627 results about "Bones regeneration" patented technology

A method of stimulating bone regeneration in a discontinuous section of a long bone in a subject requiring same, comprising the step of applying to said discontinuous section of the bone an effective vacuum for an effective length of time. A device for carrying out the method consisting of a sealable tubular-shaped sleeve or cuff that fits snugly and sealably around the bone section to be treated and that can be evacuated via a port that is integral to the sleeve or port.

A system and method for the repair of damaged tissue and bones, congenitally missing tissue / cosmetic reconstruction of tissue is described. The system has a layered porous structure with a sufficiently large area of exposed pores to promote neo-vascularization as well as bone and tissue formation. The disclosed porous implant system can contain bioactive agents necessary for rapid tissue formation and keep ingrowth of unwanted tissue out of the implant surgical site. The implant can be reinforced with an additional, stronger polymer layer and / or may include an endoskeleton or exoskeleton for dimensional stability.

Systems for bone fracture repair are disclosed. One system includes a biocompatible putty that may be packed about a bone fracture to provide full loadbearing capabilities within days. The disclosed putties create an osteoconductive scaffold for bone regeneration and degrade over time to harmless 5 resorbable byproducts. Fixation devices for contacting an endosteal wall of an intramedullary (IM) canal of a fractured bone are also disclosed. One such fixation device includes a woven elongated structure fabricated from resorbable polymer filaments. The woven elongated structure has resilient properties that allow the woven 10 structure to be radially compressed and delivered to the IM canal using an insertion tube. When the insertion tube is removed, the woven structure expands towards its relaxed cross-sectional width to engage the endosteal wall. The woven elongated structure is impregnated with a resorbable polymer resin that cures in situ, or in the IM canal.

Disclosed are biomedical scaffolds that may be used, for example, for treatment of bone diseases and bone repair. Methods of preparing such scaffolds are also disclosed. These scaffolds permit nutrient and ion flow such that bone regeneration in the area surrounding the scaffold is promoted. Also disclosed are kits that include the scaffolds set forth herein.

A composition for modulating bone regeneration composition comprises a matrix selected from the group consisting of glycolic acid, lactic acid, collagen, demineralized bone, or a combination thereof. A first biologically active molecule comprising a fibronectin is attached to a portion of the matrix, to facilitate osteoblast activity and for promoting an increase in bone formation. A second biologically active molecule comprising a vitronectin, selected for its ability to attract osteoclasts and produce an inhibiting effect on osteoclast activity to thereby promote a decrease in bone resorption, is also attached to a portion of the matrix.

The present invention relates to new plasma or new platelet-rich plasma preparations, new cell dissociation methods, new cell associations or compositions, a method of preparation thereof, a use thereof, devices for the preparation thereof and preparations containing such a platelet-rich plasma preparation and cell associations or compositions. Specifically, the invention provides compositions comprising plasma or platelet-rich plasma alone or in combination with cell preparations for use in tissue regeneration and bone regeneration and pain reduction.

The invention discloses an injectable composite material capable of promoting bone regeneration and repair. The injectable composite material is prepared by mixing sodium alginate, chitosan, multiple trace element, calcium phosphate porous microsphere and bioactive glass nanometer granules, preparing the mixture by using deionized water and cell culture fluid, and compounding the prepared mixture. The injectable composite material comprises the following components in percentage by mass: 0.10 to 0.50 percent of sodium alginate, 0.01 to 0.20 percent of chitosan, 5 to 30 percent of multiple trace element codoped calcium phosphate porous microsphere, 0.05 to 0.50 percent of bioactive glass, 25 to 55 percent of cell culture fluid and 30 to 45 percent of deionized water. The preparation process is simple; the prepared injectable composite material has the characteristics of excellent injectability and quick degradation; and a hydrogel network can concentrate calcium, phosphorous ion and trace elements degraded and released by inorganic particles and can promote the migration, growth, multiplication and differentiation of bone cell, thereby having effects of quickly inducing bone regeneration and promoting bone repair on endosteal microdamage, fracture or bone defect.

Systems for bone fracture repair are disclosed. One system includes a biocompatible putty that may be packed about a bone fracture to provide full loadbearing capabilities within days. The disclosed putties create an osteoconductive scaffold for bone regeneration and degrade over time to harmless resorbable byproducts. Fixation devices for contacting an endosteal wall of an intramedullary (IM) canal of a fractured bone are also disclosed. One such fixation device includes a woven elongated structure fabricated from resorbable polymer filaments. The woven elongated structure has resilient properties that allow the woven structure to be radially compressed and delivered to the IM canal using an insertion tube. When the insertion tube is removed, the woven structure expands towards its relaxed cross-sectional width to engage the endosteal wall. The woven elongated structure is impregnated with a resorbable polymer resin that cures in situ, or in the IM canal.

The invention relates to a biologically degradable composite material and to a process for the preparation thereof. The biologically degradable composite material according to the invention is preferably a bone reconstruction material which can be used in the field of regenerative medicine, especially as a temporary bone defect filler for bone regeneration.

The invention discloses a porous calc silicate bioceramic material, a preparation method and application. The porous bioceramic material comprises the following components in an oxide form in percentage by weight: 44 to 52 percent of CaO, 47 to 54 percent of SiO2, 0 to 3.0 percent of B2O3, 0 to 3.4 percent of ZnO and 0.2 to 4.8 percent of MgO, wherein the content of B2O3 and ZnO is not simultaneously 0; the ratio of the content of MgO and the content sum of B2O3 and ZnO is 1:(0.2-5). The preparation method comprises the following steps: preparing boron, zinc and magnesium-containing calc silicate superfine powder by using a wet-chemical method and a sol-gel method, preparing a porous material of which the shape is consistent with that of a skeleton of each part of a human body and the pore passage size is 80 to 800[mu]m by using a three-dimensional printing technology, and performing high-temperature sintering treatment. The material can be applied to the bone defect repair and bone regeneration medicine of the department of orthopedics, department of stomatology, plastic surgery, maxillofacial surgery, thoracic surgery department or ophthalmology department.

A method of inducing biomineralization in a tissue, which method comprises administering to the tissue a source of Phosphophoryn (PP) in an amount sufficient to induce biomineralization; a method of treating tooth sensitivity or injured pulp tissue; a method of inducing differentiation of a cell into an osteogenic cell or odontogenic cell; a method of inducing bone or dentin regeneration; a method of inducing periodontal regeneration; a method of inducing differentiation of a cell into a cementoblast, osteoblast, or periodontal ligament cell; and a composition comprising a source of PP and a carrier.

The present invention provides gradient porous scaffolds for bone regeneration and osteochondral defect repair, methods for making such gradient porous scaffolds, and methods for using the gradient porous scaffolds.

Scaffolds made of composite materials and uses thereof in the field of biomedical engineering are disclosed, wherein the composite materials comprise bioactive microparticles that could induce the human bone tissue to regenerate. The scaffolds uses the combination of silicon, calcium, and phosphorus microparticles as bioactive substance that could actively induce the human osteoblasts to proliferate and differentiate, promote the formation and calcification of new bone. Furthermore, the scaffolds employs organic polymer as carrier, takes a three-dimensional structure and external anatomical shape, and exhibits several characteristics compatible with the regeneration of bones and the neogenesis of blood vessels, thereby it could be used safely, economically and effectively for repairing the defect of bone tissue as well as in orthopedic operation of human bone. The present invention also discloses the methods for preparing the scaffolds.

The invention discloses a biological active porous structure support suitable for bone regeneration and repair.The support comprises an inner support body and an outer support body.The inner support body is surrounded by the outer support body.The inner support body and the outer support body are both a porous support with a completely through internal channel structure.The outer support body has high porosity and high mechanical strength.The inner support body has degradation speed lower than that of the outer support body and has high mechanical strength.The support has good mechanical matching performance, biodegradability and bone tissue repair performance.The shape, the size and the aperture of the support are controllable.Material components and material distribution of the inner support body and the outer support body in the support are controllable.Meanwhile, the invention further provides a manufacturing method of the porous structure support.The method is simple, convenient to use and low in production cost, and the porous support capable of being customized according to bone defect repair and capable of being degraded stage by stage corresponding accordingly to requirements can be obtained.

The invention relates to the technical field of medical devices, in particular to a skull restoration body for inducing bone tissue regeneration and a preparation method thereof. The skull restorationbody has biological activity and comprises an inner inducing layer, a supporting layer and an outer inducing layer sequentially from the inside to the outside. The support layer is made of polyaryletherketone material which is equivalent to human bone strength, hardness and weight, and plays a supporting role. The inner inducing layer and the outer inducing layer are made of bioactive material, respectively arranged on the inner surface and the outer surface of the supporting layer, have good bioactivity and osteoinductivity, and can induce bone tissue regeneration. The support layer is provided with a plurality of mesh holes, and each mesh hole is filled with a bioactive material, which can promote the exchange of nutrients inside and outside the skull repair body, and is conducive to the growth of tissue. The preparation method of the skull prosthesis builds a digital model according to the skull data of the patient, so that the skull prosthesis and the skull defect part have high matching degree, and the operation difficulty is reduced.

The present invention relates to an electrospun chitosan scaffold. The scaffold mimics natural bone mechanical properties and structure through mineralization without hindering the biocompatibility for osteoblasts. The electrospun mineralized scaffold is useful in bone regeneration therapies.

A system and method for the repair of damaged tissue and bones, congenitally missing tissue / cosmetic reconstruction of tissue is described. The system has a layered porous structure with a sufficiently large area of exposed pores to promote neo-vascularization as well as bone and tissue formation. The disclosed porous implant system can contain bioactive agents necessary for rapid tissue formation and keep ingrowth of unwanted tissue out of the implant surgical site. The implant can be reinforced with an additional, stronger polymer layer and / or may include an endoskeleton or exoskeleton for dimensional stability.

An orthopaedic implant for filling voids in bones, and methods of using the same. The orthopaedic implant comprises an open porous metal component, having pores for promoting bone regeneration, and a resorbable bone growth promoting component which is resorbed into new bone. The orthopaedic implant and methods of the present disclosure provide structural support for the bone as well as osteoconductive and / or osteoinductive matrix for promoting bone re-growth within bone void. Advantageously, the orthopaedic implants and methods disclosed herein are useful in filling critically sized bone voids.

The present invention relates to a complex support body for regenerating bone-cartilage, a method for manufacturing thereof, and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient, and more particularly, to a complex support body for regenerating bone-cartilage, which comprises a bone regeneration layer consisting of a biodegradable polymer and a biocompatible ceramic, and a cartilage regeneration layer, which is coupled to the bone regeneration layer and in which cells that can be differentiated into cartilages cells are fixed; a method for manufacturing thereof; and a composition for treating bone and cartilage related diseases comprising the same as an active ingredient. The complex support body of the present invention for regenerating bone-cartilage is manufactured as a three-dimensional support body, which is similar to a living tissue, according to a bioplotting method, and exerts the effect of regeneration into a bone tissue and a cartilage tissue, respectively, depending on materials encountered in the environment where the complex support body for regenerating bone-cartilage is used.

The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillo facial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and / or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20% to a 95%, preferably between 40% and 90% in mass of monetite [Ca1-XMXHPO4, where 0≦x≦0.05, and where M can be a divalent metallic ion], and which in their final composition incorporate between 5% and 80%, preferably between 0% and 60%, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80% in total mass of bioactive silicon compounds chosen from calcium silicates and / or bioactive silica glasses and gels.

The present invention is directed to a moldable biomaterial comprising a particulate solid porous material and a biodegradable paste material. The paste material and the particulate solid porous material form a matrix usable for the replacement or augmentation of bone. In various embodiments the matrix has a high structural integrity, which does not immediately or shortly after implantation collapse into an amorphous non-porous mass, maintains its porosity after implantation, shows biphasic degradation after implantation and / or has a good resistance against being washed out when it is applied to a wet opened implant site. Active agents can be incorporated in the moldable biomaterial of the present invention, such as bone growth factors. Kits, implants, method of manufacturing as well as medicinal uses are also provided.

The invention discloses a preparation method of a natural-tissue-derived decellularized and decalcified bone material. According to the method, any bone tissue of a mammal is treated with a protease inhibitor-containing normal saline buffer, an organic solvent, Tirton X-containing PBS (phosphate buffer saline), SDS (sodium dodecyl sulfonate)-containing PBS, pancreatin-containing PBS, deoxyribonuclease-containing PBS, an EDTA (ethylene diamine tetraacetic acid) isotonic solution and ultrasonic waves, and the decellularized and decalcified bone material is obtained. Cancellous bones and cortical bones can be decellularized completely and simultaneously, the conditions are mild, damage to an ECM (extracellular matrix) is avoided, rapidness and stability are realized, and the obtained decellularized and decalcified bone material has the advantages of good biocompatibility, high plasticity, high biomechanical strength and the like and can be used for clinically repairing bone regeneration and repair disorder such as bone defects, nonunion and the like caused by various causes.

The present invention discloses one kind of bone repairing material capable of inducing bone regeneration and its preparation process. The bone defect repairing material is composition of calcined bone powder of different sizes and bioabsorbable polymer material, the calcined bone powder has sizes of 0.05-2.5 mm; while the bioabsorbable polymer material is collagen, polyester, chitosan, etc. The bone defect repairing material has the preparation process includes the steps of mixing bone powder and bioabsorbable polymer material in acetic acid or NaHCO2 solution, ultraviolet irradiation of the mixture and fumigating with ethylene oxide. The bone defect repairing material possesses obvious effect of inducing bone healing, high biocompatibility, certain hardness and strength and other advantages.

The present invention is comprised within tissue engineering and, specifically, within bone regeneration. The invention relates to a porous three-dimensional matrix of monetite which is biocompatible, has structured porosity and is predefined and reabsorbable, as well as to the method of synthesis capable of producing said material and the applications thereof. These matrices are a perfect base for cell colonization and proliferation, allowing the application thereof in tissue engineering and bone regeneration as a result of their advantageous properties of biocompatibility, reabsorption, osteoinduction, revascularization, etc.

The invention relates to composite materials based on polysilicic acid, said materials containing novel compositions which have improved material properties and can be in the form of dispersions, pastes, powders, granulated materials, layers or compact moulded bodies. The aim of the invention is to produce composite materials based on polysilicic acid with improved mechanical properties. To this end, the composite materials contain polysilicic acid, between 0.01 and 20 mass % of an organic polymer, more than 15 mass % of at least one calcium phosphate phase, and optionally a use-specific additive. The material produced according to the invention can be implanted or injected. The composition of the composite material with the resulting properties enables the composite material to be used for bone substitution and / or bone regeneration in both human medicine and animal medicine. The inventive material can also be used to heal wounds.

The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillofacial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and / or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20% to a 95%, preferably between 40% and 90% in mass of monetite [Ca1-XMXHPO4, where 0≦x≦0.05, and where M can be a divalent metallic ion], and which in their final composition incorporate between 5% and 80%, preferably between 0% and 60%, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80% in total mass of bioactive silicon compounds chosen from calcium silicates and / or bioactive silica glasses and gels.

Hydroxyapatite is treated by a combination of nitridation and the application of bone morphogenetic protein to improve the tissue compatibility and affinity of the hydroxyapatite, rendering the hydroxyapatite more useful as a material for biomedical implants.

The present invention provides a biocompatible membrane which has a configuration that conforms well to an affected part and can be used in fields such as dentistry, oral surgery, orthopedics, etc., by a compatible membrane production process in which a biocompatible material is subjected to a lamination forming process or a powder electrostatic coating process. Examples of lamination forming processes include (a) selective laser sintering, (b) powder adherence, (c) fused deposition molding, (d) laminated object manufacturing, and (e) optical molding. The biocompatible membrane is useful as, for example, a tissue regeneration membrane or a bone regeneration membrane for periodontal tissue, bone tissue, and like tissue regeneration treatment.