7 results about "Occlusive disease" patented technology

The invention discloses a pharmaceutical composition for treating cardiovascular blockage diseases and cognitive impairment and new application thereof.The pharmaceutical composition is a traditional Chinese medicine compound heart-tonifying and mental-tranquilizing formula, and the compound has the effects of tonifying qi, activating blood, dispersing blood stasis, replenishing essence, nourishing yin and the like; the traditional Chinese medicine composition can be used for integrally intervening a plurality of pathological links of cardiovascular blockage diseases such as myocardial infarction and cognitive impairment diseases such as Alzheimer's disease, not only can improve the functions of the heart and the brain, but also can obviously improve the life quality of a patient, achieves a good clinical curative effect, and does not have obvious adverse reaction.

The present application relates to the technical field of medicine, and discloses application of gastrodin in preparation of medicine for preventing and treating radioactive liver injury, wherein the radioactive liver injury is liver injury caused by ionizing radiation exposure. It is found that the gastrodin can effectively intervene in specific mechanism of the radioactive liver injury, significantly reduce the mortality of the radioactive liver injury mice, reverse the hepatic veno-occlusive disease and the core pathological features of liver fibrosis of the radioactive liver injury, and more specifically treat the radioactive liver injury. On the other hand, the gastrodin can be used before radiation exposure to prevent serious radioactive liver injury after radiation exposure.

The application discloses a kind of drug composition for treating cardiovascular occlusion diseases and cognitive impairment and its new purposes, and the drug composition is traditional Chinese medicine compound Yixin Yangshen formula, the comprehensive effect of the compound, such as invigorating qi, promoting blood circulation, removing blood stasis, filling essence, nourishing yin, etc., can be used for the whole intervention of multiple pathological links of cardiovascular occlusion diseases such as myocardial infarction and cognitive impairment diseases such as Alzheimer's disease, not only can improve the function of heart and brain, but also can significantly improve the quality of life of patients, and good clinical efficacy is obtained, and no obvious adverse reactions occur.

The invention relates to the technical field of medicines, and discloses application of gastrodin in preparation of a medicine for preventing and treating radioactive liver injury, and the radioactive liver injury is liver injury caused by ionizing radiation exposure. The gastrodin is found to be capable of effectively intervening a specific mechanism of the radiation-induced liver injury, so that the death rate of mice with the radiation-induced liver injury is remarkably reduced, meanwhile, the core pathological characteristics of hepatic vein occlusion and hepatic fibrosis of the radiation-induced liver injury are reversed, and the radiation-induced liver injury is treated in a more targeted manner. On the other hand, gastrodin is used before radiation exposure, so that serious radioactive liver injury after radiation exposure can be prevented.

An object of the present invention is to provide a compound having a PDGF receptor kinase inhibitory activity.Examples of the present invention may include, for example, a compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof.The compound of the present invention has an inhibitory activity against the PDGF receptor kinase. In addition, since the compound of the present invention has an inhibitory activity against the PDGF receptor kinase, it is useful as a therapeutic agent for respiratory diseases, cancers, smooth muscle proliferative diseases, vasoproliferative diseases, autoimmune / inflammatory diseases, metabolic diseases, vasoocclusive diseases, and the like.

The utility model relates to a kind of vein stents with high compliance, distal end braided stent is formed by wire with coating weaving, with high compliance, stent expanded diameter is slightly larger than target vein pipe diameter but smaller than proximal end laser engraved stent;Distal end braided stent includes wire, and coating located outside wire, coating is divided into inside coating and outside coating, inside coating curvature ratio is greater than outside coating, the surface roughness of inside coating is smaller than outside coating;A group of metal connecting short rod is connected by welding proximal end laser engraved stent and braided stent two parts.This stent has different structure and mechanical characteristics in different anatomical and kinematic characteristics vein segments, better adaptability, can better meet the needs of non-thrombotic iliofemoral vein stenosis occlusive disease patient iliofemoral vein stent implantation in stent fixation, cross joint placement stent.

Z maps combined with a standardized stimulus in the form of a targeted arterial partial pressures of carbon dioxide provide surprisingly enhanced images for the assessment of pathological CVR. For example, the z-map assessment of patients with known steno-occlusive diseases of the cervico-cerebral vasculature showed an enhanced resolution of the presence, localization, and severity of the pathological CVR. Z-map have been found to be useful to reduce the confounding effects of test-to-test, subject-to-subject, and platform-to-platform variability for comparison of CVR images showing the importance of combining this analysis with the standardized stimulus.