297 results about "Bone implant" patented technology

A high-performance near-pure zinc alloy, a preparation method therefor and a use thereof, relating to the technical field of zinc alloys. The alloy component is that the content of Zn is greater than or equal to 99.5%, and the remaining trace alloy elements include at least two of the following 14 elements: Mg, Mn, Li, Cu, Ag, Ca, Sr, Fe, Zr, Ti, Al, C, Ga, and Si. The alloy has the yield strength ≥ 250 MPa, the tensile strength ≥ 320 MPa, the elongation ≥ 25%, the mechanical property change during one year of room-temperature storage ≤ 5%, the maximum bending force ≥ 2 kN, the stress corrosion sensitivity factor ≤ 15%, the size of corrosion pits after 60 days of immersion ≤ 15 μm, and the standard deviation of the size of corrosion pits ≤ 3 μm. The alloy is suitable for the preparation of biodegradable stents, bone implant devices, medical staplers or anastomotic nails for intestines, blood vessels or nerves, vascular clamps, guided bone or tissue regeneration membranes, heart valve protheses, dura mater repair membranes, soluble bridge plugs and fracturing balls for oil drilling, zinc alloy die castings, electroplated zinc materials, building zinc materials, battery-grade zinc, printing-grade zinc, and zinc-based brazing alloys.

A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and / or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and / or have bone ingrowth surface features that create a strong bond with the bone.

The invention provides a directional solidification preparation method of a degradable high-hardness zinc alloy material. The preparation method of the zinc alloy material comprises the machining processes of vacuum induction melting, vacuum directional solidification melting and the like, through the preparation method, growth of Zn + Mg2Zn11 trilobal eutectic and Zn + MgZn2 spiral eutectic is regulated and controlled, microscopic structures are arranged in the specific direction, fine and uniform structure morphology is formed, and the corrosion resistance and the mechanical property of the alloy are improved. The Zn-Mg series alloy prepared by the preparation method disclosed by the invention shows excellent microhardness (181.19 to 243.10 HV). Besides, the corrosion rate of the ideal degradable bone implant is within the range of 0.1 mm / y to 0.5 mm / y, and the corrosion rate of the degradable medical Zn-Mg alloy bone implant material is within the range of 0.0316 mm / y to 0.2280 mm / y, so that the requirement on the corrosion rate in the bone repair process is met; and after the Cu element is added on the basis of Zn-3% Mg, the microhardness of the Zn-3% Mg-Cu-Cu alloy material is improved to about 200HV, and the advantages in the aspect of mechanical support are improved.

The invention discloses a multifunctional coating capable of forming a long-term stable endogenous electric field to promote antibiosis, and a preparation method and application thereof, and belongs to the technical field of biological functional modification. According to the coating, through the elaborately designed Ta / Ag heterostructure, long-term stable generation of an endogenous electric field is achieved, the antibacterial performance is enhanced, osseointegration is promoted, and the problem of drug resistance is avoided; the coating does not need external electrical stimulation, so that the operation process is simplified, and the clinical application risk is reduced; due to the Ta material, the osseointegration capacity is improved, and Ag has broad-spectrum and efficient antibacterial performance. The TC4-Ta / Ag group has excellent charge storage capacity and a stable electric field, and the long-term osseointegration effect is remarkably improved; according to the preparation method of the coating, the coating which is stable in structure and not prone to falling off can be obtained, the long-term stable antibacterial performance is kept, the coating has wide application prospects in the field of titanium alloy bone implants, a new solution is provided for orthopedic surgery and implant treatment, and the treatment effect and life quality of patients are improved.

The invention discloses a method and a system for testing corrosion fatigue of a bone implantation device under a pathological condition, and relates to the technical field of orthopedic medical device evaluation, and the method comprises the following steps: constructing a dynamic load spectrum database covering physiological and pathological states; in-vitro reproduction of a dynamic mechanical environment borne by the bone implantation instrument in physiological and pathological states is completed through a multi-axis servo system; and acquiring service state data of the bone implantation instrument, and analyzing the service state data of the bone implantation instrument to obtain coupling experiment data. According to the invention, the defects of single load mode and environment simulation distortion in the traditional test method are overcome, high-fidelity simulation and comprehensive monitoring of the corrosion fatigue behavior of the bone implantation device under the pathological condition are realized, the consistency of the in-vitro test result and the in-vivo actual service performance is improved, and the application prospect is wide. And a scientific and unified evaluation basis is provided for material screening, structure optimization and service life evaluation of different types of bone implantation instruments.

Threaded bone implants, such as pedicle screws, are provided with an elongate body comprising a first portion, a second portion distal to the first portion, and a third portion distal to the second portion. The first, second and third portions may be provided with different features that correspond to first, second and third anatomical regions of interest in a vertebrae or other bone segment(s). The bone implants, systems, methods of manufacture, and methods of use disclosed herein may be used for the stabilization, fixation and / or fusion of the sacroiliac joint, the spine and or other bone segments.

The invention relates to the technical field of bone implant measuring devices, and discloses a device for measuring the push-out force of a bone implant, the device comprises a base, a bone sample and an implant sample, the upper surface of the base is fixedly connected with a plurality of supporting columns, the top ends of the supporting columns are jointly and fixedly connected with a detection table, and the detection table is fixedly connected with the bone sample. A first electric push rod is fixedly connected to the upper surface of the base, a measuring assembly is installed on the surface of the detection table, the driving end of a second electric push rod is fixedly connected with a force sensor, and the lower surface of a limiting plate is fixedly connected with the upper surface of the detection table. The height of the fixing layer can be adjusted through the first electric push rod, and when the height of the fixing layer changes, the fixing layer can be flexibly switched between an axial push-out test mode and a shear push-out test mode, so that the axial push-out test and the shear push-out test can be performed on the bone implant without carrying and repeatedly fixing a sample; the device improves the measurement efficiency and flexibility, is simple in structure, and is convenient to use.

The invention relates to the technical field of bone implants for minimally invasive surgery, and particularly discloses an implant for percutaneous minimally invasive thoracolumbar vertebral fracture, which comprises a vertebral body forming body, the vertebral body forming body comprises a vertebral body forming body head and a plurality of blade parts arranged at the rear end of the vertebral body forming body head in a surrounding manner, the vertebral body forming body head is provided with a needle guide hole penetrating along the axial direction, and the needle guide hole is communicated with the blade parts; a containing cavity is defined by the blade parts; the front end of the threaded guide rod and the head of the cone forming body are integrally formed, the needle guide hole penetrates through the threaded guide rod in the axial direction, and the rear end of the threaded guide rod extends out of the containing cavity; the pedicle screw is provided with a threaded hole penetrating in the axial direction, the threaded hole is in threaded connection with the threaded guide rod, the pedicle screw comprises a screw head and a threaded part arranged at the rear end of the screw head, and the screw head is arranged in the containing cavity and expands the blade part. According to the implant for the percutaneous minimally invasive thoracolumbar vertebral fracture, surgical wounds are reduced, the vertebral restoration effect is good, the stability of a vertebral formed body is guaranteed, and the surgical time can be saved.

The invention discloses a bionic heterogeneous composite structure bone implant and a preparation method thereof, and relates to the technical field of medical implants.The bionic heterogeneous composite structure bone implant comprises an inner-layer cross-shaped structure, a middle-layer negative Poisson's ratio structure and an outer-layer honeycomb structure, and the cross-shaped structure, the negative Poisson's ratio structure and the honeycomb structure jointly form a bionic composite structure; and immersing the bionic composite structure subjected to double-network crosslinking into a drug-containing solution for post-treatment and drug loading to obtain the bionic heterogeneous composite structure. According to the invention, bionic adaptation and intelligent optimization of mechanical properties are realized, and the stress shielding problem is solved; according to the invention, osseointegration and vascularization processes are obviously accelerated and enhanced, and leap-type improvement of biological activity is realized; a novel intelligent treatment mode based on in-vivo microenvironment response is developed, and on-demand and accurate drug delivery is achieved.

The invention provides a ZIF-8 gene-loaded hydrogel bone repair scaffold as well as a preparation method and application thereof, and belongs to the technical field of biomedical material manufacturing. The bone repair scaffold of the ZIF-8 gene-loaded hydrogel comprises a porous base material, hydrogel and ZIF-8 particles. The porous base material is a bone implant material; the hydrogel is sodium alginate hydrogel, the surface of the porous base material is coated with the hydrogel, and pores of the porous base material are filled with the hydrogel; the ZIF-8 particles are distributed in the hydrogel, the genes are loaded in the ZIF-8 particles, the genes are osteogenesis promoting genes, and the bone repair scaffold has multiple functions of resisting bacteria, promoting osseointegration, promoting osteogenesis and the like, so that the clinical application requirements of the bone repair scaffold are better met.

Bone implants and stabilizing rod coupling assemblies to secure a stabilizing rod relative to the bone implant. Bone implants may include a radially recessed collet receiving region that includes a proximal end with an undercut ledge configuration that is sized and configured to interface with and couple to a collet of a tulip assembly.

The invention of the gradient porous structured sacral prosthesis and the manufacturing process aims to create an alternative replacement for bone loss in patients who require bone replacement. The gradient porous structured sacral prosthesis consists of an artificial bone fragment, a metal rod, and a set of screws for fixing the fragments. The manufacturing process consists of seven steps: Identifying the position and boundaries of the bone, First-step topology optimization, Second-step topology optimization, Defining the structural pattern and unit cell size, Designing the artificial bone implant, Mechanical performance testing of the implant, and Fabrication of the sacral implant. The devices and processes according to the present invention are clearly sequenced and characterized. Modification or change in the manufacturing sequence or use may reduce the capabilities of the present invention or make it unusable for the purposes of the present invention.

The invention belongs to the technical field of biological materials, and discloses a PEEK bone implant material of a piezoelectric catalysis biological heterojunction and a preparation method of the PEEK bone implant material, the material comprises a PEEK bone implant loaded with the biological heterojunction, the biological heterojunction is composed of BiVOO and a chalcogenide calcium compound in a molar ratio of 1-3, and the chalcogenide calcium compound is calcium sulfide, calcium selenide or calcium telluride; during preparation, the BiVO / CaX biological heterojunction is firstly prepared by a hydrothermal method or an in-situ composite method, then PEEK is sequentially subjected to acetone, ethanol and deionized water cleaning, sulfuric acid ultrasonic treatment for 5-10 minutes and dopamine modification, the biological heterojunction is in contact with the modified PEEK at 4 DEG C for 12 hours to complete loading, and improvement means can be introduced into part of schemes. The material has the acoustic catalytic antibacterial function and the bone repair promoting function, the antibacterial effect can be regulated and controlled through ultrasound, the process is simple, and the reaction condition is mild; the multi-drug-resistant bacterial infection can be dealt with, and the heterojunction loading stability and the material cell compatibility are improved.

An implant system that includes an implant having a base portion, that has a body and at least a portion of which includes a lattice structure, and an upper portion configured to releasably couple with the base portion. The implant system includes at least one first fastener configured to be received and extend at least partially through at least one bore of the base portion, and at least one second fastener configured to be received within a cavity of the base portion. Also disclosed is an implant that includes a body that has various elements configured to facilitate arthrodesis of the subtalar joint and talonavicular joint. The body includes an upper surface that is configured to interface with the tibia of a patient, and a lower surface that is configured to interface with the subtalar joint and / or calcaneus of the patient.

A microcirculation reconstruction bone implant capable of generating internal stress comprises a support shell and a support inner core. The support inner core is sleeved with the support shell, and the support shell and the support inner core form a matched structure. The stent shell is located between the bone tissue and the stent inner core, and the stent shell generates elastic deformation to generate internal stress and applies the internal stress to the surrounding bone tissue when the stent is implanted and loaded; a microcirculation reconstruction passage is also loaded on the stent inner core; by adopting a mode that the stent inner core is matched with the stent shell, the stent inner core is matched with the stent shell to form an elastic effect, so that internal stress can be continuously applied to bone tissues in postoperative application to promote bone growth and integration; and a complex stress environment can be adaptively adjusted, so that the stress compatibility between the implant and a bone tissue is ensured, new intraosseous circulation is established, and the postoperative healing effect after the implant is applied is promoted.

The invention provides a testing device for evaluating the degradation behavior of a degradable bone fixing instrument under complex mechanical loading, and the device can simulate complex mechanical conditions and liquid environment after the degradable bone fixing instrument is implanted into a human body in vitro, and can load pressure and fluid impact force in 1-3 directions at the same time; the temperature can be regulated and controlled to realize degradation at a specific temperature, and a plurality of test samples and degradation liquid can be collected at the same time for characterization analysis due to the multi-flux design, so that the degradation condition of the degradable bone fixation instrument under the complex mechanical loading condition is evaluated. The mechanical loading device is easy and convenient to operate, low in cost, good in universality and expansibility and adjustable in parameter, and the simulation condition is closer to the in-vivo real condition. Compared with a traditional non-mechanical condition, the device can provide a new thought for in-vitro prediction in vivo and short-term prediction of degradation evaluation of the degradable bone implant, and finally facilitates promotion of marketing of the novel degradable bone implant.

The invention discloses a magnesium-titanium composite material with an interpenetrating phase structure for bone implantation, the magnesium-titanium composite material is formed by interpenetrating a reinforced phase made of a titanium alloy material and a matrix phase made of magnesium or a magnesium alloy material, and the reinforced phase and the matrix phase are respectively kept continuous in a three-dimensional space; a reinforcing phase and a matrix phase of the magnesium-titanium composite material have gradient structures in the radial direction; the invention further discloses a preparation method of the interpenetrating phase structure magnesium-titanium composite material for bone implantation. According to the magnesium-titanium composite material disclosed by the invention, the structure is designed into a structure in which the reinforcing phase and the matrix phase are three-dimensionally continuous and interspersed with each other and the two phases are in gradient in the radial direction, so that the magnesium-titanium composite material implant and healthy bone tissue at a bone defect part of a patient realize good biomechanical adaptation; the material is suitable for being used as a bone implant in the field of biomedical metal materials.

Bone implants, assemblies, and methods thereof. The implants may include non-threaded triangular implants configured to promote fixation and fusion of the sacroiliac joint. The implants may have a triangular body configured to prevent or minimize rotational motion of the implant. The implants may include an inner core or an outer shell, which provides structural support for a lattice structure. The structural geometry may be generated through topology optimization software, such as finite element analysis, based on anatomical loading conditions for the implant.

The invention relates to an antibacterial and antioxidant Ti-MXene bone implant material triggered by near-infrared light and a preparation method of the Ti-MXene bone implant material. The material is composed of a pure Ti substrate and a plurality of Ti3C2TX MXene coatings which are electrostatically self-adsorbed on the pure Ti substrate, and then is crosslinked and coated by gelatin. The multi-layer Ti3C2TX MXene is combined with the surface of a metal matrix, and has excellent biocompatibility and antibacterial and antioxidant effects. According to the coating, multiple layers of Ti < 3 > C < 2 > TX MXene are stripped from an MAX phase (Ti < 3 > Al < 2 >) through hydrochloric acid etching, then a Ti sheet is soaked in alkali liquor with dispersed MXene, and titanate and MXene are subjected to electrostatic self-bonding on the surface; and the combination is further enhanced through gelatin coating. The material can realize photo-thermal antibacterial ability under the irradiation of 808nm NIR with lower power, and has good antioxidant ability and osteoblast compatibility.

The invention discloses a bark crack bionic lattice structure design method based on a three-period minimal curved surface, a bark crack bionic lattice structure and a bone implantation stent. The bark crack bionic lattice structure design method comprises the following steps: S1, constructing a parent lattice structure by adopting a three-period minimal curved surface function; s2, crack characteristics are constructed in the matrix lattice structure through a bidirectional offset contour surface method, a bark crack bionic lattice structure is formed, and the crack size and the relative density are controlled through offset parameters; s3, the relative density of the bark crack bionic lattice structure is calculated through triple integration, and the volume fraction of the generated model is controlled; and S4, crystal orientation design and rotation angle design are conducted on the bark crack bionic lattice structure, so that the elastic modulus and mass transfer performance of the bark crack bionic lattice structure are regulated and controlled.

The invention discloses a bionic Voronoi-nickel titanium-hydrogel heterostructure implant and a preparation method thereof, and relates to the technical field of bone implantation, the construction of a Voronoi porous structure and the preparation of a bionic Voronoi-nickel titanium skeleton are completed through an innovative design method by referring to the structural concept of human bone trabecula, and then the bionic Voronoi-nickel titanium skeleton is used as a substrate to prepare the bionic Voronoi-nickel titanium hydrogel heterostructure implant. And preparing the bionic Voronoi-nickel titanium-hydrogel heterostructure implant by adopting a drying gel forming method. The implant integrates the mechanical advantages of high strength and low modulus of the nickel-titanium alloy and the structural characteristics of high connectivity and high specific surface area of the bionic Voronoi porous structure, the defect that hydrogel is weak in bearing is effectively overcome, meanwhile, the hydrogel has the buffering and energy absorbing effects, multifunctional time sequence delivery and release of antibiosis, anti-inflammation and bone regeneration promotion can be achieved, and the requirements of all stages of bone repair are met.

In some embodiments, a bone implant for percutaneous use is provided. The bone implant comprises a head, a body adjacent to the head and a tip opposite the head. At least the head, body or tip is configured to contact bone. An expandable member contacts at least one of the head, tip or body and is movable from an unexpanded configuration to an expanded configuration when deployed at a bone implant site. In some embodiments, a system for percutaneous bone harvesting is provided.

The invention provides a bifunctional polymer stabilized calcium phosphate precursor nano-material, a preparation method thereof and application of the bifunctional polymer stabilized calcium phosphate precursor nano-material in surface modification of a PPESK coating. The bifunctional polymer stabilized calcium phosphate precursor nano-material comprises the following components according to concentration: a bifunctional polymer with the concentration of 0.05-0.2 g / mL; the concentration of PO4 < 3-> is 0.05 to 0.5 mol / L; the concentration of Ca < 2 + > is 0.05-0.5 mol / L, and the solvent is deionized water; the diameter of the calcium phosphate precursor nano material is 20 to 100 nm. The preparation method comprises the following steps: preparing a polyacrylamide block polymer by adopting free radical polymerization, and then grafting a calcium chelating agent to obtain a bifunctional polymer; combining the difunctional polymer with a calcium-phosphorus solution to prepare a difunctional polymer stabilized calcium phosphate precursor nano material; according to the invention, the polymer is endowed with calcium chelating ability and collagenous fiber binding ability, so that the material can enter the collagenous fiber to be fully mineralized, the surface of the PPESK coating is mineralized, the biocompatibility of the material is improved, the material has osteogenesis promoting ability, and the material has a wide application prospect in the aspect of bone implant materials.

The present invention relates to a zirconia ceramic containing a glass phase, comprising 1.0-5.5 wt% of a YASZ glass phase and the balance a 3Y-TZP crystalline phase, wherein the YASZ glass phase is located between grains of the 3Y-TZP crystalline phase. The YASZ glass phase comprises 15-35 wt% Y2O3, 10-30 wt% Al2O3, 35-55 wt% SiO2, and 4-10 wt% ZrO2, and the dihedral angle formed between the YASZ glass phase and the 3Y-TZP crystalline phase is 62-85°. The present invention also relates to a bone implant prosthesis prepared from the zirconia ceramic containing the glass phase.

A bone insert includes a cap having a convex top surface, an elongated stem, and a barrier between the cap and the stem. The stem of the bone insert is inserted into a hole formed in a host bone until the barrier is pressed against the exposed bone. The bone implant can be placed against a small focus contact point on the cap. Liquid cement can be injected into a space volume between the host bone and a bone implant. The cap can be made of a material and / or have surface features that create a strong bond with the cement when the liquid cement cures. The stem can be made of a material and / or have bone ingrowth surface features that create a strong bond with the bone.

The invention discloses a spine intervertebral fusion implant positioning structure, which relates to the technical field of intervertebral fusion cage, and comprises a fusion cage upper moving part and a fusion cage lower moving part, which are mutually clamped, bone grafting holes for implanting bone blocks are formed in the fusion cage upper movable part and the fusion cage lower movable part in a penetrating manner; through the arrangement of the fusion cage upper moving part, the fusion cage lower moving part and the expandable connecting rods, stable support is formed between adjacent vertebral bodies, the correct height between the vertebral bodies is maintained, meanwhile, through the arrangement of the connecting rods, the connecting rods and the push rods, the situation that the interbody fusion cage is deformed in the process of bearing pressure between the adjacent vertebral bodies in the use process is avoided, and the use safety of the interbody fusion cage is improved. And through the arrangement of the helical tooth blocks and the clamping blocks, the fusion cage is prevented from being deformed due to the fact that the adjacent intervertebral pressure is too large in the using process.

The present application relates to the technical field of composite biological coating. Specifically, the present application relates to a hydrophobic composite layer on a medical degradable magnesium alloy substrate and a preparation method thereof. In the preparation method, firstly, a porous ceramic oxide layer is formed on the magnesium alloy substrate through micro-arc oxidation treatment, so as to reduce the corrosion rate of the magnesium alloy; then, a strontium-doped hydroxyapatite layer is prepared on the surface of the micro-arc oxidation layer using a chemical deposition method, so as to improve the biocompatibility of the magnesium alloy; finally, the magnesium alloy subjected to the micro-arc oxidation and chemical deposition treatment is immersed and pulled once or more times in a polylactic acid solution containing nano-hydroxyapatite, so as to form a hydrophobic polymer layer. The hydrophobic composite layer prepared by the present application improves the corrosion resistance and biocompatibility of the magnesium alloy at the same time. The present application also relates to a magnesium alloy implant product comprising the hydrophobic composite layer.

Disclosed herein are compositions and methods to create bone implants that are biocompatible and custom designed to implant in a bone lesion. The implant comprises a unique scaffolding customized to the bone lesion and combined with one or more specialized proresolving mediators (SPM). According to certain embodiments, the scaffolding matrix comprises an alloplastic material developed into a matrix and including one or more SPM including synthetic SPM and natural SPM wherein the SPM is released over time.

The present invention provides a proximal femoral cancellous bone harvesting and implanting device, belonging to the field of medical device technology. The device comprises a femoral head X and a cancellous bone harvesting region Y at the distal end of the femoral head. The device comprises an outer tube, the outer tube comprising a lower sleeve and an upper sleeve, a connecting mechanism being provided between the lower sleeve and the upper sleeve, the connecting mechanism enabling an adjustable angle between the lower sleeve and the upper sleeve, the central axis of the lower sleeve being arranged along the bone harvesting region Y toward the femoral head X, the lower sleeve being implanted into the femoral body to establish a bone harvesting and implanting channel, the lower sleeve, the upper sleeve, the inner tube, and the connecting mechanism being provided in the present invention cooperating with each other to achieve bone harvesting and implanting operations, eliminating the need to replace instruments during the bone harvesting and implanting processes, and facilitating operation. Specifically, the inner tube can be simultaneously passed through the upper sleeve and the socket member to reach the bone harvesting region Y for bone harvesting, or the inner tube can be simultaneously passed through the lower sleeve and the upper sleeve to reach the interior of the femoral head X for bone implanting.

Provided is a total talar replacement prosthesis that has a metallic body shell and a metallic or biologic core, where the metallic body shell includes one or both of a removable calcaneus attachment and a removable navicular attachment. The attachments, when removed, exposes a respective calcaneus-facing surface or a navicular-facing surface that can enhance fusion to the respective bones, calcaneus and / or navicular.