109results about "Tripeptide ingredients" patented technology

The present application provides a method for diagnosing and / or evaluating the presence or absence, severity or degree of the improvement of a retinal disease in a subject, which comprises determining and / or evaluating circulatory parameters, retinal function, retina morphology and / or visual relating quality of life (QOL).

The invention relates to a composition for the treatment of neuropathic pain, also chronic, nociplastic, and mixed. In particular, the composition of the invention comprises an association of active ingredients, i.e. N-acetyl-carnitine, citicoline, uridine monophosphate, N-acetyl cysteine, and L-glutathione, which has proved to be particularly effective in boosting anti-inflammatory action and therefore improving analgesic action in cases of neuropathic pain, also chronic, nociplastic, and mixed.

An injectable viscoelastic gel formulation suitable for use in intra-articular applications comprising at least one cellulose derivative, at least one sulfated glycosaminoglycan, at least one vitamin, at least one local anaesthetic and at least one antioxidant is provided.

This application relates to the technical fields of biomedicine and cosmetics, specifically disclosing a multi-target synergistic composition for preventing hair loss and promoting hair growth, and its preparation method. The composition includes co-delivery nanoliposomes of pyrrolidine diaminopyrimidine oxide and diaminopyrimidine oxide; caffeine; type 17 collagen peptide; ginsenosides; pea sprout extract; co-delivery nanoliposomes of melatonin; biotin; and adenosine. This multi-target synergistic composition for preventing hair loss and promoting hair growth increases the number of hair follicles and dermal thickness through multi-target synergistic effects such as promoting angiogenesis, stabilizing stem cell niches, activating growth-promoting signals, inhibiting regression signals, and providing antioxidant and nutritional enhancement. It is particularly effective than minoxidil in effectively downregulating the key hair follicle regression factor TGF-β1, and more effectively inhibits the miniaturization process of hair follicles.

The present invention is directed to a method of treating acute ischemic stroke in a human comprising administering one of more low doses of DC009, wherein the dose is about 0.01-0.075 mg / kg / dose. The low dose administration is safe and effective in treating acute ischemic stroke in a human subject.

This invention provides compounds and methods for regulating dmpk expression and treating diseases and conditions in which dmpk plays an active role. [Solution] A transcription modulator molecule is provided having a first end, a second end, and an oligomeric skeleton, wherein a) the first end includes a DNA-binding portion that can non-covalently bind to a nucleotide repeat sequence GAA, b) the second end includes a protein-binding portion that binds to a regulatory molecule that modulates the expression of a gene containing the nucleotide repeat sequence GAA, and c) the oligomeric skeleton includes a linker between the first end and the second end.

The present invention provides a composition and method for increasing muscle mass, preventing muscle atrophy, and promoting muscle growth. [Solution] In certain aspects, the disclosed composition comprises dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, the disclosed composition is administered to subjects in need to increase muscle mass, prevent muscle atrophy, and / or promote muscle growth.

The application belongs to the technical field of biological medicine and medical cosmetology, and particularly relates to a kind of composition for mitochondrial protection type cosmetology and skin repair based on hydrogel and application thereof, the composition comprises a mitochondrial protection system and a synergistic active ingredient, the mitochondrial protection system comprises a hydrogel and a mitochondrial protection solution, the hydrogel comprises a synthetic polymer, and the mitochondrial protection solution comprises 200-300 mM mannitol, 0.2-5 mM ATP and 0-5% w / v trehalose; the synergistic active ingredient comprises a mixture of one or more of 0.01-0.1% ascorbyl palmitate, 0.1-1 mM glutathione and 0.5-2% nicotinamide. The composition is applied to microneedle repair, ice needle patch preparation and mask preparation and other aspects; through microneedle repair, ice needle patch or mask and other forms, effective delivery of mitochondria is realized, all-round care and repair are provided for the skin, and the delivery capacity is improved.

There is provided a drug which exhibits preventive and therapeutic effects on virus infectious diseases by inhibiting virus-derived protease on the basis of various physiological activity actions of an active sulfur compound(s) which exists in living organisms.

The present invention is directed to a method of treating acute ischemic stroke in a human comprising administering one of more low doses of DC009, wherein the dose is about 0.01-0.075 mg / kg / dose. The low dose administration is safe and effective in treating acute ischemic stroke in a human subject.

This invention belongs to the field of biomedical materials and nanotechnology, specifically relating to the synthesis and application of a multifunctional mesoporous nanomaterial. The inventors synthesized a core-shell structured mesoporous nanoparticle using mesoporous silica nanoparticles and dopamine via emulsion epitaxy. The core of the core-shell structured mesoporous nanoparticle is S-nitrosoglutathione supported on mesoporous silica, and the outer shell is pentafluorophenyl chlorophyll supported on mesoporous polydopamine, forming MSN / G@mPDA / F nanoparticles. These nanoparticles rapidly increase in temperature to 45°C under 808 nm laser irradiation. o At temperatures above a certain temperature, S-nitrosoglutathione decomposes to produce nitric oxide. Further irradiation at 750 nm generates a large amount of reactive oxygen species, killing bacteria. This combination of photothermal and photodynamic therapy effectively inhibits bacterial growth. Therefore, this method exhibits excellent antibacterial effects and can play a role in the future treatment of bacterial infections.

Methods of treating, reducing, or preventing lung infections and / or lung inflammation include identifying a patient in need of treatment and administering a therapeutically or prophylactically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Treatment of cystic fibrosis lung infections, COPD lung infections, inflammation of the lungs in these patient populations, and lung scarring in these patient populations is also described.

Described herein is a composition and methods for treating, reducing the symptoms of, or prophylaxis of viral infections, and particularly SARS-CoV-2. The composition enhances delivery of oxygen to the tissues. Also described herein is a composition and methods for treating cancers, particularly, adenocarcinomas, infiltrating ductal adenocarcinoma, metastatic ductal adenocarcinoma, and neuroendocrine tumors. The composition inhibits the growth of tumor cells and promotes cytoreduction of tumors.

This invention provides an antibacterial hydrogel formulation for postoperative wound regeneration and its preparation method. The formulation comprises chitosan quaternary ammonium salt, collagen, an antibacterial complex solution, an angiogenesis and epidermal repair active carrier, a cross-linking agent, and a solvent. The antibacterial complex is a compound of antibacterial peptides obtained through fermentation of traditional Chinese medicine. Genipin or ethylene glycol diglycidyl ether is selected as the cross-linking agent. Vascular endothelial growth factor is encapsulated in liposomes, and epidermal growth factor is loaded into mesoporous silica microspheres to achieve sustained release of the active ingredients. The preparation process involves premixing the solution, dispersing the antibacterial complex, loading the active carrier, and ultrasound-assisted cross-linking to ensure uniform dispersion and stable cross-linking of all components. This hydrogel can significantly shorten wound healing time, increase angiogenesis density and epithelial coverage, and exhibits excellent antibacterial effects against Staphylococcus aureus and Escherichia coli, showing broad application prospects in the field of drug preparation for promoting postoperative wound repair.

This invention discloses an endogenous peptide from monkfish with antioxidant and anti-inflammatory activities, its preparation method, and its applications. The endogenous peptide from monkfish includes at least one of HPLK, PRK, VLPN, LGPQ, EVL, and LGYPPQ. The preparation method includes the following steps: monkfish is skinned, the flesh is minced, and then extracted with formic acid solution overnight. After homogenization, the supernatant is collected by centrifugation to obtain a supernatant of the fish meat sample. A Fe3O4@PDA magnetic material solution is added to the supernatant of the fish meat sample, and after shaking incubation and magnetic separation, the Fe3O4@PDA sample is collected. NaCl solution is added to elute the adsorbed endogenous peptides. The eluent is collected, dialyzed to remove salt, and freeze-dried to obtain the endogenous peptide from monkfish. The invention also provides applications of the above-mentioned endogenous peptide from monkfish in the preparation of antioxidants and anti-inflammatory reagents. The advantage is that it possesses antioxidant and anti-inflammatory activities.

This application discloses a precise active peptide of hemoglobin with the functions of replenishing qi and blood, improving microcirculation, and promoting vasodilation, as well as its preparation method and application, belonging to the field of hemoglobin peptide technology. The precise active peptide of hemoglobin contains at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII, or FPHFD. The prepared precise active peptide of hemoglobin exhibits multiple biological activities: it exerts a hypotensive effect by inhibiting ACE and vasoconstrictive substances; it promotes vasodilation by activating the PI3K / AKT / eNOS signaling pathway; and it has been shown to significantly improve microcirculation and replenish qi and blood in a zebrafish model. The preparation method has low equipment requirements, is simple and easy to operate, and is suitable for large-scale industrial production. This invention enriches the bioactive peptide library and is of great significance for promoting technological progress and industrial upgrading in the field of hemoglobin peptides.

This invention discloses a liver peptide composition for enhancing liver metabolism, belonging to the technical field of liver peptide compositions. It includes liver peptides with the amino acid sequence LLVF and LVF. When liver peptides LLVF and LVF with specific amino acid sequences are combined in a specific ratio, they can synergistically enhance alcohol metabolism, lipid metabolism, and detoxification capabilities. Furthermore, when combined with different pharmaceutically acceptable excipients, it can be adapted to various routes of administration and dosage forms, solving the problems of existing products such as single efficacy, limited dosage forms, and insufficient bioavailability.

This invention discloses a contraceptive antibacterial cream capable of killing HIV and sexually transmitted disease viruses, and its preparation method, belonging to the field of biopharmaceutical manufacturing technology. The contraceptive antibacterial cream comprises water, hydroxypropyl methylcellulose, benzalkonium chloride, lyophilized aloe vera gel powder, vitamin C, and functional excipients. The functional excipients are obtained by activating carboxymethyl chitosan, cross-linking it with spermine, and then coupling it with amino active molecules. The contraceptive antibacterial cream is prepared by dissolving hydroxypropyl methylcellulose in hot water to form a colloidal solution, cooling it, and then adding the remaining components and mixing thoroughly. Compared with existing technologies, the contraceptive antibacterial cream of this invention utilizes an antioxidant cycle to inhibit the oxidative degradation of benzalkonium chloride, improving product storage stability. Simultaneously, it synergistically scavenge free radicals, reducing vaginal mucosal irritation, achieving a balance of sterilization, protection, and stability while maintaining highly effective bactericidal capabilities.

Provided is a medical agent that exerts preventative and therapeutic effects against viral infections, by inhibiting proteases of viral origin on the basis of the effects of various physiological activities of an active sulfur compound present in vivo.

The application belongs to the technical field of new use of medicines, and particularly discloses an As(III)-containing compound Darinaparsin and application thereof, and the As(III)-containing compound Darinaparsin is applied to preparation of a medicine for treating inflammatory bowel disease. The As(III)-containing compound Darinaparsin and application thereof are used to solve the defects of low response rate and easy drug resistance of the existing medicines for treating inflammatory bowel disease, and provide a new use of the As(III)-containing compound Darinaparsin, which is used for treating inflammatory bowel disease, and provide a new treatment scheme with definite curative effect and clear mechanism.

Provided herein are methods of treating and / or managing cancer, comprising administering to a patient Compound A, or an enantiomer or mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. Additionally, provided herein are methods of treating and / or managing cancer, comprising administering to a patient Compound A, or an enantiomer or mixture of enantiomers thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, clathrate, or polymorph thereof, in combination with a second active agent selected from the group consisting of an anti-CD20 antibody, an HDAC inhibitor, a proteasome inhibitor, an anti-CD38 antibody, an anti-SLAMF7 antibody, a nuclear export inhibitor, a BCL-2 inhibitor, and an immune checkpoint inhibitor. Also provided herein are combination therapies for treating and / or managing cancer, further comprising dexamethasone as a third active agent.

The invention relates to application of sulfated glycogen synthase kinase-3 in prevention and treatment of liver insulin resistance. Specifically, the invention provides an application of a hyposulfated GSK-3beta inhibitor in preparation of a medicine, and the medicine is used for preventing or treating insulin resistance; the invention further discloses application of the GSK-3beta knockout reagent in preparation of a medicine. The medicine is used for preventing or treating insulin resistance.

The application discloses a kind of tripeptide compounds and its preparation method and its machine enhances the use of body immune function, the amino acid sequence of the compound is L-proline-L-threonine-L-tyrosine amide (L-Pro-L-Thr-L-Tyr-NH2), structural formula is, pharmacological experiment result shows, the compound can significantly promote macrophage activation of the application, dose-dependently enhance macrophage phagocytosis, up-regulate the secretion of TNF-alpha, IL-1 beta and NO, by synergistic control macrophage immune function activation innate immune response, with significant immune enhancing activity and new drug development potential.

A method of treating an aging-related disorder includes identifying a subject having an aging-related disorder and administering to the subject a therapeutically effective amount of a desialylated O-glycosylated glycoprotein, wherein the therapeutically effective amount is between 0.1 mg / kg and 500 mg / kg with respect to a body weight of the subject. Also disclosed are methods for producing the desialylated O-glycosylated glycoprotein using a clonal cell lacking sialyltransferase activity.

The present invention pertains to a cyclic(glycine-proline)-enriched peptide composition and the use thereof particularly for ameliorating neurological conditions or fibrosis. The present invention furthermore pertains to a method for obtaining a peptide composition enriched in cyclic(glycine-proline), the method comprising providing a collagen hydrolysate enriched in gly-pro-x tripeptides, and heat-treating the collagen hydrolysate to allow cyclization of at least part of the gly-pro-x tripeptides to cyclic(glycine-proline).

A method or use related to administering an anti-B7H3 antibody-drug conjugate in combination with other therapeutic agents selected from an anti-PD-L1 antibody or an antigen-binding fragment thereof or / and a chemotherapeutic drug for treating cancer, and a use of a pharmaceutical composition and a pharmaceutical kit of the combination for treating cancer.