284 results about "Biologic Assays" patented technology

The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to PCA3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding PCA3 proteins; a method of detecting nucleic acids encoding PCA3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.

Biometric data, which may be suitably transformed are obtained from a biometric input device contained within a stand-alone computer or a mobile device, which may contain an ASIC chip connected to or incorporated within the stand-alone computer or mobile device and which includes the capability for capturing one or more biometric samples and for biometric feature extraction, matching and encryption. For extra security, the biometric matching is used in conjunction with a PIN to authenticate the user to the stand-alone computer or mobile device. The biometric template and other sensitive data residing on the mobile device are encrypted using hardware elements of the mobile device (or the ASIC) together with the PIN hash and/or the Password hash. An obfuscated version of the Password, stored on the ASIC or the mobile device is de-obfuscated and released to the mobile device authentication mechanism, including a Trusted Platform Module if present, in response to a successfully decrypted template and matching biometric sample and PIN. A de-obfuscated password is used to authenticate the user to the mobile device and the same or a different de-obfuscated password may be used to authenticate the user to a remote computer using the SSL/TLS or a process based upon a symmetric encryption algorithm. The locally generated password may be used to encrypt data at rest on the mobile device or ASIC and the remote authentication password may be used to encrypt data in transit to and from a remote computer. This creates a trusted relationship between the stand-alone computer or mobile device and the remote computer. The system also eliminates the need for the user to remember and enter complex passwords on the mobile device or for secure transmission of data. A similar method may be used, with the signature/sign biometric modality to determine whether the holder of an IC chip card is, in fact the card owner.

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

In some embodiments, an automated system comprises one or more biometric sensors, an interactive screen, and an exercise routine generation application communicable with a mobile application. In some embodiments, the mobile application receives data from an automated station and displays exercise routines, other exercise information, or both. In some embodiments, the mobile application includes a scanner to scan labels, other indicia, or physical or other features of an exercise machine or other exercise apparatus to identify the machine or apparatus. In some embodiments, the mobile application communicates with one or more local or remote databases identifying differing exercise facility locations within a geographic area and identifying exercise apparatus available in each of the differing facilities.

Microarrays are made from sections of a molded block having many channels. These channels, which are formed by casting and/or embedding a rod in a moldable solid, are used to immobilize biological and chemical binding components after rod removal. The microarrays can be used in general biological assays, clinical evaluations and chemical library analyses.

The invention provides high sensitivity bioassay sensor systems in which non-specific adsorption of impurities such as, for example, proteins, in biological samples is inhibited. Polyethylene glycolated particles enclosing metal or semi-conductor which is in common with the sensor material are used for amplification.

The invention discloses a method for trapping tea plantation insects comprising the steps of, (1) separating and determining 10 pest damage volatile matters by adopting adsorptive separation method, (2) determining four volatile constituents with inducement activity by biological assay method, (3) preparing four active constituents into flavor source substances, matching the four flavor source substances, so as to formulate the insect attractant, (4) determining three colors with inducement effect to insects by tea plantation small zone inducement experiments, (5) combining the bud greening color with the attractant to prepare insect trapper, and (6) placing the trapper into the field to trap the insects.

Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in multiplexed bioassays with ICP-MS detection.

Fabrication of surfaces with reduced protein adsorption and/or cell adhesion comprising a vapor deposition coating process such that the coating includes polymer interfaces containing chemical groups reducing the protein adsorption and/or cell adhesion. The invention allows precise anchoring and presentation of biomolecules in their biological context. The resulting systems comprise superior surfaces for design of protein- or cellbased bioassays, because of high-signal-to-noise ratios. Background adsorption is suppressed while specific interaction with capturing molecules is not affected.

Beverages are provided and administered for producing LIS samples containing cells exfoliated from throughout the gut in sufficient numbers and free of interfering substances such as formed fecal particles for chemical assays and biologic assays for nucleic acid sequence information, and medical diagnosis. A kit is also provided for use by patients without assistance to produce a LIS sample suitable for analysis. A collection kit employs a sequence of the beverages and other ingested substances to produce preserved cells for medical diagnosis, allowing cytologic analysis of the LIS for diagnosis of foregut and hindgut disease. A preliminary cathartic lavage is used to cleanse a patient's digestive tract; at least one stool induced by the preliminary cathartic lavage is collected; and a final cathartic lavage is used to exfoliate and preserve cells from a patient's digestive tract. Time release capsules containing a cathartic medicament can also be used after completing preliminary lavage administration. The kit also allows provides apparatus for collection, sealing, and packing of the collected LIS specimen for analysis.

An apparatus is provided for performing an chemical, biochemical, or biological assay on a sample comprising: a microfluidic assay cartridge (1) that contains at least one sample inlet well (2) configured to receive a sample; and a microfluidic sub-unit (3) associated with the microfluidic assay cartridge (1) and comprising microfluidic channels (8), micro-valves (4, 4a, 9) and at least one separate and fluidicly-isolated isolation channel (5), and at least one hollow element (14); the at least one hollow element (14) being functionalized with a capture moiety or molecules (15) so as to form at least one reaction vessel (19); the microfluidic channels (8) and micro-valves (4, 4a, 9) configured to respond to signaling containing information about performing the assay and to controllably receive the sample and at least one reagent in the at least one reaction vessel (19), and to provide from the at least one reaction vessel (19) light containing information about the assay performed on the sample inside the at least one reaction vessel (19) as a result of said at least one reagent.

The present invention provides methods of cleaving a nucleic acid strand to initiate, assist, monitor or perform biological assays.