738 results about "Bio sensor" patented technology

The invention discloses a staphylococcus aureus biosensor based on a nucleic acid aptamer and a preparation method of the staphylococcus aureus biosensor. Three fluorine atoms (F) are introduced into the 5'end, the 3 'end and the middle position of an aptamer 2' F3-(5 '3'm DNA) sequence (SEQ ID NO: 1) for modification, so that the binding force of the aptamer and graphene is remarkably enhanced, the signal stability and the anti-interference capability of the biosensor are remarkably improved, non-specific fluorescence leakage can be effectively blocked, and reliable guarantee is provided for complex sample detection. According to the present invention, with the cooperation of the graphene oxide quenching substrate, the high-sensitivity detection of the staphylococcus aureus is achieved, the detection limit of the sensor within 5 min can achieve 5 cells / mL, the sensitivity is high, the specificity on the complex sample is more than 95.4%, and the sensor is suitable for the food safety rapid screening and the clinical diagnosis.

The present invention relates to a system and method for generating lighting effects based on contextual data. The system includes one or more sources, including microphones, cameras, biometric sensors, environmental sensors, and digital feeds providing information including time, date, season, geolocation, weather, calendar events, or current events. A processor analyzes the contextual data to determine a contextual state associated with an ongoing event or user condition. The processor further identifies secondary trigger conditions through computer vision analysis of screen content, developer-scripted events, generative AI-derived cues, optical character recognition, gameplay events, or transformation of on-screen 2D or 3D visual regions. Based on the contextual or composite contextual state, the processor determines one or more lighting effects, which are then triggered on one or more output devices. This enables dynamic and contextually adaptive lighting responses to both real-world and digital stimuli.

The invention discloses a nano biomass-based flexible electrode as well as a preparation method and application thereof, and belongs to the technical field of biosensors. According to the invention, biomass is used for preparing the flexible electrode, and the biomass has the advantages of being natural, renewable, biodegradable, high in yield, low in cost and the like; the sensor prepared by taking the biomass-based flexible electrode as the substrate cannot cause environmental pollution, and the biomass has good biocompatibility, so that skin discomfort cannot be caused when the sensor prepared by taking the biomass-based flexible electrode as the substrate is worn. The sensor prepared by taking the nano biomass-based flexible electrode as a substrate has high air permeability and high sensitivity, and can promote rapid evaporation of sweat, so that the problem that the continuous monitoring precision is reduced due to sweat accumulation is solved.

A physiological signal monitoring device includes a base and a transmitter. The base is provided with a biosensor. The transmitter is removably coupled to the base, and includes a casing and an electrostatic-discharge protective unit. The casing has a socket for the biosensor to be removably inserted thereinto. The electrostatic-discharge protective unit is disposed to at least surround the periphery of the socket to dispel static electricity when electrostatic discharge occurs.

The invention discloses a biosensor identification and prediction method and system based on deep learning. The method and system are suitable for pest monitoring and intervention in storage environments such as grain piles. According to the method, multi-modal sensing data of temperature and humidity, oxygen, carbon dioxide, VOCs and the like are preprocessed, a continuous scalar field of temperature and humidity gas and the like is reconstructed by adopting a multi-modal fusion Transform, a multi-scale space gradient is calculated, and an environment gradient map with confidence is generated; constructing a potential function and a stress field based on a gradient map, identifying target features such as an attraction source, a rejection source and a migration channel, and combining observation evidences such as trap triggering and VOCs abnormity; and under stress guidance, performing sampling and online updating on an individual activity track by using a diffusion type generation model, calculating a comprehensive risk index and performing graded early warning. According to the method, the closed loop from discrete sensing reading to force field-track-risk-intervention is realized, the accuracy and timeliness of early warning are improved, on-demand and accurate prevention and control are supported, and the false alarm and prevention and control cost is reduced.

The invention relates to the field of block chains, in particular to an intelligent cabin digital twin recommendation system, method and device based on a block chain, and the method comprises the steps: obtaining data collected by an OBD sensor, a camera, an environment sensor and a biosensor; carrying out fuzzy processing on the collected data through edge calculation; performing feature extraction on the data after fuzzy processing, and generating a six-dimensional feature vector based on a context awareness recommendation algorithm; according to the scene label distribution weight of the six-dimensional feature vector, determining a recommendation priority; obtaining corresponding twinborn decision data according to the priority score; calculating a feature hash value of the twinborn decision data by adopting an SHA-3 algorithm, and generating a data fingerprint; dividing the data fingerprints into vehicle condition data and user data according to data types, and performing cross-chain storage; and performing credibility evaluation and screening on the multi-source data stored in a cross-chain manner, and feeding back the data to a user side. According to the scheme, a data island is broken, the security protection of privacy is enhanced, and the credibility and transparency of information recommendation are improved.

A microneedle device comprises a device structure, insertable to a living body and being formed with an opened niche at least partially surrounded by walls of micrometric heights above a base of the niche for allowing the niche to be filled with a blood sample upon the insertion. The device also comprises a biosensor configured to sense a bioanalyte in the blood sample and having a sensing element formed on the base. The thickness of the sensing element is less than the micrometric heights of the walls.

Novel tools and techniques are provided for implementing novel finger swipe-based smart watch user interface (“UI”) control or novel micro finger gesture-based UI control for wrist-wearable device. In various embodiments, a computing system may analyze biosensor data to identify micro-gestures of a user's finger, the biosensor data being received from biosensor(s) disposed on a wrist-wearable device when it is being worn by the user. In response to identifying a first micro-gesture of the user's finger in the biosensor data, the computing system may determine whether the first micro-gesture corresponds to one of a finger-swipe command or a finger-drag command for controlling a UI of the wrist-wearable device. If so, the computing system may cause the UI of the wrist-wearable device to perform one or more first functions in response to the one of the finger-swipe command or the finger-drag command.

The invention relates to the technical field of water quality pollution monitoring, in particular to a toxic pollutant real-time monitoring method fusing biosensing and machine learning, which comprises the following steps: acquiring an electrochemical signal in a water body through a biosensor, extracting features after preprocessing, and inputting the features into a machine learning model (such as SVM) to realize toxicity grade classification or regression prediction; the method solves the problems that a traditional chemical detection method is high in delay, cannot evaluate the comprehensive biotoxicity and the like, and has the advantages of second-level response, high accuracy and low cost. The method is suitable for continuous online monitoring of drinking water, waste water and other scenes, and provides technical support for pollution early warning.

This invention belongs to the field of microcystin-LR detection technology, providing anti-microcystin-LR nanobodies and their applications. The anti-microcystin-LR nanobodies have amino acid sequences as shown in SEQ ID NO.1, SEQ ID NO.2, or SEQ ID NO.3. This invention uses phage display technology to screen for nanobodies with high affinity and high specificity for recognizing microcystin-LR, exhibiting advantages such as strong stability and ease of large-scale expression. Various detection tools can be designed based on anti-microcystin-LR, including test strips, immunoassay kits, immunoaffinity columns, biosensor detection chips, or detection probes. This provides novel antibody resources for rapid monitoring of microcystin-LR and lays a material foundation for developing low-cost, high-performance immunoassay technologies, which is of great significance for promoting the monitoring and control of microcystin-LR pollution.

The present invention provides a device (100) and method for measuring and / or monitoring auscultation and other biomedical signals of a body part of a subject, the device (100) comprising: a plurality of sonographic sensors sensitive to surface vibrations-PG sensors (110) configured to measure acoustic activity of the body part, and providing a PG signal (115) indicative of acoustic activity of the body part, the PG sensor (110) being adapted to be arranged on the body part to cover different independent auscultation areas of the body part. The device further comprises at least one other biomedical sensor-BIO sensor (120) configured to independently measure a respective activity of the body part according to the sensor type and to provide at least one BIO signal (125) indicative of the respective activity of the body part. The device further comprises a signal processing unit (160) configured to acquire a signal (115, 125) from each sensor (110, 120) and to collectively perform a signal source specific analysis by combining information of the PG signal (115) with corresponding arrangement information of the PG sensor (110) on the body part and information of the BIO signal (125).

Devices, systems and methods for biological sensing and communication using optogenetics and electronics are described. One example method includes generating a light beam incident on multiple regions in a device, wherein each region comprises an optogenetic system to generate, upon interacting with the light beam, biosensors, wherein an interaction between the biosensors and stimulus molecules in each region is associated with a threshold for a production of an output molecule or an alteration of an output property of the output molecule, the biosensors, or the stimulus molecules, wherein the production or the alteration is based on a value associated with an information source, detecting an output received from one or more of the multiple regions corresponding to the output molecule or the output property in that region, and generating an electric signal associated therewith, and processing the electrical signal to determine the value associated with the information source.

The invention provides methods for associating volatile compounds or mixtures of volatile compounds with combinatorial response patterns of Olfactory Receptors (OlfRs), a biosensor array comprising a plurality of biosensors, the use of said biosensor and of the method of the invention to screen for diseases, a molecule identified by a method of the invention as well as the use se of said molecule to modify the behavior of an insect.

The invention firstly comprises a junction field effect transistor (JFET), namely a SiC JFET, which is completely made of SiC. The transistor is preferably manufactured by adopting a top-down method, and the manufacturing process is suitable for large-scale production. The electrical properties of the proposed SiC JFET have been evaluated under dry conditions and in a liquid medium. The concept feasibility of the SiC JFET as a biosensor 0 is verified through pH value measurement. The sensitivity of the SiC JFET provided by the invention is up to 495 mV / ph, that is, the sensitivity is nearly 100 times higher than the theoretical Nernst limit. Therefore, the device is suitable for various in-vitro and in-vivo biochemical detection applications because the device meets performance indexes generally required in the field, such as sensitivity and chemical stability, especially long-term stability.

The application discloses a kind of biological sensor of nucleic acid aptamer-based paratyphoid A salmonella and preparation method thereof, it is introduced 3 fluorine atoms (F) modification in the 5' end, 3' end and intermediate position of aptamer 2'F3-(5'3'mDNA) sequence (SEQ ID NO:1), significantly enhance the binding force of aptamer and graphene, significantly improve the signal stability and anti-interference ability of biosensor, and can effectively block non-specific fluorescence leakage, provide reliability guarantee for complex sample detection.The application is matched with graphene oxide quenching substrate, realizes the high sensitivity detection of paratyphoid A salmonella, the detection limit of the sensor reaches 10 cells / mL within 5 min, the specificity to complex sample is >93.4%, and it is suitable for food safety rapid screening and clinical diagnosis.

The invention relates to the technical field of photoelectric detection, in particular to a photocurrent imaging system based on a probe station and an electrometer. The system generates a focused detection light beam through a light path system, the focused detection light beam irradiates a sample carried by a probe station after being spatially modulated by a mask plate, weak light current signals generated by the sample are collected by an electrometer, and a high-resolution light current distribution image is generated by combining scanning motion of a high-precision electric control displacement platform and intelligent processing of computer software. A physically-driven signal enhancement model, a multi-dimensional noise suppression algorithm and a dynamic imaging optimization formula are innovatively designed, the problems that in the prior art, weak light current detection precision is low, the scale connection error is large, and imaging efficiency is insufficient are solved, accurate quantitative analysis of the photoelectric characteristics of materials is achieved, and the method is suitable for popularization and application. The method is suitable for semiconductor device research and development, solar cell performance evaluation, biosensor detection and other scenes, and has both detection precision and application flexibility.

The invention discloses an Au (at) PtNCs nano-enzyme probe for detecting novel nicotine pesticides as well as a preparation method and application of the Au (at) PtNCs nano-enzyme probe, and belongs to the field of rapid detection of biosensors. The invention provides an Au (at) PtNCs nano-enzyme probe, which is generated by combining AuNCs and PtNCs and coupling with a second antibody, and can effectively realize rapid specific detection of novel nicotine pesticides such as imidacloprid and the like. The linear range of the biosensor probe for detecting the imidacloprid pesticide is 0.1-100 [mu] g / L, and the limit of detection (LOD) can reach 0.127 [mu] g / L and 0.119 [mu] g / L respectively by combining a colorimetric method and a fluorescence method.

The utility model provides automatic film coating equipment for a biosensor, the automatic film coating equipment is provided with an automatic atmosphere maintaining mechanism and a closed cavity for coating, the automatic atmosphere maintaining mechanism is connected with the closed cavity through a connecting pipeline, and the automatic atmosphere maintaining mechanism comprises an atmosphere generating device, an atmosphere transferring device and a pressure detecting device, the atmosphere generating device and the atmosphere transferring device are arranged in the automatic atmosphere keeping mechanism, and the pressure monitoring device is arranged in the closed cavity. And when the atmosphere in the closed cavity is lower than the preset range, the atmosphere in the automatic atmosphere maintaining mechanism is transferred into the closed cavity through the connecting pipeline, so that the atmosphere change of the closed cavity in the coating process is effectively reduced, and the coating is more uniform and stable. The automatic film coating equipment for the biosensor further comprises an automatic feeding mechanism, an automatic taking and placing mechanism, an automatic discharging mechanism and a controller. In addition, assembly line automatic film coating can be carried out, the product quality is high, the operation consistency is good, and the device is suitable for large-scale production.

In one embodiment, a dental appliance includes a dental-appliance body and a core sensor module embedded within the dental-appliance body. The core sensor module includes one or more processors. The dental appliance further includes at least one biological sensor coupled to the dental-appliance body and conductively coupled to the core sensor module, and further includes a conductive layer running through at least a portion of the dental-appliance body and conductively coupling the core sensor module with the at least one biological sensor.

The application provides cross-linked esterification modified microcrystalline cellulose and a preparation method thereof, wherein the agglomeration of the microcrystalline cellulose is improved by a double modification method of cross-linking and then esterification, the prepared cross-linked esterification modified microcrystalline cellulose has nanoscale size and high crystallinity, and has good mechanical properties and biocompatibility, and is particularly suitable for the fields of biological stents, tissue repair, drug delivery and biosensors. The application also uses the cross-linked esterification modified microcrystalline cellulose to prepare a collagen composite matrix, and the collagen composite matrix has better mechanical properties, water absorption properties and spatial structure stability, and brings new choices for biomedical material research and application.

The invention relates to a biosensor which comprises a first working electrode, a second working electrode and a reference electrode, the voltage difference value between the first working electrode and the reference electrode is a first voltage, the voltage difference value between the second working electrode and the reference electrode is a second voltage, and the first voltage is higher than the second voltage.

The invention provides a biosensor, a preparation method thereof and a neurotransmitter detection system. The biosensor comprises a substrate and a plurality of sensing units arranged on the substrate, wherein each sensing unit comprises an electrode pair, a boehmite functional layer, a functional organic molecule and an aptamer molecule. The electrode pair comprises a first electrode and a second electrode which are oppositely arranged to form a gap area. The boehmite functional layer is arranged in the gap area so as to connect the first electrode and the second electrode. The functional organic molecules are covalently connected with hydroxyl functional groups of the boehmite functional layer. And the aptamer molecule is covalently linked with the functional organic molecule. The aptamer molecules of different sensing units have different spatial configurations. According to the application, a plurality of sensing units are integrated and aptamer molecules of different sensing units are endowed with differential spatial configurations, so that the core problems of serious cross interference and incapability of synchronously detecting multiple targets caused by similar target molecular structures in multi-neurotransmitter detection of a traditional sensor are effectively solved.

The invention relates to the field of biological materials, in particular to an amphiphilic block copolymer self-assembled biomimetic membrane and a molecular membrane anchoring method and application. Wherein the biomimetic membrane is formed by self-assembly of membrane forming molecules; the film-forming molecule comprises an amphiphilic triblock copolymer, the configuration of the amphiphilic triblock copolymer is a hydrophilic chain segment A-hydrophobic chain segment B-hydrophilic chain segment A, and the amphiphilic triblock copolymer is modified by an organic silicon surfactant and then is self-assembled into the amphiphilic triblock copolymer biomimetic film. And the biological nanopore protein is promoted to be embedded into the biomimetic membrane by adopting anchoring molecules through a molecular membrane anchoring method, so that the application of the biomimetic membrane in preparation of a biosensor is realized. An organic silicon surfactant is added as a bridge, polarity repulsion between the substrate and the polymer is eliminated, and the triblock polymer is stably attached to the surface of the substrate. Anchoring molecules are adopted to form covalent bonds with the surface of the membrane and biomacromolecules to realize anchoring, so that the stability is extremely high, the elution resistance and the environmental interference resistance are high, and the method is suitable for biosensors.

The invention provides a double-antibody directionally-coupled FET (Field Effect Transistor) biosensor and a preparation method thereof, and belongs to the technical field of biosensors. The FET biosensor adopts a reference electrode to provide grid voltage, a buffer solution is a conductive electrolyte, the FET biosensor comprises a field effect transistor, a capture antibody and a detection antibody, the field effect transistor is composed of a source electrode, a drain electrode and a channel between the source electrode and the drain electrode, the bottom layer of the channel is an indium oxide thin film layer, the indium oxide thin film layer is modified with amino, and the detection antibody is a detection antibody. An amino-modified channel is obtained; carrying out passivation treatment on the source electrode and the drain electrode by adopting a mercaptan passivator; and cross-linking and fixing the capture antibody and the detection antibody on the channel modified with the amino group through a cross-linking fixing agent to obtain the FET biosensor. The two antibodies are combined according to different epitopes of antigens to form a sandwich structure, and double recognition of the antibodies on target antigens is utilized to enhance antigen capture efficiency and signal enrichment, so that a double-site recognition mode is formed, and low-concentration antigen detection is realized.

A working wire for a biological sensor is disclosed. The working wire includes a substrate comprising cobalt-chromium (Co-Cr) alloy or Nitinol alloy, a platinum layer comprising platinum on the substrate, and a membrane layer comprising a biological membrane applied over the platinum layer.

The invention relates to the technical field of biosensors, and particularly discloses a preparation method of a multi-channel solid nanopore array. The method comprises the following steps: respectively constructing a group of parallel and independent micro-channels on the front and back surfaces of a chip prepared with a suspended dielectric film window array, enabling the micro-channels on the two surfaces to be orthogonally arranged in space, integrating an independent electrode in each micro-channel, and injecting electrolyte; the electrodes of the micro-channel on one side and the electrodes of the micro-channel on the other side are selectively connected through an external control circuit, namely controllable electric fields can be established on the two sides of the thin film window at the unique intersection point corresponding to the electrodes, so that addressing and selective dielectric breakdown of the window are achieved, all the windows on the whole chip are automatically and sequentially addressed, traversed and processed, and the yield of the chip is improved. And forming a nanopore array. By means of the method, a large number of nanopore arrays can be controllably manufactured on a single chip at a time, and nanopore array machining with high throughput, low cost and high consistency is achieved.

The application discloses a rare earth ion doped lithium niobate micro-ring laser and a preparation method thereof, and utilizes femtosecond laser direct writing combined with chemical mechanical polishing technology to prepare a micro-ring and a coupling waveguide shape on the surface of a lithium niobate film doped with rare earth ions, and further realizes a micro-ring laser on a lithium niobate sheet. The application can realize low-cost mass production of the micro-ring laser on the sheet, and has important significance in optical communication, photonic integrated circuit, precision measurement and large-scale sensing and the like. Meanwhile, the laser based on the thin film lithium niobate micro-ring can generate multi-mode laser near multiple wave bands, and is a multi-wave channel light source with wide application prospect in optical communication and biosensors.

This invention relates to a pyridoxal phosphate-responsive biosensor and its application, belonging to the field of synthetic biology biosensor technology. This invention is the first to discover and identify the relationship between pyridoxal phosphate and Cgl1185-P. cgl2838 The transcriptional regulation and response relationship between these factors was investigated, and this relationship was used as the basis for constructing a biosensor responsive to pyridoxal. The transcription factor regulatory system Cgl1185-P derived from Corynebacterium glutamicum was used. cgl2838 A biosensor for the specific detection of pyridoxal phosphate was constructed by assembling a reporter gene as the main component onto a plasmid, enabling effective detection of pyridoxal phosphate concentrations in intracellular or culture environments. This biosensor possesses advantages such as clear structure, high sensitivity, and good host adaptability, and can be used for fermentation process monitoring, cofactor metabolism research, and screening of relevant strains, showing promising application prospects in the fields of cofactor concentration monitoring and metabolic regulation.