6results about How to "Good bone conduction" patented technology

The application belongs to the technical field of medical materials, and provides a composite hydrogel loaded with rare ginsenoside Rh4-Ce nanoparticle, wherein the rare ginsenoside Rh4 is complexed with cerium ions to form a nanoparticle, the dispersibility and stability of the rare ginsenoside Rh4 in the hydrogel system are significantly improved, and the Ce 3+ / Ce 4+ valence state is cycled to endow the material with sustained antioxidant and microenvironment regulation capabilities, the GelMA provides a three-dimensional scaffold structure and cell attachment space, the HA provides mechanical enhancement and mineralization induction, and the CeRh4NCs cooperatively improve the local inflammatory oxidative stress microenvironment and potentially promote osteogenesis and angiogenesis. The application overcomes the technical defects of conventional bone repair materials in the application of active factors, microenvironment regulation and mechanical support, forms a multifunctional craniomaxillofacial bone defect repair material with anti-inflammatory and antioxidant properties, and promotes osteogenesis and vascularization, and has application value.

The application relates to the technical field of biomedical materials, and specifically discloses a preparation method of a double-crosslinked 3D-printed bone repair scaffold. The scaffold is made of a biphasic calcium phosphate matrix and a gelatin methacrylate hydrogel outer layer. The preparation method comprises the following steps: firstly, preparing biphasic calcium phosphate ink, and constructing a porous scaffold blank through 3D printing; then, carrying out double-crosslinking treatment of calcium chloride solution and glutaraldehyde solution in sequence to obtain a scaffold matrix with enhanced mechanical properties; then, preparing gelatin methacrylate hydrogel loaded with modified teriparatide, and compounding the gelatin methacrylate hydrogel with the scaffold matrix; and finally, obtaining the final product after blue light crosslinking and solidification. The bone repair scaffold has good biocompatibility and osteogenic activity, and can effectively promote bone defect repair. In addition, the preparation method is controllable and has good repeatability, the structure of the scaffold is accurately controlled through the 3D printing technology, and a new approach is provided for the preparation of personalized bone repair materials.

This invention relates to medical-grade polyetheretherketone (PEEK) composite materials, their preparation method, and human bone implants, belonging to the field of medical materials technology. It addresses the limitations of existing human bone implants in promoting bone tissue regeneration and repair, as well as their poor antibacterial properties. The composite material comprises 1000 parts PEEK powder, 100-500 parts of HAP-modified ZIF-8 composite material after sizing, 1-3 parts of silane coupling agent, and 2-5 parts of calcium stearate. The sizing-treated HAP-modified ZIF-8 composite material is obtained by reacting HAP, methylimidazole, and anhydrous zinc nitrate in a DMF solution of polyetherimide; wherein HAP comprises 3-21 parts, methylimidazole 100-350 parts, and anhydrous zinc nitrate 120-380 parts. This invention can be used in human bone implants, possessing antibacterial properties, strong binding ability to bone cells and tissues, and the ability to promote the regeneration and repair of bone cells and tissues, showing broad application prospects in the medical field.

This invention provides a glass-ceramic composite material, which is a degradable and osteoconductive composite material composed of CaO-MgO-SiO2 (CMS glass) + CaMgSi2O6 (CMS ceramic) and CaSO4 (CS ceramic). In addition to CaO-MgO-SiO2 glass, this synthesized composite material mainly contains two ceramic phases: crystalline CaMgSi2O6 and CaSO4. CMS glass and CMS ceramic both have high mechanical strength, biocompatibility and osteoconductivity, while CaSO4 has the property of rapid degradation to promote bone inward growth.

The application discloses a kind of sisal fiber reinforced high osteogenic activity chitosan-based antibacterial porous material and preparation method thereof, the porous material refers to the compound of carboxylated modified sisal fiber and chitosan, multifunctional hybrid nanometer apatite and sodium agastache rugosus in aqueous solution is uniformly mixed after ultrasonic stirring, then add a small amount of glacial acetic acid, i.e. composite gel material is obtained, it is placed in pre-cooled after freeze-drying in petri dish, finally with NaOH solution immersion washes to neutral, drying can be used.The porous material in poly anion sisal fiber and cation chitosan acid solution have strong ionic crosslinking effect, so that the mechanical properties of the porous material are greatly improved;And added hybrid nanometer apatite is strontium doped and contains a small amount of auren phosphate, and its osteogenic activity is better;In addition, hybrid nanometer apatite also introduces phytic acid to chelate, and sodium agastache rugosus is also loaded in the porous material, so it can coordinate to play the slow and fast dual release antibacterial effect.The raw material used in the new porous material is rich in source, and the preparation method is simple and easy to operate, and its mechanical properties, degradation performance, osteogenic activity and antibacterial property can be regulated by changing the content of each component of the porous material, and an excellent bone tissue engineering scaffold material is expected to be obtained.

The invention relates to the technical field of biomedical materials, discloses a preparation method of a bone repair mineralized biological membrane capable of inducing gene expression and a product, and aims at solving the problems that an existing bone repair material HAP crystal is difficult to regulate and control, the mechanical activity and the biological activity are not matched, bone induction is weak, the process is complex and the like. The preparation method comprises the following steps: S1, preparing a decellularized small intestinal submucosa (SIS) membrane and sterilizing; s2, constructing a pDA-PAM (at) SIS composite membrane; s3, inducing directional growth of HAP through ion permeation biomimetic mineralization; and S4, cleaning and drying to obtain the HAP / SIS collagen mineralized biological membrane. The product contains an SIS collagen matrix and low-crystallinity nano HAP (the width is 4-20nm, the length is 31-105nm, and the product is oriented along a c axis), the tensile strength is greater than or equal to 13MPa, the elastic modulus is greater than or equal to 75MPa, the specific surface area is greater than or equal to 60m < 2 > / g, and osteogenic genes such as ALP, Runx2 and the like can be up-regulated by more than or equal to 2 times. The method is mild in process, easy to operate, good in biocompatibility, high in bone conduction and inductivity, suitable for large-scale production and capable of meeting the clinical bone defect repair requirement.