Direct Imaging of Pharmacokinetic Parameters of Fluorescent Agents with Helical Discrete Scanning

Abstract

The invention discloses a direct imaging method for spiral discrete scanning type fluorescent agent pharmacokinetic parameters. The direct imaging method includes the steps that fluorescent agent scanning data is obtained according to a three-dimensional spiral discrete scanning mode, a multi-mesooecium fluorescent agent kinetic model and a pharmacokinetic parameter direct imaging state equation are set up, a pharmacokinetic parameter image is obtained based on self-adaption extended Kalman filtering, the mesooecium concentration and middle vector are obtained through an obtained final estimated value of the state vector, and finally the penetration rate and the excretion rate are obtained. The method has the advantages that complete data is not needed in each step of an algorithm, the real-time measurement data is obtained in a spiral discrete scanning mode, and the requirement for high time resolution of data collection equipment is reduced; an organizer is described more accurately through the multi-mesooecium kinetic model, and corresponding physiological significance is achieved; median concentration reconstruction errors of an indirect method are avoided; the influence caused by system original state priori knowledge deficiency is eliminated by self-adaptation extended Kalman filtering.

Description

technical field [0001] The invention relates to the field of pharmacokinetic parameter analysis and imaging, in particular to the imaging method of pharmacokinetic parameters of fluorescent agents used in near-infrared optical imaging, and in particular to the direct imaging method of helical scanning fluorescent agent pharmacokinetic parameters. Background technique [0002] Tumor has become the biggest killer of human health, and early diagnosis is crucial to save patients' lives. Near-infrared fluorescence diffusion tomography (Diffuse fluorescence tomography, DFT) has attracted more and more attention in the field of tumor diagnosis and other related research fields due to its advantages of non-invasiveness, no radiation damage and high specificity. [1] . Studies in recent years have shown that the diagnosis of a fixed time point cannot represent all the characteristics of the disease, and the dynamic fluorescence imaging method developed on the basis of traditional sta...

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Problems solved by technology

[0014] The present invention aims to overcome the deficiencies of the existing methods, solve the deficiencies of the existing imaging methods for the time resolution requirements of the data acquisition equipment and the accuracy of the kinetic model, and develop a three-dimensional method for the pharmacokinetic parameters of the helical discrete scanning fluorescent agent. direct imaging method

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