248 results about "Biologic Assays" patented technology

The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and / or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

The present invention relates to CRISPR / Cas based biosensing materials, assays, and methods. Specifically, the present technology relates to CRISPR / Cas-based ultra-sensitive detection methods for nucleic acid assays using specific molecular constructs, including constructs referred to as nucleic acid mediators, comprising single-stranded and double-stranded nucleic acid sequences of a cyclic conformation, and palindromic oligonucleotides. The materials and methods according to the invention can also be used to enhance the sensitivity of existing bioassays.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

The present disclosure relates generally to implementing biometric authentication, including providing user interfaces for: while the electronic device is in a first state in which a respective function of the electronic device is disabled, detecting one or more activations of the button; and in response to detecting the one or more activations of the button: capturing, with the one or more biometric sensors that are separate from the button, biometric data; if the biometric data satisfies biometric authentication criteria, transitioning the electronic device to a second state in which the respective function of the electronic device is enabled; and if the biometric data does not satisfy the biometric authentication criteria, maintaining the electronic device in the first state and displaying, on the display, an indication that biometric authentication has failed.

The invention discloses a europium-based metal-organic framework as well as a preparation method and application thereof, and belongs to the technical field of bioassay materials. The preparation method of the europium-based metal-organic framework comprises the following steps: adding europium salt, H4BTA-2OH and ascorbic acid into a binary solution, and sequentially performing ultrasonic treatment, heating and post-treatment to prepare the europium-based metal-organic framework (the molecular formula is {[(CH3) 2NH2] [Eu (BTA-2OH) (H2O) 2]. 4H2O} n). In addition, the invention also discloses an application of the europium-based metal-organic framework in detection of a bacillus anthracis biomarker 2, 6-dipicolinic acid (DPA). The europium-based metal-organic framework Eu-MOF prepared by the method can rapidly detect 2, 6-dipicolinic acid, and has high selectivity and sensitivity, and the excellent fluorescence sensing ability means that the europium-based metal-organic framework Eu-MOF is a potential bacillus anthracis detection material.

When a gamer's sensed heart rate or other biometric indicator indicates that the gamer is excited or otherwise that an interesting part of a computer game is commanding the gamer's attention, a clip of the game is automatically recorded. A heat map of heart rate may be presented to the gamer showing the gamer his reactions as he moves around the game space. Also, a specific heart rate capture mechanism on a game controller is presented.

Disclosed are a method, system, and apparatus of a biometric sensor of a tactical gear to monitor health and stress of a wearer. In one embodiment, personal protective equipment includes a language translator module integrated in a tactical gear, a biometric sensor, and a responsive device integrated in the tactical gear. A wearer bi-directionally communicates with an individual in an ambient environment using any language other than a primary language spoken by the wearer when the language translator module is activated. The biometric sensor detects the health condition of the wearer. The responsive device vibrates to notify the wearer when the biometric sensor detects an elevated stress level of the wearer of the tactical gear. The biometric sensor is detachable from the tactical gear and placeable on an injured person nearby to the wearer through an armband extendable from the biometric sensor when it is removed from the tactical gear.

The invention provides an FPVA biochip layout method considering reagent type difference in unit multiplexing, which comprises the following steps of: modeling a biochip layout task as a Markov decision process: according to the size of an input FPVA chip, the dependency relationship of each operation in a biochemical reaction sequence diagram, the reagent type contained in each operation and a binding scheduling scheme, determining the FPVA biochip layout task; initializing an FPVA mesh model and defining a state space, an action space and a reward function; wherein the reward function is set according to the total unit multiplexing complexity of the current layout scheme, the legality of the current component layout and the distance between the component and the center point of the FPVA chip; and finally, completing the FPVA biochip layout through the dual deep Q network based on a Markov decision process. By designing a reward function, the unit multiplexing complexity is minimized, and the distance between components containing the same type of reagents is reduced, so that the purposes of minimizing the cross contamination degree of a final layout scheme, the total length of a fluid transportation path and the bioassay completion time are achieved.

A spectral sensing device and associated methods for enhanced diagnostic capabilities across medical fields are disclosed. The device incorporates multispectral, hyperspectral, and photoplethysmography technologies to analyze biological features including tongue, oral cavity, saliva, teeth, and other tissues. The system transforms any standard RGB camera into a multispectral imaging device by training machine learning models to associate RGB values with spectral values inside and outside the visible spectrum using measurements from a single pixel detector spectroradiometer. A multimodal neural network with separate processing branches analyzes spectral images, non-spectral images, and tabular data to predict microbiome composition. The system generates health risk assessments by comparing predicted microbial abundances to thresholds associated with various medical conditions. Near-infrared sensing enables blood flow monitoring, subcutaneous imaging, and assessment of physiological parameters. Convolutional neural networks enable spectral reconstruction without requiring the physical device, while supporting continuous monitoring in various form factors.

The present invention provides methods and devices for detecting and quantifying multiple biomolecules at single-molecule level using an integrated droplet microfluidic system. In one embodiment, the present invention provides real-time and digital measurement of multiple biomolecules in a sample, thereby quantifying multiple biomolecules in an absolute and simultaneous manner. In one embodiment, the present invention provides a diagnostic method for a disease, comprising real-time and digital measurement of multiple biomolecules in a sample using the method or device described herein.

A biometric handcuff device is disclosed, which identifies medical emergencies for those who are detained by police or security. The biometric handcuff device comprises a pair of law enforcement handcuffs that include a biometric sleeve inside the cuffs. The sleeve is constructed as a rubber insert that permanently stays in place within the cuffs. The biometric sleeve allows officers to track the breathing, blood pressure, and pulse of a handcuffed individual. The measurements taken may be observed remotely by police or medical personnel.

The present invention relates to a system and method for acquiring and analyzing physiological data from a user. The system includes a plurality of interconnected devices, which may communicate sensor data to a personal mobile electronic device. Each interconnected device includes at least one sensor to acquire physiological data. In addition, at least one sensor is operably connected to the body of the user. Further, the interconnected biometric devices may be implanted medical devices and / or wearable electronic devices. The personal mobile electronic device is wirelessly connected to each of the plurality of interconnected biometric devices. In addition, the personal mobile electronic device is configured to receive and analyze physiological data acquired by each of the plurality of interconnected devices and to compute the difference between the values of the same physiological parameter measured at a different location of the user's body.

The present disclosure relates generally to implementing biometric authentication, including providing user interfaces for: while the electronic device is in a first state in which a respective function of the electronic device is disabled, detecting one or more activations of the button; and in response to detecting the one or more activations of the button: capturing, with the one or more biometric sensors that are separate from the button, biometric data; if the biometric data satisfies biometric authentication criteria, transitioning the electronic device to a second state in which the respective function of the electronic device is enabled; and if the biometric data does not satisfy the biometric authentication criteria, maintaining the electronic device in the first state and displaying, on the display, an indication that biometric authentication has failed.

The present disclosure generally relates to managing user inputs. In some examples, devices receive user inputs via a biometric sensor, such as a fingerprint sensor. In some examples, devices receive user inputs via a button. In some examples, devices receive user inputs via touch sensors. In some examples, the biometric sensor and / or the touch sensor is integrated into the button.

Provided herein are systems and methods for authenticating users during payment transactions and other types of interaction events using biometric information. The disclosed systems involve a biometric orchestration platform that receives biometric data of a user from a biometric module or device, intelligently routes this data to a biometric verification service, and retrieves a positive identification if a match is found. This identification is then used in various ways, e.g., to retrieve a payment card token linked to the user's authorized payment method.

The present invention is directed to fluorescent rhodamine dyes having spectral properties suited to the creation of multiplex assay systems for use in molecular biology, cell biology and molecular genetics. The rhodamine dyes have the following structure.

A display device is disclosed that includes a display panel configured to display images. A biometric sensor module is disposed on the display panel. The biometric sensor module is configured to output a first transmission signal having a first frequency in a fingerprint sensing mode to sense fingerprint information. The biometric sensor is also configured to output a second transmission signal having a second frequency different from the first frequency in a skin measurement mode to sense skin condition information.

This utility model relates to the field of experimental chamber technology and discloses a multi-angle observation pest biological measurement experimental chamber device, including a supporting base plate and four supporting bases. The top of the supporting base plate has a mounting groove, and a servo motor is fixedly installed on the inner bottom wall of the mounting groove. A supporting box is fixedly installed at the output end of the servo motor. A first hydraulic rod is fixedly installed on the inner top wall of the supporting box, and a fixing ring is fixedly installed at the bottom end of the first hydraulic rod. A supporting disc is detachably connected to the bottom of the fixing ring, and a fixing disc for storage is inserted into the inner bottom wall of the supporting box. This multi-angle observation pest biological measurement experimental chamber device, through the setting of the servo motor, allows the supporting box to rotate when the servo motor is working, thereby facilitating observation of the internal conditions of the supporting box from multiple angles, thus improving the applicability of the device.

A digital healthcare architecture including a cloud-based virtual clinic platform configured to facilitate remote therapy of one or more patients based on biometric authentication systems and methods. In an example arrangement, one or more biometric indicia of a user (e.g., a clinician and / or a patient) as well as one or more non-biometric input factors may be used in authenticating the user prior to granting access to a protected resource or application (e.g., a therapy application executing on a UE device) configured for effectuating remote programming of an implantable medical device (IMD) operative to provide therapy to the patient.

The invention provides a secretory protein with insecticidal activity and an application of the secretory protein in pest control, an entomopathogenic fungus beauveria bassiana is used as a research material, and the secretory protein BbTsp1 is identified by using a protein spectrum technology. The protein is prepared and purified by using a prokaryotic expression system. A host blood cavity injection experiment proves that the protein has the activity of killing a host. Through a gene recombination technology, the BbTsp1 gene is introduced into beauveria bassiana, and an overexpression strain of the gene is constructed. Bioassay shows that the insecticidal activity of the strain is remarkably improved. The construction of a recombinant strain of the toxicity related gene identified by the invention improves the pest control efficiency of insecticidal fungi.

Devices and methods for performing rapid low-cost bioassays, including some embodiments for multiplexed detection of multiple amplified biomolecules for identifying one or more diseases, disorders, or infections, are disclosed herein. Such methods can include isolating a first biomolecule in a first detection chamber, isolating a second biomolecule in a second detection chamber, illuminating the first detection chamber with a first light source, and illuminating the second detection chamber with a second light source, where the illumination induces the production of an emitted light signal.

Described herein are devices, systems, and methods for performing serial biological assays using selectively degradable hydrogels. Aspects of the present disclosure provide a method for analyzing an analyte that includes inputting the analyte and a biological material into a fluidic device and detecting an interaction between the analyte and the biological material. The analyte and the biological material may initially be separated by a hydrogel polymer wall, and may later be combined by degrading the hydrogel polymer wall.

A system and method to configure a rule set used in connection with a medical monitoring system for monitoring patients and patient care equipment, especially medication delivery pumps, based on a variety of conditions and parameters associated with monitored biometric information and equipment information and for providing user-defined responses to those conditions and parameters.

A drinking bottle including a bottle body, a lid or a cap, and an electronic nose sensor. The bottle body has a base, at least one sidewall extending from the base, a neck extending from the at least one sidewall, and an opening at a top of the neck that fluidly connects an internal volume of the bottle body with an exterior environment. The lid or cap is configured to engage with the neck of the bottle body to selectively close off and seal the opening of the bottle body for adding or removing liquid contents within the volume of the bottle body. The electronic nose sensor is in electrical communication with a power source and is configured to collect and analyze a plurality of breath biomarkers. The electronic nose sensor and the power source are both disposed on one of the bottle body or the lid or cap.

An electronic device may comprise a biometric sensor and at least one processor. At least one processor may be configured to obtain a PPG signal through the biometric sensor. At least one processor may be configured to obtain a blood flow rate of a user wearing a wearable electronic device on the basis of the PPG signal. At least one processor may be configured to obtain the blood pressure of the user. At least one processor may be configured to determine cardiovascular resistance indicating a degree to which blood flow is affected in a cardiovascular system of the user based on the obtained blood flow rate and the obtained blood pressure.