1011 results about "Tissue damage" patented technology

The invention provides a first-aid tourniquet pressure monitoring and automatic alarm system, and relates to the technical field of pressure monitoring. The system comprises a biological reaction monitoring module, a pressure adjustment analysis module, a real-time pressure adjustment module, a safety threshold detection module and an emergency response activation module. According to the invention, through real-time monitoring of biological reactions, changes of micro blood flow, skin electrical impedance and tissue morphology of a patient after the patient uses the tourniquet are captured, so that monitoring of individual reactions is more comprehensive, the safety and effect of pressure are evaluated in combination with the actual physiological state of the patient, monitoring is more dynamic and personalized, and the monitoring accuracy is improved. Through the combination of pressure real-time adjustment and emergency response, it is ensured that when the pressure exceeds a safety range, pressure adjustment is conducted rapidly, warning is given out through an alarm, secondary injury caused by improper pressure is avoided, the use safety and response speed of the tourniquet are improved, tissue injury of a patient can be more accurately prevented, and the patient can be more accurately protected. And the real-time effectiveness and safety in the emergency treatment process are ensured.

The invention provides a liposuction needle cannula system and method, and the system comprises a cannula assembly which is used for forming a liposuction space at a liposuction part; the liposuction needle assembly is arranged in the sleeve assembly in a sliding and penetrating mode and used for conducting liposuction operation in the liposuction space. According to the technical scheme, tissue damage is reduced, and the fat cell survival rate and the liposuction efficiency are improved.

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.

A digital intelligent control system for perceiving a puncture state is characterized in that a sensor signal is converted into a state expression vector of an interaction behavior of a tissue and a puncture tool, and characteristics including tissue elasticity, a fracture threshold value and interface slippage are extracted; a time domain and frequency domain feature mapping mechanism of a nested structure is used, and micro-characterization including piercing micro-shock and tissue layer transition points in continuous puncture is extracted; describing logic mapping between puncture path evolution and a prediction result by constructing a state and intention space diagram relationship; introducing a semantic dynamic weight mechanism, and judging whether the current state is a path expected by a doctor so as to identify a potential deviation puncture or abnormal invasion risk; through real-time identification of key states such as tissue level transition points, piercing micro-shock, interface slippage and the like, the mistaken entry risk of a high-risk area is effectively pre-judged. The system can adjust the puncture angle, speed and torque in advance, and common concurrent problems such as over-puncture, deviation or tissue damage in an operation are avoided.

The invention relates to the technical field of ischemia training, in particular to a limb ischemia pre-adaptation training method and device.The limb ischemia pre-adaptation training method comprises the steps that feature parameters, training purposes and cuff feature parameters of an individual AOP of a target user are collected; inputting the obtained feature parameters of the individual AOP of the target user, the training purpose and the feature parameters of the cuff into a pressure prediction model, and outputting a pressure value; inputting the obtained blood vessel health coefficient, the limb perimeter, the pressure value and the training purpose into a pressure blocking time prediction model, and outputting pressure blocking time; according to the method, the optimal pressure value under different training scenes can be dynamically predicted, so that the physiological requirements of different training targets are met, and then the blood vessel health coefficient and pressure application blocking time prediction model is introduced, so that the blood vessel health coefficient and pressure application blocking time prediction accuracy is improved. The training safety is further optimized, and tissue damage caused by too large pressure or too long time is avoided.

The invention relates to the technical field of medical care, in particular to a massage method for avoiding tissue damage through flexible mechanical conduction by Taoist massage, and discloses a massage method named'massage method for avoiding tissue damage through flexible mechanical conduction by Taoist massage '. The invention aims to solve the problems that the existing massage technology is easy to cause tissue damage due to force application rigidity, and the safety, the accuracy and the treatment depth of the massage technology are limited. The method is characterized in that a closed-loop system of tissue stress dynamic dispersion, layer-controlled shear wave guidance and biological impedance coupling feedback is adopted, traditional rigid force is converted into flexible conduction of low-frequency and small-amplitude transverse shear waves, and layer-by-layer, dispersion-type and non-invasive penetration of mechanical energy is achieved. By the adoption of the technical scheme, tissue damage can be effectively avoided, and the deep treatment effect and safety are improved.

The invention relates to an intelligent eyelid fixing and tear flow guide composite device, which belongs to the technical field of medical instruments and comprises an arc-shaped main body frame, a multi-section pressure sensing fixing wing, a miniature liquid guide groove, a humidity compensation module and a central control unit. The multi-section pressure sensing fixed wing can be dynamically attached to the shape of an eyelid and is matched with the flexible contact layer to achieve biomechanical self-adaptive adjustment, and contact pressure is evenly dispersed. The miniature liquid guide groove serves as an efficient tear drainage path, and tears are rapidly discharged in combination with negative pressure suction. The humidity compensation module accurately covers the cornea surface through an annular atomization nozzle, and the ocular surface is kept moist. And the central control unit is used for monitoring in real time and adjusting fixed pressure, atomization intensity and negative pressure parameters in a linkage manner to form an intelligent feedback closed loop. The device solves the problems that a traditional rigid eye speculum is uneven in pressure distribution, low in tear management efficiency, poor in dissection adaptability and the like, the steady state maintaining effect of the ocular surface microenvironment in an ophthalmologic operation can be improved, and tissue damage and operation interruption are reduced.

The invention is applicable to the technical field of medical instruments, and provides a subskull epidural micro-invasive flexible brain-computer interface electrode, which comprises a plurality of electrode branches, each electrode branch comprises a linear flexible main body, and the flexible main body comprises a micro power supply circuit and a signal circuit which are solidified. A plurality of electrode units are arranged on the micro power supply circuit and the signal circuit at intervals, and the electrode units are electrically connected with the micro power supply circuit and the signal circuit. The brain-computer interface electrode is in a flexible line type, can be implanted into the middle artery of the meninx, does not need craniotomy, is a micro-invasive brain-computer interface, has data monitoring accuracy close to that of an invasive brain-computer interface, does not need to worry about inflammatory response, immunostimulation, biocompatibility, brain tissue damage and other adverse factors after long-term implantation, and is suitable for popularization and application. And the thrombogenic risk of a vein stent brain-computer interface does not exist.

The invention provides a visual guiding device for surgical robot instrument positioning and a surgical robot, and relates to the technical field of surgical robotics.The visual guiding device comprises an image rendering module used for obtaining image data of a target environment and rendering the image data to generate an environment image; the path guiding module is used for acquiring the position information of a slave end holding arm of the surgical robot, and generating an instrument virtual guiding model based on the position information and according to a mapping relation between a holding arm coordinate system and a display coordinate system; the display control module is in communication connection with the image rendering module and the path guiding module; and the display control module is configured to superpose the instrument virtual guide model on the environment image to generate a composite image in response to an operation instruction of the instrument, and output the composite image to the display equipment. According to the invention, accurate instrument movement visual guidance can be provided, and instrument insertion distance overrun and tissue damage are avoided.

Pulmonary treatment devices, systems and methods of use are provided which take into account the vast tissue damage of advanced COPD sufferers and provide treatments designed specifically to treat the particularly compromised lung tissues that are present in these patients. These treatments reduce trapped air volume, tension lung tissue and enhance lung elastic recoil. In particular, a variety of embodiments of pulmonary treatment devices are provided. The devices are comprised of a shape memory material wherein the devices are able to be expanded under tension, and then are able to recoil back toward an original relaxed or resting shape as the devices are deployed into the tissue. This action causes the pulmonary treatment devices to corkscrew into damaged tissue, becoming sufficiently entwined to allow pulling of the tissue by retraction of the device. This in turn re-tensions the lung causing lung volume reduction.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

The invention discloses a man-machine suitability evaluation method for a mattress, and relates to the field of human engineering health monitoring, and the method comprises the steps: screening testers according to a BMI grading standard, and collecting the height, weight, gender, age, sleep habit and chronic pain medical history basic data of the testers to obtain the BMI values of the testers; inputting the BMI value of the tester into the mattress hardness selection model to obtain the hardness range of the tested mattress, arranging a to-be-tested mattress with selected hardness in a constant-temperature and constant-humidity experimental environment, and enabling the tester to lie on the to-be-tested mattress in sequence at a standard supine position and a standard lateral position. According to the method, the spine stiffness demand curve is predicted in real time through the LSTM neural network, millisecond-level dynamic support adjustment is achieved, the response speed is remarkably increased compared with a traditional method, and spine compensatory bending in sleep can be prevented; and in combination with pressure-blood oxygen coupled IRI index calculation, microcirculation disturbance is accurately warned before tissue injury, and the problem of local ischemia is solved through partition adjustment.

The invention belongs to the technical field of high polymer material synthesis, and particularly relates to an artificial antioxidant enzyme material with an interlayer structure and a preparation method of the artificial antioxidant enzyme material. The preparation method of the artificial antioxidant enzyme material comprises the following steps: dissolving an aldehyde monomer and an amine monomer in a reaction solvent, performing thermal polymerization under the action of an acid catalyst, and then loading interlayer coordination metal, and further defining an aldehyde monomer and an amine monomer as well as an interlayer coordination metal. According to the present invention, the treatment-level oxidation resistance can be achieved through the space-optimized catalysis center and the fully-conjugated frame structure, and the innovative strategy is provided for solving the inflammation-driven tissue damage through the precise oxidation-reduction regulation and the immune microenvironment engineering.

Pulmonary treatment devices, systems and methods of use are provided which take into account the vast tissue damage of advanced COPD sufferers and provide treatments designed specifically to treat the particularly compromised lung tissues that are present in these patients. These treatments reduce trapped air volume, tension lung tissue and enhance lung elastic recoil. In particular, a variety of embodiments of pulmonary treatment devices are provided. The devices are comprised of a shape memory material wherein the devices are able to be expanded under tension, and then are able to recoil back toward an original relaxed or resting shape as the devices are deployed into the tissue. This action causes the pulmonary treatment devices to corkscrew into damaged tissue, becoming sufficiently entwined to allow pulling of the tissue by retraction of the device. This in turn re-tensions the lung causing lung volume reduction.

The invention relates to the technical field of medical instruments, and provides an organ low-temperature perfusion system and a perfusion device.The organ low-temperature perfusion system comprises an organ bin and a perfusion assembly; the perfusion assembly is used for providing perfusion power and perfusing perfusion liquid into the blood vessel of the biological organ through the perfusion channel; the perfusion assembly comprises an oscillation generator, and the oscillation generator is used for applying alternating oscillation to perfusate, so that the perfusate flows in the perfusion channel and the blood vessel of the biological organ in a periodic oscillation state; a boundary layer can be broken by oscillating fluid flow, so that perfusate is more tightly attached to the surface of an organ, and the heat transfer efficiency is improved; the ice crystal structure which is being formed can be damaged, and the icing process is slowed down; a dead zone of fluid in an organ can be reduced, the uniformity of perfusate is ensured, the local temperature gradient is reduced, and tissue damage is reduced; in addition, the oscillating flow of the perfusate can more accurately simulate the physiological conditions in a real living body, and an environment closer to the interior of the living body is provided.

The invention discloses application of capsaicin to resistance of grass carp to hypoxia stress, and belongs to the technical field of agricultural cultivation. Aiming at the problems of red blood cell function damage, liver and gill tissue damage and the like of grass carps under hypoxia stress, a trace amount of capsaicin is added into the grass carp feed, so that the feed formula is optimized, the reduction of red blood cell quantity and brittleness increase of grass carps in the later growth period caused by hypoxia stress are relieved, liver damage is relieved, and the growth period of grass carps is prolonged. The death rate of the grass carp in a low-oxygen environment is reduced, the culture risk is reduced, and the method has the characteristics of being green, safe, low in cost and remarkable in economic benefit and is suitable for large-scale grass carp culture industry.

The traction type midwifery assist device comprises an outer head sleeve and an inner head sleeve, and the outer head sleeve comprises an outer sleeve and an elastic clamping jaw; the inner head sleeve comprises a sleeve body, a traction pull rod and a covered edge. On one hand, on the basis of collaborative design of the elastic clamping jaws and the sleeve body, initial wrapping can be formed along with automatic outward expansion and inward contraction of the fetal head during midwifery, the edge of the sleeve opening is driven to be overturned and tightened inwards by means of the opposite acting force of the traction pull rod and the outer sleeve, dynamic gradual wrapping of the fetal head is achieved, wrapping traction can be achieved after the outer head sleeve is detached outwards, and the operation is convenient. The risk of fetal head slippage is reduced, the traction stability is enhanced, scalp hematoma, tissue injury and maternal soft birth canal injury possibly caused by traditional negative pressure suction are effectively avoided, and the safety of a mother and an infant is improved; and on the other hand, the matching of the claw tips and the covered edges is ingeniously utilized, so that the interference of the covered edges on the size change of the sleeve opening is reduced, and a smaller covering opening can be provided during inward turning covering so as to increase the covering force formed by the sleeve body and the fetal head.

The invention belongs to the field of microorganisms, and relates to lactobacillus paracasei. In particular discloses a lactobacillus paracasei strain HNGD-AL1, the taxonomic name is Lactobacillus paracasei, the lactobacillus paracasei strain HNGD-AL1 is preserved in China Center for Type Culture Collection on February 27, 2025, the preservation number is CCTCC M 2025303, and the preservation address is No. 299 on eight road in Wuchang District, Wuhan, Hubei. The method for degrading the sulfur-containing amino acid by adopting the lactobacillus paracasei is found for the first time, the effect of degrading 53.39% of the sulfur-containing amino acid can be achieved by culturing the probiotics in a fermentation culture medium for 24 hours, and the probiotics can be colonized in intestinal tracts and play a role in degrading the sulfur-containing amino acid in intestinal contents; the content of metabolite hydrogen sulfide of sulfur-containing amino acid in the intestinal tract is reduced by 60.92%, intestinal tract tissue damage, permeability and inflammatory response are reduced, and the purpose of improving ulcerative colitis is achieved. The preparation method has a wide application prospect in the aspects of preparation of low-sulfur-content amino acid foods and probiotic preparations for improving colitis.

A construction and use of an environmentally adaptive co-regulated mRNA nanodelivery system. By incorporating EACR molecules into mRNA nanoparticles, the microenvironment is remodeled to be suitable for robust and sustained mRNA expression, while tissue damage associated with the self-immunogenicity of mRNA drugs is avoided. The nanodelivery system is compatible with ionizable lipid nanoparticles, cationic liposomes, cationic nanoemulsions, and polymeric nanoparticles. The EACR molecules include: anti-inflammatory drugs, tyrosine kinases / adaptors, JAK / STAT and MAPK pathway inhibitors, nutrients and metabolites, membrane transporters / ion channels, phosphodiesterase and cellular stress inhibitors, and natural viral proteins. The therapeutic mRNAs may encode tumor, viral, or bacterial antigens, immunomodulatory factors, therapeutic antibodies, or functional proteins / enzymes, and can play a role in the fields of regenerative medicine, protein supplementation / replacement therapy, targeted gene editing, and immunotherapy.

The invention provides a piezoelectric-driven ophthalmic surgical robot. The piezoelectric-driven ophthalmic surgical robot comprises a supporting mechanism, a bottom plate, a folding mechanism, a tail end executing mechanism, a rotary driving mechanism, a first piezoelectric driving mechanism and a second piezoelectric driving mechanism. The bottom plate is movably connected with the supporting mechanism, the folding mechanism is installed on the bottom plate, the second piezoelectric driving mechanism is arranged on the folding mechanism, and the second piezoelectric driving mechanism can drive the tail end executing mechanism to move linearly; the rotary driving mechanism can drive the bottom plate to turn left and right; the first piezoelectric driving mechanism is arranged below the bottom plate, is in driving connection with the folding mechanism and can drive the folding mechanism to deform so as to adjust the angle of the tail end executing mechanism; a piezoelectric pre-tightening compensation mechanism is further arranged to prevent the tail end executing mechanism from sliding down due to gravity, and the operation stability is guaranteed. The piezoelectric characteristic is combined with the advantages of the guide rail, accurate, rapid, stable and compact motion control of the ophthalmologic operation executing mechanism can be achieved, the fine operation requirement of the ophthalmologic operation is met, and the tissue damage risk is reduced.

The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived from human astrovirus protein, called CP1. The invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of CP1 having, for example, internal peptide deletions and substitutions, deletions and substitutions at the N-terminus and C-terminus, and that are able to regulate complement activation. The invention further provides pharmaceutical compositions of therapeutically effective amounts of the peptide compounds and a pharmaceutically acceptable carrier, diluent, or excipient for treating a disease or condition associated with complement-mediated tissue damage.

The invention relates to the field of new application of traditional Chinese medicinal materials, and particularly provides application of ash grass root in preparation of medicine for treating ulcerative colitis, DSS-induced mouse colitis model experiments and UC patient control experiments show that ash grass root has remarkable technical effects in treatment of ulcerative colitis, and the application of ash grass root in preparation of medicine for treating ulcerative colitis in preparation of medicine for treating ulcerative colitis in preparation of medicine for treating ulcerative colitis. The gray couchgrass root shows the effect of relieving inflammatory response, tissue damage and immune disorder related to colitis; the intestinal mucosa repair is promoted; the intestinal barrier function is strengthened; the pathological state of colon tissue is improved; the level of inflammatory factors is reduced; and flora metabolism can be adjusted. The invention provides a new natural medicine source for preventing and treating ulcerative colitis, and has good application value and industrial transformation prospect.

The invention belongs to the technical field of medicines, and particularly relates to application of hordenine in preparation of a medicine for treating and relieving tissue damage. It is found that hordenine shows the effect of relieving immunological liver injury and spleen injury on an animal model, therefore, the application of hordenine to preparation of the medicine for treating and relieving tissue injury is provided, hordenine shows a remarkable curative effect, symptoms of immunological liver injury and pathological injury of spleen and thymus can be effectively relieved, and the hordenine can be used for preparing the medicine for treating and relieving tissue injury. The conditions include abnormal liver cell morphology, inflammatory cell tissue infiltration, pathological injuries such as extravasated blood and necrosis, cell apoptosis and the like. Animal experiments show that no obvious toxic reaction or side effect is observed while the hordenine is used for relieving immunological liver injury, spleen injury and thymus injury.

The invention relates to the technical field of food component analysis and testing, in particular to a fruit pectin sampling and testing method which comprises the following steps: step 1, directionally freezing and crushing, and calculating a target freezing temperature according to a tissue freezing point temperature and cell structure characteristics of a to-be-tested fruit; step 2, gradient centrifugal separation: mixing the crushed particles with a low-temperature protection buffer solution, and maintaining the temperature to be lower than the critical gelation temperature; executing three-stage centrifugation; parameters of each stage are corrected in real time according to physical characteristics of a preorder isolate; 3, dynamic turbidity detection: mixing a pure pectin component with a reaction solution containing a chelating agent and positive ions; calculating the pectin content according to the geometrical characteristic parameters of the characteristic inflection points, and calibrating a calculation model through a standard atlas database. The method can effectively solve the problems of tissue damage and impurity interference in berry fruits and seed-containing fruits, ensures the accuracy and reliability of pectin detection, and has important technical advantages and application prospects.

The invention belongs to the technical field of biology, discloses application of naringenin in resisting siniperca chuatsi and frog iridovirus, and discovers the antiviral activity of the naringenin to the siniperca chuatsi and frog iridovirus, the naringenin can down-regulate the expression level of NF-kB and MAPK pathway genes triggered by MRV, effectively inhibit MRV-induced excessive inflammatory response and inhibit MRV proliferation, and the application of the naringenin in resisting the siniperca chuatsi and frog iridovirus. In addition, tissue damage caused by MRV infection can be relieved, and the survival rate of MRV infected fishes is effectively increased; a foundation is provided for preparing a product for resisting the siniperca chuatsi and frog iridovirus by adopting naringenin; meanwhile, the invention also discloses a drug containing naringenin, a fish feed and a fish feed additive.

The invention discloses injectable oxygen-carrying and medicine-carrying microbubble composite hydrogel with immunoregulation performance and a preparation method of the injectable oxygen-carrying and medicine-carrying microbubble composite hydrogel, and belongs to the field of tissue damage treatment. The preparation method comprises the following steps: carrying out a reaction on hyaluronic acid HA and dipalmitoyl phosphatidyl ethanolamine DPPE to construct a microbubble monomer DPPE-HA; the preparation method comprises the following steps: fully dissolving DPPC (dipalmitoyl phosphatidylcholine), DPPE-HA (dipalmitoyl phosphatidylcholine) and a therapeutic drug into a solvent, introducing oxygen and carrying out mechanical oscillation to obtain oxygen-carrying and drug-carrying microbubbles; the oxygen-carrying and drug-carrying microbubbles are uniformly doped into a vinyl modified natural polymer solution, and the oxygen-carrying and drug-carrying microbubble composite hydrogel is formed through photo-crosslinking. The obtained injectable microbubble hydrogel can be used for treatment of different tissue injuries, including wound repair and burn treatment, osteochondral injury repair, cardiovascular disease treatment and nerve injury repair, in addition, the injectable microbubble hydrogel can also be applied to the fields of cosmetic plastic surgery, skin regeneration and the like, and has a wide clinical application prospect.

The invention provides a handheld photoacoustic multi-mode vascular puncture and tissue damage diagnosis system and device, and belongs to the technical field of photoacoustic imaging. According to the handheld multispectral photoacoustic imaging device, elastic force feedback and blood vessel real-time development are integrated, and the puncture success rate is increased by 30%; by virtue of hemoglobin / collagen double-index imaging, the stress injury can be pre-warned 72 hours in advance; the 3D hematoma volume automatically calculates an error lt; and repeated puncture and missed diagnosis are remarkably reduced. The invention provides a quantitative evaluation and real-time navigation integrated scheme for vascular puncture and tissue damage, and is safe and efficient.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

The invention provides a wound hemostasis device for the emergency department, and relates to the technical field of wound hemostasis. The wound hemostasis device for the emergency department comprises an inflatable hemostasis air bag, and a constant-temperature film bag is fixedly connected to the lower surface of the inflatable hemostasis air bag. During working, a second infusion pump is started and pumps water in a constant-temperature water storage tank through a second infusion pipeline, the water enters a constant-temperature film bag through a fourth infusion pipeline, the temperature of a wound is guaranteed, meanwhile, a first infusion pump is started, a first water valve on a first infusion pipeline is opened, and a second water valve on a second infusion pipeline is opened. Water in the constant-temperature film bag is pumped through the first liquid pumping pipeline, and finally the water enters the constant-temperature water storage tank, so that the water in the constant-temperature film bag is always in a constant-temperature state, the temperature is ensured to be close to the optimum point of thrombin reaction, platelet aggregation and fibrin formation can be accelerated, and the method is safe and efficient, can minimize tissue damage, and is suitable for clinical application. And the hemostasis speed is accelerated.

The invention belongs to the technical field of biology, and discloses application of wogonin in resisting siniperca chuatsi and frog iridovirus, the wogonin can effectively inhibit over-generation of ROS caused by MRV virus infection, and oxidative stress damage of host cells is relieved in a dose-dependent mode. The wogonin can be used for preventing and treating the siniperca chuatsi and frog iridovirus, the high expression state of a proinflammatory gene can be reduced, intestinal tissue damage induced by MRV infection can be relieved, proliferation of MRV in the micropterus salmoides is effectively inhibited, the MRV challenge survival rate of the micropterus salmoides is increased, a basis is provided for preparing a product for resisting the siniperca chuatsi and frog iridovirus from wogonin, and the wogonin has important application value. Meanwhile, the invention also discloses a medicine, a fish feed and a fish feed additive of the wogonin.