504 results about "Tissue damage" patented technology

The invention is applicable to the technical field of medical instruments, and provides a subskull epidural micro-invasive flexible brain-computer interface electrode, which comprises a plurality of electrode branches, each electrode branch comprises a linear flexible main body, and the flexible main body comprises a micro power supply circuit and a signal circuit which are solidified. A plurality of electrode units are arranged on the micro power supply circuit and the signal circuit at intervals, and the electrode units are electrically connected with the micro power supply circuit and the signal circuit. The brain-computer interface electrode is in a flexible line type, can be implanted into the middle artery of the meninx, does not need craniotomy, is a micro-invasive brain-computer interface, has data monitoring accuracy close to that of an invasive brain-computer interface, does not need to worry about inflammatory response, immunostimulation, biocompatibility, brain tissue damage and other adverse factors after long-term implantation, and is suitable for popularization and application. And the thrombogenic risk of a vein stent brain-computer interface does not exist.

Pulmonary treatment devices, systems and methods of use are provided which take into account the vast tissue damage of advanced COPD sufferers and provide treatments designed specifically to treat the particularly compromised lung tissues that are present in these patients. These treatments reduce trapped air volume, tension lung tissue and enhance lung elastic recoil. In particular, a variety of embodiments of pulmonary treatment devices are provided. The devices are comprised of a shape memory material wherein the devices are able to be expanded under tension, and then are able to recoil back toward an original relaxed or resting shape as the devices are deployed into the tissue. This action causes the pulmonary treatment devices to corkscrew into damaged tissue, becoming sufficiently entwined to allow pulling of the tissue by retraction of the device. This in turn re-tensions the lung causing lung volume reduction.

The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived from human astrovirus protein, called CP1. The invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of CP1 having, for example, internal peptide deletions and substitutions, deletions and substitutions at the N-terminus and C-terminus, and that are able to regulate complement activation. The invention further provides pharmaceutical compositions of therapeutically effective amounts of the peptide compounds and a pharmaceutically acceptable carrier, diluent, or excipient for treating a disease or condition associated with complement-mediated tissue damage.

The invention relates to the technical field of probiotics and application thereof, in particular to a plant lactobacillus ZKAW02 strain, a fungicide and application of the fungicide. The invention relates to a plant lactobacillus ZKAW02 strain, which is classified and named as plant lactobacillus, the plant lactobacillus ZKAW02 strain is preserved in Guangdong Province Microbial Culture Collection Center on September 27, 2024, and the preservation number is GDMCC No: 65219. The invention further discloses a preparation method of the plant lactobacillus ZKAW02 strain. The plant lactobacillus ZKAW02 strain has the advantages that the plant lactobacillus ZKAW02 strain is named as plant lactobacillus, and the plant lactobacillus ZKAW02 strain is preserved in Guangdong Province Microbial Culture Collection Center on September 27, 2024. The lactobacillus plantarum ZKAW02 has the effects of remarkably reducing the cholesterol level, remarkably regulating the blood fat level of the liver and excrement and remarkably increasing the short-chain fatty acid level in the excrement of a high-fat rat, so that the expression level of lipid metabolism related signal channel genes is regulated, the intestinal flora homeostasis is regulated, the liver tissue damage is repaired, and the anti-tumor effect is achieved. The effects of regulating lipid metabolism and intestinal health are achieved.

There is provided a pharmaceutical dosage form that is suitable for peroral administration to the gastrointestinal tract, which dosage form comprises a pharmaceutical composition in the form of a particulate mixture comprising solid particles of N-butyloxycarbonyl-3-(4-imidazol-1-ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide (C21), or a pharmaceutically-acceptable salt thereof, admixed with a blend of carrier particles with weight- and / or a volume-based mean diameter, and / or a structural / particle density, that is / are similar to the weight- and / or volume-based mean diameter, and / or the structural / particle density, of the solid particles of C21, and a glidant, which composition is contained within a capsule that is suitable for such peroral administration. Preferred carrier particles have a weight- and / or a volume-based mean diameter that is less than about 100 μm. Preferred carrier particle materials include mannitol. Preferred glidants comprise colloidal silica. Such dosage forms find utility in the treatment of lung diseases, such as idiopathic pulmonary fibrosis, sarcoidosis and respiratory virus-induced tissue damage.

The invention discloses a cleaning machine and a cleaning control method thereof.The cleaning machine comprises a water tank, a water outlet valve and at least one cleaning device, the water tank is used for containing objects to be cleaned, the water outlet valve is located above the water tank, and the cleaning device is installed below the water tank in an attached mode; the cleaning control method of the cleaning machine comprises the steps that when it is determined that a to-be-cleaned article is placed in a water tank, the type of the to-be-cleaned article and the stain thickness of the to-be-cleaned article are obtained; when it is determined that the stain thickness is larger than the first preset thickness, the water outlet valve is controlled to be opened, and the cleaning device is controlled to operate according to the type and the stain thickness, so that various pollutants including stubborn pesticide residues, microorganisms and embedded dirt can be efficiently removed; fruit and vegetable epidermis damage, tissue damage or nutritional ingredient loss caused by improper cleaning force is avoided to the maximum extent, and the dual purposes of efficient and deep cleaning and maximum protection of fruit and vegetable form integrity, taste and nutritional value can be achieved.

A first aspect of the invention relates to a method of treating or preventing tissue damage, or treating or preventing tissue destruction, in a subject, said method comprising administering to the subject a therapeutically or prophylactically effective amount of a soluble epoxide hydrolase (sEH) inhibitor. A further aspect of the invention relates to a method of treating or preventing leishmaniasis in a subject, said method comprising administering to the subject a therapeutically or prophylactically effective amount of a soluble epoxide hydrolase inhibitor.

The invention relates to application of NMRK2 in regulating and improving myocardial ischemia reperfusion injury, and belongs to the technical field of biological medicine. Based on the lack of medicines for effectively preventing and treating myocardial ischemia-reperfusion injury at present, the invention develops a protection method based on NMRK2 signal regulation and control, specifically, a preparation for enhancing NMRK2 expression or activity is adopted to prepare the medicines for preventing or treating myocardial ischemia-reperfusion injury, and the medicines can systematically enhance the anti-oxidation defense capability of myocardial cells, so that the anti-oxidation defense capability of myocardial cells is enhanced. The tissue injury caused by reperfusion is improved, so that the myocardial ischemia reperfusion injury is effectively prevented and treated. Furthermore, it is found that the NMRK2 can inhibit excessive activation of MST1 / p-MST1 in a Hippo pathway and promote YAP nuclear translocation, so that NADK expression is up-regulated, a Trx1 antioxidant system is enhanced, and a new 'NMRK2-YAP-NADK-Trx1 antioxidant signal pathway' is formed.

The application discloses a plant lactobacillus strain and application thereof, and belongs to the technical field of microorganisms. The preservation number of the strain is CGMCC No. 33864. The strain has good tolerance to gastrointestinal juice and bile salts and has no hemolytic activity. Concentrated cell-free supernatant prepared from the strain can inhibit salmonella, including inhibiting the growth of salmonella, killing bacteria, inhibiting or removing biofilm. Animal experiments show that the strain and the concentrated cell-free supernatant thereof can prevent salmonella infection, alleviate weight loss caused by infection, maintain intestinal barrier integrity, reduce the level of pro-inflammatory factors, alleviate tissue damage, improve the expression of colon tight junction proteins and mucin, promote the generation of short-chain fatty acids, and restore the intestinal flora structure. The application further provides a microbial preparation containing the strain and / or the concentrated cell-free supernatant thereof. The strain and the microbial preparation can be used for preparing products for resisting salmonella, preventing salmonella infection or improving intestinal health.

The invention belongs to the technical field of medicines, and particularly relates to application of isodan leaf emodin in preparation of an Icam1 inhibitor, related experiments of establishment of a sepsis liver injury model induced by cecum ligation puncture (CLP) show that by applying the isodan leaf emodin, the Icam1 inhibitor can be used for preparing Icam1. According to the present invention, the level of liver tissue proinflammatory factors TNF-alpha, IL-1beta and IL-6 in the liver injury caused by sepsis is reduced, the level of the anti-inflammatory factor IL-10 is increased, and the HE dyeing of the liver tissue proves that the emodin can alleviate the CLP induced inflammatory cell infiltration in the liver tissue, can protect the structural integrity of the liver tissue, and can provide the anti-inflammatory effect on the liver tissue, such that the liver injury caused by sepsis can be inhibited, and the liver injury caused by sepsis can be inhibited. The data shows that the isodan leaf emodin can relieve sepsis liver injury and reduce liver function indexes. In research, it is found for the first time that the action mechanism of the isodan-leaf emodin in relieving the sepsis liver injury is that liver function indexes and inflammatory response are relieved by inhibiting expression of a transmembrane protein intercellular adhesion molecule-1 (Icam1), and it is indicated that the isodan-leaf emodin has a good application prospect in treating sepsis-related tissue injury.

The invention provides a method for treating AR negative TNBC through combination of quercetin and enzalutamide, the quercetin up-regulates the AR expression level by inhibiting a high-expression solute carrier SLC7A5, so that tumor cells which are not sensitive to enzalutamide originally obtain drug sensitivity again; the combined use of an AR antagonist enzalutamide (1-80 [mu] M) can cooperatively block an AR signal channel and significantly inhibit cell proliferation (the inhibition rate of drug combination is 70%, Plt, 0.01 higher than that of a single drug). In-vitro experiments prove that the scheme has a synergistic effect (the effect is optimal when the mass ratio is 1: 1-5: 1) in MDA-MB-231 cells, and an animal model shows that the tumor volume inhibition rate reaches 70% or above. Safety evaluation shows that the drug combination does not cause abnormity of serum biochemical indexes (ALT / AST / BUN / CREA) or damage of main organs and tissues. The invention further provides a preparation method of an oral preparation (tablets / capsules / nanoparticles) containing quercetin (50-500 mg / day) and enzalutamide (40-160 mg / day), and a new strategy is provided for reversing AR-TNBC drug resistance.

The ultrasonic scalpel device comprises a base, an instrument rod, an inner rod, a scalpel head, the scalpel rod, a scalpel head transmission mechanism, a scalpel rod telescoping mechanism and a scalpel rod rotating mechanism. The instrument rod is of a hollow structure, one end of the instrument rod is located in the base, the inner rod is movably arranged in the instrument rod and is of a hollow structure, and the cutter rod is movably arranged in the inner rod; the tool bit transmission mechanism is connected with the inner rod and can drive the tool bit to be opened and closed through the inner rod. The cutter bar telescoping mechanism is used for driving the cutter bar to axially telescope, the cutter bar rotating mechanism is fixedly connected with the cutter bar, and the cutter bar rotating mechanism is used for driving the cutter bar to rotate; the cutter bar telescoping mechanism and the cutter bar rotating mechanism are arranged in the base, the input end of the cutter bar rotating mechanism is connected with the first input part, the input end of the cutter bar telescoping mechanism is connected with the second input part, and the first input part and the second input part are fixed in the base and suitable for being externally connected with a driving device respectively. The ultrasonic knife device disclosed by the utility model has better flexibility, is beneficial to operation of an operation, reduces tissue damage, is beneficial to grasping and pulling tissues, can shorten the operation time and improves the working efficiency of a doctor.

The invention relates to a touch fluid neuron specific tracing imaging agent, a preparation method and application, and belongs to the technical field of nuclear medicine imaging, the tracing imaging agent is composed of a nerve tracer agent horseradish peroxidase (HRP), zirconium-89 isotope chelated by deferoxamine and a pharmaceutically acceptable carrier, the effective tracking window of the tracer agent is prolonged to 120 hours, and the effective tracking window of the tracer agent is prolonged to 120 hours. The multi-stage synaptic transfer period of the fluid touching neuron can be completely covered; the spatial resolution is improved by 5-8 times compared with that of traditional FDG-PET, and a fluid touching neuron cluster can be accurately presented; the in-vitro serum stability is excellent, the radiochemical purity is still larger than or equal to 80.5% within 120 hours, PET / MRI bimodal imaging can be adapted, drug administration is conducted through lateral ventricle minimally invasive injection, the probe is suitable for various animal models such as mice, rats and non-human primates, in-vivo dynamic tracing of sympathetic fluid neuron trans-synapses can be achieved on the premise that no tissue damage exists, and the probe has a good application prospect. And a key technical tool is provided for neural circuit analysis, neuroscience basic research and preclinical research of neurodegenerative diseases.

The utility model relates to medical consumables technical field especially, more particularly to a function improved pipette handle for fundus operation, including handle body, still including installation groove, the right side of handle body is provided with installation groove, the bottom of handle body is provided with the plug -in component, the top of plug -in component is connected with the connecting pipe, the top of connecting pipe is connected with the press valve, and the through -hole is opened in press valve, and the position that corresponds through -hole is provided with the hole plugging mechanism on press valve, the top of press valve is connected with the hose, the top of handle body is provided with the docking assembly, and pressure assembly is arranged in the inside of installation groove, the utility model discloses through the integration press valve and flow regulator on handle body, has improved the operating efficiency and security of ophthalmic surgery significantly, the initiative suction function makes the doctor be able to accurate control suction intensity, and the flexible response different operation stage's demand, the passive suction function maintains stable negative pressure environment, avoids the tissue damage, and the adaptability and controllability of operation have been enhanced greatly.

The utility model discloses a kind of spinal tumor puncture devices, belong to medical instrument technical field, the spinal tumor puncture device includes dilator, ring saw, divider and first push rod, wherein: ring saw includes ring saw main body and the first handle located above ring saw main body, first passageway is equipped on ring saw vertically through, the lower end of ring saw main body is equipped with sawtooth;Divider includes the divider main body that can be inserted into first passageway and the second handle located above divider main body, second passageway is equipped on divider vertically through, the lower side of divider main body is equipped with slot, the lower side of divider main body is equipped with the first blade edge of vertically extending in the side edge of slot close to;First push rod includes the first push rod main body that can be inserted into second passageway and the third handle located above first push rod main body.The utility model is convenient for sampling to hardened bone and non-hardened bone, sampling is sufficient, and it is easy to puncture, amount of bleeding is less, and tissue damage is small.

The invention discloses a construction and analysis method and a simulation system of a dynamic model of bubbles in a liquid cavity in a viscoelastic tissue, and a numerical simulation system for performing a cavitation effect in high-intensity focused ultrasound therapy based on the model, and the method comprises the following steps: firstly, establishing a modified microbubble dynamic model based on a Keller-Miksis equation; microbubbles are placed in a liquid cavity wrapped by viscoelastic tissue, the constraint relation of the radius of the liquid cavity to the radius of the bubbles is introduced, and the viscoelastic stress-strain relation of the tissue is described by adopting a Voigt model, so that a cavitation kinetic model closer to the actual biological tissue is constructed. Secondly, the sound pressure waveform of the focus area is obtained through HIFU sound field simulation; and finally, taking the simulated sound pressure as a drive input kinetic model, and solving to obtain a microbubble oscillation behavior, tissue internal stress distribution and maximum compression stress. The system comprises a model building module, a sound field simulation module and a dynamics simulation module. According to the method, the cavitation dynamic process in the tissue under the action of the HIFU can be more accurately simulated, and an effective numerical analysis tool is provided for analyzing the tissue damage related to cavitation.

The application discloses a snake and insect bite venom diffusion prevention emergency equipment based on a field environment and belongs to the technical field of outdoor rescue equipment, which comprises a bandage assembly, a mounting seat and a blood sampling assembly. The bandage assembly comprises a bandage and air bags arranged on the lower surface of the bandage. The mounting seat is arranged at the middle part of the bandage and between the two groups of air bags. The blood sampling assembly is detachably mounted in the mounting seat. The mounting seat is provided with movable pressure adjusting mechanisms on both sides. The blood sampling assembly has an arc-shaped blood sampling pipeline. Through the cooperation of the pressure adjusting mechanisms and the driving mechanisms, the dynamic adjustment of the air bag pressure is realized, and the tissue damage caused by the continuous high pressure is avoided. The traditional bundling method cannot adjust the pressure in real time. Through the linkage of the motor driving protrusions and the push plates, the periodic change of the pressure is realized, the venom diffusion is effectively controlled, and the local blood circulation is ensured to be smooth.

The present invention is directed to a monitoring apparatus and method for preventing pressure injuries. More specifically, an apparatus and method that is portable, multi-functional, and easy to use, capable of passive monitoring, AI triage monitoring, and EMR integration that can detect deep tissue injuries, falls, and / or bed wetness, using an equitable approach to detection.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

The invention provides a composition and a medicine for preventing and treating acute liver injury and protecting liver. The composition comprises sweet orange flavone and dauricine. According to the traditional Chinese medicine composition disclosed by the invention, through a large number of researches, the sweet orange flavone and the dauricine can be synergistically interacted when being used for preventing and treating the acute liver injury; the sweet orange flavone and dauricine combined treatment group can more effectively relieve liver dysfunction, tissue injury and inflammatory state of acute liver injury model mice. Therefore, the combination of the sweet orange flavone and the dauricine can more effectively prevent and treat the acute liver injury and related diseases of the acute liver injury, and has the effect of protecting the liver.

Several embodiments disclosed herein relate to methods and compositions for treatment of inflammation. In several embodiments, therapeutic nucleic acids enriched in extracellular vesicles from fibroblasts engineered to overexpress TDO2 are provided. In several embodiments, a therapeutically effective amount of the isolated nucleic acid is administered to treat an inflammatory condition. In several embodiments, the inflammation is secondary to tissue damage or an infection.

The present application relates to a kind of arthroscopic approach water leakage prevention device, including the elastic cover with dome structure, the sealing valve being arranged in the center position of cover and negative pressure suction mechanism, sealing valve has the conical hollow structure extending to base direction and gradually reducing outer diameter, reverse compensation sealing is realized using joint cavity infusion liquid pressure, cover base edge is equipped with flexible sealing skirt, by the negative pressure interface connection external negative pressure source, so that cover and skin form negative pressure sealing space, the device can be connected in series by negative pressure interface multiple occluder, and equipped with detachable guide rod auxiliary coaxial positioning.The present application uses non-insertion type surface adsorption occlusion, effectively solve the space interference and tissue damage problem in multiple tunnel operation, realize the dynamic water stop of pressure self-adaption, with the advantages of simple operation, sealing stable, strong dissection adaptability, can significantly improve the operation visual clarity and maintain joint cavity pressure stability.

The application provides an eye Tibetan medicine composition, a preparation and a preparation method and application thereof, and relates to the technical field of dry eye. The eye Tibetan medicine composition contains 80-120 parts by weight of berberis bark extract and 80-120 parts by weight of Qinghai dracocephalum extract. The eye preparation is prepared by mixing the eye Tibetan medicine composition and a solvent. The eye preparation can repair ocular surface tissue damage caused by dry eye and restore the normal secretion function of lacrimal glands.

The magnetic double-cavity mesh bag ophthalmologic operation foreign matter forceps comprise a handle and a magnetic sheathing canal capable of penetrating through a 23G minimally invasive tunnel portal, a partition plate is horizontally connected to the middle of an inner cavity of the magnetic sheathing canal, and the partition plate is used for vertically dividing the inner cavity of the magnetic sheathing canal into a sheathing canal upper cavity and a sheathing canal lower cavity; meanwhile, clamping type material taking assemblies are installed on the front side of the inner cavity of the handle and in the lower cavity of the sheath tube, and wrapping type material taking assemblies are installed in the inner cavity of the handle and in the upper cavity of the sheath tube. According to the scheme, through three independent and flexibly switchable working states of magnetic adsorption, mechanical clamping and net bag wrapping, the 23G minimally invasive operation requirements are met, various intraocular foreign matters can be accurately, safely and efficiently taken out, the risk of secondary injury of tissues is greatly reduced, and the operation convenience and success rate are improved.

The invention discloses a hand traction belt skin protection device for shoulder arthroscopy surgery, and relates to the technical field of medical instruments, the hand traction belt skin protection device comprises a traction assembly used for traction of a wrist, and an angle adjusting assembly used for changing the traction angle is arranged on the outer surface of one side of the traction assembly; a stepping assembly used for adjusting the height is arranged on the outer surface of one side of the angle adjusting assembly, the traction assembly comprises a traction belt body, and the outer surface of the traction belt body is fixedly connected with a buffering cushion layer used for dispersing pressure. According to the hand traction belt skin protection device for the shoulder arthroscopy operation, the traction assembly, the first hook-and-loop fastener and the second hook-and-loop fastener are detachably attached, so that the hand traction belt skin protection device can adapt to different wrist sizes, the viscosity is stable after attachment, and a certain traction force can be borne without falling off; the flexible material of the buffer cushion layer can disperse the contact pressure between the wrist and the traction belt, tissue damage caused by too large local pressure intensity is avoided, and therefore stable and comfortable fixation is achieved.

To provide Akt3 modulators and compounds and pharmaceutical compositions for treating diseases by modulation of Akt3 signaling.SOLUTION: A compound of Formula Ib or Ic, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising said compound for treating a disease in a subject in need thereof, A pharmaceutical composition wherein the treatment comprises administering to a subject an effective amount of the compound; optionally wherein the disease is selected from the group consisting of neurodegenerative diseases, cachexia, eating disorders, obesity, complications of obesity, inflammatory diseases, virally-induced inflammatory reactions, Gulf War Syndrome, tuberous sclerosis, retinitis pigmentosa, graft rejection, cancer, autoimmune diseases, ischemic tissue injury, traumatic tissue injury and combinations thereof.SELECTED DRAWING: Figure 6

The invention discloses an application of a grifola frondosa extract in preparation of a medicine for inhibiting myeloid-derived suppressor cells. The polysaccharide extract is a grifola frondosa sporocarp polysaccharide extract, and the molecular weight range of the polysaccharide extract is 0.5 * 10 < 4 >-149 * 10 < 4 > Da. The grifola frondosa extract inhibits the spleen of a tumorigenic mouse from generating MDSCs, inhibits the proportion and quantity of MDSCs in the blood and tumor tissue of the tumorigenic mouse, and improves the content and activity of CD3 + T and CD8 + T lymphocytes, so that the immune response ability of the body is improved, and the grifola frondosa extract is not only suitable for preparing anti-tumor drugs, but also suitable for treating inflammatory-mediated tissue damage, infectious diseases and other diseases. And preparing medicines for treating MDSCs related diseases such as autoimmune diseases and the like.

The invention discloses a catheter fixing device with an intelligent pressure alarm function, and relates to the technical field of catheter fixing. The pressure sensing element alarm is used for monitoring the pressed state of the drainage tube in real time, and when the catheter is distorted, pressed or the traction force exceeds a preset threshold value, sound-light alarm is automatically triggered, so that medical staff are helped to find the risk of tube blockage or non-planned tube drawing at the first time, and complications such as infection and tissue damage caused by unsmooth drainage are avoided; a medical-grade adhesive layer and anti-skid textures of the fixed base ensure the skin fitting firmness, and the traction force of the catheter is effectively dispersed in combination with a double-locking structure of the fixed clamping groove and the magnetic type fixed cover; the double-color LED indicating lamp visually displays the state of the catheter (normal green / alarm red), remote inspection is facilitated, the workload of medical staff is relieved, and the nursing quality and the safety of a patient are improved.

The utility model discloses a traction patch for crissum surgery. The traction patch comprises traction assemblies which are in bilateral symmetry. The sticking piece is composed of a release paper layer, a sticking layer made of acrylic ester sticking materials, a polyurethane middle layer, a soft rubber reinforcing layer and a nylon outer coating layer, and the sticking layer can be torn and replaced. The outer covering layer is provided with three traction belts made of flat elastic bands, the upper traction belt and the lower traction belt are tightened and fastened on the fixing rod for standby traction, the middle traction belt is connected with an air bag, the air bag is connected with a pedal type air pump through an air pipe and used for inflation traction and capable of accurately adjusting force, and notches are formed in all the layers so that drainage can be facilitated. The traction patch can accurately and stably draw crissum tissue, enables the operation view to be completely exposed, is controllable in exposure range, reduces operation interference and tissue damage, has a reliable standby traction mode, can reduce cost, guarantees sanitation and safety, effectively improves the quality and safety of crissum operation, and promotes postoperative recovery of a patient.