348 results about "Biologic Assays" patented technology

Facilitating transactions using non-traditional devices and biometric data to activate a transaction device is disclosed. A transaction request is formed at a non-traditional device, and communicated to a reader, wherein the non-traditional device may be configured with an RFID device. The RFID device is not operable until a biometric voice analysis has been executed to verify that the carrier of the RFID equipped non-traditional device is the true owner of account information stored thereon. The non-traditional device provides a conduit between a user and a verification system to perform biometric voice analysis of the user. When the verification system has determined that the user is the true owner of one or more accounts stored at the verification system, a purchase transaction is facilitated between the verification system. Transactions may further be carried out through a non-RF device such as a cellular telephone in direct communication with an acquirer / issuer or payment processor

The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.

A skin site of an individual is illuminated and light scattered from the skin site under multispectral conditions is received. The light includes light scattered from tissue beneath a surface of the skin site. Multiple biometric modalities are derived from the received light. The biometric modalities are fused into a combined biometric modality that is analyzed to perform a biometric function.

Biometric data, which may be suitably transformed are obtained from a biometric input device contained within a stand-alone computer or a mobile device, which may contain an ASIC chip connected to or incorporated within the stand-alone computer or mobile device and which includes the capability for capturing one or more biometric samples and for biometric feature extraction, matching and encryption. For extra security, the biometric matching is used in conjunction with a PIN to authenticate the user to the stand-alone computer or mobile device. The biometric template and other sensitive data residing on the mobile device are encrypted using hardware elements of the mobile device (or the ASIC) together with the PIN hash and / or the Password hash. An obfuscated version of the Password, stored on the ASIC or the mobile device is de-obfuscated and released to the mobile device authentication mechanism, including a Trusted Platform Module if present, in response to a successfully decrypted template and matching biometric sample and PIN. A de-obfuscated password is used to authenticate the user to the mobile device and the same or a different de-obfuscated password may be used to authenticate the user to a remote computer using the SSL / TLS or a process based upon a symmetric encryption algorithm. The locally generated password may be used to encrypt data at rest on the mobile device or ASIC and the remote authentication password may be used to encrypt data in transit to and from a remote computer. This creates a trusted relationship between the stand-alone computer or mobile device and the remote computer. The system also eliminates the need for the user to remember and enter complex passwords on the mobile device or for secure transmission of data. A similar method may be used, with the signature / sign biometric modality to determine whether the holder of an IC chip card is, in fact the card owner.

A system for permission confirmation incorporates a terminal device for transmitting an authorization request on a network. The terminal device includes capability for encryption of the request and for decryption of a response. A request arbitrating server (RAS) is connected to the network for receiving the authorization request from the terminal device. The RAS incorporates capability for decryption of the request from the terminal display and determines an authorizing party responsive to the request. The RAS then has capability for encryption of a request to an authorizing party for transmission on the network, and, for decryption of a response and biometric data from the authorizing party. The RAS has capability to confirm biometric data received and encrypt a response to the terminal device. A user biometric device (UBD) is connected to the network having capability for receiving an authorization request from the RAS and decrypting the request. A display for the decrypted request and a sensor for entry of biometric data along with an input device for entry of a response to the request is incorporated in the UBD. The UBD provides capability for encrypting the biometric data and response and transmission of the encrypted biometric data and response to the network for receipt by the RAS.

The movement and mixing of microdroplets through microchannels is described employing microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. Microdroplets are metered into defined volumes and are subsequently incorporated into a variety of biological assays. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

An integrated lab-on-a-chip device for carrying out an assay to detect the presence of a biological molecule in a fluid sample, the device comprising: (a) an inlet for a fluid sample; (b) one or more reaction sites each in fluid communication with the inlet; (c) one or more reagent reservoir systems each containing reagents required for an assay to detect a biological molecule, the reagents being arranged sequentially in each reservoir system in the order in which they are required for the assay and separated from one another by a fluid.

A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering element, and (c) a property-altering element is disclosed. Both the fluorescent polymer and the receptor are co-located on a support. When the chemical moiety is bound to the receptor, the property-altering element is sufficiently close to the fluorescent polymer to alter the fluorescence emitted by the polymer. When an analyte sample is introduced, the target biological agent, if present, binds to the receptor, thereby displacing the chemical moiety from the receptor, resulting in an increase of detected fluorescence. Assays for detecting the presence of a target biological agent are also disclosed.

A methodology for bioassays and diagnostics in which a particulate label (ranging in size from nm-scale molecular assemblages to organisms on the scale of tens or hundreds of microns), such as, but not limited to, nanoparticles, bacteria, bacteriophage, Daphnia, and magnetic particles, serve carriers for analytes bound by molecular recognition elements such as antibodies, aptamers, etc. The described methodology is generally applicable to most pathogen assays and molecular diagnostics and also leads to enhanced sensitivity and convenience of use.

Inorganic membrane structures of high stability, high permeability, and large surface area. Zeolite membranes can be disposed onto an intermediate pore size modification layer which reduces the pore size of the inorganic porous support. The intermediate pore size modification layer minimizes the defects in the zeolite membrane and provides a more continuous and uniform zeolite membrane. The inorganic membrane structure can be in the form of a honeycomb monolith. The applications for the zeolite membranes include, for example, membrane ultra-filtration of gas or liquid fluids, biological assays and cell culture surfaces.

The present invention relates to a method for verifying the integrity of biological source samples subjected to multistep bioassays that comprise massively parallel sequencing of the sample genomic nucleic acids. The integrity of the biological source samples is verified using unique marker nucleic acids that are combined with the biological source sample, and are sequenced concomitantly with the genomic nucleic acids of the biological source sample. The method provides verification of individual samples in single- and multiplex massively parallel sequencing assays.

The present invention generally relates to microfabricated devices for carrying out and controlling chemical reactions and analysis. In particular, the present invention provides systems, methods, devices and computer software products related to multiplex liquid handling systems utilizing lab cards related to biological assays.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

In some embodiments, an automated system comprises one or more biometric sensors, an interactive screen, and an exercise routine generation application communicable with a mobile application. In some embodiments, the mobile application receives data from an automated station and displays exercise routines, other exercise information, or both. In some embodiments, the mobile application includes a scanner to scan labels, other indicia, or physical or other features of an exercise machine or other exercise apparatus to identify the machine or apparatus. In some embodiments, the mobile application communicates with one or more local or remote databases identifying differing exercise facility locations within a geographic area and identifying exercise apparatus available in each of the differing facilities.

A device for use by an authorized person having an unique biometric parameter to obtain information for use in accessing a secured site. The device comprises a biometric interface unit engaged with a portable body member. The device further comprises biometric circuitry adapted to generate and store an initialized biometric template upon presentment of the person's unique biometric parameter to the biometric interface unit. The biometric circuitry is further adapted to generate a second biometric template upon subsequent presentment of the person's unique biometric parameter to the biometric interface unit. The device further comprises compare circuitry adapted to generate an first signal indicative that the second biometric template is substantially identical to the initialized biometric template. The device further comprises a storage device for storing a plurality of passwords. The device further comprises password circuitry adapted to generate a password in response to the first signal from the compare circuitry. The password circuitry being adapted to store the password in the storage device. The device further comprises water marking circuitry adapted to generate and embed a watermark within the password. The water marking circuitry may further comprise a plurality of memory registers and a data base having a plurality of public domain watermarks randomly assigned to each memory register. The device further comprises pager circuitry adapted to receive a signal from the secure site indicative that access has been attempted using said password and to generate an audible tone.

A programmable microprocessor-controlled weight device capable of storing a plurality of user profiles, each individual user profile comprising, a biometric identifier used for secured access to said individual user profile, measured information and, optionally, custom data The biometric identifier is preferably placed such that identification of the user is conveniently performed while the user is positioned for measurement on the weight device. The biometric identification data is used to scan the plurality of user profiles, determine whether the current user has a profile, or whether one must be created, and allows access to the user profile associated with the current user. Measured information and, optionally, custom data can then be loaded to and from the current user's profile. The information in a user's profile is, therefore, easily accessible by the proper user, and is securely maintained to prevent unauthorized access by others.

Microarrays are made from sections of a molded block having many channels. These channels, which are formed by casting and / or embedding a rod in a moldable solid, are used to immobilize biological and chemical binding components after rod removal. The microarrays can be used in general biological assays, clinical evaluations and chemical library analyses.

The present invention provides an automated analyzer system for performing chemical, biochemical or biological assays using changes / no changes in diffraction of light by the presence / absence of analytes which may or may not be present in a sample binding to their analyte specific receptors laid out in a preselected pattern in a disposable sensor. The analyzer is a modular, bench-top instrument that compactly integrates subsystems for sample dispensing, liquid handling, and optical generation of laser light beams and detectors for detecting for diffracted light. An internal processor is included for automating the instrument, and a user interface to provide communication with the operator.

The invention provides high sensitivity bioassay sensor systems in which non-specific adsorption of impurities such as, for example, proteins, in biological samples is inhibited. Polyethylene glycolated particles enclosing metal or semi-conductor which is in common with the sensor material are used for amplification.

The invention discloses a method for trapping tea plantation insects comprising the steps of, (1) separating and determining 10 pest damage volatile matters by adopting adsorptive separation method, (2) determining four volatile constituents with inducement activity by biological assay method, (3) preparing four active constituents into flavor source substances, matching the four flavor source substances, so as to formulate the insect attractant, (4) determining three colors with inducement effect to insects by tea plantation small zone inducement experiments, (5) combining the bud greening color with the attractant to prepare insect trapper, and (6) placing the trapper into the field to trap the insects.

The present invention relates generally to the enantiomers of para-hydroxy-milnacipran or congeners thereof. Biological assays revealed that racemic para-hydroxy-milnacipran is approximately equipotent in inhibiting serotonin and norepinephrine uptake (IC50=28.6 nM for norepinephrine, IC50=21.7 nM for serotonin). Interestingly, (+)-para-hydroxy-milnacipran is a more potent inhibitor of norepinephrine uptake than serotonin uptake (IC50=10.3 nM for norepinephrine, IC50=22 nM for serotonin). In contrast, (−)-para-hydroxy-milnacipran is a more potent inhibitor of serotonin uptake compared to norepinephrin uptake (IC50=88.5 nM for norepinephrine, IC50=40.3 nM for serotonin). The invention also relates to salts and prodrug forms of the aforementioned compounds. In certain embodiments, the compounds of the present invention and a pharmaceutically acceptable excipient are combined to prepare a formulation for administration to a patient. Finally, the present invention relates to methods of treating mammals suffering from various afflictions, e.g., depression, chronic pain, or fibromyalgia, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of the present invention.

Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.

A pointing device incorporates a biometric sensor at a location such that when operating the pointing device in a normal manner, a user's hand rests naturally in a position to place a finger of the user's hand in proximity to and readable by the biometric sensor. In one embodiment, a computer trackball pointing device includes a fingerprint sensor which is equally well suitable for use by either a right-handed or a left-handed user. Along with positional information from a position sensor and user selection information from at least one user-depressable button, the pointing device also conveys to an attached computer system information associated with the user's identity detected by the fingerprint sensor. Such a pointing device is well suited to both transparent verification as well as continuous verification, for if a user removes his or her hand from the natural position when using the device, the user's fingerprint will no longer be detectable by the fingerprint sensor, and the computer system to which the pointing device is attached can be alerted as to the need to re-authenticate any additional attempts at using the pointing device.

Fabrication of surfaces with reduced protein adsorption and / or cell adhesion comprising a vapor deposition coating process such that the coating includes polymer interfaces containing chemical groups reducing the protein adsorption and / or cell adhesion. The invention allows precise anchoring and presentation of biomolecules in their biological context. The resulting systems comprise superior surfaces for design of protein- or cellbased bioassays, because of high-signal-to-noise ratios. Background adsorption is suppressed while specific interaction with capturing molecules is not affected.