38 results about "Artery diseases" patented technology

This application is directed to systems, methods, and devices for image based analysis of plaque. In some embodiments, the approaches herein can be used for developing treatment plans, which can include local treatment, systemic treatment, or both. In some embodiments, the approaches herein can be used for stent selection. In some embodiments, the approaches herein can be used for surgical planning, which can include robotic surgical planning. In some embodiments, the approaches herein can be used for image normalization. In some embodiments, the approaches herein can be used for identifying plaque calcification thresholds. In some embodiments, the approaches herein can be used for identifying thin cap fibroatheroma. In some embodiments, the approaches herein can be used for coronary artery tree reconstruction. Some embodiments are directed to coronary artery disease risk stratification.

This application is directed to systems, methods, and devices for image based analysis of plaque. In some embodiments, the approaches herein can be used for developing treatment plans, which can include local treatment, systemic treatment, or both. In some embodiments, the approaches herein can be used for stent selection. In some embodiments, the approaches herein can be used for surgical planning, which can include robotic surgical planning. In some embodiments, the approaches herein can be used for image normalization. In some embodiments, the approaches herein can be used for identifying plaque calcification thresholds. In some embodiments, the approaches herein can be used for identifying thin cap fibroatheroma. In some embodiments, the approaches herein can be used for coronary artery tree reconstruction. Some embodiments are directed to coronary artery disease risk stratification.

To provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue.SOLUTION: In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective in injuring or damaging tissue, nerves and nerve endings in order to relieve disease symptoms.SELECTED DRAWING: Figure 3B

A polygenic risk score (PRS) for coronary artery disease, a construction method therefor, and an application thereof in combination with clinical risk assessment. The present invention first provides an application of a reagent for detecting individual information in preparation of a detection device for assessing the onset risk of the coronary artery disease, wherein the individual information comprises 311 CAD-related single nucleotide polymorphic sites, and the individual information preferably also comprises one or more of BP, BMI, DM, TC and Stroke-related single nucleotide polymorphic sites. The present invention further provides a method for constructing a comprehensive metaPRS for the coronary artery disease. In the present invention, the PRS and the conventional clinical risk factor score are further integrated, such that re-layering of the onset risk of the coronary artery disease can be realized. The present invention is of great significance to primary prevention of the coronary artery disease.

The invention provides an application of a super enhancer inhibitor JQ-1 in preparation of peripheral artery disease related drugs, relates to the technical field of biomedicine, and discloses a core effect of the super enhancer inhibitor JQ-1 in peripheral artery disease ischemia repair. The traditional Chinese medicine composition can significantly accelerate blood flow recovery of ischemic limbs, up-regulate mRNA and protein expression of a vascular marker CD31 in gastrocnemius muscle tissues, effectively increase vascular density and promote angiogenesis. Aiming at the defects of the existing treatment means in the aspect of ischemic tissue angiogenesis, the application provides a brand new molecular targeted treatment scheme for high-risk groups such as patients with diabetes-related peripheral artery diseases, and can significantly reduce the risk of lower limb amputation and the incidence rate of related cardiovascular adverse events such as coronary heart disease and stroke; the technical blank of specific targeted therapy of peripheral artery diseases is filled, a solid scientific basis and a key direction are provided for research and development of novel drugs, and the specific targeted therapy method has extremely high clinical application value and wide research and development prospects.

The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or phenyl; R2 is hydrogen, cyano, halogen, alkylsulfonyl, alkyl, cycloalkyl or alkoxy; R3, R4, R5, R6, R7 and R8 are independently hydrogen, halogen, alkyl or alkoxy; most groups being optionally substituted; with the proviso that at least one of R2, R3, R4 is H; X1, X2, X3, X4, X5 and X6 are independently N or C; with the proviso that in each ring maximal one X is N.

Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

This invention relates to methods of lowering plasma levels of endothelial lipase (EL) in patients in need thereof comprising administering MEDI5884 to subjects at a dose of from about 50 mg to about 600 mg per month.

The present disclosure relates to pharmaceutical formulations of angiotensin converting enzyme inhibitor and / or diuretic, particularly stable oral pharmaceutical formulations comprising angiotensin converting enzyme inhibitor and / or diuretic with one or more pharmaceutically acceptable excipients for the treatment of hypertension, coronary artery disease, heart failure, acute myocardial infarction and other related cardiovascular diseases.

A siRNA for inhibiting LPA gene expression, and a modifier and the use thereof, belonging to the field of biomedicine. Provided are a double-stranded RNA molecule targeting an LPA gene, and a modifier thereof. Both in vivo and in vitro experiments show that the provided double-stranded RNA molecule can effectively inhibit LPA gene expression, and can be used for preventing and / or treating Lp(a)-related diseases, such as thrombosis, atherosclerotic thrombosis, coronary artery disease, ischemic strokes, aortic valve stenosis, heart failure, atrial fibrillation, and peripheral artery disease.

The invention discloses a coronary artery disease early risk prediction and typing method based on deep learning, and belongs to the technical field of medical image processing. According to the method, cardiac angiography CTA image pixel-level segmentation is completed by using an image segmentation model, loss is optimized by using a medical image text feature fusion module and multi-modal feature alignment, and early risk prediction and typing of coronary artery diseases are completed. By introducing the multi-scale state space feature encoder, the hierarchical feature reconstruction module and the multi-modal feature alignment optimization loss module, efficient and accurate segmentation and risk assessment of the coronary artery CTA image are realized, a new technical means is provided for segmentation and risk assessment of the coronary artery CTA image, and the segmentation and risk assessment efficiency of the coronary artery CTA image is improved. The development of a multi-modal fusion technology in the field of medical image processing is promoted, powerful support is provided for early diagnosis, risk stratification and personalized treatment of coronary artery diseases, and the method has wide application prospects and important practical value.

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and / or track coronary artery disease.

Methods of treating diseases and conditions in human subjects in need thereof using pharmaceutical compositions comprising an ANGPTL3 RNAi agent are described, the treatment being partially mediated by reducing expression of the ANGPTL3 gene. When administered to a human subject in need thereof according to the methods disclosed herein, the disclosed pharmaceutical compositions comprising an ANGPTL3RNAi agent treat diseases and conditions associated with elevated triglyceride (TG) levels and / or elevated low density lipoprotein cholesterol (LDL-C), such as hypertriglyceridemia (including severe hypertriglyceridemia (SHTG)), homozygous familial hypercholesterolemia (HoFH), hypertriglyceridemia-induced pancreatitis, metabolic syndrome, obesity, hyperlipidemia, mixed dyslipidemia, abnormal lipid and / or cholesterol metabolism, atherosclerosis, cardiovascular disease, type II diabetes, coronary artery disease, and the like. The present invention relates to compounds of formula (I), in particular to compounds of formula (I), such as non-alcoholic steatohepatitis, non-alcoholic fatty liver disease, heterozygous familial hypercholesterolemia (HeFH), statin-resistant hypercholesterolemia, other dyslipidemia, and other metabolism-related conditions and diseases.

The present invention discloses a compound represented by formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The present invention also provides the use of the compound, its stereoisomer or pharmaceutically acceptable salt in the preparation of a drug for treating and / or preventing diseases associated with FXIa receptors, especially in the preparation of a drug for treating and / or preventing cerebrovascular arterial disease and / or peripheral arterial disease.

Providing quinazolindione compounds and their uses. [Solution] Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, cardiomyopathy, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, galactosemia, asthma, PMM2-CDG and the like.

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, cardiomyopathy, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, galactosemia, asthma, PMM2-CDG and the like.

A computer-implemented method is proposed that utilizes medical imaging (i.e., invasive coronary angiography, invasive optical coherence tomography, or other catheter-based imaging and / or non-invasive computed tomography) to generate a 3D computer model of the arteries / vasculature to provide a risk score that predicts future changes in coronary artery disease based on artificial intelligence and biomechanical simulation. The computer-implemented method preferably analyzes images from one or more imaging systems to extract data regarding arterial structure and function, including augmenting or simulating missing information, and generates the 3D geometry and predicted outcomes of the artery or arterial system.

Quinazoline dione compounds are provided for treating cardiac indications such as hypertrophic cardiomyopathy and diastolic dysfunction. Diseases treated by the methods described herein include, but are not limited to, cardiomyopathy, hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism.

The invention relates to the technical field of intelligent medical treatment, in particular to a method and device for predicting coronary artery diseases based on porphyromonas gingivalis concentration, and the method comprises the following steps: obtaining a sample data set; preprocessing the sample; selecting a plurality of machine models based on machine learning; screening of feature variables: inputting the sample data set into a plurality of machine models for training, and screening the feature variables in the first feature variable set in combination with a corresponding algorithm to obtain a maximum contribution degree feature variable set; each machine model is correspondingly screened to obtain a maximum contribution degree feature variable set; retraining the corresponding machine model based on the maximum contribution degree characteristic variable set, and evaluating performance indexes through a Bootstrap resampling method to obtain an optimal machine model; and based on the optimal machine model and the maximum contribution degree characteristic variable set, constructing a coronary artery disease prediction model and performing prediction.

The present disclosure relates to pharmaceutical formulations of angiotensin converting enzyme inhibitor and / or diuretic, particularly stable oral pharmaceutical formulations comprising angiotensin converting enzyme inhibitor and / or diuretic with one or more pharmaceutically acceptable excipients for the treatment of hypertension, coronary artery disease, heart failure, acute myocardial infarction and other related cardiovascular diseases.

Belongs to the technical field of medicine and health, and provides application of a novel compound containing a diaza subunit sulfonyl structure as a PKM2 agonist. The compound can be used for treating diseases related to PKM2 mediated regulation, including but not limited to tumors, immune diseases, hair loss, metabolic diseases, proliferation-dependent diseases, coronary artery diseases, Bloom syndromes, pulmonary arterial hypertension and the like. The specific diseases also relate to liver cancer, lung cancer, colorectal cancer, glioblastoma, breast cancer, kidney cancer, inflammatory bowel disease, ulcerative colitis, alopecia, lusterless disease, less hair and the like.

Early diagnosis of cardiovascular diseases can potentially cure subjects and save innumerable lives. Diagnosis and treatment of subjects at early stages by cardiologists remain a challenge. Here, the inventors have measured baseline sTREM-1 (triggering receptor expressed on myeloid cells-1) in 10,000 initially healthy participants without prevalent cardiovascular disease (CVD) from the Paris Prospective Study 3 (PPS3). They have quantified the association and predictive value of baseline sTREM-1 for incident CVD events over 10 years of follow-up. The analysis reveals strong, significant and independent association with incident CVD events combined and its subtypes (coronary heart disease, stroke, peripheral artery diseases, and heart failure). Furthermore, adding sTREM-1 to existing risk prediction algorithms such as SCORE2 or the US pooled risk equation improved the discrimination capacity of these models in a significant and more importantly in a clinically meaningful manner, including among those at moderate CVD risk. Furthermore, the inventors have examined CVD events such as aneurysm, arrythmias and thromboembolic events. Given the ongoing development of pharmacological molecules blocking blood sTREM-1, the inventors believe these findings support future intervention trials testing to which extent sTREM-1 could be a relevant target for the primary prevention of CVD in the general population.

The present disclosure relates to compositions and methods, including prodrugs of (S)-3-(3-(((3,4- dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H- benzo[d]azepin-2-one that find use in the treatment of diseases and disorders, such as therapies for cardiovascular disease, including cardiac arrhythmias, including, without limitations, sinus tach (e.g. inappropriate sinus tachycardia (IST)), postural orthostatic tachycardia syndrome (POTS), coronavirus (COVID-19) (e.g. long COVID) and COVID-associated cardiovascular abnormalities, supraventricular tachycardia (SVT), tachycardia (e.g. rapid heart rate, atrial tachycardia), heart failure (e.g. congestive heart failure (CHF), systolic heart failure, pediatric heart failure, chronic heart failure), myocardial ischaemia, angina (e.g. angina pectoris), myocardial infarct, rhythm disturbances (e.g. supraventricular rhythm disturbances), chest pain, cardiomyopathy, coronary artery disease, and left ventricular dysfunction (LVD).

The present invention provides a method for measuring the geometric morphology of the carotid artery, which is used for quantitative analysis of the three-dimensional structure of the carotid artery. This method uses an improved Fast Marching algorithm to automatically generate the parameterized centerlines of each blood vessel branch at the carotid artery bifurcation. The maximum inscribed spheres are defined on the centerlines, and the radius of the inscribed spheres is determined by calculating the minimum distance from each point on the centerline to the blood vessel wall. Based on this, the local blood vessel diameter is calculated, and the Gaussian weighted average method is used to obtain the characteristic diameter of the blood vessel. Based on the parameterized centerlines and the weighted average diameters, a series of carotid artery geometric morphology parameters are calculated, including the weighted blood vessel diameter ratio, the bifurcation angle tensor, and the normalized curvature index. The method of the present invention has a high degree of automation and strong reliability, reduces the human measurement error, and provides an objective and accurate quantitative index for the early diagnosis and risk assessment of carotid artery diseases.

The present invention relates to 4-oxoretinoate for use in treatment or prevention of cardiac dysfunction, heart failure, or adverse cardiac remodelling after myocardial infarction or impaired cardiac blood flow. The present invention also relates to 4-oxoretinoate for use in treatment of coronary artery disease, or of ischemia-reperfusion injury.

Electrocardiogram technology is a method for monitoring the health state of the heart by measuring and recording the electrical activity of the heart. The technology is generally used for diagnosing various heart diseases, such as arrhythmia, coronary artery diseases, myocardial infarction and the like. Traditional electrocardiogram equipment is usually configured in hospitals and heart diagnosis and treatment centers and is operated by professional medical personnel. Along with the development of the technology, especially the progress of the sensor technology and the data processing technology, the electrocardiogram equipment has gradually developed towards the miniaturization and portability direction so as to meet the requirements of daily family use. Such devices allow ordinary users to perform self-monitoring of cardiac health without professional medical personnel present. However, in order to achieve monitoring accuracy and user experience similar to those of medical-grade equipment in household equipment, technical challenges in multiple aspects still face. The technical solution provided by the invention aims to overcome the limitation of the existing household electrocardiograph, provides a more advanced heart health monitoring tool, and the tool is high in accuracy, simple and convenient to operate and high in user friendliness, so that a non-professional user can easily use the tool, thereby better serving the vast family users, and improving the user experience. And the heart health management level is improved.

This disclosure provides crystalline forms of a compound of Formula (I), as well as pharmaceutically acceptable compositions thereof, and methods for their preparation and use in methods of treating hypercholesterolemia and other conditions related to PCSK9 activity, e.g., atherosclerosis, atherosclerotic cardiovascular disease, peripheral arterial disease, cerebrovascular disease, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.

Various embodiments described herein relate to systems, devices, and methods for non-invasive image-based plaque analysis and risk determination. In particular, in some embodiments, the systems, devices, and methods described herein are related to analysis of one or more regions of plaque, such as for example coronary plaque, using non-invasively obtained images that can be analyzed using computer vision or machine learning to identify, diagnose, characterize, treat and / or track coronary artery disease.

This disclosure generally relates to substituted quinolinone amide compounds or salts of formula (I), (II-A), (IV), or (III), and pharmaceutically active compositions thereof. The substituted quinolinone amide compounds or salts of formula (I), (II-A), (IV), or (III) disclosed herein may be used to treat or prevent heart disease in individuals where such treatment is necessary. Diseases treated by the methods described herein include, but are not limited to, heart disease. Cardiac diseases treated by the methods described herein include, but are not limited to, myocardial disease (cardiomyopathy), hypertrophic cardiomyopathy (HCM), abnormal heart rhythms, aortic disease, Marfan syndrome, coronary artery disease, heart attack, heart failure, rheumatic heart disease, peripheral vascular disease, stroke, deep vein thrombosis, and pulmonary embolism. TIFF2026514388000407.tif65134