Method for preparing strontium-containing hydroxyapatite coating on surface of biodegradable magnesium alloy

Abstract

The invention relates to a method for preparing a strontium-containing hydroxyapatite coating on the surface of a biodegradable magnesium alloy. The method comprises the following steps: polishing a magnesium alloy matrix to remove a surface oxidation layer, and cleaning; preparing a hydrothermal solution from calcium nitrate tetrahydrate, EDTA-2 Na, sodium dihydrogen phosphate dihydrate and strontium nitrate; and placing the well treated magnesium alloy matrix into the hydrothermal solution for hydrothermal reaction to obtain the strontium-containing hydroxyapatite coating, a biomimetic calcium phosphate coating, wrapping the magnesium alloy matrix. Compared with the prior art, as the hydrothermal method is adopted to prepare hydroxyapatite, not only is the degradation rate of the magnesium alloy in a human body effectively slowed down, but also the biocompatibility of the magnesium alloy is further improved. As strontium element is added into the hydroxyapatite coating, and as one of trace elements of the human body, strontium has the functions of promoting bone formation and inhibiting bone breakage, both the biological activity and the biocompatibility are improved.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a method for preparing a strontium hydroxyapatite coating on the surface of a biodegradable magnesium alloy. Background technique [0002] In recent years, magnesium and its alloys have gradually become a research hotspot in the field of degradable biomaterials due to their excellent degradation properties, mechanical properties, and biocompatibility, and have attracted extensive attention from researchers at home and abroad. Compared with the existing bone repair materials, the elastic modulus of magnesium alloy is close to that of bone, and the stress shielding is small; it can be degraded in vivo, avoiding secondary surgery; the degradation products are non-cytotoxic, and magnesium ions can also induce osteogenesis, promote fracture healing, and Stimulates bone formation. These properties make magnesium and its alloys likely to be ideal bone repair materials....

AI Technical Summary

Problems solved by technology

[0003] However, magnesium alloys are used as bone implant scaffold materials, especially in terms of corrosion resistance, there are some key problems: as bone tissue engineering scaffold materials, the degradation speed of the implant material is required to match the speed of bone tissue repair and reconstruction

[0010] At present, many researchers have prepared nano strontium-doped hydroxyapatite powder, and also prepared hydroxyapatite on the surface of magnesium alloy by different methods, and added strontium (Sr) to the hydroxyapatite coating on the surface of magnesium alloy. There are very few of them, on the one hand, because many previous studies mainly focused on how to improve the corrosion resistance of the magnesium alloy material system to achieve the matching of the degradation rate of the material and the speed of bone tissue reconstruction; on the other hand, due to the existing Various methods, such as sol-gel method, electrochemical deposition, micro-arc oxidation method, magnetron sputtering, solution dipping, etc., are difficult to achieve a balance in terms of bonding strength, porosity and formability on complex surfaces.