8 results about "Stent restenosis" patented technology

The invention discloses a cryoablation catheter system for pulmonary artery stent internal restenosis, and belongs to the field of medical instruments, the cryoablation catheter system comprises a catheter main body arranged on a guide wire, the catheter main body is provided with a treatment assembly, the treatment assembly is located at the far end of the catheter main body, the catheter main body is provided with a control handle, and the control handle is located at the far end of the catheter main body. The control handle is located at the near end of the catheter body, and the treatment assembly comprises a near-end balloon, a far-end balloon and a freezing balloon. When the near-end balloon and the far-end balloon are simultaneously full, a closed treatment cabin isolated from near-end blood flow and far-end blood flow can be formed in a blood vessel of a target treatment section, the freezing balloon is located in the treatment cabin, the closed treatment cabin thoroughly eliminates the blood flow hot pool effect, cold is prevented from being taken away by the blood flow, and the treatment effect is improved. Freezing energy is intensively acted on a diseased region, so that the ablation efficiency and accuracy are improved; meanwhile, thrombus, tissue debris and whole body blood flow which fall off in the treatment process are isolated, the risk of far-end embolism is reduced from the source, and damage to the blood vessel wall is avoided.

The invention belongs to the technical field of cardiovascular repair, and discloses a biodegradable vascular stent material for cardiovascular repair. The material comprises a medical stainless steel intravascular stent body and a composite coating coated on the surface of the medical stainless steel intravascular stent body. The inner layer contains RGD peptide modified chitosan derivatives and polyphenol substances, is used for promoting adhesion and proliferation of endothelial cells and has anti-inflammatory and anti-oxidation effects. The outer layer is a ginsenoside (MPEG)-PLGA microsphere loaded with heparin sodium, and is prepared by carrying out hydrophobic modification on ginsenoside through (2-allyl) succinic anhydride and carrying out co-loading with MPEG-PLGA, so that synergistic controlled release of anticoagulation and vascular repair promoting drugs is realized. The excellent mechanical property of the stainless steel stent is combined with the multifunctional biodegradable coating, and through the synergistic effect of the inner layer and the outer layer, endothelialization can be accelerated, smooth muscle hyperplasia can be inhibited, inflammatory response can be relieved, thrombosis can be prevented, and therefore the risk of restenosis and advanced thrombosis in the stent can be effectively reduced.

The utility model discloses a medicine support which comprises a support body, the support body comprises a plurality of supporting frames, and every two adjacent supporting frames are connected with each other. A first open groove and a plurality of second open grooves are formed in the outer wall of the supporting frame, the supporting frame is divided into a plurality of independent areas by the first open groove and the second open grooves, and a plurality of micropores are formed in each area; the first open groove and the second open groove are filled with anti-inflammatory drugs; the micropores are filled with an anti-atherosclerosis medicine; an anti-proliferation drug is sprayed on the outer wall of the stent body, and the anti-proliferation drug covers the anti-atherosclerosis drug and the anti-inflammatory drug. Therefore, the pathological process can be accurately matched, different drugs are made to act on different time periods after the PCI operation respectively, different effects are achieved according to the pathological characteristics of the different time periods, short-term stent restenosis is prevented, and long-term stent restenosis can be effectively prevented.

The utility model discloses a kind of reinstallation devices after windowing of film-covered stent in vitro, stent system includes mandrel tube, handle assembly, outer sheath, film-covered stent, fixator and receiver, and the film-covered stent after release can be hung on fixator and can be separated from fixator;Reinstallation device includes pull wire for pulling the overall movement of stent system by passing through mandrel tube and handle assembly, converging device for exerting the clamping force of radial inward to fixator, loading tube and loading tool for loading the film-covered stent after windowing into outer sheath, and breaker for cutting loading tube.This kind of reinstallation device, in the process of film-covered stent reinstallation, converging device can prevent fixator from deforming, and film-covered stent after windowing is pulled into loading tube and outer sheath by loading tool, not easy to cause damage to film-covered stent, pull wire can pull film-covered stent into outer sheath with straight path, and the position of film-covered stent after windowing is not easy to change after reinstallation.

The application provides a multifunctional nano-coated stent for preventing and treating in-stent restenosis and a preparation method and application thereof. Based on the multifunctional nano interface of EGCG-Cys, the liposome targeting VCAM-1 is used to deliver MnO2 nanoscale enzyme and FGF21 growth factor, so that the triple treatment effects of active oxygen scavenging, immune regulation and endothelial regeneration can be realized at the vascular lesion site. The EC-MFVL-WE43 stent creates a new paradigm for the design of interventional instruments, realizes the spatiotemporal precise release of drugs through the oxidative stress triggered degradation mechanism, and verifies the excellent anti-restenosis and anti-thrombosis performance in mouse, rabbit and pig models. Mechanism research shows that the nano-coated stent can reprogram macrophages to M2 repair type polarization, and effectively inhibit the abnormal proliferation of smooth muscle cells, providing a biological activity solution to break the vicious cycle of "inflammation-oxidation-restenosis".

The application discloses a recyclable intracranial artery stent system and belongs to the technical field of medical auxiliary instruments. The recyclable intracranial artery stent system comprises a stent and a recycling device. The stent comprises a stent body and a recyclable joint arranged at the proximal end of the stent body. The recycling device comprises a recycling catheter, a push rod and a recycling cage. The push rod is arranged inside the recycling catheter and can slide in the recycling catheter. The recycling cage is connected to the distal end of the push rod and can grasp the joint for recycling. The recyclable intracranial artery stent system can relieve intracranial artery stenosis in a short period, repair the vascular lumen structure, and take out the stent from the body after the intracranial artery lumen structure is repaired and stabilized, thereby avoiding long-term retention of the stent and effectively reducing the loss of the effective lumen of the intracranial artery. The stent can be recycled and replaced according to the recovery of the blood vessel and the stent fitting degree, the treatment scheme can be adjusted in the subsequent period, the problem of in-stent restenosis is solved, and the treatment effect of patients with intracranial artery stenosis is ensured.

The application discloses a kind of composite probiotic microspheres and its preparation method and application.The method of the present application first uses the dehydration condensation of-COO- in sodium alginate and-NH2 in aminated beta-glucan, to obtain stable Alg-betaG crosslinking material, then using O / W complex emulsion desolventizing microfluidic device to prepare double crosslinking structure composite probiotic microspheres, the microspheres prepared by the method of the present application are uniform in particle size, about 50-100 μm, the particle size distribution is monodisperse, with good microsphere morphology.Animal experiment results prove that the microspheres can significantly enhance the intestinal colonization activity of probiotics, are beneficial to the long-term treatment of anti-in-stent restenosis, and have a certain therapeutic effect on atherosclerosis.