The present invention is directed to the pharmaceutical sector and describes methods for administering
vitamin D parenterally using
resorbable polymers in the form of in situ forming implants; compression-formed implants,
extrusion-formed implants, and liquid preparations. For long-acting
vitamin D
delivery system formulations, 0.5% to 99% by weight of
resorbable polymers and 0.5% to 60% of organic solvents are used. Additionally, plasticisers in the concentration range of 0.1% to 50% may be used to assist in the
extrusion process. The
vitamin D dosage ranges from 2,000 to 2,000,000 IU, delivering 400 to 2,000 IU daily, without an initial peak release, thus reducing the risk of hypercalciuria.