2390results about "Burettes/pipettes" patented technology

A bodily-fluid transfer device includes a housing, a pre-sample reservoir, and an actuator. The housing defines an inner volume between a substantially open proximal end portion and a distal end portion that includes a port couplable to a lumen-defining device. The pre-sample reservoir is fluidically couplable to the port to receive a first volume of bodily fluid. The actuator is at least partially disposed in the inner volume and has a proximal end portion that includes an engagement portion and a distal end portion that includes a sealing member. The engagement portion is configured to allow a user to selectively move the actuator between a first configuration such that bodily fluid can flow from the port to the pre-sample reservoir, and a second configuration such that bodily fluid can flow from the port to a sample reservoir defined at least in part by the sealing member and the housing.

The invention relates to the technical field of pipetting tools, and discloses a pipetting device. The pipetting device comprises a corrugated pipe, a pipette, a motor, a pressure sensor and a controller, the pipette is communicated with the corrugated pipe; the motor is connected with the corrugated pipe and can drive the corrugated pipe to deform; the pressure sensing device is configured to collect internal pressure parameters of the corrugated pipe; the controller is configured to control the motor according to the preset target liquid suction amount when the liquid suction end of the liquid suction pipe makes contact with liquid to be transferred, so that the motor drives the corrugated pipe to stretch, and the liquid suction pipe sucks the liquid to be transferred through negative pressure till the internal pressure parameter of the corrugated pipe reaches the target pressure parameter. According to the embodiment of the invention, the liquid taking precision can be improved.

According to an embodiment of the present invention, provided is a dropper cap which can be detached from a container part accommodating contents and which suctions or discharges the contents. The dropper cap comprises; an inner cap which can be detached from the container part; and an outer cap coupled to the inner cap so as to encompass at least a part of the inner cap, wherein the inner cap and the outer cap can be formed from a metal material.

A multichannel pipetting head comprises a plunger actuator comprising at least one groove with an upper border, and a lower border. A plurality of plunger-cylinder units, wherein each plunger-cylinder unit comprises a cylinder and a plunger comprising a plunger head. The plunger head comprises a projecting upper abutment region adjoining the upper border, a projecting lower abutment region adjoining the lower border and laterally offset relative to the projecting upper abutment region, a plurality of guides. Each of the cylinders is coupled to a neck and held on each of the plurality of guides. During lateral movement of the plurality of guides, the plunger head is configured to tilt in the groove and to be held with the upper abutment region abutting the upper border and with the lower abutment region abutting the lower border of the groove due to restoring forces that occur during tilting in the plunger-cylinder units.

The invention discloses an exosome enrichment microfluidic device based on a synergistic effect. The exosome enrichment microfluidic device comprises a continuous phase injection device, a dispersed phase injection device, a laser, a microfluidic enrichment module, a continuous phase infusion tube, a dispersed phase infusion tube, a continuous phase variable-diameter connecting tube, a dispersed phase variable-diameter connecting tube and a liquid outlet tube. According to the device disclosed by the invention, through a synergistic driving mechanism of a thermophoresis effect, natural convection and thermal capillary convection, the exosome is directionally migrated and efficiently enriched on the surface of the dispersed phase liquid drop, the dispersed phase liquid drop is used as a targeted interface carrier for exosome enrichment, the exosome is stably adsorbed by utilizing interface force, and the enrichment specificity and efficiency are improved.

A microfluidic chip liquid inlet device disclosed by the present invention comprises a bottom plate and supporting legs, a liquid inlet structure is arranged above the bottom plate, the liquid inlet structure comprises a liquid inlet mechanism, a liquid injection mechanism and a feeding mechanism, and the liquid inlet mechanism comprises a first motor, a rotating rod, a mounting plate, a rotating rod and a first bearing plate. The output end of the first motor is connected with the bottom of the rotating rod, the top of the rotating rod is connected with the bottom of the mounting plate, and the bottom of the mounting plate is connected with the top of the rotating rod. According to the invention, micro-fluidic chips with different sizes can be rapidly and conveniently clamped and fixed, and a plurality of micro-fluidic chips can be subjected to liquid feeding work at the same time, so that the problem that the plurality of micro-fluidic chips cannot be rapidly and conveniently used at the same time is solved; and moreover, the problem that the micro-fluidic chips with different sizes cannot be quickly and conveniently clamped and fixed is solved, and the working efficiency of the liquid inlet device is improved.

The present invention discloses a pipette tip comprising a molded body made from an electrically insulating material, with an outer surface, an inner surface, and a translucent or transparent feature allowing visibility through both surfaces. The pipette tip further includes at least one impedance or capacitance electrode made from an electrically conductive material, positioned on the outer surface away from the translucent or transparent feature. Each electrode is electrically isolated on the outer surface, ensuring accurate and reliable measurements during liquid handling operations. This innovative design provides enhanced visibility and precise electrical measurements, making the pipette tip ideal for various laboratory applications.

A high-throughput automated chemical synthesis workstation, relating to the technical field of chemical synthesis. The workstation comprises a base. The base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-throughput chemical reaction module, a pipette tip box, a cover plate, and a liquid storage tank, wherein the negative pressure suction filter and the magnetic stirring reactor can be replaced with other testing instruments; a screw is lap-jointed on the cover plate; a moving device is also mounted on the base, and a tightening assembly, a gripper assembly, and a pipetting assembly are mounted on the moving device; and pipetting is performed by the pipetting assembly, the gripper assembly drives the cover plate to move to the high-throughput chemical reaction module for sealing, and after tightening is performed by the tightening assembly, the gripper assembly drives the sealed module to move to the reactor, thereby achieving real-time observation during remote operation.

The present disclosure provides flow cell devices, systems, and methods for facilitating and performing DNA sequencing analysis with reduced system complexity and cost, significant cost of goods (COGS) savings and reduced contamination levels.

The technology relates in part to a segmented pipette tip adapter that includes a plurality of plate segments and a junction between adjacent plate segments. Each of the plate segments often includes a proximal surface, a distal surface, edges, one or more nozzles disposed on the proximal surface, and one or more tubular projections disposed on the distal surface. Each of the nozzles often includes a nozzle bore, each of the tubular projections often includes a tubular projection bore, each of the plate segments often includes a plate bore disposed at each of the nozzles, and each nozzle bore often is aligned with a tubular projection bore and a plate bore. Each junction often is between adjacent edges of a pair of adjacent plate segments.

A trace meter and a method for calibrating a dynamic ultra-micro pipetting device are provided, which relate to the technical field of dynamic pipetting precision calibration. The trace meter includes a measuring compartment, a temperature sensor, a pressure sensor and a controller. A top of the measuring compartment is open, the temperature sensor is provided at a bottom of the measuring compartment, the pressure sensor is provided below the measuring compartment, both the temperature sensor and the pressure sensor are electrically connected with the controller, the temperature sensor is configured to measure the temperature of liquid in the measuring compartment, and the pressure sensor is configured to measure the weight of liquid in the measuring compartment.

Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and / or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and / or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

The invention provides a liquid drop continuous generation device which comprises a first flow channel and a second flow channel, the first flow channel and the second flow channel comprise first positions which are tightly attached to each other, and each first position comprises a through hole communicating with the first flow channel and the second flow channel; the first flow channel and the second flow channel are used for introducing a first liquid and a second liquid respectively; the special ultrasonic device can act on the first liquid in the first flow channel, when the special ultrasonic device is driven in a first power period, an acoustic beam current facing the through hole is generated in the first liquid, the acoustic beam current enters the second liquid through the through hole, and liquid drops formed by the first liquid are formed in the second liquid. The invention also correspondingly provides a method for continuously generating liquid drops. The liquid drop generation mode is more flexible, the controllability is higher, and the cost is lower.

The embodiment of the utility model discloses a filter pressing system which comprises a filter pressing bottle group transferring module, a liquid transferring module and a filter pressing transferring module, the filter pressing bottle group transferring module is used for driving a filter pressing bottle group carrier to move, and a first filter pressing bottle is communicated with a second filter pressing bottle through an arranged filter pressing membrane; the pipetting and transferring module is used for driving a pipetting assembly containing reaction liquid to move, and the controller controls the pipetting assembly to inject the reaction liquid into a target filter pressing bottle; the filter pressing transferring module is used for driving the first clamping device to clamp the first filter pressing bottle and move the first filter pressing bottle to a filter pressing position, the first filter pressing bottle is matched with the second filter pressing bottle moving to the filter pressing position, and pressure is applied to the second filter pressing bottle through the first filter pressing bottle, so that reaction liquid in the target filter pressing bottle is subjected to filter pressing through the filter pressing membrane. The pressure filtration system realizes automatic pressure filtration, solves the problem of low manual production efficiency, reduces the pressure filtration cost, improves the pressure filtration efficiency, can avoid hand pollution of testers, and meets the requirement of high-strength operation.

The invention relates to a high-precision micro-pipetting device and a control method thereof, and the pipetting device, the high-precision micro-pipetting device comprises a control module, a positive pressure system, a negative pressure system, a three-way solenoid valve and a pipetting head, the control module controls the switching of the three-way solenoid valve to enable a micro-control solenoid valve to be communicated with the positive pressure system or the negative pressure system, and the control module controls the opening time of the micro-control solenoid valve; a proportional valve, a pressure sensor and a flow sensor are arranged between the three-way electromagnetic valve and the micro-control electromagnetic valve, the proportional valve is used for adjusting the pressure and the flow of a gas circuit, and the control module conducts PID control on the proportional valve according to measurement data of the pressure sensor and the flow sensor. The positive / negative pressure value and the gas flow rate of the gas circuit are adjusted through the proportional valve, so that the positive / negative pressure at the liquid suction head can be changed, the suction and discharge of samples with different viscosities can be realized, the switching time of the liquid suction head is controlled through the micro-control electromagnetic valve, and the sample amount of each time of pipetting can be accurately controlled.

The invention discloses a self-adaptive pipetting system and method based on multi-mode sensing fusion. The system comprises a PLC (Programmable Logic Controller), a fusion multi-mode sensing module, a high-throughput execution module, a self-adaptive protocol matching module and a man-machine interaction module. According to the invention, through multi-channel cooperation and continuous transmission, the experiment efficiency is greatly improved; multi-modal sensing data are fused, and real-time closed-loop control and dynamic compensation are performed by adopting algorithms such as fuzzy PID (Proportion Integration Differentiation) and the like, so that the pipetting volume precision reaches + / -1%, and the repeatability is improved by 20-30%; a protocol feature library and an intelligent matching algorithm are built in, and experimental parameters can be automatically analyzed, matched and optimized; equipment state and process parameters are monitored in real time, faults and pollution risks are automatically early warned, and the operation safety and reliability are remarkably improved in combination with automatic anti-pollution design; a PLC is deeply fused with a sensing module and a decision module, a sensing-decision-execution intelligent closed loop is constructed, and an accurate and reliable integrated solution is provided for automatic pipetting.

The utility model discloses a multichannel pipettor which comprises a handle base body, a pipette head and a suction head, a multichannel and a multichannel piston rod synchronous execution connecting rod are arranged in the pipette head, piston cylinder assemblies are respectively installed in the multichannel, and a buffer and a pipette withdrawing push plate are further arranged in the pipette head. The buffer and the gun retreating push plate are arranged to achieve self-adaptive suction head installation and automatic gun retreating, the spring guide rod, the compression spring and the piston cylinder in the buffer are not concentric, the buffer enables the piston cylinder to have an independent buffering function, the installation space of a multi-channel inner piston cylinder assembly is not occupied, the inner space of the gun head is fully and compactly utilized, and the service life of the gun head is prolonged. The range is increased; the automatic gun withdrawing device is provided with the gun withdrawing push plate with a sectional gun withdrawing function, the suction head is pushed out in a sectional mode, automatic gun withdrawing is completed, and the automatic gun withdrawing device is suitable for automatic gun withdrawing of the suction head of the wide-range multi-channel pipettor; the runway-shaped piston cylinder, the piston and the sealing ring are arranged, so that the measuring range of the multi-channel pipettor is greatly increased under the condition that the axial length is not increased.

The invention discloses a sampler, a sampling module and a biological tissue surface sampling method. The sampler comprises a multi-channel micro-droplet generating assembly, a connecting assembly and a pressure sensing assembly. The multi-channel micro-droplet generation assembly comprises a sampling pen point, a liquid channel, a gas channel and a recovery channel, the liquid channel, the gas channel and the recovery channel are formed in the sampling pen, and micro-droplets are generated on the contact interface of the sampling end by regulating and controlling the pressure, the flow speed and the time sequence of gas / liquid media and used for making contact with tissue. Biological component information on the surface of the tissue is intercepted by the micro-droplets through dissolution and diffusion, so that the volume of the micro-droplets formed at each sampling point is not influenced by a sampling process and a mechanical structure, the to-be-detected tissue is not damaged, rapid on-line nondestructive extraction of the metabolite on the surface of the tissue can be realized, and the detection accuracy is improved. And high time-space resolution extraction of metabolites can be realized. The sampler and the sampling module can also be used for sampling on the surface of non-biological tissue.

The invention discloses a high-flux automatic chemical synthesis workstation, which relates to the technical field of chemical synthesis, and comprises a base, the base is detachably provided with a negative pressure suction filter, a magnetic stirring reactor, a high-flux chemical reaction module, a gun head box, a cover plate and a liquid storage tank, and the negative pressure suction filter and the magnetic stirring reactor can be replaced by other detection instruments. The cover plate is in lap joint with a screw, the base is further provided with a moving device, the moving device is provided with a button assembly, a clamping jaw assembly and a pipetting assembly, the pipetting assembly is used for pipetting, and the clamping jaw assembly drives the cover plate to the high-flux chemical reaction module for sealing. The sealing module is driven to the reactor through the clamping jaw assembly after being fastened through the fastening assembly, and real-time observation can be carried out during remote operation. By means of the technical scheme, it is guaranteed that high-throughput chemical synthesis experiments including pipetting, reaction system sealing, reaction starting, gradient dilution and suction filtration are completed in one work station.

Described herein are various fluid provision systems that may be used in a laboratory setting. The fluid provision systems minimize waste of pipetted liquid sample or reagents and may be used, e.g., in combination with a multi-well plate such as in NGS processes. Other systems include those configured for compatibility with centrifuge rotors or multichannel pipettes with 12 or more channels.

The utility model relates to the technical field of water conservancy projects, and discloses a water conservancy project water quality detection device which comprises a working table, a rotating table is arranged on the upper side of the working table, an L-shaped connecting plate is fixedly connected to the upper surface of the working table, and a water quality detector body is arranged on the surface of the L-shaped connecting plate. The water quality detector body comprises a detection probe arranged on the lower surface of a transverse plate of an L-shaped connecting plate, a positioning groove is formed in the surface of a rotating table, a detection cup can be conveniently placed through the positioning groove, a gear makes contact with a tooth groove through rotation of the rotating table, a sealing plate rotates subsequently, and then the detection cup is exposed; the water quality detection device is simple in structure and convenient to use, subsequent water quality detection is facilitated, the situation that a detected sample is polluted by the external environment is avoided as much as possible, the accuracy of subsequent water quality detection is guaranteed, meanwhile, the situation that the sample in the detection cup is scattered is avoided, the safety of the device is greatly improved, and the quality and effect of subsequent water quality detection are guaranteed. And the practicability is high.

[Problem] To provide a powder supply device and a powder supply method in which surplus powder adhering to a suction measurement tool having a measuring chamber and a suction port can be removed by a simple process. [Solution] This powder supply device 1 comprises: a suction measurement tool 13 connected to a negative pressure source and having a measuring chamber 15, which is partitioned by a filter 14, and a suction port, which is provided at the tip; a nozzle 12 relatively moved by relative movement robots (501, 502, 503); and a powder removal brush 20 having brush bristles 22 extending in a direction crossing the vertical direction. The tip of the suction measurement tool 13 is embedded in the powder in a powder tank 101, and the powder is suctioned into the measuring chamber 15. After the powder is suctioned, surplus powder adhering to the suction measurement tool 13 is removed by relatively moving the suction measurement tool 13 and the brush bristles 22 while elastically deforming the brush bristles 22.

The utility model relates to a non-contact pipetting device. The device comprises a pipetting assembly, a driving assembly and a first valve, the pipetting assembly comprises a base body and a pipetting needle, the base body is provided with an air inlet connector and a pipetting cavity, and the pipetting needle is arranged on the base body and used for being communicated with the pipetting cavity; the driving assembly comprises a piston rod, and the piston rod is inserted into the pipetting cavity; the first valve is arranged on the base body, an inlet of the first valve is used for being communicated with the air inlet connector, and an outlet of the first valve is used for being communicated with the pipetting cavity; the piston rod is used for moving along the pipetting cavity in a direction far away from the pipetting needle when the first valve is closed, so that target liquid enters the pipetting cavity through the pipetting needle; and the gas inlet interface is used for enabling gas generated by the gas source to enter the pipetting cavity through the gas inlet interface when the first valve is opened, so that the target liquid in the pipetting cavity is discharged through the pipetting needle. According to the non-contact pipetting device, a complicated pipeline system is not introduced, so that the pressure path is shortened, the transmission stability of the pressure in the pipetting cavity is improved, and the pipetting precision is further improved.

The present invention relates to a multichannel pipette with a discarded suction tip recovery function, comprising a multichannel pipette body, a multichannel suction tip supply and collection device with suction tip supply and recovery functions, and a supply and collection device driving mechanism, the supply and collection device driving mechanism is arranged beside the multichannel pipette body, the multichannel suction tip supply and collection device is installed at the lower end of the supply and collection device driving mechanism and moves up and down under the drive of the supply and collection device, the multichannel suction tip supply and collection device comprises a supply and collection device housing, a multichannel suction tip storage bin slider and a storage bin driving mechanism, the multichannel suction tip storage bin slider is slidably installed in the supply and collection device housing and slides forward and backward under the drive of the storage bin driving mechanism, the supply and collection device housing is provided with n suction tip outlet through holes that are connected up and down, the multichannel suction tip storage bin slider is provided with m×n suction tip supply channels, wherein the rear (m‑1)×n suction tips are provided, and a disengagement pin is provided on the upper inner side of the suction tip supply channel. The multichannel pipette can realize automatic loading and unloading and recovery of multiple suction tips, which can not only improve the pipetting efficiency, but also avoid the waste suction tips from polluting the environment.

The utility model provides a sample treatment and detection device provided with a liquid transfer structure, which comprises an upper cover, a lower cover, a liquid transfer structure and a liquid transfer structure, a hollow containing space is formed by the base plate and the upper cover, a plurality of liquid containing spaces are formed in the base plate, a center shaft containing hole is formed in the center of the base plate, and a center shaft is detachably connected into the center shaft containing hole; the upper portion of the liquid transfer assembly penetrates through the center hole to be connected with the power device, and the liquid transfer assembly is driven by the power device to move in the vertical direction with the center shaft as the axis and / or rotate around the axis; the lower portion of the liquid transfer assembly is connected with a liquid suction head, and the liquid suction head is driven by a power device to achieve liquid transfer among different liquid containing spaces.

To provide a micropipette system with which it is possible for an operator to control suction and discharge of fluid with the same intuitiveness as with operation by a mouthpiece.SOLUTION: A micropipette system according to the present invention includes: a barrel part which has a long axis, a proximal end, and a distal end, and which further has a tubular cavity extending along at least a portion of the long axis; a rotatable wheel having a rotation axis within the proximal-side region of the barrel part; a pump member configured to move forward and rearward in a distal direction or a proximal direction within the barrel part in conjunction with the rotational movement of the wheel; and a microcapillary needle extending so as to protrude from the barrel part in the proximal direction. The outer edge of the wheel is at least partially exposed from the barrel part. The internal space of the microcapillary needle communicates with the tubular cavity of the barrel part. The forward and rearward movement of the pump member increases or reduces the volume of the tubular cavity, thereby enabling suction or discharge of fluid within the internal space of the microcapillary needle.SELECTED DRAWING: Figure 1

Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and / or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and / or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

The utility model relates to the technical field of experimental equipment, and provides a reagent adding device which comprises a peristaltic assembly, an air pump, a first switch valve and a controller, the peristaltic assembly comprises a peristaltic pump, and an inlet of the peristaltic pump is communicated with a reagent bottle through an input pipe; an outlet of the peristaltic pump is communicated with the sample cup through an output pipe; an inlet of the air pump is communicated with air, and an outlet of the air pump is communicated with an inlet of the peristaltic pump through an exhaust pipeline; the first switch valve is arranged on the exhaust pipeline; the peristaltic pump, the air pump and the first switch valve are electrically connected with the controller, the controller controls the peristaltic pump to operate based on a target value, and after the target value is reached, the controller controls the peristaltic pump to stop, the air pump to start and controls the first switch valve to open. By controlling the operation of the peristaltic pump, the air pump and the first switch valve, the reagent adding amount can be accurately controlled, the reagent is prevented from being retained in the peristaltic pump and the output pipe, and the reliability and the accuracy of the reagent adding process are improved.

A pipette tip extension having a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end is disclosed. The exterior wall has an outer side and an inner side and encloses an inner cavity which is delimited by the inner side of the exterior wall. The exterior wall forms at the proximal end a reception aperture. The pipette tip extension further has one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity.