3 results about "Phosphatidyl ethanolamine" patented technology

The application discloses a liposome of a FOXO1 inhibitor AS1842856 and a preparation method and application thereof. The liposome comprises the following raw materials: phospholipid, cholesterol, phospholipid PEG derivative and AS1842856; wherein the proportion of the phospholipid, the cholesterol and the phospholipid PEG derivative (for example, distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 (DSPE-PEG2000)) is preferably in the range of 10:0.2-2:0.5-5 (w / w); wherein the AS1842856 is wrapped in the liposome. The AS1842856 liposome of the application has excellent physical and chemical properties and has a wide application prospect in the field of fibrosis disease treatment.

The application discloses a high-performance composite aluminum film packaging bag and a preparation method thereof, and belongs to the technical field of packaging bags. The packaging bag has a three-layer structure, and comprises, from outside to inside, an aluminized film layer, an intermediate film layer and a heat-seal film layer. The aluminized film layer, the intermediate film layer and the heat-seal film layer are connected through a two-component polyurethane adhesive. The two-component polyurethane adhesive comprises a main agent and a curing agent. The main agent contains a Ti3AlC2 / SiO2 composite material modified by distearoyl phosphatidyl ethanolamine-polyethylene glycol-silane and loaded with menthol. Through optimization of the composition of the adhesive, the adhesive not only realizes the close connection between the layers, but also greatly improves the adhesion of the adhesive under high-temperature and high-humidity conditions, thereby guaranteeing the cooking resistance of the packaging bag. In addition, the packaging bag has certain heat storage performance, can better maintain the stability of the internal temperature, and optimizes the use experience of consumers.

The application discloses a kind of loaded manganese doped ceria nanoscale enzyme's Pachyman hydrogel and its preparation method and application, it is related to biomedical technical field.The preparation method is first prepared by high-temperature thermal decomposition method fat-soluble manganese doped ceria nanoscale enzyme, then it is surface-modified using distearoyl phosphatidyl ethanolamine to obtain water-soluble nanoscale enzyme;Polyvinyl alcohol solution is mixed uniformly with Pachyman powder, water-soluble nanoscale enzyme, borax solution is added to crosslink and form hydrogel, after freeze-room temperature processing alternately, it is obtained.The energy storage modulus of the prepared hydrogel is 120-350 Pa at pH 6.5-7.2, 37 ℃, and the adhesion is greater than or equal to 8.5 kPa.The hydrogel prepared by the application has good biocompatibility, can efficiently remove active oxygen, relieve intestinal oxidative stress, and has suitable adhesion and degradation characteristics, can be administered by enema, and be used for preparing drugs for treating irritable bowel syndrome.