322results about How to "Promote osseointegration" patented technology

An intraluminal medical device comprises a stent having a coating applied to at least part of an interior surface, an exterior surface, or both. The coating comprises a sustained release formulation of a combination of pharmaceutical compounds dispersed within a biologically tolerated polymer composition. The choice of the combination of pharmaceutical compounds are intended to reduce neointimal hyperplasia restenosis.

A dynamic porous coating for an orthopedic implant, wherein the dynamic porous coating is adapted to apply an expansive force against adjacent bone so as to fill gaps between the dynamic porous coating and adjacent bone and to create an interference fit between the orthopedic implant and the adjacent bone.

Embodiments of the present invention provide an osseointegrative implant and related tools, components and fabrication techniques for surgical bone fixation and dental restoration purposes. In one embodiment an all-ceramic single-stage threaded or press-fit implant is provided having finely detailed surface features formed by ceramic injection molding and / or spark plasma sintering of a powder compact or green body comprising finely powdered zirconia. In another embodiment a two-stage threaded implant is provided having an exterior shell or body formed substantially entirely of ceramic and / or CNT-reinforced ceramic composite material. The implant may include one or more frictionally anisotropic bone-engaging surfaces. In another embodiment a densely sintered ceramic implant is provided wherein, prior to sintering, the porous debound green body is exposed to ions and / or particles of silver, gold, titanium, zirconia, YSZ, α-tricalcium phosphate, hydroxyapatite, carbon, carbon nanotubes, and / or other particles which remain lodged in the implant surface after sintering. Optionally, at least the supragingival portions of an all-ceramic implant are configured to have high translucence in the visible light range. Optionally, at least the bone-engaging portions of an all-ceramic implant are coated with a fused layer of titanium oxide.

The present invention is directed to implants that include therapeutic molecules bonded to their surfaces. The therapeutic molecules interact with cells that are adjacent, near, or adhering to the implant. The covalently-bonded therapeutic molecules may be released from the implant surface by changes in pH or enzymes characteristic of cells adjacent to the implant. Preferably the covalently-bonded agents include an antibiotics that are released from the implant surface by bacteria and in this way ensures that the antibiotic is released at sites on the implant that would serve as centers for both bacterial colonization and biofilm formation.

A dental implant has a body with a porous metal portion for engaging bone. The porous metal portion has an outer coronal to apical height and an outer diameter. Both the height and diameter are about 4 mm to about 6 mm. This permits the implant to be placed on a jaw with a reduced bone volume.

A radial-capitellar implant for surgical replacement of the capitellum of the humerus and, optionally, the head of the radius. The radial-capitellar implant includes a capitellar implant or surface replacement arthroplasty of the capitellum and a radial prosthesis for replacement of the head of the radius. In one embodiment the radial prosthesis includes an articular head which moveable articulates with a stem implantable in the radius.

Compositions and materials for making soft suture anchors comprising materials that improve osteointegration have been developed. These compositions and materials comprise bioceramics, resorbable materials, and combinations thereof. A preferred embodiment comprises a soft suture anchor comprising a resorbable ceramic and a resorbable suture.

A dental implant can comprise a shaft defining a longitudinal axis and having an apical end, a coronal end, and an exterior surface. A portion of the exterior surface can include a porous material. The dental implant can comprise at least one thread, including a non-porous material, having an interior surface and a bone-engaging surface. The interior surface can engage and wind around the exterior surface of the shaft and the bone-engaging surface can extend outwardly from the exterior surface of the shaft. The shaft can include one or more channels configured to communicate a flowable material, stored within the shaft, to the exterior surface. Each channel can include an opening at the exterior surface to release the flowable material. At least one channel can extend between a cavity of the shaft and the exterior surface and can optionally be angled toward the apical end.

Apparatus for use in supporting a graft ligament within a bone tunnel, the apparatus comprising a graft ligament plug, the graft ligament plug comprising a groove extending along one side of the plug, across the front end of the plug, and then back down the opposing side of the plug, with the groove being sized such that when a graft ligament is disposed in the groove, the graft ligament will protrude out of the groove and engage adjoining portions of the bone tunnel so as to facilitate osseointegration therewith; wherein the graft ligament plug is formed in two opposing halves, such that the graft ligament can be positioned within the groove and thereafter clamped between the opposing two halves of the graft ligament plug when the two opposing halves are brought together so as to form the complete graft ligament plug.

A femur fixture for a hip-joint prosthesis comprising an intraosseous anchoring structure of a generally circular cross-section for screwing laterally into a complementary bore drilled laterally into the neck of a femur after resection of the femur head to an anchored position. The intraosseous anchoring structure has a proximal end, a distal end, a relatively short frusto-conical proximal section at the proximal end, and a proximal cylindrical section having a screw thread profile thereon. The proximal cylindrical section extends from the frusto-conical proximal section towards the distal end of the anchoring structure. The frusto-conical proximal section and the proximal cylindrical section each being dimensioned so as to bear against the cortex of the femur neck when the intraosseous anchoring structure is in the anchored position. The invention also relates to a set of such femur fixtures, wherein the frusto-conical proximal section and the proximal cylindrical section of each fixture in the set have different dimensions, whereby the fixture in the set having the frusto-conical proximal section and the proximal cylindrical section of correct size for abutting the cortex of the femur neck of a particular patient can be selected for use in that patient.

The invention relates to a method for modification of a biocompatible component comprising the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of said component, which part is covered by said metallic oxide, with an aqueous composition comprising oxalic acid; whereby a modified metallic oxide is obtained. The invention also relates to a biocompatible component comprising a substrate having a surface comprising a) a microstructure comprising pits separated by plateus and / or ridges; and b) a primary nanostructure being superimposed on said microstructure, said primary nanostructure comprising depressions arranged in a wave-like formation.

A section of the implant is treated successively and separately with three different acids—hydrofluoric, sulphuric and hydrochloric acid— to create evenly distributed peaks on the surface and sufficient surface area. Plasma rich in growth factors is then applied to said surface.

An orthopedic device adapted for implantation into a body where it contacts bone tissue is disclosed which has at least one spaced apart polarized magnetic element, at least one piezoelectric element or a combination of a polarized magnetic element and a piezoelectric element which are in direct contact with one another or are separately mounted on the implant. The piezoelectric element being at least partially embedded in a surface of the device which contacts bone tissue for the promotion of osteogenesis or osseointegration.

The invention provides a porous titanium alloy human cervical interbody fusion cage with bioactivity and a preparation method thereof. The method comprises the following steps: firstly, inputting model data into electron beam melting equipment according to a design requirement to prepare a porous titanium alloy human cervical interbody fusion cage; secondly, preparing gelatin microspheres; and immersing gelatin microsphere dry powder in an rhBMP-2 solution for gelatin coating modification, preparing a gelatin solution A in double distilled water, immersing the porous titanium alloy human cervical interbody fusion cage in the gelatin solution A, mixing the rhBMP-2 gelatin microspheres and absolute ethanol to obtain suspension B, and immersing the gelatin-coating-modified porous titanium alloy human cervical interbody fusion cage in the suspension B to prepare the porous titanium alloy human cervical interbody fusion cage internally containing an rhBMP-2 sustained-release system. The cervical interbody fusion cage prepared with the method has modulus of elasticity close to that of natural bone tissues, and the porous structure and the bioactivity factor sustained-release system inside the cervical interbody fusion cage can induce growth of new bone tissues, so that the binding problem of bone-material interfaces is solved. Therefore, the cervical interbody fusion cage has bettermechanical compatibility and bone integration capability than those of a compact material.

A bone restoration body with a composite porous structure and a preparation method of the bone restoration body. The bone restoration body comprises a porous metal bracket and an infill body with a porous structure, wherein the porous metal bracket is of a three-dimensional net structure, a plurality of pores are arranged in the inner part of the porous metal bracket, and the infill body with the porous structure is fully filled in all the pores. The preparation method combines the direct metal rapid prototyping technology and the freeze drying technology and comprises the steps of preparing the porous metal bracket by a structural design and the direct metal rapid prototyping technology, pouring uniformly-mixed polymer solution or polymer / biological ceramics mixing solution into the porous metal bracket, carrying out freezing treatment, and then forming the infill body with the porous structure through freeze drying so as to obtain the bone restoration body with the composite porous structure, wherein the infill body with the porous structure has micropore characteristics. The bone restoration body has good mechanics compatibility, can obtain good bone conduction performance and bone induction performance, improves bone integration efficiency and can be used for clinical treatment of segmental bone defect of a bearing part.

Methods and compositions are provided for the therapeutic use of Wnt proteins, for enhancing bone growth and regeneration, including repair following injury, osseointegration of implants, and the like. In some embodiments of the invention, the compositions are administered locally, e.g. by injection at the site of an injury. For certain conditions it is desirable to provide Wnt activity for short periods of time, and an effective dose will be administered over a defined, short period of time.

A prosthesis for partial replacement of a long bone in humans or animals, the prosthesis including: a proximal or distal end component forming one component of a prosthetic joint; a shaft on or assembled with the distal or proximal end component in use; a stem for engagement in a resected bone; and an initially separate collar assembled to the shaft or an extension thereof in use, the collar being dimensioned to abut the resected end face of the bone into which the prosthesis is to be fitted, wherein the end face of the collar facing the resected face of the bone is sized and shaped to correspond to the resected end face of the bone.

The invention relates to a biological medical porous titanium material and a preparation method thereof. The preparation method, namely a method adopting powder metallurgy, is to add spherical particles of novel polymethyl methacrylate pore-forming agent to prepare a structure provided with a rough surface and three-dimensionally communicated open pores, wherein the number, the shape and the size of the pores can be controlled, namely, the porosity degree is less than 70vol. percent, the open porosity factor is more than 60 percent, the average pore diameter is less than 500 mums, the Young's modulus in compression is more than 0.3 GPa, the compressive strength is more than 40MPa, and the bending strength is more than 50MPa. The biological medical porous titanium material can be widely applied in the field of biological medical implants such as dental implants, artificial joints, spinal orthopaedic internal fixed systems, medullary internal nails and orthopaedic armor plates.

A fluted osteotome is rotated in one direction to enlarge an osteotomy by burnishing, and by cutting / drilling when turned in an opposite direction. A conically tapered body has an apical end with lips. The lips are set to grind bone when rotated in the burnishing direction and cut bone when turned in the cutting / drilling direction. Helical flutes and interposed lands are disposed about the body. The flutes each have a working edge that burnishes bone when rotated in the burnishing direction and cuts bone when turned in the cutting / drilling direction. The lips and lands generate an opposing axial reaction force that improves surgical control. The osteotome auto-grafts bone by reapplying ground particles in a compacted manner along the entire depth of the osteotomy, particularly at the bottom.

The invention discloses a surface treatment method for an SLM molded titanium implant. The surface treatment method comprises the following steps: carrying out SLM molding on the titanium implant; carrying out sand blasting treatment: adopting corundum or titanium dioxide to carry out surface sand blasting treatment on the surface of the SLM molded titanium implant; picking to remove impurities: putting the SLM molded titanium implant subjected to the sand blasting treatment into a pickling solution to carry out pickling treatment; carrying out alkali thermal treatment: putting the SLM molded titanium implant subjected to the pickling treatment into an alkali solution to carry out hydro-thermal treatment; carrying out calcification treatment: taking a calcium salt solution as a cationic exchange fluid, putting the SLM molded titanium implant subjected to the alkali thermal treatment into the cationic exchange fluid at a temperature of 100-200 DEG C to carry out hydro-thermal treatment for 1-5 hours; and after teach step, sequentially putting the SLM molded titanium implant into acetone, 95% alcohol and deionized water to respectively ultrasonically clean and dry. The surface treatment method is simple in step, and is easy to operate; and the surface, with a micro-nano grading structure, of the SLM molded titanium implant is constructed, so that the roughness, the microstructure, the mineralization characteristics and the biological activity of the surface of the SLM molded titanium implant are effectively improved.

An implant for stabilizing two separated bone portions relative to each other an implant includes a peg, a bridge assembly and a securing element. The peg and bridge assembly include at least two peg portions and a bridge portion, wherein the bridge portion is arranged between the peg portions and wherein the peg and bridge portions are rigidly connected. The peg and bridge assembly is positioned relative to the bone portions such that one peg portion extends into the bone tissue of each one of the bone portions and the bridge portion extends across the gap separating the bone portions. The securing element is anchored in the bone tissue of one of the bone portions, its proximal end extending through an opening in an assembly portion extending parallel to a bone surface or across a notch in a proximal edge of an assembly portion.

The invention provides a preparation method of nanolayer medical titanium alloy with antibacterial and osteocyte-facilitating functions. The method comprises the following steps: firstly, preparing different concentrations of chitosan-lauric acid (1%, 1.67% and 2.5%) conjugates by esterification reaction; secondly, utilizing a physical adsorption method and a chemical fixation method, adopting poly-dopamine as an intermediate layer, fixing the chitosan-lauric acid conjugates on the surface of a titanium implant, so as to build a nano structure layer with dual antibacterial and osteocyte proliferation facilitating properties on the titanium material surface, so as to regulate and control the biological function of the osteocyte, and improve the short-term antimicrobial capability of the titanium implant.

Provided herein are implants and methods for producing implants. In at least one embodiment, the implants include sheet-based, triply periodic, minimal surface (TPMS) portions. According to one embodiment, the TPMS portions include a gyroid architecture that provides for improved osseointegration and mechanical performance over previous implants due to novel ratios of porosity to compressive strength, among other features. In one or more embodiments, the gyroid architecture is organized into unit cells that demonstrate anisotropic mechanical performance along an insertion direction. In various embodiments, the present methods include novel selective laser melting (SLM) techniques for forming the TPMS portions of implants in a manner that reduces defect formation, thereby improving compressive performance and other implant properties.

The invention provides a dental implant of a composite structure and a manufacturing method of the same. By adopting effective structural design, different materials and different manufacturing modes, the dental implant is divided into a fastening screw, a screw thread implanting section, a multi-hole implanting section, a tentacle supporting structure and an implant main body which are integrated to form a composite structure, and the dental implant has good strength, good bone combining capability and good initial stability. The thread implanting section, the fastening screw and the implant main body form a main frame of a composite implant, thus strength of the whole implant is guaranteed; meanwhile, the composite structure can be used for overcoming the defects caused by a single manufacturing mode, and the respective advantages of structural design, the manufacturing modes and materials are fully realized; a tentacle supporting structure made from a degradable material has the effects of well inducing osteogenesis and enhancing initial stability of the implant whole and can be applied to immediate implantation; elasticity modulus of the implant overall material is optimized by virtue of a porous structure of the outer layer, combination of bone growth and guiding in initial stage can be facilitated, and initial stability with osseointegration is also improved by the combined expanded-type structure.

A bone screw and a method for manufacturing the same includes a screw thread configuration having one or more grooves cut into a leading face of the thread, a trailing face of the thread, and / or the shaft between the threads. Other implementations include the incorporation of facets into the one or more grooves. The implementation of the one or more grooves increases the surface are of the orthopedic screw and functions to increase in anchoring the bone screw within the bone once inserted therein, and thereby reduce the possibility for the screw backing out after insertion.

The present invention discloses a composition of a knee implant comprising biomaterials such as combination of Ti—Nb—Zr alloy and tantalum to support osseointegration. The present invention further discloses a method of manufacturing customized patient-specific knee implant using 3D printing technology to suit the patient. The method involves the use of high energy source such as fiber laser or electron-beam. The base plate is mounted on the CNC. The energy source creates a melt pool on the base plate and the energy source is fed with a biomaterial in the form of wire or powder. The biomaterial is deposited on the base plate layer by layer, which solidifies in the melt pool of the base plate. The knee implant thus fabricated suits the elastic modulus of the bone and is useful as customized implant in patient undergoing replacement surgery.

The invention discloses a method for designing and manufacturing an individual 3D printed implant. According to the method, the pore diameter of a porous net rack body is evenly divided into n1 grades, the porosity is evenly divided into n2 grades, the thickness is evenly divided into n3 grades, the elasticity modulus corresponding to n1*n2*n3 porous net rack bodies is divided into n4 grades, and densities of n4 bone substances are accorded; premaxillary bone quantitative CT photo-shooting is carried out on a patient, an average bone elasticity modulus E is calculated by utilizing three-dimensional reconstruction software and an empirical formula, and the thickest porous net rack body is selected from implants close to the range of the elasticity modulus; the implant is subjected to 3D printing, and the head part and the body part are integrally molded. The pore diameter, porosity and thickness of the porous net rack bodies are arranged in different grades, so that different sizes of elasticity modulus for the implants can be achieved, and the implant is suitable for people with different bone densities.

A coating on an implant, said implant being intended for implantation in / on an implantation area, is provided. The coating comprises nitric oxide (NO) for obtaining an anti-viral, anti-fungal, and anti-bacterial effect, and for promotion of osteo-integration of the implant, bone healing, bone growth, and wound healing at said implantation area. A nitric oxide (NO) eluting polymer is integrated with a carrier material, such that said carrier material, in use, regulates and controls the elution of a therapeutic dosage of nitric oxide (NO). An implant and a kit of implants, comprising said coating are also provided. Furthermore, a manufacturing method for the implant is disclosed.