Drug-coated intravascular stent capable of preventing in-stent restenosis and preparation method of drug-coated intravascular stent
A drug coating and vascular stent technology, applied in coatings, stents, pharmaceutical formulations, etc., can solve problems such as poor efficacy and achieve biological activity protection, good biocompatibility and compliance, and good practical application value Effect
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Embodiment 1
[0038] A specific preparation method of a drug-coated vascular stent for preventing in-stent restenosis is as follows:
[0039] (1) Preparation of net-shaped nickel-titanium memory alloy bare metal stent: weave the nickel-titanium alloy into metal wires, and bend the metal wires to form a nickel-titanium alloy mesh skeleton. Specifically, a nickel-titanium alloy wire is bent to form a plurality of sequentially connected wave-shaped bending rings connected to form a pipe-shaped nickel-titanium alloy skeleton.
[0040] (2) Pretreatment of the stent: Use propanol analytically pure solution or medical ethanol solvent for the obtained net-shaped nickel-titanium memory alloy bare metal stent, the concentration of propanol analytically pure solution is 99.5%, and the concentration of medical ethanol solvent is 75% ;Use ultrasonic waves to clean the bracket body to remove impurities on the surface of the bracket body, and then use distilled water to clean the bracket body with ultraso...
Embodiment 2
[0048] A specific preparation method of a drug-coated vascular stent for preventing in-stent restenosis is as follows:
[0049] (1) Preparation of net-shaped nickel-titanium memory alloy bare metal stent: weave the nickel-titanium alloy into metal wires, and bend the metal wires to form a nickel-titanium alloy mesh skeleton. Specifically, a nickel-titanium alloy wire is used to bend a single ring, and then a plurality of independent zigzag-shaped bent rings are connected to form a pipe-shaped nickel-titanium alloy skeleton with the nickel-titanium alloy wire.
[0050] (2) Pretreatment of the stent: Use propanol analytically pure solution or medical ethanol solvent for the obtained net-shaped nickel-titanium memory alloy bare metal stent, the concentration of propanol analytically pure solution is 99.5%, and the concentration of medical ethanol solvent is 75% ;Use ultrasonic waves to clean the bracket body to remove impurities on the surface of the bracket body, and then use di...
Embodiment 3
[0058] A specific preparation method of a drug-coated vascular stent for preventing in-stent restenosis is as follows:
[0059] (1) Preparation of net-shaped nickel-titanium memory alloy bare metal stent: weave the nickel-titanium alloy into metal wires, and bend the metal wires to form a nickel-titanium alloy mesh skeleton. Specifically, the nickel-titanium alloy mesh skeleton is laser-engraved from nickel-titanium alloy tubes, and has a wavy pattern after expansion.
[0060] (2) Pretreatment of the stent: Use propanol analytically pure solution or medical ethanol solvent for the obtained net-shaped nickel-titanium memory alloy bare metal stent, the concentration of propanol analytically pure solution is 99.5%, and the concentration of medical ethanol solvent is 75% ;Use ultrasonic waves to clean the bracket body to remove impurities on the surface of the bracket body, and then use distilled water to clean the bracket body with ultrasonic waves. The frequency of ultrasonic cl...
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