13 results about "Vascular flow" patented technology

The invention relates to the technical field of image processing, and discloses an interventional navigation method and system based on multi-modal image fusion. The method comprises the following steps: segmenting CT angiography data to form a three-dimensional vascular skeleton model, calculating MRI perfusion data to generate a vascular flow velocity field, and constructing a vascular geometric constraint matrix; performing diffusion reconstruction on the constraint matrix and the instrument position information, and outputting an instrument motion prediction track; estimating the postures of the tips of the X-ray perspective imaging instruments to form instrument-blood vessel space correlation features; safety navigation constraint parameters are generated through distance field calculation; and generating a real-time navigation instruction containing a propulsion distance and a rotation angle by adopting a path planning algorithm. The technical problems that in a traditional interventional navigation system, multi-modal image data fusion is insufficient, instrument motion prediction is inaccurate, and a safety constraint mechanism is incomplete are solved, and the precision, safety and real-time performance of interventional operation navigation are improved.

The application relates to the technical field of image processing, and discloses an interventional navigation method and system based on multi-modal image fusion. The method comprises the following steps: CT angiography data is segmented to form a three-dimensional vascular skeleton model, MRI perfusion data is calculated to generate a vascular flow field, and a vascular geometric constraint matrix is constructed; the constraint matrix and instrument position information are diffused and reconstructed, and an instrument motion prediction trajectory is output; an X-ray fluoroscopy image instrument tip posture is estimated, and instrument-vascular spatial correlation features are formed; safe navigation constraint parameters are calculated and generated through a distance field; and a path planning algorithm is used to generate real-time navigation instructions containing a pushing distance and a rotation angle. The application solves the technical problems of insufficient multi-modal image data fusion, inaccurate instrument motion prediction and imperfect safety constraint mechanism in a traditional interventional navigation system, and improves the precision, safety and real-time performance of interventional surgery navigation.

A method for characterizing a blood vessel includes receiving anatomical information of the blood vessel and receiving four-dimensional flow data of multiple blood vessels from multiple subjects. The method further includes, using the four-dimensional flow data to train a flow model to determine blood vessel properties, and using the anatomical information of the blood vessel as an input to the trained flow model to estimate one or more properties of the blood vessel.

Self-expanding implants useful as vascular flow reducers are disclosed with minimized wall porosity configured to maximize the percentage of total vascular flow routed through the reduced orifice while maintaining an overall stable structure that avoids or minimizes distortions such as in-folding when the implant is compressed to a smaller diameter suitable for delivery through the vasculature to the treatment site.

System and method for deploying a flow restriction device in patient vascular and recapturing and repositioning the flow device after full or partial deployment. Disclosed systems and methods permit confirmation of device placement, such as by measuring a pressure drop across the partially or fully deployed device in the coronary sinus before release of the device and permanent implantation.

This invention discloses an automatic liver segmentation method and system based on anatomical prior guidance of vascular flow direction, belonging to the fields of medical image processing, computer-aided diagnosis, computer vision, and artificial intelligence. The method includes acquiring liver medical images and vascular flow direction features, constructing a three-dimensional vascular direction vector field and vascular topology map, and extracting vascular anatomical prior features using a graph convolutional network; enhancing key vascular region features by combining an attention mechanism and fusing them with liver image features; outputting a liver segment probability map through a decoding network; training the model based on cross-entropy loss, boundary alignment loss, and region consistency loss to achieve end-to-end optimization; and finally outputting the liver segmentation result, which can be used for medical image visualization and surgical planning assistance. This invention improves the accuracy, robustness, and anatomical consistency of liver segmentation, and has good clinical application value.

Self-expanding implants useful as vascular flow reducers are disclosed with minimized wall porosity configured to maximize the percentage of total vascular flow routed through the reduced orifice while maintaining an overall stable structure that avoids or minimizes distortions such as in-folding when the implant is compressed to a smaller diameter suitable for delivery through the vasculature to the treatment site.

A method for detecting biometric parameters includes the steps of performing a bone graft procedure on at least one vertebra of a spine, providing at least one biometric sensor at the at least one vertebra, the sensor measuring at least one parameter selected from the group consisting of pressure, tension, shear, relative position, and vascular flow in an adjacent surrounding, and measuring the at least one biometric parameter at the vertebra with the sensor.

A self-expanding implant useful as a vascular flow reducer is disclosed. This implant has a variable cell angle and limits the amount of diameter change in a specific part of the implant (e.g., the throat or the inner diameter of the central throat of an hourglass shape). A method for fabricating such an implant is also described.

This invention relates to a vascular flow restrictor, comprising: a tubular body, a first fixing member, and at least one second fixing member; the tubular body includes an inflow end and an outflow end; the inflow end is provided with a first opening, and the outflow end is provided with a second opening, the continuous cavity defined between the first opening and the second opening forming a hollow cavity of the tubular body; the outflow end of the tubular body is constricted into at least two connecting bundles, the connecting bundles being fixed by the first fixing member or the second fixing member; the first fixing member has a connecting portion for connecting with an external connecting member; the second fixing member has a communicating hole for the external connecting member to pass through. The vascular flow restrictor of this invention, by constricting the outflow end into at least two connecting bundles, creates a tapered structure in the hollow cavity, reducing the blood flow rate, and allowing the connection of at least two connecting bundles to be achieved with a single connecting member, thus reducing the required inner diameter of the delivery sheath.

Described herein is a microfluidic assay device that mimics in vitro the in vivo biological environment, supporting endothelization, allowing for perfusive flow similar to in vivo blood flow conditions, and providing for realistic interactions between T-cells and solid tumor cells, such as glioblastoma multiforme tumor cells. Also described herein are methods of using this microfluidic assay device for the study of interactions of immune cells with tumor cells, such as glioblastoma multiforme tumor cells, and the development of improved immunotherapeutic approaches against cancers, such as glioblastoma multiforme.

Described herein is a microfluidic assay device that mimics in vitro the in vivo biological environment, supporting endothelization, allowing for perfusive flow similar to in vivo blood flow conditions, and providing for realistic interactions between T-cells and solid tumor cells, such as glioblastoma multiforme tumor cells. Also described herein are methods of using this microfluidic assay device for the study of interactions of immune cells with tumor cells, such as glioblastoma multiforme tumor cells, and the development of improved immunotherapeutic approaches against cancers, such as glioblastoma multiforme.

Systems and methods are disclosed for providing intraprocedural guidance and feedback during a vascular intervention via intraprocedural Doppler ultrasound performed on one more distal peripheral vessels impacted by the vascular intervention. According to various example embodiments, intraprocedural Doppler ultrasound is performed to detect the changes in flow characteristics and / or anomalous vascular flow signatures of the peripheral vasculature impacted by the intervention, such as the detection of an adverse vascular event. The detected changes in flow characteristics are intraprocedurally communicated to guide and / or assist clinical decision making, and / or employed to autonomously send control signals to interrupt or modify treatment. In other embodiments, intraprocedural guidance and / or feedback is autonomously provided during a neuromodulation procedure via Doppler ultrasound performed on one more peripheral vessels for which blood flow is modulated by the neuromodulation procedure, with the neuromodulation device optionally being controlled according to the detected changes in blood flow.