293results about How to "Good bone conduction" patented technology

The present invention provides a composite nanofiber construct comprising: at least a first nanofiber comprising at least a polymer and at least a calcium salt nanoparticle, wherein the ratio of polymer to calcium salt nanoparticle is between the range of 99:1 and 10:90 weight percent; and at least a second nanofiber comprising at least a polymer and at least a calcium salt nanoparticle, wherein the ratio of polymer to calcium salt nanoparticle is between the range of 100:0 and 70:30 weight percent. The present invention also provides a method of preparing the composite nanofiber construct.

Tissue repair compositions, particularly bone repair compositions, containing (a) bone fragments and (b) homogenized connective tissue, and methods for making the same are provided. Some of the inventive tissue repair compositions contain a radioprotectant. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form. Kits for using such tissue repair compositions are also provided.

A section of the implant is treated successively and separately with three different acids—hydrofluoric, sulphuric and hydrochloric acid— to create evenly distributed peaks on the surface and sufficient surface area. Plasma rich in growth factors is then applied to said surface.

The invention relates to a medical polyurethane complex film and the preparation method thereof. The complex film is composed of fatty group polyurethane and nanometer hydroxylapatite, wherein the content of the anometer hydroxylapatite is 20-50 wt percent. The fatty group polyurethane is polymerized by at least one of fatty group vulcabond and polyether or polyester polyol, wherein the mol ratio of the fatty group vulcabond-NCO and -OH in the polyol is 1.5-3 to 1. The film belongs to a thermoplasticity elastic film, has favorable elasticity and easy moulding, can load microspheres containing medicine or active components such as biological nutrilit and the like and structures distributed with through holes, thereby having favorable biological performance, and the film does not contain aromatic components but contains ester groups and/or hydrophilic ether groups which can be hydrolyzed or biologically degraded; the hydrophile and hydrophobic nature balance and the degradation of the film can be changed through adjusting the proportion, and the film can be applied to the medical health field of bone tissue guiding regeneration film and medicine slow-released film, and the like.

A novel usage of poly-L-lactic acid as medical shape memory material is provided. Forming the poly-L-lactic acid to initial shape under the temperature of 190í½210íµ and pressure of 2í½10Mpa to obtain the poly-L-lactic acid with shape memory property. The present invention uses poly-L-lactic acid as medical degradable shape memory material for the first time. It can be widely applied in minor trauma invasive stent, vessel jointing, operation suture line, bone fracture fixation and other medical field.

The invention discloses a 3D printed digital artificial bone. The artificial bone consists of a cortical bone, a cancellous bone and a marrow cavity, wherein the cortical bone is composed of poly-L-lactic acid or polyester-ester-ketone; the cancellous bone is formed by mixing poly-L-lactic acid and hydroxyapatite; the molecular weight of the poly-L-lactic acid of which the cortical bone is composed higher than that of which the cancellous bone composed; the cortical bone and the cancellous bone are simultaneously prepared by a 3D printing technology. The invention also discloses a 3D printing method for the digital artificial bone. According to the artificial bone disclosed by the invention, in micrometer and millimeter scales, the porosity of the cortical bone is 10 percent; the porosity of the cancellous bone is 60-80 percent, and the pore size of the cancellous bone is 120-220 micrometers. The 3D printed digital artificial bone has the porosity, the pore size and the mechanical property as those of a bone structure of human beings.

The invention relates to a preparation method of a hydroxyapatite/polylactic acid composite coating on the surface of medical magnesium alloy, which comprises the following steps of polishing a magnesium alloy basal body to remove an oxidation layer on the surface; carrying out acid etching pretreatment and neutralizing treatment on the magnesium alloy basal body; preparing transfer solution from sodium dihydrogen phosphate dihydrate and calcium nitrate terahydrate; preparing a biomimetic calcium-phosphate coating; dissolving polylactic acid in a chloroform solvent to prepare polylactic acid solution; immersing the prepared magnesium alloy/hydroxyapatite composite material in the polylactic acid solution, and coating the polylactic acid coating on the surface of the magnesium alloy/hydroxyapatite composite material by adopting the solution dip-coating method; and putting the magnesium alloy material for 2-3 days till chloroform in the polylactic acid solution is completely volatilized, thereby obtaining the composite material of which the surface of magnesium alloy is wrapped with the hydroxyapatite/polylactic acid composite coating. Compared with the prior art, the preparation method of the hydroxyapatite/polylactic acid composite coating on the surface of medical magnesium alloy overcomes the disadvantages of the single coating, and therefore, the corrosion resistance and the biocompatibility of magnesium alloy are obviously increased.

The present invention discloses an injectable-porous-drug loaded polymethyl methacrylate-based composite scaffold bone transplant material and a preparation method thereof, and belongs to the field of organic functional materials preparation. The polymethyl methacrylate-based composite scaffold bone transplant material uses polymethyl methacrylate (PMMA) as a scaffold for providing mechanical supporting, and a chitosan-based thermosensitive hydrogel as a pore forming agent and an osteoconductive material and a drug carrier, and the polymethyl methacrylate (PMMA) and the chitosan-based thermosensitive hydrogel are mixed with each other to form an injectable-porous three-dimensional structural bone cement composite. The scaffold bone transplant material is simple in preparation method, suitable in reaction temperature, and good in biocompatibility, has matched mechanical properties, good biological mineralization and corresponding anti-bacterial, anti-inflammatory or anti-tumor capabilities, and has broad prospects in clinical application of reconstruction of bone tissues in future.

The invention relates to a preparation method of a hydroxylapatite/sodium alginate nanometer composite material, which mixes calcium hydroxide and phosphoric acid water solution according to the chemical stoichiometric ratio of Ca/P in the hydroxylapatite and carries out the in-situ composite reaction with sodium alginate water gel, and a three dimensional net shaped structure similar to a natural bone is formed by adding calcium chloride to realize the intercrossing reaction with the sodium alginate. The method has the advantages that: the hydroxylapatite/sodium alginate nanometer composite material maintains the good biological compatibility, biological activity and bone conductibility of HA; the combination of the sodium alginate as an organic substrate with the HA can bestow the HA good processing and forming property, thus effectively inhabiting the moving of HA particles from the transplanting parts; and the sodium alginate has rich source and low price, and the preparation process can be operated at normal temperature and pressure, and has simple operation and low cost, and is an ideal bone repairing substitute materials of the new generation.

The invention provides a moldable bone repairing material for bone repairing. The material is prepared from the following raw materials in parts by weight: 20-90 parts of alpha-calcium sulfate hemihydrate and hydroxyapatite, 20-40 parts of bioactive mineral powder, 10-80 parts of autologous bone powder particles or DBM (demineralized bone matrix) particles, and hydrogel, wherein the ratio of hydrogel to the total usage of the raw materials is 1:0.5-1:15, the hydrogel is optimally PEO-PPO-PEO (polyoxyethylene-polyoxypropylene-polyoxyethylene) segmented copolymer solution. The prepared moldable bone repairing material for bone repairing is applicable to in-situ curing after wound injection and in-vitro quick curing for bone repairing, wherein all components are proved to be degradable materials with excellent biocompatibility.

Disclosed are a mixed porous structure interbody fusion cage and a preparation method thereof. The interbody fusion cage comprises a porous metal support and porous structure filling bodies, the porous metal support is a three-dimensional net-shaped structure, a plurality of holes are arranged in the porous metal support, and the porous structure filling bodies are fully filled in the holes. The preparation method includes steps that the metal rapid forming technology is directly combined with the freeze drying technology, the porous metal support is manufactured via a structural design and the direct metal rapid forming technology, then uniformly mixed polymer gel or polymer/ biological ceramic compound gel is poured in the porous metal support to realize freeze treatment, so that the porous structure filling bodies with the micropore feature are formed after freeze drying, and the mixed porous structure interbody fusion cage is obtained. Mechanical compatibility is good, contact area between the mixed porous structure interbody fusion cage and natural centrum is further increased, instant stability is good, fusion rate is improved, and the mixed porous structure interbody fusion cage and the preparation method thereof can be used for treating clinical degenerative disc diseases.

The invention relates to a method for preparing a strontium-containing hydroxyapatite coating on the surface of a biodegradable magnesium alloy. The method comprises the following steps: polishing a magnesium alloy matrix to remove a surface oxidation layer, and cleaning; preparing a hydrothermal solution from calcium nitrate tetrahydrate, EDTA-2 Na, sodium dihydrogen phosphate dihydrate and strontium nitrate; and placing the well treated magnesium alloy matrix into the hydrothermal solution for hydrothermal reaction to obtain the strontium-containing hydroxyapatite coating, a biomimetic calcium phosphate coating, wrapping the magnesium alloy matrix. Compared with the prior art, as the hydrothermal method is adopted to prepare hydroxyapatite, not only is the degradation rate of the magnesium alloy in a human body effectively slowed down, but also the biocompatibility of the magnesium alloy is further improved. As strontium element is added into the hydroxyapatite coating, and as one of trace elements of the human body, strontium has the functions of promoting bone formation and inhibiting bone breakage, both the biological activity and the biocompatibility are improved.

The invention relates to a preparation method of an amino-terminated hyperbranched poly benzimidazole composite film, belonging to the technical field of composite thin films. The preparation method comprises the following two steps of compositing an amino-terminated hyperbranched poly benzimidazole thin film matrix, and precipitating hydroxyapatite, wherein the matrix is composited with a methodusing tetramine as an A2 monomer and benzene-1,3,5-tricarboxylic acid as a B3 monomer; and the hydroxyapatite is precipitated by combining alternative immersing and simulated body fluid immersing. The invention provides a method for preparing the composite thin film using an alkaline group as a matrix at normal temperature and pressure. The formed hydroxyapatite and polymeric matrix are in a sandwich structure. The hydroxyapatite can be properly fixed on the surface of the composite thin film so that not only the biocompatibility and the bone conductivity of the thin film can be improved but also the hydrophilicity of the thin film can be increased.

The invention relates to a surface treatment process of a bioactive metallic titanium implant having a multistage micro-pit structure, and the surface treatment process comprises the following steps: pretreatment, sandblasting treatment, acid etching treatment, sputtering treatment and glow discharge treatment; according to the surface treatment process, a multistage micro-pit three-dimensional structure having a bioactive tantalum coating is formed on the surface of the metallic titanium implant, so that the binding strength between the tantalum coating and the metallic titanium implant is very good, the tantalum coating is not easy to shed, shedding of the tantalum coating during or after an implantation process is avoided, the biological activity of the metal titanium implant can be improved, bone deposition of the surface of the metal titanium implant is accelerated, the tissue healing time is shortened, and through the formation of synostosis between the metal titanium implant and a surrounding bone tissue, the effect of improvement of the stability of the metal titanium implant can be achieved.

The invention discloses a medical titanium/magnesium composite material which comprises a porous skeleton, wherein the porous skeleton is prepared from medical-grade titanium wires or titanium alloy wires and prepared into a preset shape and a preset porosity by using a conventional winding or knitting machine, the porous skeleton is filled with three-dimensional through pores with different porosities capable of meeting various bone implantation requirements, then a medical magnesium or magnesium alloy melt is infiltrated in the pores of the porous skeleton by pressureless infiltration or negative-pressure suction casting, and after the porous skeleton is cooled, a medical titanium/magnesium composite material is formed. The composite material disclosed by the invention is reasonable in structure and excellent in mechanical properties; in the early stage of body implantation, the mechanical properties of the composite material can be matched with bones well, thereby avoiding stress shielding; after the composite material is implanted, with the degradation of magnesium, a porous structure of an implant is constantly restored, so that bone conduction is facilitated, and the requirements of most of bone filling, bone repair and bone transplantation applications can be met, therefore, the composite material is applicable to bone implanting operations with relatively high strength requirements.

The invention relates to a polylactic acid-hydroxyapatite whisker compound porous scaffold for bone tissue engineering and a preparation method thereof, and belongs to the field of biomedical material technique application. The compound porous scaffold is prepared from, by weight, 0.5%-50% of hydroxyapatite whiskers and 50%-99.5% of polylactic acid. The compound porous scaffold is prepared by adopting a solvent casting-vacuum volatilizing-particle leaching method, the technology is simple, operation is convenient, and the yield is stable; according to the prepared compound porous scaffold, the porosity is 45.8%-91.1%, the diameter of irregular straight-through holes is 50-600 micrometers, the compressive strength is 1.2-19.1 MPa, the cell toxicity is qualified, and the good clinical application prospect is achieved.

The invention relates to a bone matrix material containing various proteins secreted by umbilical cord mesenchymal stem cells and a preparation method thereof. The material is an animal bone matrix material with the umbilical cord mesenchymal stem cells inoculated on the surface of a decalcified bone matrix and used for secreting osteogenic induction function proteins to promote osteogenesis. The bone matrix material has natural structures and characteristics of bone tissues and a good osteogenic induction effect, has a better osteogenesis promoting effect in a bone defect repair process, and is helpful for large-scale preparation and clinical application of tissue-engineered bones.

The invention specifically relates to a nanometer bionic scaffold material and a preparation method thereof. The nanometer bionic scaffold material is assembled in synergy with a dimolecular template, wherein the dimolecular template comprises a protein and protein template, a protein and polyoses template, a polyoses and polyoses molecule template, a synthesis molecule and synthesis molecule template, a synthesis molecule template and a natural molecule template. The preparation method comprises the following steps: mixing one template with solution containing calcium ion; mixing the other template with solution containing phosphate radical ion; adding the solution containing phosphate radical ion into the solution containing calcium ion after evenly mixing the two plates; regulating thepH value of the mixed solution to be 7.4 and then transferring to the water at a constant temperature of 37 DEG C to obtain sediment, i.e, the nanometer bionic scaffold material. The bionic scaffold material not only has favorable biocompatibility and degradability, but also has bionic multi-layer assembling structure of highly-approximate natural scaffold, thereby being a bionic scaffold material in true sense and having wide application prospect in clinical scaffold repair.

The invention provides an interbody fusion cage for posterior lumbar spinal surgery and a preparation method thereof, and belongs to the application field of biomedical composite materials. The rectangular interbody fusion cage has side surface drainage through-holes, end surface chamfers, and triangle toothed structures on the upper and the bottom surfaces. The preparation method comprises the following steps of profiling the interbody fusion cage with carbon/carbon composite material as target, and preparing hydroxyapatite coating layers on the upper and the bottom surfaces of the interbody fusion cage sequentially by sandblasting pretreatment, plasma spraying, vacuum heat treatment and simulated body fluid immersion. The interbody fusion cage prepared by the inventive method has the advantages of novel material, advanced preparation method, reasonable structural design and good osteoconductivity function.