3465results about "Burettes/pipettes" patented technology

A bodily-fluid transfer device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

The utility model discloses a mechanical arm pipetting station, and relates to the technical field of pipetting devices. The pipetting robot is used for sucking liquid and transferring the liquid to a test tube, and the pipetting robot is arranged on the base; the test tube rack is used for storing test tubes, and the test tube rack is arranged on the base; the liquid supply assembly is used for providing at least two reagents, and the liquid supply assembly is arranged on the base; the pipetting robot sucks liquid through the liquid supply assembly and transfers a reagent to a test tube. According to the mechanical arm pipetting station, the efficiency is improved, errors are reduced, and liquid is accurately added.

Examples of syringe assemblies and sets of components are disclosed for transferring a fluid sample for testing. In some examples, the syringe assembly comprises a housing, a barrel, a plunger reciprocally moveable in the barrel, a narrow tube connected to the barrel, and a metering actuator configured to control movement of the plunger at least in a proximal direction relative to the barrel. The metering actuator is configured to draw a precise microvolume of the fluid sample into a fluid chamber within the syringe assembly. In some examples, while the fluid chamber holds the fluid sample, the distal tip of the narrow tube remains covered, for example inside the housing or a reaction container. The syringe assembly is configured to expel the fluid sample from the fluid chamber into the reaction container.

The invention discloses an intelligent tracking and parallel control method for a liquid drop array in a photoelectric wetting micro-fluidic chip, and the method comprises the following steps: obtaining the current position and the ID of each liquid drop in the liquid drop array through employing a target tracking algorithm, and carrying out the parallel planning of a moving path of each liquid drop based on the ID, the current position and the target position of the liquid drop; projecting a plurality of optical virtual electrode patterns onto a photoelectric wetting micro-fluidic chip, and guiding and controlling the corresponding liquid drops to move according to the moving path in parallel; in the moving process of each liquid drop, the current position of each liquid drop is continuously tracked and updated; and adjusting the corresponding optical virtual electrode pattern according to the updated deviation between the current position of the liquid drop and the target position, and driving the corresponding liquid drop to move according to the moving path in parallel until all the liquid drops reach the target position. Automatic tracking and parallel control of the liquid drop array are achieved, and the requirement for manual intervention is reduced.

The invention relates to the technical field of pipetting tools, and discloses a pipetting device. The pipetting device comprises a corrugated pipe, a pipette, a motor, a pressure sensor and a controller, the pipette is communicated with the corrugated pipe; the motor is connected with the corrugated pipe and can drive the corrugated pipe to deform; the pressure sensing device is configured to collect internal pressure parameters of the corrugated pipe; the controller is configured to control the motor according to the preset target liquid suction amount when the liquid suction end of the liquid suction pipe makes contact with liquid to be transferred, so that the motor drives the corrugated pipe to stretch, and the liquid suction pipe sucks the liquid to be transferred through negative pressure till the internal pressure parameter of the corrugated pipe reaches the target pressure parameter. According to the embodiment of the invention, the liquid taking precision can be improved.

According to an embodiment of the present invention, provided is a dropper cap which can be detached from a container part accommodating contents and which suctions or discharges the contents. The dropper cap comprises; an inner cap which can be detached from the container part; and an outer cap coupled to the inner cap so as to encompass at least a part of the inner cap, wherein the inner cap and the outer cap can be formed from a metal material.

The utility model provides a pipetting workstation and relates to the technical field of medical instruments. Comprising a base, a pipetting device, a carrier assembly and a waste box, the pipetting device comprises a rack, a pipetting mechanism and an adjusting mechanism, the rack is arranged on the upper end face of the base, the pipetting mechanism is installed on a supporting bottom plate of the rack, and the pipetting mechanism comprises an X-direction moving assembly, a Y-direction moving assembly and a Z-direction moving assembly; the first end of the Y-direction moving assembly is fixedly connected to the X-direction moving assembly, the Z-direction moving assembly is movably connected to the Y-direction moving assembly in the Y direction, and the pipette is movably connected to the Z-direction moving assembly in the Z direction; the adjusting mechanism is connected with the second end of the Y-direction moving assembly so as to adjust the Y-direction moving assembly to be in a horizontal state; the carrier assembly and the waste box are arranged on the supporting bottom plate, the carrier assembly is used for containing a container, and the waste box is used for containing waste. According to the pipetting workstation, the pipetting precision and the pipetting stability can be improved, and pipetting and waste liquid treatment can be systematically completed.

A multichannel pipetting head comprises a plunger actuator comprising at least one groove with an upper border, and a lower border. A plurality of plunger-cylinder units, wherein each plunger-cylinder unit comprises a cylinder and a plunger comprising a plunger head. The plunger head comprises a projecting upper abutment region adjoining the upper border, a projecting lower abutment region adjoining the lower border and laterally offset relative to the projecting upper abutment region, a plurality of guides. Each of the cylinders is coupled to a neck and held on each of the plurality of guides. During lateral movement of the plurality of guides, the plunger head is configured to tilt in the groove and to be held with the upper abutment region abutting the upper border and with the lower abutment region abutting the lower border of the groove due to restoring forces that occur during tilting in the plunger-cylinder units.

The invention discloses a device for generating and collecting micro-droplets. The device comprises a-80 DEG C refrigerating system, a micro-droplet preparation system and a collecting system. Wherein a liquid outlet pipe and a liquid inlet pipe of the-80 DEG C refrigerating system are respectively inserted into a condensate inlet and a condensate outlet of the collecting system; the micro-droplet preparation system consists of a carrier gas device, a three-way pipe fitting and an injection pump; liquid drops of liquid injected by the injection pump are scattered into micro liquid drops by high-pressure carrier gas; the collecting system is a glass device similar to a U shape and is communicated with the micro-droplet blowing-in end on the left side, the liquid taking opening in the bottom and the gas outlet on the right side; the micro-droplet reaction is completed at the micro-droplet blowing-in end, and the micro-droplets are condensed in the S-shaped condensation pipe of the U-shaped glass device and then are collected through a liquid taking opening in the bottom. According to the device, a micro-droplet generating device and a micro-droplet collecting device are ingeniously integrated into one device, so that the device is simple in structure and convenient to operate, ultra-high-efficiency micro-droplet collection can be achieved, and the device has very high application value.

The invention discloses an exosome enrichment microfluidic device based on a synergistic effect. The exosome enrichment microfluidic device comprises a continuous phase injection device, a dispersed phase injection device, a laser, a microfluidic enrichment module, a continuous phase infusion tube, a dispersed phase infusion tube, a continuous phase variable-diameter connecting tube, a dispersed phase variable-diameter connecting tube and a liquid outlet tube. According to the device disclosed by the invention, through a synergistic driving mechanism of a thermophoresis effect, natural convection and thermal capillary convection, the exosome is directionally migrated and efficiently enriched on the surface of the dispersed phase liquid drop, the dispersed phase liquid drop is used as a targeted interface carrier for exosome enrichment, the exosome is stably adsorbed by utilizing interface force, and the enrichment specificity and efficiency are improved.

The present invention provides a micro-droplet generating device, including a control module, an air supply module, a chip moving module and an air pressure regulating module, etc. The air supply module has a gas cylinder, the air pressure regulating module has an air cavity, the gas cylinder is provided with a first pressure sensor for real-time monitoring of the gas pressure in the gas cylinder, the air cavity is provided with a second pressure sensor for real-time monitoring of the gas pressure therein, the gas path output side of the gas cavity is provided with an oil phase solenoid valve and a water phase solenoid valve in parallel, the control module is configured to be able to monitor the pressure value in real time according to the first pressure sensor and the second pressure sensor, and when the pressure value exceeds the preset pressure threshold range, control the deflation valve or the oil phase solenoid valve, the water phase solenoid valve to produce a deflation action. The micro-droplet generating device of the present invention can realize secondary real-time monitoring and voltage stabilization control of the gas pressure in the gas path, prevent excessive fluctuations in the gas pressure, and thus ensure the stability of micro-droplet generation.

The invention discloses a friction-driven precise pipettor and a use method thereof. The friction-driven precise pipettor comprises a fixed frame, a pipette and a driving mechanism arranged in the fixed frame, the driving mechanism comprises a disc motor, the disc motor is fixedly connected to the outer wall of one side of the fixing frame, a driving shaft is rotationally connected to the inner wall of one side of the fixing frame, one end of an output shaft of the disc motor penetrates through the fixing frame and is fixedly connected with the driving shaft, and a driving friction wheel is movably connected to the circumferential outer wall of the output shaft of the disc motor; the circumferential outer wall of the output shaft of the disc motor is in threaded connection with a locking nut; a friction wheel frame is slidably connected between the inner walls of the two sides of the fixing frame, and a driven friction wheel is rotationally connected between the inner walls of the two sides of the friction wheel frame. Through the arrangement of a controller, a pressure sensor, a displacement sensor, an actuator and a liquid level sensor, it is ensured that key parameters are controlled in the pipetting process; the compression degree of the compression spring is adjusted in a self-adaptive mode, the radial pre-tightening force is changed, and the stability of the pipettor in long-term operation is achieved.

The utility model provides a pipetting device and relates to the technical field of medical instruments. The pipetting device comprises a rack, a pipetting mechanism and an adjusting mechanism, the pipetting mechanism is installed on a bottom plate of the rack and comprises an X-direction moving assembly, a Y-direction moving assembly and a Z-direction moving assembly, the X-direction moving assembly is movably connected to the bottom plate in the X direction, the first end of the Y-direction moving assembly is fixedly connected to the X-direction moving assembly, and the second end of the Y-direction moving assembly is fixedly connected to the Z-direction moving assembly. The Z-direction moving assembly is movably connected to the Y-direction moving assembly in the Y direction, the Z-direction moving assembly is provided with a fixing frame movably connected in the Z direction, and the fixing frame is used for installing a pipettor; the adjusting mechanism is connected with the pipetting mechanism so as to adjust the pipetting mechanism to be in a horizontal state. The pipetting device can improve the pipetting precision and the pipetting stability.

The invention relates to a serum test tube agglutination test auxiliary instrument applied to immunological detection and a detection method of the serum test tube agglutination test auxiliary instrument. A plurality of groups of test tubes are arranged on the bearing plate; the deflection oscillation structure is connected with the test tube and the bearing plate, and an abutting wheel is formed at one end of the deflection oscillation structure; the telescopic rod piece is connected with the electronic dropper and the base, a bearing plate is arranged on the telescopic rod piece, and the bearing plate is matched with the abutting wheel to drive the test tube to move in the vertical direction of the space; the driving plate is connected with the base, a switching groove is formed in the driving plate, and after the test tube rises to a preset height, the switching groove is matched with the embedding wheel connected with the bearing plate, so that the bearing plate and the abutting wheel can be staggered; the switching mechanism is connected with the telescopic rod piece and the bearing plate, when the bearing plate moves to the stroke end, the switching mechanism can drive the telescopic rod piece to rotate by a preset angle, and the operation difficulty in the test process is reduced.

Automated biological testing systems may advantageously allow users to perform some maintenance or upkeep of the system, such as replacing or refilling reagent, or replacing gaskets, hoses, filters, and other components. A manifold seal and filtration system including a gasket, retaining ring, and filter is usable with a manifold of such a system to transport reagent from a bottle to the testing system. The gasket includes features to prevent leakage and erroneous installation, and may be replaced by a user during normal maintenance or to select a gasket material to accommodate a particular type of reagent. The retention ring and filter include features to prevent particulate from passing into the testing system when reagent bottles are changed, and to prevent accidental displacement during removal of the gasket, or flushing of the manifold to clean the filter.

A microfluidic chip liquid inlet device disclosed by the present invention comprises a bottom plate and supporting legs, a liquid inlet structure is arranged above the bottom plate, the liquid inlet structure comprises a liquid inlet mechanism, a liquid injection mechanism and a feeding mechanism, and the liquid inlet mechanism comprises a first motor, a rotating rod, a mounting plate, a rotating rod and a first bearing plate. The output end of the first motor is connected with the bottom of the rotating rod, the top of the rotating rod is connected with the bottom of the mounting plate, and the bottom of the mounting plate is connected with the top of the rotating rod. According to the invention, micro-fluidic chips with different sizes can be rapidly and conveniently clamped and fixed, and a plurality of micro-fluidic chips can be subjected to liquid feeding work at the same time, so that the problem that the plurality of micro-fluidic chips cannot be rapidly and conveniently used at the same time is solved; and moreover, the problem that the micro-fluidic chips with different sizes cannot be quickly and conveniently clamped and fixed is solved, and the working efficiency of the liquid inlet device is improved.

The invention discloses a delivery window with a through-wall system, a sterile solution transfer system and an operation method of solution cross-regional transfer, and belongs to the technical field of sterile solution transfer. The sleeve penetrates through the wall, one end of the sleeve extends into the cavity of the VHP delivery window, and the other end of the sleeve is located on the outer side of the VHP delivery window; blind plates are arranged at the two ends of the sleeve, and chucks are arranged on the blind plates. Compared with a wall penetrating system installed on a solid wall of a clean area, the VHP delivery window is provided with a glass visual window, operators in the two areas can conveniently observe the solution delivery progress in real time, and personnel operation is better facilitated; vHP disinfection can be performed on the through-wall system after the operation is finished, so that the biological safety is further guaranteed.

The present invention discloses a pipette tip comprising a molded body made from an electrically insulating material, with an outer surface, an inner surface, and a translucent or transparent feature allowing visibility through both surfaces. The pipette tip further includes at least one impedance or capacitance electrode made from an electrically conductive material, positioned on the outer surface away from the translucent or transparent feature. Each electrode is electrically isolated on the outer surface, ensuring accurate and reliable measurements during liquid handling operations. This innovative design provides enhanced visibility and precise electrical measurements, making the pipette tip ideal for various laboratory applications.

A high-throughput automated chemical synthesis workstation, relating to the technical field of chemical synthesis. The workstation comprises a base. The base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-throughput chemical reaction module, a pipette tip box, a cover plate, and a liquid storage tank, wherein the negative pressure suction filter and the magnetic stirring reactor can be replaced with other testing instruments; a screw is lap-jointed on the cover plate; a moving device is also mounted on the base, and a tightening assembly, a gripper assembly, and a pipetting assembly are mounted on the moving device; and pipetting is performed by the pipetting assembly, the gripper assembly drives the cover plate to move to the high-throughput chemical reaction module for sealing, and after tightening is performed by the tightening assembly, the gripper assembly drives the sealed module to move to the reactor, thereby achieving real-time observation during remote operation.

The present disclosure provides flow cell devices, systems, and methods for facilitating and performing DNA sequencing analysis with reduced system complexity and cost, significant cost of goods (COGS) savings and reduced contamination levels.

The technology relates in part to a segmented pipette tip adapter that includes a plurality of plate segments and a junction between adjacent plate segments. Each of the plate segments often includes a proximal surface, a distal surface, edges, one or more nozzles disposed on the proximal surface, and one or more tubular projections disposed on the distal surface. Each of the nozzles often includes a nozzle bore, each of the tubular projections often includes a tubular projection bore, each of the plate segments often includes a plate bore disposed at each of the nozzles, and each nozzle bore often is aligned with a tubular projection bore and a plate bore. Each junction often is between adjacent edges of a pair of adjacent plate segments.

A trace meter and a method for calibrating a dynamic ultra-micro pipetting device are provided, which relate to the technical field of dynamic pipetting precision calibration. The trace meter includes a measuring compartment, a temperature sensor, a pressure sensor and a controller. A top of the measuring compartment is open, the temperature sensor is provided at a bottom of the measuring compartment, the pressure sensor is provided below the measuring compartment, both the temperature sensor and the pressure sensor are electrically connected with the controller, the temperature sensor is configured to measure the temperature of liquid in the measuring compartment, and the pressure sensor is configured to measure the weight of liquid in the measuring compartment.

Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and / or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and / or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

The invention provides a liquid drop continuous generation device which comprises a first flow channel and a second flow channel, the first flow channel and the second flow channel comprise first positions which are tightly attached to each other, and each first position comprises a through hole communicating with the first flow channel and the second flow channel; the first flow channel and the second flow channel are used for introducing a first liquid and a second liquid respectively; the special ultrasonic device can act on the first liquid in the first flow channel, when the special ultrasonic device is driven in a first power period, an acoustic beam current facing the through hole is generated in the first liquid, the acoustic beam current enters the second liquid through the through hole, and liquid drops formed by the first liquid are formed in the second liquid. The invention also correspondingly provides a method for continuously generating liquid drops. The liquid drop generation mode is more flexible, the controllability is higher, and the cost is lower.

The high-precision piston injector comprises an injection cavity, an adapter, a piston assembly, a piston rod sleeve and a spring, the piston assembly comprises a piston head and a piston rod, and the injection cavity comprises a first cavity and a second cavity which are sequentially communicated; an adapter installation position is arranged at the end, away from the second cavity, of the first cavity, an avoiding groove is formed in the end, away from the abutting section, of the threaded section, and an oil storage groove is concavely formed in the position, corresponding to the avoiding groove, of the first cavity. The piston rod is sleeved with the piston rod sleeve, the end, close to the piston head, of the piston rod sleeve is provided with an abutting portion, the piston rod sleeve is sleeved with the spring and clamped between the abutting portion and the end, close to the second cavity, of the first cavity, and the end, away from the piston head, of the piston rod extends out of the second cavity. Direct friction between the piston rod and the injection cavity can be avoided, the service life of the injector is effectively prolonged, noise generated by friction between the spring and the piston rod when the spring is compressed can be avoided, and the mute effect is better.

The embodiment of the utility model discloses a filter pressing system which comprises a filter pressing bottle group transferring module, a liquid transferring module and a filter pressing transferring module, the filter pressing bottle group transferring module is used for driving a filter pressing bottle group carrier to move, and a first filter pressing bottle is communicated with a second filter pressing bottle through an arranged filter pressing membrane; the pipetting and transferring module is used for driving a pipetting assembly containing reaction liquid to move, and the controller controls the pipetting assembly to inject the reaction liquid into a target filter pressing bottle; the filter pressing transferring module is used for driving the first clamping device to clamp the first filter pressing bottle and move the first filter pressing bottle to a filter pressing position, the first filter pressing bottle is matched with the second filter pressing bottle moving to the filter pressing position, and pressure is applied to the second filter pressing bottle through the first filter pressing bottle, so that reaction liquid in the target filter pressing bottle is subjected to filter pressing through the filter pressing membrane. The pressure filtration system realizes automatic pressure filtration, solves the problem of low manual production efficiency, reduces the pressure filtration cost, improves the pressure filtration efficiency, can avoid hand pollution of testers, and meets the requirement of high-strength operation.

Method of analysis. In the method, a microfluidic device defining a flow path extending from an inlet to an outlet may be selected. A sample-containing fluid may be introduced into the flow path via the inlet. Volumes of the sample-containing fluid may be isolated from one another on the flow path. A two-dimensional monolayer of the volumes may be imaged. The two-dimensional monolayer may be formed along the flow path between the inlet and the outlet.

The invention provides a quantitative detection reagent filling device for a clinical laboratory of a hospital, and relates to the technical field of medical treatment, the quantitative detection reagent filling device comprises a filling machine, a discharging bin is arranged below the filling machine, a first motor is fixedly installed in the filling machine, a curved frame is installed on the side edge of the first motor, the cross section of the curved frame is in an inverted U shape, and the first motor and the curved frame are fixedly installed on the lower portion of the discharging bin. A material storage pipe is fixedly installed in the filling machine, the lower section of the material storage pipe is located in the discharging bin, the other section of the curved frame is located in the material storage pipe, a rubber plug is driven to be inserted into the material storage pipe through a connecting rod, and meanwhile a fifth magnetic block is driven to be magnetically attracted to the lower end of the material storage pipe. Therefore, the reagent in the material storage pipe can slowly fall, pollution and damage caused by splashing of the reagent in the material storage pipe during falling due to the fact that the material storage pipe is far away from a reagent bottle are effectively avoided, the stability of the reagent during falling is greatly improved, and the sanitation degree of a material taking link is guaranteed.

The invention relates to a high-precision micro-pipetting device and a control method thereof, and the pipetting device, the high-precision micro-pipetting device comprises a control module, a positive pressure system, a negative pressure system, a three-way solenoid valve and a pipetting head, the control module controls the switching of the three-way solenoid valve to enable a micro-control solenoid valve to be communicated with the positive pressure system or the negative pressure system, and the control module controls the opening time of the micro-control solenoid valve; a proportional valve, a pressure sensor and a flow sensor are arranged between the three-way electromagnetic valve and the micro-control electromagnetic valve, the proportional valve is used for adjusting the pressure and the flow of a gas circuit, and the control module conducts PID control on the proportional valve according to measurement data of the pressure sensor and the flow sensor. The positive / negative pressure value and the gas flow rate of the gas circuit are adjusted through the proportional valve, so that the positive / negative pressure at the liquid suction head can be changed, the suction and discharge of samples with different viscosities can be realized, the switching time of the liquid suction head is controlled through the micro-control electromagnetic valve, and the sample amount of each time of pipetting can be accurately controlled.