21 results about "Stent restenosis" patented technology

A device for therapeutic ablative treatment of residual plaque on, in, and / or surrounding a stent within a blood vessel of a subject includes a jacket configured for insertion within a stent within a blood vessel of a subject. The device further includes an ultrasound transducer located within the jacket and having at least one active element oriented to deliver ultrasound energy in a radial and / or axial direction of the jacket from within the stent to ablate the residual plaque.

The invention relates to the technical field of biomarkers, in particular to application of C1qa as a marker for diagnosing rapid recurrent coronary artery in-stent restenosis with unknown reasons. The invention relates to a biomarker for diagnosing rapid recurrence type coronary artery in-stent restenosis caused by unknown reasons. The biomarker is C1qa; and the serial number of the C1qa in the NCBI (National Center of Biotechnology Information) is NM001347465.2. Compared with traditional imaging detection, the C1qa biological detection method is more suitable for noninvasive or minimally invasive diagnosis, and invasive injury to patients is reduced. The expression change of C1qa may be earlier than the structural lesion of ISR, so that the C1qa can be used as an early biomarker of RECUR, and is suitable for screening high-risk groups.

The invention discloses a cryoablation catheter system for pulmonary artery stent internal restenosis, and belongs to the field of medical instruments, the cryoablation catheter system comprises a catheter main body arranged on a guide wire, the catheter main body is provided with a treatment assembly, the treatment assembly is located at the far end of the catheter main body, the catheter main body is provided with a control handle, and the control handle is located at the far end of the catheter main body. The control handle is located at the near end of the catheter body, and the treatment assembly comprises a near-end balloon, a far-end balloon and a freezing balloon. When the near-end balloon and the far-end balloon are simultaneously full, a closed treatment cabin isolated from near-end blood flow and far-end blood flow can be formed in a blood vessel of a target treatment section, the freezing balloon is located in the treatment cabin, the closed treatment cabin thoroughly eliminates the blood flow hot pool effect, cold is prevented from being taken away by the blood flow, and the treatment effect is improved. Freezing energy is intensively acted on a diseased region, so that the ablation efficiency and accuracy are improved; meanwhile, thrombus, tissue debris and whole body blood flow which fall off in the treatment process are isolated, the risk of far-end embolism is reduced from the source, and damage to the blood vessel wall is avoided.

The invention discloses an elutable medicine electronic balloon as well as a preparation method and application thereof, and belongs to the technical field of medical instruments. The medicine electronic balloon provided by the invention comprises a balloon body and a functional film attached to the balloon body, the functional film comprises a flexible electronic film and a medicine functional layer which are stacked from the balloon body; the flexible electronic film comprises a flexible substrate and a conductive circuit embedded in the flexible substrate; the conductive circuit is in contact with the medicine function layer; the medicine functional layer comprises a biodegradable spinning layer and paclitaxel loaded in the biodegradable spinning layer. The medicine electronic balloon provided by the invention can effectively improve the absorption efficiency of cells at a restenosis position in a stent to paclitaxel medicine, and the balloon body can be repeatedly utilized. The invention further provides a preparation method and application of the medicine electronic balloon.

The invention belongs to the technical field of cardiovascular repair, and discloses a biodegradable vascular stent material for cardiovascular repair. The material comprises a medical stainless steel intravascular stent body and a composite coating coated on the surface of the medical stainless steel intravascular stent body. The inner layer contains RGD peptide modified chitosan derivatives and polyphenol substances, is used for promoting adhesion and proliferation of endothelial cells and has anti-inflammatory and anti-oxidation effects. The outer layer is a ginsenoside (MPEG)-PLGA microsphere loaded with heparin sodium, and is prepared by carrying out hydrophobic modification on ginsenoside through (2-allyl) succinic anhydride and carrying out co-loading with MPEG-PLGA, so that synergistic controlled release of anticoagulation and vascular repair promoting drugs is realized. The excellent mechanical property of the stainless steel stent is combined with the multifunctional biodegradable coating, and through the synergistic effect of the inner layer and the outer layer, endothelialization can be accelerated, smooth muscle hyperplasia can be inhibited, inflammatory response can be relieved, thrombosis can be prevented, and therefore the risk of restenosis and advanced thrombosis in the stent can be effectively reduced.

Disclosed in the present invention is a novel anti-in-stent-restenosis protein-eluting stent. Specifically, disclosed in the present invention is a medical stent. The stent comprises: (a) a supporting structure, wherein the surface of the supporting structure comprises a coating, and the coating contains polydopamine; and (b) a CCN5 recombinant protein, wherein the recombinant protein is immobilized to the supporting structure by binding to the polydopamine. The medical stent of the present invention is used for preventing in-stent restenosis after PCI, and is also used for promoting the proliferation and migration of a human aortic endothelial cell (HAEC) line and / or promoting endothelialization to inhibit in-stent restenosis.

The utility model discloses a medicine support which comprises a support body, the support body comprises a plurality of supporting frames, and every two adjacent supporting frames are connected with each other. A first open groove and a plurality of second open grooves are formed in the outer wall of the supporting frame, the supporting frame is divided into a plurality of independent areas by the first open groove and the second open grooves, and a plurality of micropores are formed in each area; the first open groove and the second open groove are filled with anti-inflammatory drugs; the micropores are filled with an anti-atherosclerosis medicine; an anti-proliferation drug is sprayed on the outer wall of the stent body, and the anti-proliferation drug covers the anti-atherosclerosis drug and the anti-inflammatory drug. Therefore, the pathological process can be accurately matched, different drugs are made to act on different time periods after the PCI operation respectively, different effects are achieved according to the pathological characteristics of the different time periods, short-term stent restenosis is prevented, and long-term stent restenosis can be effectively prevented.

The utility model discloses a kind of reinstallation devices after windowing of film-covered stent in vitro, stent system includes mandrel tube, handle assembly, outer sheath, film-covered stent, fixator and receiver, and the film-covered stent after release can be hung on fixator and can be separated from fixator;Reinstallation device includes pull wire for pulling the overall movement of stent system by passing through mandrel tube and handle assembly, converging device for exerting the clamping force of radial inward to fixator, loading tube and loading tool for loading the film-covered stent after windowing into outer sheath, and breaker for cutting loading tube.This kind of reinstallation device, in the process of film-covered stent reinstallation, converging device can prevent fixator from deforming, and film-covered stent after windowing is pulled into loading tube and outer sheath by loading tool, not easy to cause damage to film-covered stent, pull wire can pull film-covered stent into outer sheath with straight path, and the position of film-covered stent after windowing is not easy to change after reinstallation.

The invention discloses a biomarker for predicting in-stent restenosis after a superior mesenteric artery stent implantation operation. The biomarker is one of isopropyl sulfide and 1-methyl-L-histidine or a combination of isopropyl sulfide and 1-methyl-L-histidine. According to the method, a new strategy is provided for preoperative prediction and early intervention of ISR after SISMAD operation.

The invention discloses a novel in-stent restenosis resistant protein coating stent, and particularly discloses a medical stent, the stent comprises: (a) a support structure, the surface of the support structure contains a coating, and the coating contains polydopamine; (b) a CCN5 recombinant protein, and the recombinant protein is fixed on the supporting structure by being combined with polydopamine. The medical stent is used for preventing in-stent restenosis after PCI (percutaneous coronary intervention), and is also used for promoting proliferation and migration of human aortic endothelial cell lines (HAECs), and / or promoting endothelialization to inhibit in-stent restenosis.

The invention discloses a piezoelectric composite intravascular stent and a preparation method and application thereof, and belongs to the technical field of biomedical materials and medical instruments.The piezoelectric composite intravascular stent comprises a stent body, and the stent body is of a tubular structure formed by weaving piezoelectric composite fibers; the piezoelectric composite fiber comprises a substrate material and a piezoelectric enhancement component, the substrate material comprises a fluorine polymer piezoelectric material, the piezoelectric enhancement component is lead-free piezoelectric ceramic nanoparticles, and the lead-free piezoelectric ceramic nanoparticles comprise at least one of barium titanate, potassium niobate and zinc oxide. The mass ratio of the lead-free piezoelectric ceramic nanoparticles in the piezoelectric composite fiber is 1%-10%; the stent body can generate output voltage of 50mV-100mV under the action of blood flow shearing force, and is used for promoting vascular endothelial repair and inhibiting proliferation and migration of vascular smooth muscle cells. The problems that a traditional intravascular stent cannot regulate and control the vascular repair process through electrical stimulation, application of existing piezoelectric materials cannot meet the characteristic requirements of the intravascular stent, and then postoperative intravascular restenosis is difficult to prevent and treat can be solved.

The invention discloses a stent coating and a preparation method thereof.The preparation method comprises the steps that firstly, dopamine is used for conducting chemical crosslinking on the surface of a stent, and an amino-rich surface is provided for subsequent grafting; then grafting p-azidobenzoic acid on the surface of the polydopamine by adopting an amidation reaction, and finally, firmly grafting the lipidosome to the surface of the material through a covalent grafting reaction of an azido group on the p-azidobenzoic acid and cycloalkyne on the lipidosome, so as to construct the multifunctional intravascular stent coating with anti-inflammatory and endothelial protection effects at the same time. The coating can adapt to long-term physiological functions required by the cardiovascular stent, and the lasting intravascular stent coating provides a solution strategy for complications such as stent restenosis and advanced thrombus.

The application provides a multifunctional nano-coated stent for preventing and treating in-stent restenosis and a preparation method and application thereof. Based on the multifunctional nano interface of EGCG-Cys, the liposome targeting VCAM-1 is used to deliver MnO2 nanoscale enzyme and FGF21 growth factor, so that the triple treatment effects of active oxygen scavenging, immune regulation and endothelial regeneration can be realized at the vascular lesion site. The EC-MFVL-WE43 stent creates a new paradigm for the design of interventional instruments, realizes the spatiotemporal precise release of drugs through the oxidative stress triggered degradation mechanism, and verifies the excellent anti-restenosis and anti-thrombosis performance in mouse, rabbit and pig models. Mechanism research shows that the nano-coated stent can reprogram macrophages to M2 repair type polarization, and effectively inhibit the abnormal proliferation of smooth muscle cells, providing a biological activity solution to break the vicious cycle of "inflammation-oxidation-restenosis".

The invention relates to application of lindelactone in preparation of a medicine for inhibiting neointimal hyperplasia in blood vessels. Based on the natural source and biological activity of the lindelactone, the invention develops a pharmaceutical molecule with application prospects, and the lindelactone can be used for preventing and / or treating endometrial neogenesis, and is especially suitable for intervention of interventional postoperative restenosis. The linderane is used for preventing neointimal neogenesis by inhibiting abnormal proliferation and migration of vascular smooth muscle cells. Experimental data show that lindelactone does not show obvious systemic toxicity under the treatment dosage and has lower potential of side effects. The lindelinolide provides parameter data for preparation of the medicine for inhibiting endovascular neointimal hyperplasia, is expected to be applied to percutaneous coronary intervention postoperative complications, especially prevention and treatment of stent restenosis, and can become a potential medicine for intervening in restenosis.

The application discloses a recyclable intracranial artery stent system and belongs to the technical field of medical auxiliary instruments. The recyclable intracranial artery stent system comprises a stent and a recycling device. The stent comprises a stent body and a recyclable joint arranged at the proximal end of the stent body. The recycling device comprises a recycling catheter, a push rod and a recycling cage. The push rod is arranged inside the recycling catheter and can slide in the recycling catheter. The recycling cage is connected to the distal end of the push rod and can grasp the joint for recycling. The recyclable intracranial artery stent system can relieve intracranial artery stenosis in a short period, repair the vascular lumen structure, and take out the stent from the body after the intracranial artery lumen structure is repaired and stabilized, thereby avoiding long-term retention of the stent and effectively reducing the loss of the effective lumen of the intracranial artery. The stent can be recycled and replaced according to the recovery of the blood vessel and the stent fitting degree, the treatment scheme can be adjusted in the subsequent period, the problem of in-stent restenosis is solved, and the treatment effect of patients with intracranial artery stenosis is ensured.

The invention relates to the technical field of medical materials, and discloses a photosensitive material with a blood vessel repairing function, a preparation method of the photosensitive material and a balloon dilatation catheter.The photosensitive material with the blood vessel repairing function has the advantages that DNA with good water solubility and photosensitive compounds are spliced through chemical bonds, the photosensitive efficiency of the material is not affected, and the photosensitive efficiency of the material is improved; the photosensitive material can be quickly dissolved, permeated and diffused into the blood vessel wall after reaching the diseased region. Meanwhile, the water solubility is increased, so that the follow-up metabolism of small molecules is facilitated, the accumulation toxicity caused by large-dose application of small molecule drugs due to low solubility is reduced, and the material is activated by light with specific wavelength, so that covalent cross-linking is generated among amino acids in the blood vessel wall, the blood vessel is stably supported, and restenosis in the stent is avoided; after the balloon is rapidly expanded within 1 minute, the treatment purpose can be well achieved, the risk of an operation is greatly reduced, and the survival rate of a patient is increased.

The invention relates to the field of medical health informatics and clinical decision support, in particular to a multi-mode magnetic resonance stent restenosis prediction method and system. The method comprises the steps of obtaining a multi-modal magnetic resonance image and structured clinical data, and performing preprocessing to generate an alignment index structure; performing segmentation and feature extraction on the image to obtain static and dynamic feature sets; performing normalization and combined coding on the features and the clinical indexes to generate individual feature vectors, performing reasoning by using a pre-training model, constructing evidence tracing mapping capable of being traced back to original data, and generating a risk probability and evidence tracing packet; and finally, performing multi-layer visual rendering, structured report typesetting and parameter adaptive adjustment to generate a visual report including image comparison, a trend curve and the like. According to the method, the multi-modal data and the clinical information are integrated, and through the interpretable prediction model and automatic report generation, the accuracy of stent restenosis prediction and the clinical decision support efficiency are improved.

The invention provides a construction method and device of a coronary heart disease patient PCI postoperative intra-stent restenosis risk prediction model, and the construction method of the coronary heart disease patient PCI postoperative intra-stent restenosis risk prediction model is characterized by comprising the following specific steps: S1, data preprocessing, collecting PCI postoperative patient multi-source data, processing missing values, standardizing numerical values, and balancing category distribution by using an SMOTE technology; s2, feature selection: evaluating and screening most important features related to ISR recurrence by using single-factor Cox regression and LASSO regression, and analyzing and evaluating independent influences of the features through multi-factor Cox regression; and S3, constructing a prediction model, processing image data by using CNN, processing clinical and laboratory data by using DNN, processing time sequence data by using LSTM, and improving prediction accuracy through an integrated learning method. And S4, verifying the prediction model, evaluating the performance of the model through an AUC-ROC curve, a confusion matrix and derivative indexes thereof, and evaluating the stability and generalization ability of the model by adopting k-fold cross validation.

The application relates to the technical field of medical materials, and discloses photosensitive material with a blood vessel repair function, a preparation method of the photosensitive material and a balloon dilatation catheter. The photosensitive material with the blood vessel repair function is obtained by splicing water-soluble DNA and photosensitive compounds through a chemical bond, does not affect the photosensitivity of the material, can quickly dissolve, permeate and diffuse into a blood vessel wall after reaching a lesion site, and has the advantages that increasing the water solubility is beneficial to metabolism of subsequent small molecules, reduces accumulation toxicity caused by large-dose application of small molecule drugs due to low solubility, the material is activated by specific wavelength light, covalent crosslinking between amino acids in the blood vessel wall is generated, the blood vessel is stably supported, in-stent restenosis does not occur, the treatment purpose can be well achieved after 1-minute balloon rapid expansion, the operation risk is greatly reduced, and the survival rate of patients is improved.

The application discloses a kind of composite probiotic microspheres and its preparation method and application.The method of the present application first uses the dehydration condensation of-COO- in sodium alginate and-NH2 in aminated beta-glucan, to obtain stable Alg-betaG crosslinking material, then using O / W complex emulsion desolventizing microfluidic device to prepare double crosslinking structure composite probiotic microspheres, the microspheres prepared by the method of the present application are uniform in particle size, about 50-100 μm, the particle size distribution is monodisperse, with good microsphere morphology.Animal experiment results prove that the microspheres can significantly enhance the intestinal colonization activity of probiotics, are beneficial to the long-term treatment of anti-in-stent restenosis, and have a certain therapeutic effect on atherosclerosis.