed through the positioning groove, a gear makes contact with a tooth groove through rotation of the rotating table, a sealing plate rotates subsequently, and then the detection cup is exposed; the water quality detection device is simple in structure and convenient to use, subsequent water quality detection is facilitated, the situation that a detected sample is polluted by the external environment is avoided as much as possible, the accuracy of subsequent water quality detection is guaranteed, meanwhile, the situation that the sample in the detection cup is scattered is avoided, the safety of the device is greatly improved, and the quality and effect of subsequent water quality detection are guaranteed. And the practicability is high.

[Problem] To provide a powder supply device and a powder supply method in which surplus powder adhering to a suction measurement tool having a measuring chamber and a suction port can be removed by a simple process. [Solution] This powder supply device 1 comprises: a suction measurement tool 13 connected to a negative pressure source and having a measuring chamber 15, which is partitioned by a filter 14, and a suction port, which is provided at the tip; a nozzle 12 relatively moved by relative movement robots (501, 502, 503); and a powder removal brush 20 having brush bristles 22 extending in a direction crossing the vertical direction. The tip of the suction measurement tool 13 is embedded in the powder in a powder tank 101, and the powder is suctioned into the measuring chamber 15. After the powder is suctioned, surplus powder adhering to the suction measurement tool 13 is removed by relatively moving the suction measurement tool 13 and the brush bristles 22 while elastically deforming the brush bristles 22.

The utility model relates to a non-contact pipetting device. The device comprises a pipetting assembly, a driving assembly and a first valve, the pipetting assembly comprises a base body and a pipetting needle, the base body is provided with an air inlet connector and a pipetting cavity, and the pipetting needle is arranged on the base body and used for being communicated with the pipetting cavity; the driving assembly comprises a piston rod, and the piston rod is inserted into the pipetting cavity; the first valve is arranged on the base body, an inlet of the first valve is used for being communicated with the air inlet connector, and an outlet of the first valve is used for being communicated with the pipetting cavity; the piston rod is used for moving along the pipetting cavity in a direction far away from the pipetting needle when the first valve is closed, so that target liquid enters the pipetting cavity through the pipetting needle; and the gas inlet interface is used for enabling gas generated by the gas source to enter the pipetting cavity through the gas inlet interface when the first valve is opened, so that the target liquid in the pipetting cavity is discharged through the pipetting needle. According to the non-contact pipetting device, a complicated pipeline system is not introduced, so that the pressure path is shortened, the transmission stability of the pressure in the pipetting cavity is improved, and the pipetting precision is further improved.

The utility model provides a sample treatment and detection device provided with a liquid transfer structure, which comprises an upper cover, a lower cover, a liquid transfer structure and a liquid transfer structure, a hollow containing space is formed by the base plate and the upper cover, a plurality of liquid containing spaces are formed in the base plate, a center shaft containing hole is formed in the center of the base plate, and a center shaft is detachably connected into the center shaft containing hole; the upper portion of the liquid transfer assembly penetrates through the center hole to be connected with the power device, and the liquid transfer assembly is driven by the power device to move in the vertical direction with the center shaft as the axis and / or rotate around the axis; the lower portion of the liquid transfer assembly is connected with a liquid suction head, and the liquid suction head is driven by a power device to achieve liquid transfer among different liquid containing spaces.

The utility model relates to the technical field of experimental equipment, and provides a reagent adding device which comprises a peristaltic assembly, an air pump, a first switch valve and a controller, the peristaltic assembly comprises a peristaltic pump, and an inlet of the peristaltic pump is communicated with a reagent bottle through an input pipe; an outlet of the peristaltic pump is communicated with the sample cup through an output pipe; an inlet of the air pump is communicated with air, and an outlet of the air pump is communicated with an inlet of the peristaltic pump through an exhaust pipeline; the first switch valve is arranged on the exhaust pipeline; the peristaltic pump, the air pump and the first switch valve are electrically connected with the controller, the controller controls the peristaltic pump to operate based on a target value, and after the target value is reached, the controller controls the peristaltic pump to stop, the air pump to start and controls the first switch valve to open. By controlling the operation of the peristaltic pump, the air pump and the first switch valve, the reagent adding amount can be accurately controlled, the reagent is prevented from being retained in the peristaltic pump and the output pipe, and the reliability and the accuracy of the reagent adding process are improved.

A pipette tip extension having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and encloses an inner cavity which is delimited by the inner side of the exterior wall. The exterior wall forms at the proximal end a reception aperture. The pipette tip extension further has one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.

The invention discloses an experimental reagent continuous quantitative dropwise adding device which comprises a reagent container, the reagent container is provided with a reagent storage part and a reagent output part, the input end of the reagent output part is provided with an elastic one-way piece used for controlling a reagent to flow out downwards, and the output end of the reagent output part is provided with a flow dividing piece; the dropping container is provided with a containing inner cavity and an elastic assembly, the containing inner cavity comprises a single dropping storage cavity with an insertion end and a dropping end, the insertion end is used for allowing the reagent output part to penetrate through in a sliding mode, and the dropping end is provided with a dropping hole communicated with the outside; a blocking assembly which is configured to keep the dripping hole closed in a non-working state and release blocking of the dripping hole in a working state is arranged in the single dripping storage cavity; the control mechanism comprises a dropping control assembly which is used for providing external force for promoting the reagent container to move downwards so as to enable the single dropping storage cavity to generate negative pressure, and the blocking assembly relieves blocking of the dropping hole under the action of the negative pressure. The device can be used for continuously and quantitatively dropwise adding reagents so as to meet the requirements of large-batch specimen pathological experiments.

The present invention discloses an intelligent tracking and parallel manipulation method for droplet arrays in an optoelectrowetting microfluidic chip. The method includes the following steps: obtaining the current position and ID of each droplet in the droplet array by using a target tracking algorithm, and based on the ID, current position, and target position of the droplet, parallelly planning the movement path of each droplet; projecting a plurality of optical virtual electrode patterns onto the optoelectrowetting microfluidic chip to parallelly guide and manipulate the corresponding droplets to move along the movement path; continuously tracking and updating the current position of each droplet during the movement of each droplet; adjusting the corresponding optical virtual electrode pattern according to the deviation between the updated current position of the droplet and the target position, and parallelly driving the corresponding droplet to move along the movement path until all droplets reach the target position. The present invention realizes the automatic tracking and parallel manipulation of the droplet array by integrating a deep learning target detection and tracking algorithm, reducing the need for manual intervention.

The invention relates to a titration speed regulation device for drug inspection and analysis and a use method thereof.The titration speed regulation device comprises a speed regulation assembly, the speed regulation assembly comprises a transmission rod and a floating plate, the floating plate is arranged in a burette and slidably connected with the inner wall of the burette, a cover plate is arranged at the top end of the burette, and an operation cylinder is fixed to the top end of the cover plate; a connecting cylinder is fixed at the bottom end of the cover plate and detachably mounted at the top end of the burette in a threaded manner, a through hole is formed in the middle of the operating cylinder, the cover plate and the connecting cylinder in a matched manner, the central axis of the transmission rod and the central axis of the burette are positioned on the same straight line and are perpendicular to the floating plate, and the bottom end of the transmission rod penetrates through the through hole, enters the burette and is connected with the top end of the floating plate; a pressure supply assembly for supplying pressure to the transmission rod and the floating plate is arranged at the top end of the transmission rod, and a friction assembly for generating friction to the transmission rod in the titration process is arranged in the operation cylinder; the titration speed regulation control is realized, the use is convenient, and the analysis efficiency is improved.

The sealing device comprises a first sealing assembly and a second sealing assembly, the first sealing assembly is arranged at the end, away from a gun head, of an inner cavity, the first sealing assembly comprises a sealing lantern ring, a first pressing plate and a first sealing ring, the sealing lantern ring is embedded in the inner cavity, and the first pressing plate is arranged on the first sealing ring. The first pressing plate is partially embedded in the inner cavity and abuts against the sealing lantern ring, the sealing lantern ring is in interference fit with the outer diameter of the piston rod, and the first sealing ring is arranged on the outer wall of the sealing lantern ring in a sleeving mode so as to apply radial pressing force to the sealing lantern ring; the second sealing assembly is arranged at the joint of the cylinder body and the gun head and comprises a second sealing ring, a second pressing plate and a push plate, the gun head is sleeved with the second sealing ring, the second pressing plate is embedded in the cylinder body and presses the gun head, and the push plate is connected to the cylinder body so as to press the second pressing plate. According to the technical scheme, the sealing effect and durability of the pipettor are improved.

Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and / or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and / or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension also has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, and one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.

A system and method for dispense characterization is disclosed. According to particular embodiments of the dispense characterization system and method, volumes of dispensed liquids can be determined. In more particular embodiments, additional characteristics, and combinations of characteristics of a liquid dispensing event can be determined. Examples of additional characteristics that can be determined include the shape of the dispensing event, the velocity of the dispensing event, and the trajectory of the dispensing event. The dispense characterization system and method can be employed in automated biological sample analysis systems, and are particularly suited for monitoring liquid reagent dispensing events that deliver liquid reagents to a surface of a microscope slide holding a biological sample.

The invention relates to virtual pipetting. The method for generating the control program of the laboratory automation equipment comprises the steps that configuration data of the laboratory automation equipment are received, and the configuration data encode the positions of components in the laboratory automation equipment; generating a three-dimensional model of the assembly of the laboratory automation equipment according to the configuration data, wherein the three-dimensional model further comprises a virtual pipette; displaying the three-dimensional model by using a virtual reality headset; receiving movement data of a motion sensing controller controlled by a user wearing the virtual reality headset, the movement data indicating three-dimensional movement of the motion sensing controller in space; determining movement of the virtual pipette in the three-dimensional model according to the movement data and updating the three-dimensional model according to the movement; a control program for the laboratory automation device is generated on the basis of the movement data, and the control program moves a pipette-bearing pipette arm of the laboratory automation device relative to the assembly on the basis of the movement of the virtual pipette in the three-dimensional model.

The invention relates to the technical field of pipetting guns for biological tests, and particularly discloses an automatic pipetting device which comprises a space mover and a pipetting assembly installed at the output end of the space mover, the space mover is used for driving the pipetting assembly to move in space, and the pipetting assembly comprises a pressing device, a rotating seat and a plurality of pipetting guns. The rotating base and the pressing device are both installed at the output end of the space mover, the multiple pipettes are distributed on the rotating base in the circumferential direction, the rotating base is used for rotating the pipettes to work stations, and the pressing device is used for pressing pressing heads of the pipettes located at the work stations so as to suck liquid or discharge the liquid. And the pressing device is used for pressing down the push head rod after the push head rod of the pipette head is replaced by aiming at the pipette. The scheme is used for solving the problems that the capacity of a pipette in an existing pipetting device is fixed and single, the wide measuring range required by scientific research experiments cannot be covered, and the replacement automation degree of a pipette head of the pipette is insufficient.

The utility model relates to the technical field of biological medicine, in particular to a liquid suction device of CTC enrichment dyeing equipment, which comprises a mounting frame, a moving component is arranged at the upper end of the mounting frame, a liquid suction component is mounted on the moving component, and the liquid suction component moves along with the moving component in the vertical direction and the horizontal direction. The liquid suction assembly comprises a limiting frame and a plurality of liquid suction devices installed in the limiting frame, and the lower ends of the liquid suction devices are connected with liquid suction heads in a sleeved mode. According to the utility model, the problem of low efficiency of manual reagent adding in the CTC cell enrichment dyeing process is solved.

Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins / toxins, viruses, DNA, and / or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect and identify. A single-use pipette tip includes fluid ports for aspirating the sample and connecting to a concentrating unit.

The invention provides a liquid level detection method based on air pressure detection, which is applied to a pipetting system, and the pipetting system comprises a suction head; the liquid level detection method comprises the steps that the whole pipetting system is driven to move towards a target container in the first direction, the suction head is driven to suck air in the second direction at the preset speed, and the preset speed is smaller than or equal to 0.6-3 uL / s; detecting real-time air pressure; whether a suction head makes contact with liquid in the target container or not is judged according to the real-time air pressure, and when the suction head makes contact with the liquid, the liquid level position of the liquid is recorded, and the suction head is controlled to stop sucking air. The liquid level detection method based on air pressure detection is beneficial to shortening the pipetting time and improving the pipetting accuracy. The invention further provides a pipetting method and system based on air pressure detection and a computer readable storage medium.