1208 results about "Tissue damage" patented technology

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

The invention discloses a bionic nanofiber-hydrogel composite biological scaffold as well as a preparation method and application thereof. The bionic nanofiber-hydrogel composite biological scaffold is a composite scaffold for simulating a gray-white matter partition structure of a spinal cord tissue, and comprises bionic nanofibers and a bionic hydrogel material, wherein the bionic nanofibers are arranged in an oriented manner and simulate a white matter ordered structure around the spinal cord, and the bionic hydrogel material is combined with the bionic nanofibers and simulates gray matter in the center of the spinal cord. According to the bionic nanofiber-hydrogel composite biological scaffold, the biological activity of loaded stem cells or adult cells can be improved, the problem that a large number of transplanted exogenous cells die due to unbalanced oxidative stress generated after tissue damage can be solved, and it is guaranteed that the transplanted cells reside in a damaged area and play a role; therefore, the spinal cord microenvironment is improved, proliferation and differentiation of endogenous neural stem cells are promoted, functional recovery after spinal cord injury is finally promoted, and great potential is achieved in spinal cord injury treatment.

The invention relates to a battle wound field real-time hemostasis method based on a biological information sensing technology, and the technical scheme comprises the steps: introducing a time sequence biological signal for modeling, and carrying out the dynamic prediction of a battle wound state; on the basis of a biosensor data flow, a multi-dimensional time sequence state space is constructed, and the multi-dimensional time sequence state space comprises a nonlinear change trend of a bleeding rate, an evolution mode of tissue physiological parameters and a dynamic evolution process of a blood coagulation process; external intervention requirements are minimized while a hemostasis strategy is dynamically adjusted through active learning; defining multi-objective optimization modeling of key objectives of hemostasis efficiency, tissue damage minimization and pressure adaptability; estimating distribution prediction of success probabilities of different hemostasis strategies; the intelligent response mechanism is composed of a nanoscale blood coagulation factor carrier and a phase change regulation and control network. An environment triggering response model is constructed, and the blood coagulation factor carrier selectively releases blood coagulation factors according to biological signals including the pH value, the temperature and the bleeding rate.

Articles including protective gear for a variety of sports and activities provide protection from one or both of linear and angular forces that either directly or indirectly impact the gear when it is donned. The articles include at least two layers of material that provide multimodal energy dissipation to minimize the extent of transmission of impact forces to tissue.

The invention provides a first-aid tourniquet pressure monitoring and automatic alarm system, and relates to the technical field of pressure monitoring. The system comprises a biological reaction monitoring module, a pressure adjustment analysis module, a real-time pressure adjustment module, a safety threshold detection module and an emergency response activation module. According to the invention, through real-time monitoring of biological reactions, changes of micro blood flow, skin electrical impedance and tissue morphology of a patient after the patient uses the tourniquet are captured, so that monitoring of individual reactions is more comprehensive, the safety and effect of pressure are evaluated in combination with the actual physiological state of the patient, monitoring is more dynamic and personalized, and the monitoring accuracy is improved. Through the combination of pressure real-time adjustment and emergency response, it is ensured that when the pressure exceeds a safety range, pressure adjustment is conducted rapidly, warning is given out through an alarm, secondary injury caused by improper pressure is avoided, the use safety and response speed of the tourniquet are improved, tissue injury of a patient can be more accurately prevented, and the patient can be more accurately protected. And the real-time effectiveness and safety in the emergency treatment process are ensured.

The invention provides a liposuction needle cannula system and method, and the system comprises a cannula assembly which is used for forming a liposuction space at a liposuction part; the liposuction needle assembly is arranged in the sleeve assembly in a sliding and penetrating mode and used for conducting liposuction operation in the liposuction space. According to the technical scheme, tissue damage is reduced, and the fat cell survival rate and the liposuction efficiency are improved.

According to the precise diagnosis and treatment integrated platform and method based on the coupling model, the cavitation effect is predicted through numerical simulation, negative feedback adjustment is conducted on microbubble mediated ultrasonic treatment, and precise control over the microbubble mediated ultrasonic treatment is achieved. Acoustic parameters are adjusted in real time, it can be ensured that treatment focuses on a lesion area, damage to surrounding healthy tissue is reduced, and therefore the accuracy and safety of treatment are improved. The platform integrates cavitation detection and an acoustic feedback mechanism, the microbubble cavitation effect can be monitored in real time, and treatment parameters can be automatically adjusted. Negative feedback closed-loop control can ensure a stable cavitation state, tissue damage caused by excessive cavitation is effectively avoided, and the stability and reliability of treatment are improved. The platform simplifies the operation process of controlling acoustic parameters. A doctor can complete the whole process from treatment to monitoring on the same operation interface through the integrated platform, and convenience and efficiency of clinical operation are improved. The platform is not only suitable for tumor treatment, ablation and drug delivery, but also can be applied to multiple treatment fields such as vascular diseases and neuromodulation, and has wide clinical application prospects and market potential.

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.

A digital intelligent control system for perceiving a puncture state is characterized in that a sensor signal is converted into a state expression vector of an interaction behavior of a tissue and a puncture tool, and characteristics including tissue elasticity, a fracture threshold value and interface slippage are extracted; a time domain and frequency domain feature mapping mechanism of a nested structure is used, and micro-characterization including piercing micro-shock and tissue layer transition points in continuous puncture is extracted; describing logic mapping between puncture path evolution and a prediction result by constructing a state and intention space diagram relationship; introducing a semantic dynamic weight mechanism, and judging whether the current state is a path expected by a doctor so as to identify a potential deviation puncture or abnormal invasion risk; through real-time identification of key states such as tissue level transition points, piercing micro-shock, interface slippage and the like, the mistaken entry risk of a high-risk area is effectively pre-judged. The system can adjust the puncture angle, speed and torque in advance, and common concurrent problems such as over-puncture, deviation or tissue damage in an operation are avoided.

The invention relates to the technical field of disease diagnosis, and comprises a disease diagnosis method and system based on neural network cognitive diagnosis, and the method comprises the following steps: obtaining medical image data, calculating the gray level change rate, gradient direction distribution and edge continuity of a lesion region, counting the lesion tissue damage area, and analyzing the pathological tissue damage degree. And obtaining a lesion distribution consistency index. According to the invention, through comprehensive calculation of the medical image data and the pathological tissue slice data, fine-grained description of a focus area is realized, association among different lesion features is realized, and calculation of a lesion propagation path matching rate is realized, so that identification of lesion diffusion conditions is more accurate, and development trends of diseases in different tissue structures can be effectively predicted; the calculation of the cross-modal feature error is combined with the adjustment of the distribution weight of the lesion region, misdiagnosis caused by modal difference and extraction of abnormal signals in a lesion diffusion range are reduced, so that screening of potential diseases is more targeted, and the accuracy of disease recognition is improved.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are systems and methods for acoustically coupling a histotripsy therapy system to the skin of a patient to provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

The invention relates to the technical field of ischemia training, in particular to a limb ischemia pre-adaptation training method and device.The limb ischemia pre-adaptation training method comprises the steps that feature parameters, training purposes and cuff feature parameters of an individual AOP of a target user are collected; inputting the obtained feature parameters of the individual AOP of the target user, the training purpose and the feature parameters of the cuff into a pressure prediction model, and outputting a pressure value; inputting the obtained blood vessel health coefficient, the limb perimeter, the pressure value and the training purpose into a pressure blocking time prediction model, and outputting pressure blocking time; according to the method, the optimal pressure value under different training scenes can be dynamically predicted, so that the physiological requirements of different training targets are met, and then the blood vessel health coefficient and pressure application blocking time prediction model is introduced, so that the blood vessel health coefficient and pressure application blocking time prediction accuracy is improved. The training safety is further optimized, and tissue damage caused by too large pressure or too long time is avoided.

The invention relates to the technical field of medical apparatus and instruments, in particular to an operation retractor which comprises four supporting arms, the four supporting arms correspond to one another end to end and are distributed in a rectangular shape, sliding holes are formed in the inner ends of the supporting arms, sliding boxes are slidably connected into the sliding holes, and sliding rods penetrate through the inner ends of the sliding boxes; a connecting piece is fixedly installed at the end, away from the supporting arm, of the sliding rod, a shifting plate is arranged below the connecting piece, rotating cylinders are arranged on the two sides of the supporting arm, driven cylinders are connected to the inner ends of the rotating cylinders, an adjusting cylinder is arranged at the end, away from the rotating cylinders, of the supporting arm, and an adjusting device used for controlling the motion trail of the connecting piece is arranged in the adjusting cylinder. Through synchronous movement of the four shifting plates, it is ensured that an incision is evenly and stably expanded, the exposure effect of an operation view is remarkably improved, meanwhile, the tissue damage risk is reduced, meanwhile, the driving plate can be directly adjusted according to actual requirements in an operation, linkage displacement of all the shifting plates is controlled in real time, and the tedious step that a traditional instrument needs to be adjusted one by one is omitted.

The invention relates to the technical field of medical care, in particular to a massage method for avoiding tissue damage through flexible mechanical conduction by Taoist massage, and discloses a massage method named'massage method for avoiding tissue damage through flexible mechanical conduction by Taoist massage '. The invention aims to solve the problems that the existing massage technology is easy to cause tissue damage due to force application rigidity, and the safety, the accuracy and the treatment depth of the massage technology are limited. The method is characterized in that a closed-loop system of tissue stress dynamic dispersion, layer-controlled shear wave guidance and biological impedance coupling feedback is adopted, traditional rigid force is converted into flexible conduction of low-frequency and small-amplitude transverse shear waves, and layer-by-layer, dispersion-type and non-invasive penetration of mechanical energy is achieved. By the adoption of the technical scheme, tissue damage can be effectively avoided, and the deep treatment effect and safety are improved.

A battery cell comprising a composite water-responsive safety layer and / or composite water- and pH-responsive safety layer to protect against bodily tissue damage and / or electrolysis, when the battery cell is exposed to aqueous solution or bodily tissue, is provided.

The invention relates to the technical field of pressure control, in particular to a prone position surgery face pressure adjusting method and system based on pressure induction, and the method comprises the following steps: based on an embedded miniature pressure sensor, detecting the pressure value of a face key area, analyzing the pressure distribution condition, and calculating the face pressure value; the concentrated stress state of each area of the face is analyzed through the pressure value change trend, and face area pressure distribution trend data are obtained. In the invention, through a pressure sensing technology and a dynamic adjustment mechanism, the problem of uneven pressure of the face in a prone position operation can be effectively identified and relieved, pressure distribution can be monitored and analyzed in real time, the pressure of a high-sensitivity area is accurately adjusted to be transferred to a low-sensitivity area, uniform distribution is realized, tissue damage caused by local long-term compression is reduced, and the operation safety is improved. The support force of each pressed point is balanced, the face pressure adjustment is optimized, the distribution stability is improved through pressure fluctuation monitoring and correction, the non-uniform phenomenon caused by fluctuation is avoided, and the surgical comfort and safety are improved.

The invention relates to an intelligent eyelid fixing and tear flow guide composite device, which belongs to the technical field of medical instruments and comprises an arc-shaped main body frame, a multi-section pressure sensing fixing wing, a miniature liquid guide groove, a humidity compensation module and a central control unit. The multi-section pressure sensing fixed wing can be dynamically attached to the shape of an eyelid and is matched with the flexible contact layer to achieve biomechanical self-adaptive adjustment, and contact pressure is evenly dispersed. The miniature liquid guide groove serves as an efficient tear drainage path, and tears are rapidly discharged in combination with negative pressure suction. The humidity compensation module accurately covers the cornea surface through an annular atomization nozzle, and the ocular surface is kept moist. And the central control unit is used for monitoring in real time and adjusting fixed pressure, atomization intensity and negative pressure parameters in a linkage manner to form an intelligent feedback closed loop. The device solves the problems that a traditional rigid eye speculum is uneven in pressure distribution, low in tear management efficiency, poor in dissection adaptability and the like, the steady state maintaining effect of the ocular surface microenvironment in an ophthalmologic operation can be improved, and tissue damage and operation interruption are reduced.

The present invention provides compositions and methods for preventing, alleviating, or treating subjects having toxic agent-induced injury. The present invention also provides compositions and methods for preventing, alleviating or treating tissue damage caused by exposure to toxic agents or restoring at least a portion of normal tissue function. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising at least one potassium channel blocker. In some embodiments, the potassium channel blocker includes 4-aminopyridine, a derivative thereof, or a combination thereof. In some embodiments, the pharmaceutical compositions may be administered with additional therapeutic agents, such as anticonvulsions.

The invention is applicable to the technical field of medical instruments, and provides a subskull epidural micro-invasive flexible brain-computer interface electrode, which comprises a plurality of electrode branches, each electrode branch comprises a linear flexible main body, and the flexible main body comprises a micro power supply circuit and a signal circuit which are solidified. A plurality of electrode units are arranged on the micro power supply circuit and the signal circuit at intervals, and the electrode units are electrically connected with the micro power supply circuit and the signal circuit. The brain-computer interface electrode is in a flexible line type, can be implanted into the middle artery of the meninx, does not need craniotomy, is a micro-invasive brain-computer interface, has data monitoring accuracy close to that of an invasive brain-computer interface, does not need to worry about inflammatory response, immunostimulation, biocompatibility, brain tissue damage and other adverse factors after long-term implantation, and is suitable for popularization and application. And the thrombogenic risk of a vein stent brain-computer interface does not exist.

The invention provides a visual guiding device for surgical robot instrument positioning and a surgical robot, and relates to the technical field of surgical robotics.The visual guiding device comprises an image rendering module used for obtaining image data of a target environment and rendering the image data to generate an environment image; the path guiding module is used for acquiring the position information of a slave end holding arm of the surgical robot, and generating an instrument virtual guiding model based on the position information and according to a mapping relation between a holding arm coordinate system and a display coordinate system; the display control module is in communication connection with the image rendering module and the path guiding module; and the display control module is configured to superpose the instrument virtual guide model on the environment image to generate a composite image in response to an operation instruction of the instrument, and output the composite image to the display equipment. According to the invention, accurate instrument movement visual guidance can be provided, and instrument insertion distance overrun and tissue damage are avoided.

Pulmonary treatment devices, systems and methods of use are provided which take into account the vast tissue damage of advanced COPD sufferers and provide treatments designed specifically to treat the particularly compromised lung tissues that are present in these patients. These treatments reduce trapped air volume, tension lung tissue and enhance lung elastic recoil. In particular, a variety of embodiments of pulmonary treatment devices are provided. The devices are comprised of a shape memory material wherein the devices are able to be expanded under tension, and then are able to recoil back toward an original relaxed or resting shape as the devices are deployed into the tissue. This action causes the pulmonary treatment devices to corkscrew into damaged tissue, becoming sufficiently entwined to allow pulling of the tissue by retraction of the device. This in turn re-tensions the lung causing lung volume reduction.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

The invention relates to a pressure damage detection method and system based on artificial intelligence, and a medium. The method comprises the following steps: respectively obtaining an infrared source image and a microwave source image corresponding to a target position; performing feature extraction on the infrared source image and the microwave source image to obtain corresponding infrared feature information and microwave feature information; based on an adversarial network, fusing the infrared feature information and the microwave feature information to obtain fused feature information; and based on the fused feature information, extracting a corresponding pressure damage feature value to obtain detection information of the pressure damage of the target position, and performing pressure damage grading on the target position based on the detection information. According to the method, the infrared image is combined with the microwave image, the images are subjected to feature extraction and feature fusion, the regular change of skin temperature distribution before and after the injury is detected by using an infrared technology, the hidden deep tissue injury is predicted, and grading is performed, so that the evaluation error of medical personnel is reduced, and the problem of non-uniform evaluation standards is solved.

The invention discloses a man-machine suitability evaluation method for a mattress, and relates to the field of human engineering health monitoring, and the method comprises the steps: screening testers according to a BMI grading standard, and collecting the height, weight, gender, age, sleep habit and chronic pain medical history basic data of the testers to obtain the BMI values of the testers; inputting the BMI value of the tester into the mattress hardness selection model to obtain the hardness range of the tested mattress, arranging a to-be-tested mattress with selected hardness in a constant-temperature and constant-humidity experimental environment, and enabling the tester to lie on the to-be-tested mattress in sequence at a standard supine position and a standard lateral position. According to the method, the spine stiffness demand curve is predicted in real time through the LSTM neural network, millisecond-level dynamic support adjustment is achieved, the response speed is remarkably increased compared with a traditional method, and spine compensatory bending in sleep can be prevented; and in combination with pressure-blood oxygen coupled IRI index calculation, microcirculation disturbance is accurately warned before tissue injury, and the problem of local ischemia is solved through partition adjustment.

The invention belongs to the technical field of high polymer material synthesis, and particularly relates to an artificial antioxidant enzyme material with an interlayer structure and a preparation method of the artificial antioxidant enzyme material. The preparation method of the artificial antioxidant enzyme material comprises the following steps: dissolving an aldehyde monomer and an amine monomer in a reaction solvent, performing thermal polymerization under the action of an acid catalyst, and then loading interlayer coordination metal, and further defining an aldehyde monomer and an amine monomer as well as an interlayer coordination metal. According to the present invention, the treatment-level oxidation resistance can be achieved through the space-optimized catalysis center and the fully-conjugated frame structure, and the innovative strategy is provided for solving the inflammation-driven tissue damage through the precise oxidation-reduction regulation and the immune microenvironment engineering.

The invention discloses application of spermidine in preparation of a medicine for relieving copper exposure injury, and relates to the field of biological medicine. The invention provides an application of spermidine in preparation of a medicine for relieving copper exposure injury, and the injury is liver injury and / or intestinal injury caused by copper exposure. Spermidine can reduce the copper content in serum and liver, promote the expression of liver copper transporters ATP7B and CTR1, copper death proteins FDX1, LIAS and Lip-DLAT, and reduce the oligomerization of HSP70 and DLAT proteins; meanwhile, transaminase activity in serum and liver and intestinal tissue damage are reduced. The medicine provided by the invention can improve intestinal health, improve liver copper metabolism capability and relieve body injury caused by copper exposure, effectively solves the problem that no reliable medicine exists for related injury caused by copper exposure, and is expected to be developed into a medicine or health food for preventing and treating copper exposure injury.

Pulmonary treatment devices, systems and methods of use are provided which take into account the vast tissue damage of advanced COPD sufferers and provide treatments designed specifically to treat the particularly compromised lung tissues that are present in these patients. These treatments reduce trapped air volume, tension lung tissue and enhance lung elastic recoil. In particular, a variety of embodiments of pulmonary treatment devices are provided. The devices are comprised of a shape memory material wherein the devices are able to be expanded under tension, and then are able to recoil back toward an original relaxed or resting shape as the devices are deployed into the tissue. This action causes the pulmonary treatment devices to corkscrew into damaged tissue, becoming sufficiently entwined to allow pulling of the tissue by retraction of the device. This in turn re-tensions the lung causing lung volume reduction.

The invention provides a pulse ablation operation system for pulmonary arterial hypertension, which comprises an intravascular 3D (three-dimensional) ultrasonic imaging module, an ablation operation planning module and a pulse ablation module, virtual operation planning is performed through information interaction among the modules, and a high-precision and high-efficiency pulmonary arterial hypertension pulse ablation operation is completed; the operation method based on the system comprises the following steps: S1) importing an intravascular 3D ultrasonic image model; s2) acquiring image data of the pulmonary artery and adjacent tissues thereof; s3) based on the image data, calculating a pulmonary artery wall narrow area, determining a pulse ablation depth, and virtualizing an operation plan; s4) calculating the surgical path constraint and the stress condition of the blood vessel wall to assess the surgical risk; after the pulmonary artery stenosis is simulated to be improved, predicting blood flow improvement; the method has the advantages that systematic virtual operation planning is achieved, images are complete and clear, data are fed back in real time and can be adjusted, precision and efficiency are improved, surrounding tissue damage is avoided, and operation comfort is improved.

The invention relates to the technical field of medical instruments, and provides an organ low-temperature perfusion system and a perfusion device.The organ low-temperature perfusion system comprises an organ bin and a perfusion assembly; the perfusion assembly is used for providing perfusion power and perfusing perfusion liquid into the blood vessel of the biological organ through the perfusion channel; the perfusion assembly comprises an oscillation generator, and the oscillation generator is used for applying alternating oscillation to perfusate, so that the perfusate flows in the perfusion channel and the blood vessel of the biological organ in a periodic oscillation state; a boundary layer can be broken by oscillating fluid flow, so that perfusate is more tightly attached to the surface of an organ, and the heat transfer efficiency is improved; the ice crystal structure which is being formed can be damaged, and the icing process is slowed down; a dead zone of fluid in an organ can be reduced, the uniformity of perfusate is ensured, the local temperature gradient is reduced, and tissue damage is reduced; in addition, the oscillating flow of the perfusate can more accurately simulate the physiological conditions in a real living body, and an environment closer to the interior of the living body is provided.

The invention discloses a preparation method of cordyceps sobolifera polysaccharide and application of the cordyceps sobolifera polysaccharide in relieving acute chemical liver injury. Monosaccharide of the cordyceps sobolifera polysaccharide (abbreviated as CCPW) is composed of glucose, mannose and galactose according to the molar ratio of 8.918: 1: 0.356, and the relative molecular mass is 2.62 * 10 < 4 > Da. Efficacy experiments show that the cordyceps sobolifera homogeneous polysaccharide CCPW can significantly inhibit increase of ALT and AST in a CCl4-induced acute chemical liver injury model mouse, effectively improve the degree of liver cell disruption and swelling, relieve liver inflammatory response, relieve CCl4-induced mouse liver tissue injury, protect mouse intestinal barriers, recover intestinal microbial balance and have obvious liver protection activity. The cordyceps sobolifera polysaccharide CCPW is clear in composition and remarkable in effect, and has wide development and application prospects in the aspect of relieving acute chemical liver injury.