1572 results about "Tissue damage" patented technology

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

The invention discloses a bionic nanofiber-hydrogel composite biological scaffold as well as a preparation method and application thereof. The bionic nanofiber-hydrogel composite biological scaffold is a composite scaffold for simulating a gray-white matter partition structure of a spinal cord tissue, and comprises bionic nanofibers and a bionic hydrogel material, wherein the bionic nanofibers are arranged in an oriented manner and simulate a white matter ordered structure around the spinal cord, and the bionic hydrogel material is combined with the bionic nanofibers and simulates gray matter in the center of the spinal cord. According to the bionic nanofiber-hydrogel composite biological scaffold, the biological activity of loaded stem cells or adult cells can be improved, the problem that a large number of transplanted exogenous cells die due to unbalanced oxidative stress generated after tissue damage can be solved, and it is guaranteed that the transplanted cells reside in a damaged area and play a role; therefore, the spinal cord microenvironment is improved, proliferation and differentiation of endogenous neural stem cells are promoted, functional recovery after spinal cord injury is finally promoted, and great potential is achieved in spinal cord injury treatment.

The invention relates to a battle wound field real-time hemostasis method based on a biological information sensing technology, and the technical scheme comprises the steps: introducing a time sequence biological signal for modeling, and carrying out the dynamic prediction of a battle wound state; on the basis of a biosensor data flow, a multi-dimensional time sequence state space is constructed, and the multi-dimensional time sequence state space comprises a nonlinear change trend of a bleeding rate, an evolution mode of tissue physiological parameters and a dynamic evolution process of a blood coagulation process; external intervention requirements are minimized while a hemostasis strategy is dynamically adjusted through active learning; defining multi-objective optimization modeling of key objectives of hemostasis efficiency, tissue damage minimization and pressure adaptability; estimating distribution prediction of success probabilities of different hemostasis strategies; the intelligent response mechanism is composed of a nanoscale blood coagulation factor carrier and a phase change regulation and control network. An environment triggering response model is constructed, and the blood coagulation factor carrier selectively releases blood coagulation factors according to biological signals including the pH value, the temperature and the bleeding rate.

The invention discloses bifidobacterium breve BBr69 with an immunoregulation function as well as application, a product and a method thereof, and belongs to the technical field of microorganisms. The preservation number of the bifidobacterium breve BBr69 with the immunoregulation function is CGMCC (China General Microbiological Culture Collection Center) NO. 32425. Based on the strain, the invention also provides application and related products of the strain. The BBr69 strain has broad-spectrum antibacterial performance, has the function of regulating intestinal flora and also has the function of enhancing immunity, and immunity is enhanced by proliferating RAW264.7 cells, increasing the content of cell factors, inhibiting weight loss, increasing the index of immune organs and reducing ileum tissue damage.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

Articles including protective gear for a variety of sports and activities provide protection from one or both of linear and angular forces that either directly or indirectly impact the gear when it is donned. The articles include at least two layers of material that provide multimodal energy dissipation to minimize the extent of transmission of impact forces to tissue.

The invention provides a first-aid tourniquet pressure monitoring and automatic alarm system, and relates to the technical field of pressure monitoring. The system comprises a biological reaction monitoring module, a pressure adjustment analysis module, a real-time pressure adjustment module, a safety threshold detection module and an emergency response activation module. According to the invention, through real-time monitoring of biological reactions, changes of micro blood flow, skin electrical impedance and tissue morphology of a patient after the patient uses the tourniquet are captured, so that monitoring of individual reactions is more comprehensive, the safety and effect of pressure are evaluated in combination with the actual physiological state of the patient, monitoring is more dynamic and personalized, and the monitoring accuracy is improved. Through the combination of pressure real-time adjustment and emergency response, it is ensured that when the pressure exceeds a safety range, pressure adjustment is conducted rapidly, warning is given out through an alarm, secondary injury caused by improper pressure is avoided, the use safety and response speed of the tourniquet are improved, tissue injury of a patient can be more accurately prevented, and the patient can be more accurately protected. And the real-time effectiveness and safety in the emergency treatment process are ensured.

The invention relates to a pathologically responsive nano-carrier as well as a preparation method and application thereof, belongs to the technical field of biological medicines, and aims to solve the problems that in the prior art, nano-particles are enriched in livers and kidneys in quantity, the risk of damaging organs and tissues exists, toxic and side effects on patients with spinal cord injury are large, the treatment effect is not obvious and the like. The carrier is a self-assembled nanoparticle which takes PLGA as a skeleton structure, is externally modified with hyaluronic acid and is connected with RVG29 through a diselenide bond. The carrier can load an active substance, such as curcumin, can be used for treating spinal cord injury, and can target spinal cord tissues through intravenous administration, penetrate a blood spinal cord barrier, target CD44 through HA at the early stage of injury, increase immune cell uptake and inhibit inflammatory infiltration and inflammatory cascade. In the late stage of injury, the nerve cell uptake is increased through RVG29 targeted acetylcholine receptor (nAchR), and nerve repair and regeneration are promoted.

The invention provides a liposuction needle cannula system and method, and the system comprises a cannula assembly which is used for forming a liposuction space at a liposuction part; the liposuction needle assembly is arranged in the sleeve assembly in a sliding and penetrating mode and used for conducting liposuction operation in the liposuction space. According to the technical scheme, tissue damage is reduced, and the fat cell survival rate and the liposuction efficiency are improved.

According to the precise diagnosis and treatment integrated platform and method based on the coupling model, the cavitation effect is predicted through numerical simulation, negative feedback adjustment is conducted on microbubble mediated ultrasonic treatment, and precise control over the microbubble mediated ultrasonic treatment is achieved. Acoustic parameters are adjusted in real time, it can be ensured that treatment focuses on a lesion area, damage to surrounding healthy tissue is reduced, and therefore the accuracy and safety of treatment are improved. The platform integrates cavitation detection and an acoustic feedback mechanism, the microbubble cavitation effect can be monitored in real time, and treatment parameters can be automatically adjusted. Negative feedback closed-loop control can ensure a stable cavitation state, tissue damage caused by excessive cavitation is effectively avoided, and the stability and reliability of treatment are improved. The platform simplifies the operation process of controlling acoustic parameters. A doctor can complete the whole process from treatment to monitoring on the same operation interface through the integrated platform, and convenience and efficiency of clinical operation are improved. The platform is not only suitable for tumor treatment, ablation and drug delivery, but also can be applied to multiple treatment fields such as vascular diseases and neuromodulation, and has wide clinical application prospects and market potential.

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.

A digital intelligent control system for perceiving a puncture state is characterized in that a sensor signal is converted into a state expression vector of an interaction behavior of a tissue and a puncture tool, and characteristics including tissue elasticity, a fracture threshold value and interface slippage are extracted; a time domain and frequency domain feature mapping mechanism of a nested structure is used, and micro-characterization including piercing micro-shock and tissue layer transition points in continuous puncture is extracted; describing logic mapping between puncture path evolution and a prediction result by constructing a state and intention space diagram relationship; introducing a semantic dynamic weight mechanism, and judging whether the current state is a path expected by a doctor so as to identify a potential deviation puncture or abnormal invasion risk; through real-time identification of key states such as tissue level transition points, piercing micro-shock, interface slippage and the like, the mistaken entry risk of a high-risk area is effectively pre-judged. The system can adjust the puncture angle, speed and torque in advance, and common concurrent problems such as over-puncture, deviation or tissue damage in an operation are avoided.

The invention relates to the technical field of disease diagnosis, and comprises a disease diagnosis method and system based on neural network cognitive diagnosis, and the method comprises the following steps: obtaining medical image data, calculating the gray level change rate, gradient direction distribution and edge continuity of a lesion region, counting the lesion tissue damage area, and analyzing the pathological tissue damage degree. And obtaining a lesion distribution consistency index. According to the invention, through comprehensive calculation of the medical image data and the pathological tissue slice data, fine-grained description of a focus area is realized, association among different lesion features is realized, and calculation of a lesion propagation path matching rate is realized, so that identification of lesion diffusion conditions is more accurate, and development trends of diseases in different tissue structures can be effectively predicted; the calculation of the cross-modal feature error is combined with the adjustment of the distribution weight of the lesion region, misdiagnosis caused by modal difference and extraction of abnormal signals in a lesion diffusion range are reduced, so that screening of potential diseases is more targeted, and the accuracy of disease recognition is improved.

The invention discloses a new medicine application of a local injection acoustic response stent in enhancing ultrasound histotripsy. The acoustic response scaffold (ARS) comprises a scaffold material, fluorocarbon gas or liquid fluorocarbon particles with liquid-vapor phase change capacity, and microbubble cloud in the scaffold generates a strong cavitation ablation treatment effect in a target area under the action of low-frequency and low-sound-pressure ultrasound. Fluorocarbon gas or liquid fluorocarbon particles contained in the ARS form microbubble cloud and ideal cavitation nuclei under low-frequency low-sound-pressure ultrasonic excitation, inertia cavitation resonance is achieved under the ultrasonic action, and then cavitation mechanical damage with local tissue controllable strength is generated. The low-intensity ultrasonic histotripsy has the characteristics of low sound pressure, low sound intensity, high targeting property, small tissue damage outside a target region, simplicity in instrument manufacturing and the like, and the targeting property and the safety of treatment are improved. The method does not need very accurate ultrasonic focusing, reduces the operation difficulty, and has application prospects in multiple medical fields such as prostatic hyperplasia, tumor ablation and tumor immunotherapy.

The invention discloses a copper ion carrier material with a photothermal effect, a preparation method and an anti-cancer drug formed by the copper ion carrier material, and belongs to the technical field of nano drug loading technologies, and the structural formula of the copper ion carrier material is as follows: # imgabs0 #. The preparation method comprises the following steps: S1, mixing butanedione and concentrated hydrochloric acid in water, stirring and reacting, adding 4-methyl thiosemicarbazide, continuously stirring and reacting, and performing post-treatment to obtain a compound (4); then dissolving the compound (3) and 4, 4-dimethyl thiourea in a DMSO solvent, dropwise adding glacial acetic acid for reaction, and performing post-treatment to obtain a compound (6); dissolving the compound (6) and 6-aminocaproic acid in an acetonitrile solvent, reacting, and performing post-treatment to obtain a compound (8); and dissolving the compound (8) and beta-cyclodextrin in a DMSO solvent, mixing, adding an activating agent and a condensing agent, reacting, and performing post-treatment to obtain the copper ion carrier material with the photothermal effect. The problems that a copper ion carrier is poor in water solubility, low in photothermal conversion efficiency and low in near-infrared light energy, ultraviolet light is not prone to penetrating into tissues, and tissue damage can be caused are solved.

The invention discloses a biologically safe and degradable cerium-based tannic acid nano-enzyme as well as a preparation method and application thereof. The nano-enzyme can be administrated through a non-invasive nasal cavity. In an area with excessive ROS, thioketone on CeTA-k1tkP is destroyed, PEG is removed, hydrogen bonds of an amino acid sequence are allowed to form beta-sheet, the beta-sheet is accumulated at an inflammation part, and a fiber or network structure is formed. Meanwhile, CeTA-k1tkP shows enzyme-like capacity, ROS is effectively eliminated, inflammation is effectively relieved, and systemic immunosuppression is avoided at the same time. In an influenza A (Flu A) virus or Sendai virus (SeV) mediated viral pneumonia model, CeTA-k1tkP can generate responsive deformation in inflammatory lung tissues, so that the nano-enzyme effectively decomposes ROS (reactive oxygen species). In addition, the CeTA-k1tkP can relieve bacterial inflammation and reduce tissue damage in a mouse viral pneumonia model with secondary bacterial infection.

A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are systems and methods for acoustically coupling a histotripsy therapy system to the skin of a patient to provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening / non-target tissues or structures.

The invention relates to the technical field of ischemia training, in particular to a limb ischemia pre-adaptation training method and device.The limb ischemia pre-adaptation training method comprises the steps that feature parameters, training purposes and cuff feature parameters of an individual AOP of a target user are collected; inputting the obtained feature parameters of the individual AOP of the target user, the training purpose and the feature parameters of the cuff into a pressure prediction model, and outputting a pressure value; inputting the obtained blood vessel health coefficient, the limb perimeter, the pressure value and the training purpose into a pressure blocking time prediction model, and outputting pressure blocking time; according to the method, the optimal pressure value under different training scenes can be dynamically predicted, so that the physiological requirements of different training targets are met, and then the blood vessel health coefficient and pressure application blocking time prediction model is introduced, so that the blood vessel health coefficient and pressure application blocking time prediction accuracy is improved. The training safety is further optimized, and tissue damage caused by too large pressure or too long time is avoided.

The invention relates to the technical field of medical apparatus and instruments, in particular to an operation retractor which comprises four supporting arms, the four supporting arms correspond to one another end to end and are distributed in a rectangular shape, sliding holes are formed in the inner ends of the supporting arms, sliding boxes are slidably connected into the sliding holes, and sliding rods penetrate through the inner ends of the sliding boxes; a connecting piece is fixedly installed at the end, away from the supporting arm, of the sliding rod, a shifting plate is arranged below the connecting piece, rotating cylinders are arranged on the two sides of the supporting arm, driven cylinders are connected to the inner ends of the rotating cylinders, an adjusting cylinder is arranged at the end, away from the rotating cylinders, of the supporting arm, and an adjusting device used for controlling the motion trail of the connecting piece is arranged in the adjusting cylinder. Through synchronous movement of the four shifting plates, it is ensured that an incision is evenly and stably expanded, the exposure effect of an operation view is remarkably improved, meanwhile, the tissue damage risk is reduced, meanwhile, the driving plate can be directly adjusted according to actual requirements in an operation, linkage displacement of all the shifting plates is controlled in real time, and the tedious step that a traditional instrument needs to be adjusted one by one is omitted.

The invention relates to the technical field of medical care, in particular to a massage method for avoiding tissue damage through flexible mechanical conduction by Taoist massage, and discloses a massage method named'massage method for avoiding tissue damage through flexible mechanical conduction by Taoist massage '. The invention aims to solve the problems that the existing massage technology is easy to cause tissue damage due to force application rigidity, and the safety, the accuracy and the treatment depth of the massage technology are limited. The method is characterized in that a closed-loop system of tissue stress dynamic dispersion, layer-controlled shear wave guidance and biological impedance coupling feedback is adopted, traditional rigid force is converted into flexible conduction of low-frequency and small-amplitude transverse shear waves, and layer-by-layer, dispersion-type and non-invasive penetration of mechanical energy is achieved. By the adoption of the technical scheme, tissue damage can be effectively avoided, and the deep treatment effect and safety are improved.

The invention belongs to the technical field of regenerated medical dressings, particularly relates to a plant polysaccharide hydrogel medical dressing for promoting tissue damage repair and application thereof, and provides the following scheme that a medical and mechanical combined product comprises a regenerated medical dressing and a low-temperature sterile storage box for storing the regenerated medical dressing, the regenerated medical dressing comprises a hydrogel main body, open pores formed in the hydrogel main body, sustained-release vesicles arranged in the open pores, and stem cells and a cell culture medium which are filled in the sustained-release vesicles. The stem cell hydrogel can rapidly break blood, rapidly stop bleeding by being attached to a wound surface and promote wound closing, stem cells are inoculated to the upper surface of the hydrogel formed by dendrobium polysaccharides, aloe, lily, coptis chinensis and honeysuckle, safe application of the stem cells is achieved, active factors secreted by the stem cells are slowly released to the skin wound surface, and the wound healing effect is achieved. Through contact stimulation between cells, various cytokines can be secreted better, and the skin repair efficiency is improved.

The invention provides a Shuanghuang nano-particle as well as preparation and application of the Shuanghuang nano-particle. The main medicinal components of the Shuanghuang nano-particles comprise the rhein compounds and the curcumin compounds, and the solubility of the two slightly soluble or insoluble compounds in water can be remarkably improved in a nanocrystallization mode, so that the bioavailability of the Shuanghuang nano-particles is enhanced. The nanocrystallization combined application of the two compounds helps the compounds to exert greater medicinal values clinically, such as antibiosis, anti-inflammation, antioxidation and tissue damage protection. In addition, the preparation method of the Shuanghuang nanoparticles is simple, convenient, rapid in preparation and convenient for industrial production.

A battery cell comprising a composite water-responsive safety layer and / or composite water- and pH-responsive safety layer to protect against bodily tissue damage and / or electrolysis, when the battery cell is exposed to aqueous solution or bodily tissue, is provided.

The invention relates to the technical field of pressure control, in particular to a prone position surgery face pressure adjusting method and system based on pressure induction, and the method comprises the following steps: based on an embedded miniature pressure sensor, detecting the pressure value of a face key area, analyzing the pressure distribution condition, and calculating the face pressure value; the concentrated stress state of each area of the face is analyzed through the pressure value change trend, and face area pressure distribution trend data are obtained. In the invention, through a pressure sensing technology and a dynamic adjustment mechanism, the problem of uneven pressure of the face in a prone position operation can be effectively identified and relieved, pressure distribution can be monitored and analyzed in real time, the pressure of a high-sensitivity area is accurately adjusted to be transferred to a low-sensitivity area, uniform distribution is realized, tissue damage caused by local long-term compression is reduced, and the operation safety is improved. The support force of each pressed point is balanced, the face pressure adjustment is optimized, the distribution stability is improved through pressure fluctuation monitoring and correction, the non-uniform phenomenon caused by fluctuation is avoided, and the surgical comfort and safety are improved.

The invention relates to an intelligent eyelid fixing and tear flow guide composite device, which belongs to the technical field of medical instruments and comprises an arc-shaped main body frame, a multi-section pressure sensing fixing wing, a miniature liquid guide groove, a humidity compensation module and a central control unit. The multi-section pressure sensing fixed wing can be dynamically attached to the shape of an eyelid and is matched with the flexible contact layer to achieve biomechanical self-adaptive adjustment, and contact pressure is evenly dispersed. The miniature liquid guide groove serves as an efficient tear drainage path, and tears are rapidly discharged in combination with negative pressure suction. The humidity compensation module accurately covers the cornea surface through an annular atomization nozzle, and the ocular surface is kept moist. And the central control unit is used for monitoring in real time and adjusting fixed pressure, atomization intensity and negative pressure parameters in a linkage manner to form an intelligent feedback closed loop. The device solves the problems that a traditional rigid eye speculum is uneven in pressure distribution, low in tear management efficiency, poor in dissection adaptability and the like, the steady state maintaining effect of the ocular surface microenvironment in an ophthalmologic operation can be improved, and tissue damage and operation interruption are reduced.

The invention relates to the field of medical instruments, in particular to a resectoscope. The resectoscope comprises an inner sheath assembly, an outer sheath assembly and an operation assembly, the side face of the end, away from an outer sheath body, of an outer sheath tube protrudes outwards to form a protruding belly, a plurality of through holes are evenly formed in the protruding belly, and the tail end of the inner sheath tube is connected with a tube head extending to the outer side of the outer sheath tube. Besides, corrugations are arranged on the outer sheath tube, a first connector and a second connector are arranged on the upper side and the lower side of the outer sheath body respectively, the inner sheath body and the outer sheath body are connected through a first quick release assembly, the operation assembly comprises a first grip and a second grip, and quick disassembly and assembly are achieved through the second quick release assembly and a third quick release assembly. The effects of improving surgical operation flexibility, reducing tissue damage and simplifying instrument cleaning and maintenance are achieved.

The present invention provides compositions and methods for preventing, alleviating, or treating subjects having toxic agent-induced injury. The present invention also provides compositions and methods for preventing, alleviating or treating tissue damage caused by exposure to toxic agents or restoring at least a portion of normal tissue function. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising at least one potassium channel blocker. In some embodiments, the potassium channel blocker includes 4-aminopyridine, a derivative thereof, or a combination thereof. In some embodiments, the pharmaceutical compositions may be administered with additional therapeutic agents, such as anticonvulsions.

The invention is applicable to the technical field of medical instruments, and provides a subskull epidural micro-invasive flexible brain-computer interface electrode, which comprises a plurality of electrode branches, each electrode branch comprises a linear flexible main body, and the flexible main body comprises a micro power supply circuit and a signal circuit which are solidified. A plurality of electrode units are arranged on the micro power supply circuit and the signal circuit at intervals, and the electrode units are electrically connected with the micro power supply circuit and the signal circuit. The brain-computer interface electrode is in a flexible line type, can be implanted into the middle artery of the meninx, does not need craniotomy, is a micro-invasive brain-computer interface, has data monitoring accuracy close to that of an invasive brain-computer interface, does not need to worry about inflammatory response, immunostimulation, biocompatibility, brain tissue damage and other adverse factors after long-term implantation, and is suitable for popularization and application. And the thrombogenic risk of a vein stent brain-computer interface does not exist.