2 results about "Coronary atherosclerosis" patented technology

This invention belongs to the interdisciplinary field of bioinformatics and traditional Chinese medicine (TCM), and discloses an algorithm for the improvement and prediction of TCM compound prescriptions, solving the problems of strong subjectivity, long cycle, and low efficiency in traditional TCM compound prescription improvement. The algorithm first acquires and preprocesses omics sequencing data from disease and healthy groups, then establishes TCM-target gene associations based on the HIT2 and TCMSP databases, and constructs a three-dimensional association matrix of TCM-target genes-5hmC loci for epigenomic data. After dimensionality reduction and extraction of core principal components using PCA, the sample-TCM association score is calculated and a matrix is ​​constructed. The p-value is obtained through t-test or Wilcoxon rank-sum test, and converted into DAS values ​​to quantify the regulatory activity of TCM, thus screening TCM for compound prescription improvement. This invention's algorithm is objective, highly targeted, efficient, and widely applicable, adaptable to various omics data and disease scenarios. Its effectiveness has been verified in a coronary atherosclerosis case, providing precise technical support for TCM compound prescription screening and optimization, personalized TCM treatment, and the development of innovative TCM drugs.

The present application provides a traditional Chinese medicine composition for treating and / or preventing coronary heart disease, and a preparation method and application thereof. Specifically, the traditional Chinese medicine composition of the present application is prepared from raw materials comprising the following components: 8-13 parts of capillaris, 8-12 parts of atractylodes, 8-12 parts of alisma, 8-14 parts of curcuma, 10-20 parts of salvia, 8-14 parts of curcuma, 1-5 parts of panax notoginseng powder, 5-10 parts of rhizoma corydalis, 8-12 parts of pinellia, 5-10 parts of berberis, 4-10 parts of ginseng, 5-12 parts of dried tangerine or orange peel, and 4-10 parts of licorice. The present application also provides a method for preparing the traditional Chinese medicine composition of the present application and the use of the traditional Chinese medicine composition in preparing a medicine for treating and / or preventing coronary atherosclerotic heart disease. The traditional Chinese medicine composition of the present application can reduce blood viscosity, improve heart function, reduce myocardial infarction area, inhibit the formation of atherosclerotic plaques, regulate blood lipid levels, or reduce the level of myocardial injury markers in serum.