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Metabolic marker for diagnosing coronary heart disease

A technology of metabolic markers and coronary heart disease, applied in the field of biochemistry, to achieve the effect of promoting standardization, high sensitivity, and improving the convenience of diagnosis

Inactive Publication Date: 2016-04-13
齐炼文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No one has used plasma metabolite levels to diagnose coronary heart disease

Method used

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  • Metabolic marker for diagnosing coronary heart disease
  • Metabolic marker for diagnosing coronary heart disease
  • Metabolic marker for diagnosing coronary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Screening and characterization of plasma differential metabolites between patients with coronary heart disease and patients without coronary heart disease (including healthy people and patients with coronary atherosclerosis)

[0028] 1. Objects and methods

[0029] 1. The source of the specimen

[0030] After obtaining the consent of the patients, the peripheral venous blood plasma of 480 patients with coronary atherosclerosis, 867 patients with coronary heart disease and 350 healthy people in Jiangsu Provincial People's Hospital from September 2010 to June 2015 was collected. Confirmed by coronary angiography. The age and sex of healthy people were matched with patients with coronary atherosclerosis and coronary heart disease. All patients with coronary atherosclerosis, coronary heart disease and healthy people have normal heart, lung, liver, kidney and hematopoietic functions.

[0031] The time of blood collection was in the morning on an empty stomach. ...

Embodiment 2

[0054] Example 2: Construction of ROC curves to compare the ability of 10 differential metabolites to diagnose patients with coronary heart disease and non-coronary heart disease (including healthy people and coronary atherosclerosis)

[0055] Receiver operating curve (ROC) method was used for verification, and the ability to diagnose coronary heart disease was judged by the expression levels of differential metabolites in the plasma of patients with coronary heart disease and non-coronary heart disease (including healthy people and coronary atherosclerosis). . The results showed that 1-palmitoyl-sn-glycerol-3-phosphatidylcholine, 1-stearatetraenoyl-sn-glycerol-3-phosphatidylcholine, 1-linoleoyl-sn-glycerol-3 - Phosphatidylcholine, 1-stearoyl-sn-glycerol-3 phosphatidylcholine, 1-linoleoyl-2-hydroxy-sn-glycerol-3-phosphatidylethanolamine, 1-linolenoyl-sn-glycerol -3-Phosphatidylcholine, 1-oleoyl-sn-glycerol-3-phosphatidylcholine, 1-hexadecenoyl-sn-glycero-3-phosphatidylcholine...

Embodiment 3

[0073] Embodiment 3: application in the screening treatment or the medicine of alleviating coronary heart disease

[0074] The blood plasma of 185 patients with coronary heart disease before and after drug treatment was detected, and the results showed that: with the increase of the course of drug treatment, the patient's condition was gradually relieved, and the levels of 10 metabolic markers provided by the present invention tended to gradually increase in the plasma. It is at the level of healthy people, and there is no significant difference (P>0.05) between the plasma levels of healthy people after complete cure. This result is consistent with the detection results of coronary angiography. Therefore, the metabolic markers provided by the present invention can be used to screen drugs for treating or alleviating coronary heart disease.

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Abstract

The invention discloses a metabolic marker for diagnosing a coronary heart disease. The metabolic marker comprises one or more of 1-palmitoyl-sn-glycerinum-3-phosphatidylcholine, 1-octadecatetraenoicenoyl-sn-glycerinum-3-phosphatidylcholine, 1-linoleoyl-sn-glycerinum-3-phosphatidylcholine, 1-stearoyl-sn-glycerinum-3-phosphatidylcholine, 1-linoleoyl-2-hydroxy-sn-glycerinum-3-phosphatidyl ethanolamine, 1-linoleoyl-sn-glycerinum-3-phosphatidylcholine, 1-oleoyl-sn-glycerinum-3-phosphatidylcholine, 1-hexadecene acyl-sn-glycerinum-3-phosphatidylcholine, phytosphingosine and hexadecanamide. The metabolic marker provided by the invention can accurately diagnose the coronary heart disease, accurately distinguish patients with the coronary heart disease and healthy persons, can also accurately distinguish the patients with the coronary heart disease from patients with atherosclerosis of coronary artery, and has high accuracy, sensitivity and specificity.

Description

technical field [0001] The invention belongs to the field of biochemistry and relates to disease diagnosis markers, in particular to a group of metabolic markers for diagnosing coronary heart disease. Background technique [0002] Coronary heart disease, also known as ischemic heart disease, involves atherosclerosis in the arteries supplying myocardial blood, that is, coronary atherosclerotic lesions cause vascular lumen narrowing or plaque formation or even rupture and complete blockage, resulting in myocardial ischemia and hypoxia. Or necrosis leads to cardiac ischemic disease, which leads to a series of serious cardiovascular events such as clinical angina pectoris and myocardial infarction. Coronary heart disease is the main killer of human health. It has the characteristics of high incidence rate, high disability rate, high recurrence rate, high mortality rate, and many complications. It has become a major disease that threatens the health of our people. [0003] Coron...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N33/48
CPCG01N30/02G01N33/48G01N2800/324
Inventor 齐炼文赵艺静范勇朱伟李萍陈彦
Owner 齐炼文
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