327 results about "Biologic Assays" patented technology

The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and / or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

A set of distance measurable encrypted feature vectors can be derived from any biometric data and / or physical or logical user behavioral data, and then using an associated deep neural network (“DNN”) on the output (i.e., biometric feature vector and / or behavioral feature vectors, etc.) an authentication system can determine matches or execute searches on encrypted data. Behavioral or biometric encrypted feature vectors can be stored and / or used in conjunction with respective classifications, or in subsequent comparisons without fear of compromising the original data. In various embodiments, the original behavioral and / or biometric data is discarded responsive to generating the encrypted vectors. In another embodiment, distance measurable or homomorphic encryption enables computations and comparisons on cypher-text without decryption of the encrypted feature vectors. Security of such privacy enabled embeddings can be increased by implementing an assurance factor (e.g., liveness) to establish a submitted credential has not been spoofed or faked.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

Described herein are multi-well separation devices configured to allow a composition comprising a target agent to be separated into multiple wells, subdivided, recombined into a single well, and / or re-separated into the same or a different configuration of wells. Also described herein are reagent loading devices configured to simultaneously deliver one or more test agents to a plurality of volumes without having to individually deliver the test agents. Together, these devices allow high throughput parallel processes without repetitive pipetting or liquid handling robotics, though they may also be used separately. Also described herein are kits and systems for chemical or biological assays, as well as methods for using the multi-well separation devices and reagent loading devices described herein.

A method for physiological detection and alerting is disclosed that includes obtaining biometric sensor data from a user; generating processed biometric sensor data from the set of biometric sensor data; generating features from the processed biometric sensor data which are associated with one or more characteristic physiological event phase; determining, the set of processed biometric sensor data, or both, a confidence score for each characteristic physiological event phase of the characteristic physiological event phases indicating a presence of that phase in a data segment; determining a final confidence score indicating an occurrence of a physiological event based on a relation between the confidence scores of all the characteristic physiological events; determining a cumulative confidence score indicating an occurrence of a particular physiological event, wherein the physiological event comprises of characteristic physiological event phases; and providing a potential physiological event alert based on the cumulative confidence score.

A method for a control system includes receiving in a biometric capture portion of a wearable device worn by a wearer, wearer biometric data associated with the wearer, storing in a memory of the wearable device authentic biometric data associated with an authorized user and a private key associated with the wearable device, receiving in a first short-range transceiver of the wearable device payload data, determining in a first processor of the wearable device if the wearer biometric data is authentic in response to the authentic biometric data associated with of the authorized user, encrypting in the first processor the payload data to form encrypted data in response the private key and in response to determining that the wearer biometric data is authentic, and outputting with the first short-range transceiver the encrypted data in response to determining that the wearer biometric data is authentic.

A robotic surgical system in which the system applies a scaling factor between user input from a user input device and corresponding movements of the robotic manipulator. Scaling factors may be applied or adjusted based on detected conditions such as the type of instrument being manipulated, detected distance between multiple instruments being manipulated, user biometric parameters.

Provided is a health monitoring system and a health monitoring method that enable constant daily health monitoring with relatively little burden on a subject, that helps prevent and improve lifestyle-related diseases while maintaining the quality of sleep, and that leads to a long and healthy life. [Solution] A health monitoring system using a non-invasive biometric device to measure the biometrics of a subject, comprising a measurement means which is remotely operated from the outside to grasp the internal condition of the body, such as within the organs and the digestive system, and measures spatiotemporal internal environmental information using an in-vivo cybernetic avatar capable of interacting within the body, and a visualization means which visualizes the spatiotemporal internal environmental information measured by the measurement means, wherein the visualization means synthesizes and displays the measurement results from the biometric device and the measurement results of the spatiotemporal internal environmental information from the in-vivo cybernetic avatar.

The present invention relates to CRISPR / Cas based biosensing materials, assays, and methods. Specifically, the present technology relates to CRISPR / Cas-based ultra-sensitive detection methods for nucleic acid assays using specific molecular constructs, including constructs referred to as nucleic acid mediators, comprising single-stranded and double-stranded nucleic acid sequences of a cyclic conformation, and palindromic oligonucleotides. The materials and methods according to the invention can also be used to enhance the sensitivity of existing bioassays.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

Interconnected computing enables the use of highly diverse environments that support a contemporary civilized operating framework. However, the computational productivity and credibility are disrupted by very immature organizations of this environment. Because current computing entity (e.g., resource) identification infrastructure designs lacking root identification reliability, these environments and their identity infrastructures are decentralized, and unnecessarily unreliable, unsecure, and inadequate of information. This reliability is achieved herein by a bioassay and activity-based portable identification and provenance infrastructure that is substantially accurate and authenticity guaranteed, close to the presence or the quality of the presence. The infrastructure provides ubiquitous available identification information, which can be commonly used in the identification process. Such biometric and activity-based identification information may be acquired contemporaneously and securely fused with or otherwise bound to an associated entity identification information set. This set is used to identify and evaluate entity suitability and / or authenticity, and / or to establish user identities (particular human entities) for individual, social and organizational activities.

The present disclosure relates generally to implementing biometric authentication, including providing user interfaces for: while the electronic device is in a first state in which a respective function of the electronic device is disabled, detecting one or more activations of the button; and in response to detecting the one or more activations of the button: capturing, with the one or more biometric sensors that are separate from the button, biometric data; if the biometric data satisfies biometric authentication criteria, transitioning the electronic device to a second state in which the respective function of the electronic device is enabled; and if the biometric data does not satisfy the biometric authentication criteria, maintaining the electronic device in the first state and displaying, on the display, an indication that biometric authentication has failed.

An electronic device performs techniques related to receiving a request to perform an operation that requires authentication, in response to receiving the request to perform the operation that requires authentication, attempting to authenticate a user, if authentication is successful, performing the operation, and if authentication is not successful and that a set of error condition criteria is met: displaying an indication of a location of the one or more biometric sensors, wherein the indication is a graphical indicator that is displayed at a respective location on the display that is a first distance from a first edge of the electronic device, and wherein the respective location on display is a second distance from a second edge of the electronic device, wherein the second edge is opposite from the first edge, and wherein the second distance is greater than the first distance, and forgoing performing the operation.

The invention discloses a europium-based metal-organic framework as well as a preparation method and application thereof, and belongs to the technical field of bioassay materials. The preparation method of the europium-based metal-organic framework comprises the following steps: adding europium salt, H4BTA-2OH and ascorbic acid into a binary solution, and sequentially performing ultrasonic treatment, heating and post-treatment to prepare the europium-based metal-organic framework (the molecular formula is {[(CH3) 2NH2] [Eu (BTA-2OH) (H2O) 2]. 4H2O} n). In addition, the invention also discloses an application of the europium-based metal-organic framework in detection of a bacillus anthracis biomarker 2, 6-dipicolinic acid (DPA). The europium-based metal-organic framework Eu-MOF prepared by the method can rapidly detect 2, 6-dipicolinic acid, and has high selectivity and sensitivity, and the excellent fluorescence sensing ability means that the europium-based metal-organic framework Eu-MOF is a potential bacillus anthracis detection material.

When a gamer's sensed heart rate or other biometric indicator indicates that the gamer is excited or otherwise that an interesting part of a computer game is commanding the gamer's attention, a clip of the game is automatically recorded. A heat map of heart rate may be presented to the gamer showing the gamer his reactions as he moves around the game space. Also, a specific heart rate capture mechanism on a game controller is presented.

Apparatus, methods and systems for continual biometric authentication of a user on a user device is provided. Methods may create, for the user, a biometric authentication reference model. Methods may store the biometric authentication reference model at a database associated with the user device. In response to an instantiation of a session by the user on the user device, methods may execute a continual biometric scan. The scanning may be executed until the session is terminated. Methods may identify a number of comparison points between the scanned and stored biometric identifiers. In response to determining that the number of identified comparison points is below a predetermined threshold number of comparison points, methods may initiate a passcode request. The passcode request may request a confirmation of a preset user-selected passcode. In response to determining that the passcode response does not match the preset user-selected passcode, methods may terminate the session.

An integrated circuit module is provided for post-lamination implanting into a smartcard body. The integrated circuit module includes a contact plate, a biometric sensor, a secure element, and means for electrical connection to an antenna embedded within the smartcard body. The secure element includes contact and contactless communication logic, and is configured to perform at least one smartcard function utilising the biometric sensor.

Disclosed are a method, system, and apparatus of a biometric sensor of a tactical gear to monitor health and stress of a wearer. In one embodiment, personal protective equipment includes a language translator module integrated in a tactical gear, a biometric sensor, and a responsive device integrated in the tactical gear. A wearer bi-directionally communicates with an individual in an ambient environment using any language other than a primary language spoken by the wearer when the language translator module is activated. The biometric sensor detects the health condition of the wearer. The responsive device vibrates to notify the wearer when the biometric sensor detects an elevated stress level of the wearer of the tactical gear. The biometric sensor is detachable from the tactical gear and placeable on an injured person nearby to the wearer through an armband extendable from the biometric sensor when it is removed from the tactical gear.

The invention provides an FPVA biochip layout method considering reagent type difference in unit multiplexing, which comprises the following steps of: modeling a biochip layout task as a Markov decision process: according to the size of an input FPVA chip, the dependency relationship of each operation in a biochemical reaction sequence diagram, the reagent type contained in each operation and a binding scheduling scheme, determining the FPVA biochip layout task; initializing an FPVA mesh model and defining a state space, an action space and a reward function; wherein the reward function is set according to the total unit multiplexing complexity of the current layout scheme, the legality of the current component layout and the distance between the component and the center point of the FPVA chip; and finally, completing the FPVA biochip layout through the dual deep Q network based on a Markov decision process. By designing a reward function, the unit multiplexing complexity is minimized, and the distance between components containing the same type of reagents is reduced, so that the purposes of minimizing the cross contamination degree of a final layout scheme, the total length of a fluid transportation path and the bioassay completion time are achieved.

A spectral sensing device and associated methods for enhanced diagnostic capabilities across medical fields are disclosed. The device incorporates multispectral, hyperspectral, and photoplethysmography technologies to analyze biological features including tongue, oral cavity, saliva, teeth, and other tissues. The system transforms any standard RGB camera into a multispectral imaging device by training machine learning models to associate RGB values with spectral values inside and outside the visible spectrum using measurements from a single pixel detector spectroradiometer. A multimodal neural network with separate processing branches analyzes spectral images, non-spectral images, and tabular data to predict microbiome composition. The system generates health risk assessments by comparing predicted microbial abundances to thresholds associated with various medical conditions. Near-infrared sensing enables blood flow monitoring, subcutaneous imaging, and assessment of physiological parameters. Convolutional neural networks enable spectral reconstruction without requiring the physical device, while supporting continuous monitoring in various form factors.

The present invention provides methods and devices for detecting and quantifying multiple biomolecules at single-molecule level using an integrated droplet microfluidic system. In one embodiment, the present invention provides real-time and digital measurement of multiple biomolecules in a sample, thereby quantifying multiple biomolecules in an absolute and simultaneous manner. In one embodiment, the present invention provides a diagnostic method for a disease, comprising real-time and digital measurement of multiple biomolecules in a sample using the method or device described herein.

A biometric handcuff device is disclosed, which identifies medical emergencies for those who are detained by police or security. The biometric handcuff device comprises a pair of law enforcement handcuffs that include a biometric sleeve inside the cuffs. The sleeve is constructed as a rubber insert that permanently stays in place within the cuffs. The biometric sleeve allows officers to track the breathing, blood pressure, and pulse of a handcuffed individual. The measurements taken may be observed remotely by police or medical personnel.

The present invention relates to a system and method for acquiring and analyzing physiological data from a user. The system includes a plurality of interconnected devices, which may communicate sensor data to a personal mobile electronic device. Each interconnected device includes at least one sensor to acquire physiological data. In addition, at least one sensor is operably connected to the body of the user. Further, the interconnected biometric devices may be implanted medical devices and / or wearable electronic devices. The personal mobile electronic device is wirelessly connected to each of the plurality of interconnected biometric devices. In addition, the personal mobile electronic device is configured to receive and analyze physiological data acquired by each of the plurality of interconnected devices and to compute the difference between the values of the same physiological parameter measured at a different location of the user's body.

Disclosed are systems and methods that, via the disclosed functionality, can involve receiving, via a wearable device, biometric data associated with a wearer of the wearable device. The systems and methods may additionally include receiving, from a management device communicatively coupled to at least one managed device, data representative of a device state of the at least one managed device. The systems and methods may also include determining, based on the biometric data, a current status of the wearer, and directing, based on the current status of the wearer and the device state, the management device to execute a management action associated with the at least one managed device. Various other systems, methods, and computer-readable media are also disclosed.

The present disclosure relates generally to implementing biometric authentication, including providing user interfaces for: while the electronic device is in a first state in which a respective function of the electronic device is disabled, detecting one or more activations of the button; and in response to detecting the one or more activations of the button: capturing, with the one or more biometric sensors that are separate from the button, biometric data; if the biometric data satisfies biometric authentication criteria, transitioning the electronic device to a second state in which the respective function of the electronic device is enabled; and if the biometric data does not satisfy the biometric authentication criteria, maintaining the electronic device in the first state and displaying, on the display, an indication that biometric authentication has failed.

The present disclosure generally relates to managing user inputs. In some examples, devices receive user inputs via a biometric sensor, such as a fingerprint sensor. In some examples, devices receive user inputs via a button. In some examples, devices receive user inputs via touch sensors. In some examples, the biometric sensor and / or the touch sensor is integrated into the button.