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Drug-coated intravascular stent capable of preventing in-stent restenosis and preparation method of drug-coated intravascular stent

A drug coating and vascular stent technology, applied in coatings, stents, pharmaceutical formulations, etc., can solve problems such as poor efficacy and achieve biological activity protection, good biocompatibility and compliance, and good practical application value Effect

Active Publication Date: 2021-08-13
TAIYUAN UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, CD34 antibody stents are not effective in promoting endothelialization in the short term to prevent in-stent restenosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A specific preparation method of a drug-coated vascular stent for preventing in-stent restenosis is as follows:

[0039] (1) Preparation of net-shaped nickel-titanium memory alloy bare metal stent: weave the nickel-titanium alloy into metal wires, and bend the metal wires to form a nickel-titanium alloy mesh skeleton. Specifically, a nickel-titanium alloy wire is bent to form a plurality of sequentially connected wave-shaped bending rings connected to form a pipe-shaped nickel-titanium alloy skeleton.

[0040] (2) Pretreatment of the stent: Use propanol analytically pure solution or medical ethanol solvent for the obtained net-shaped nickel-titanium memory alloy bare metal stent, the concentration of propanol analytically pure solution is 99.5%, and the concentration of medical ethanol solvent is 75% ;Use ultrasonic waves to clean the bracket body to remove impurities on the surface of the bracket body, and then use distilled water to clean the bracket body with ultraso...

Embodiment 2

[0048] A specific preparation method of a drug-coated vascular stent for preventing in-stent restenosis is as follows:

[0049] (1) Preparation of net-shaped nickel-titanium memory alloy bare metal stent: weave the nickel-titanium alloy into metal wires, and bend the metal wires to form a nickel-titanium alloy mesh skeleton. Specifically, a nickel-titanium alloy wire is used to bend a single ring, and then a plurality of independent zigzag-shaped bent rings are connected to form a pipe-shaped nickel-titanium alloy skeleton with the nickel-titanium alloy wire.

[0050] (2) Pretreatment of the stent: Use propanol analytically pure solution or medical ethanol solvent for the obtained net-shaped nickel-titanium memory alloy bare metal stent, the concentration of propanol analytically pure solution is 99.5%, and the concentration of medical ethanol solvent is 75% ;Use ultrasonic waves to clean the bracket body to remove impurities on the surface of the bracket body, and then use di...

Embodiment 3

[0058] A specific preparation method of a drug-coated vascular stent for preventing in-stent restenosis is as follows:

[0059] (1) Preparation of net-shaped nickel-titanium memory alloy bare metal stent: weave the nickel-titanium alloy into metal wires, and bend the metal wires to form a nickel-titanium alloy mesh skeleton. Specifically, the nickel-titanium alloy mesh skeleton is laser-engraved from nickel-titanium alloy tubes, and has a wavy pattern after expansion.

[0060] (2) Pretreatment of the stent: Use propanol analytically pure solution or medical ethanol solvent for the obtained net-shaped nickel-titanium memory alloy bare metal stent, the concentration of propanol analytically pure solution is 99.5%, and the concentration of medical ethanol solvent is 75% ;Use ultrasonic waves to clean the bracket body to remove impurities on the surface of the bracket body, and then use distilled water to clean the bracket body with ultrasonic waves. The frequency of ultrasonic cl...

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Abstract

The invention discloses a composite drug intravascular stent which comprises a bare metal stent (prepared from a nickel-titanium memory alloy material), recombinant human collagen and folic acid are loaded on a stent body, HMGB1 fragment peptide and a VEGFR-2 antibody are crosslinked on the surface of the bare metal stent. Specifically, a dynamic liquid electrospinning technology is utilized to load a composite spinning solution of recombinant human collagen, folic acid, HMGBI fragment peptide and the VEGFR-2 antibody onto a nickel-titanium memory alloy bare metal stent to form an intravascular stent loaded with the recombinant human collagen and folic acid and cross-linked with the HMGBI fragment peptide and the VEGFR-2 antibody, so that EPCs capture, homing, proliferation and differentiation are promoted, and rapid endothelialization of the blood vessel is realized. The stent not only can be used for coronary stents, but also can be used for cerebrovascular stents, renal artery stents, main artery stents and the like.

Description

technical field [0001] The invention relates to the technical field of medical vascular stents implanted in the human body, in particular to the construction of a recombinant human collagen and folic acid, cross-linked high mobility group box 1 (High Mobility Group Box 1, HMGB1) fragment peptide and human blood vessels Endothelial growth factor receptor 2 antibody (VEGFR-2 / KDR / CD309 antibody) vascular stent, the purpose is to further specifically promote the capture and homing of endothelial progenitor cells (Endothelial Progenitor Cells, EPCs) on the basis of meeting the requirements of general vascular stents , Proliferation, and differentiation, while inhibiting the hyperplasia of the intimal, realize the rapid endothelialization of blood vessels and increase the biocompatibility of the stent surface, so as to achieve the postoperative effect of reducing in-stent restenosis and late stent thrombosis. Background technique [0002] Nowadays, with the improvement of people's...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/08A61L31/16A61L33/04A61F2/82D01D5/00
CPCA61L31/022A61L31/08A61F2/82A61L31/16A61L33/0011D01D5/0084D01D5/003A61L2400/16A61L2400/12A61L2300/256A61L2300/216A61L2300/252A61L2300/606A61L2300/42A61L2300/416
Inventor 安美文郭继强张锦高宇平高颖王立刘阳杨彩仙吕营岳志杰曹烨李芳王昭月
Owner TAIYUAN UNIV OF TECH
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