12 results about "Transplant Procedure" patented technology

Disclosed herein are anti-CD45 antibodies, antigen-binding fragments thereof, and antibody drug conjugates (ADCs) that specifically bind to human CD45. The antibodies and ADCs can be used in therapeutic methods including methods of depleting CD45 + cells in a patient. The compositions and methods described herein can be used for direct treatment of conditions, for example, by depleting CD45 + cancer cells or populations of autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplantation therapy and to improve the implantation of hematopoietic stem cell grafts by selectively depleting endogenous CD45 + cells prior to the transplantation procedure.

1. The name of the design product: corneal visible trepan. 2. The use of the design product: the design product is used for drilling cornea in corneal transplantation operation. 3. The design points of the design product: in shape. 4. The picture or photo that can best show the design points: perspective view.

A powder formulation for preserving tissue and organ function, and more particularly to shelf stable powder formulations that can be reconstituted at point of use, including during a fat grafting process, coronary artery bypass graft surgery, and peripheral bypass surgery, or other grafting / transplant surgery prior to or during the medical procedure to preserve the tissues / organs used in these procedures. The powder formulation includes a reducing agent; an antioxidant; a sugar; a nitric oxide substrate; a buffering agent; and physically acceptable salt. Also provided are a method of preparing an organ or tissue preservation solution by reconstituting the powder formulation, and a method of preserving tissue or an organ using same.

There is disclosed a defect sizer tool for selection of an appropriately sized pre-cut core for a cryopreserved osteochondral allograft (COCA) transplantation procedure. In an embodiment, the tool includes an elongated connector that provides a handle portion. A ring measurement guide at one end, with a given diameter, and alignable with a cartilage defect to provide an estimated measurement of a diameter. There is disclosed an instrument kit with a pin, a pin guide, and a reamer configured to slidingly receive the pin, blades at one end, and a rotational drive connector at the other end. In an embodiment, a method for a COCA transplantation procedure includes providing an instrument kit, using the pin guide to place the pin in the subchondral bone, and operating the reamer to score surrounding cartilage prior to the reamer bit portion reaming the subchondral bone to the desired depth. Other embodiments are also disclosed.

Provided herein are methods and systems of transplant cells and growing an ectopic tissue in a lymph node of a subject. In certain embodiments, the methods and systems provided herein enable minimally invasive cell transplantation to treat patients in need thereof. In certain embodiments, the methods and systems provided herein include the use of ultrasound endoscopy.

The embodiment of the application discloses a kind of fecal bacteria transplantation donor-recipient dynamic matching method, device, equipment and medium, in response to donor-recipient matching request, the fecal bacteria transplantation after monitoring data of current preset sampling time of to-be-matched recipient is acquired;Wherein, the fecal bacteria transplantation after monitoring data is determined based on the fecal bacteria group of any one target donor to to-be-matched recipient after completing fecal bacteria transplantation operation, and the target donor is determined based on the genetic feature information, immune feature information and clinical feature information of to-be-matched recipient and multiple candidate donors for adaptability matching;Fecal bacteria transplantation after monitoring data is input into transplantation strategy control model, and at least one of the donor switching strategy and dose adjustment strategy for adjusting to-be-matched recipient in next period is output, overall compatibility evaluation is realized by multi-modal data integration, and treatment scheme is continuously optimized by means of dynamic feedback mechanism, which significantly improves the precision and adaptability of fecal bacteria transplantation treatment.

Amatoxins, as well as antibody-drug conjugates (ADCs) and compositions have amatoxin and can be used for cancer therapy, to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions treat various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases and prevent graft-versus-host disease (GVHD).

A method for detecting biometric parameters includes the steps of performing a bone graft procedure on at least one vertebra of a spine, providing at least one biometric sensor at the at least one vertebra, the sensor measuring at least one parameter selected from the group consisting of pressure, tension, shear, relative position, and vascular flow in an adjacent surrounding, and measuring the at least one biometric parameter at the vertebra with the sensor.

Amatoxins, as well as antibody-drug conjugates (ADCs) comprising an amatoxin are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can be used for cancer therapy. They can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, as well as prevention of graft-versus-host-disease (GVHD), are provided.

The invention concerns a method, and a device that can implement this method, adapted to obtain adipose based compounds, of selectively variable particle sizes, distinguished by high levels of purity and by high concentrations of viable mesenchymal stem cells, which can be used in autologous transplantation procedures mainly for regenerative purposes, as well as for filling and / or volumizing purposes.

The present disclosure provides a solution for maintaining, by monitoring and guidance operations, a desired condition state in an eye of the subject, following an ophthalmological procedure. For example, the procedure may be corneal transplant, either a complete transplant of a corneal or a partial transplant of some layers of the cornea. Following the procedure, a gas bubble is injected into the eye to maintain the corneal graft in position. As long as the gas bubble is located below the corneal graft, it assists in maintaining the graft in position. As the gas bubble is lighter than the medium in the eye, it keeps pushing upwards and applying forces on the graft and preventing it from dislocating. The present disclosure provides a solution that keeps monitoring the gas bubble, or any other condition state resulted by an ophthalmological procedure and providing instructions to the subject in case the gas bubble deviates from certain allowed boundaries within the eye.

Disclosed are anti-CD45 antibodies, antigen binding fragments thereof, and antibody drug conjugates (ADCs) that specifically bind to human CD45. Such antibodies and ADCs are useful in therapeutic methods, including methods of depleting CD45+ cells from a patient. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy, and to improve the engraftment of hematopoietic stem cell transplants, by selectively depleting endogenous CD45+ cells prior to the transplant procedure.