33 results about "Physiological significance" patented technology

An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present invention allow for close control over the dimensional features of the various components and layers established on a suitable substrate. Such control extends to those parts of the devices which incorporate the biological components which enable these devices to function as biological sensors. The materials and methods disclosed herein thus provide an effective means for the mass production of uniform wholly microfabricated biosensors. Various embodiments of the devices themselves are described herein which are especially suited for real time analyses of biological samples in a clinical setting. In particular, the present invention describes assays which can be performed using certain ligand / ligand receptor-based biosensor embodiments. The present invention also discloses a novel method for the electrochemical detection of particular analyte species of biological and physiological significance using an substrate / label signal generating pair which produces a change in the concentration of electroactive species selected from the group consisting of dioxygen and hydrogen peroxide.

The present invention provides a non-contact sleep monitoring method and system. The method includes the following steps: using an infrared monitoring camera to collect video images of the head area and the chest and abdomen area of ​​the human body, and using a somatosensory device to collect the posture information of the human body; Sleep information of the human body; compare the sleep information of the human body with the preset standard sleep information, and analyze the health degree of the sleep quality of the human body. The invention collects human sleep signals in a non-contact method based on image processing technology, tries to maintain the user's natural sleep state, and extracts physiologically meaningful sleep state information through video image processing technology. In addition, the equipment cost is low, which is convenient for daily use at home.

The invention provides a dynamic PET (Positron Emission Tomography) image reconstruction and tracing kinetic parameter estimation method based on image segmentation. A statistics reconstruction model is combined with a model with physiological significance can be combined to more accurately combine a reconstruction result. When reconstruction and segmentation are coupled to one a combined or concurrent solving frame, for a segmentation task, the information of a noise model for carrying out modeling on original projection data can be obtained, and a segmentation-based result can enhance homogeneity in each area so as to realize a reconstruction result which more conforms to a true situation. Compared with other algorithms which singly reconstruct PET images or estimation kinetic parameters, the method can obtain a good reconstruction result. Through the combination of the performance of the method in simulated data experiments and true data experiments, compared with other algorithms which singly reconstruct PET images, the estimation kinetic parameters and image segmentation, the method disclosed by the invention can obtain a good reconstruction result.

The invention provides a physiological signal detection system based on multi-channel flexible fusion, which is characterized in that it includes n physiological signal detection channels, each physiological signal detection channel is equipped with a single-channel feature extraction module, and each single-channel feature The output end of the extraction module is connected with a soft judgment evidence generation module, and the soft judgment evidence generation modules of n channels are all connected to the multi-channel information fusion module, and the output end of the multi-channel information fusion module is connected with a diagnostic decision module. The effect is: it solves the problem of conflicting information fusion in multi-channel binary detection, and realizes the robust detection of weak electrophysiological characteristic signals. The empirical threshold value summarized for a long time can be used normally in the soft decision process, and has strong versatility for multi-channel detection of weak electrophysiological signals.

The present invention provides a method for screening a cytostatic agent characterized by determining an effect of inhibiting intracellular signaling mediated by a remaining fragment of a cell membrane-anchored growth factor, and the cytostatic agent. In growth factors of the EGF family, the physiological significance of the remaining fragment is clarified, and a method for controlling its action is searched, and thus a novel pharmaceutical can be provided.

The invention discloses an ultrasonic extraction method for complete ladderane lipids in anammox bacteria. Intact ladder is a special phospholipid present in the anammoxosome membrane in the cells of anammox bacteria. Existing studies have shown that taking the complete ladder as the research object can provide new ideas and new supporting information for the study of anammox, and has high ecological and physiological research significance. The operation process of the method is as follows: sampling→freeze drying→adding the extract solution→ultrasonic extraction→adjusting the component ratio of the extract solution→centrifuging liquid separation→concentrating by nitrogen blowing. The high-performance liquid chromatography tandem mass spectrometry analysis proves that the method is effective and the extraction purity is high.

The invention discloses a direct imaging method for spiral discrete scanning type fluorescent agent pharmacokinetic parameters. The direct imaging method includes the steps that fluorescent agent scanning data is obtained according to a three-dimensional spiral discrete scanning mode, a multi-mesooecium fluorescent agent kinetic model and a pharmacokinetic parameter direct imaging state equation are set up, a pharmacokinetic parameter image is obtained based on self-adaption extended Kalman filtering, the mesooecium concentration and middle vector are obtained through an obtained final estimated value of the state vector, and finally the penetration rate and the excretion rate are obtained. The method has the advantages that complete data is not needed in each step of an algorithm, the real-time measurement data is obtained in a spiral discrete scanning mode, and the requirement for high time resolution of data collection equipment is reduced; an organizer is described more accurately through the multi-mesooecium kinetic model, and corresponding physiological significance is achieved; median concentration reconstruction errors of an indirect method are avoided; the influence caused by system original state priori knowledge deficiency is eliminated by self-adaptation extended Kalman filtering.

In diabetes management applications, recent glucose measurements can be clinically useful for serious diagnosis and for calculation of corrective therapy. However, the physiological significance of these measurements may diminish over time, which may cause them to become less relevant for calculating effective treatments. A technique is presented for emphasizing analyte values ​​in diabetes management applications during the therapeutic window. In this way, the user is notified that the glucose measurement is the most current measurement and remains available for therapeutic applications, such as insulin bolus calculations.

The invention discloses a method for automatically removing movement artifacts of near-infrared spectral signals. The method includes steps of firstly, computing movement standard deviation of the near-infrared spectral signals, automatically selecting threshold values and marking movement artifact regions of original signals; secondly, decomposing empirical modes of the near-infrared spectral signals to obtain intrinsic mode functions with clear physiological significances; thirdly, computing suspected movement artifact regions of each intrinsic mode function, combining the suspected movement artifact regions with the movement artifact regions, which are obtained in the first step, of the original signals, processing the different intrinsic mode functions and removing the movement artifacts; fourthly, reconstructing the signals. The method has the advantages that the threshold values are automatically selected according to probability distribution features of the near-infrared spectral signals, and intervals containing the movement artifacts are automatically detected according to the probability distribution features of the near-infrared spectral signals; the empirical modes of the near-infrared spectral signals are decomposed, accordingly, the intrinsic mode functions with the clear physiological significances can be obtained, obviously abnormal intrinsic mode functions can be processed, and the movement artifacts can be removed while physiological information in the NIRS (near-infrared spectral) signals can be effectively reserved.