1868results about "Tripeptide ingredients" patented technology

In various embodiments, the disclosure provides compositions, such as polypeptides, polynucleotides, gene editing systems, small molecules, vectors, or host cells, comprising and / or modulating the expression or activity of an immunomodulatory-related protein. In various embodiments, the disclosure also provides for the treatment of aging, senescence, fibrosis, metabolic diseases, cardiovascular diseases, endocrine-related disorders, genetic diseases, cancer, infections, immune diseases, and the like using agents comprising and / or modulating the expression or activity of an immunomodulatory-related protein. Methods of replacing an adaptation of therapy or combinations thereof with hormones, growth factors and / or proteins, as well as methods of identifying the agents.

The present application provides a method for diagnosing and / or evaluating the presence or absence, severity or degree of the improvement of a retinal disease in a subject, which comprises determining and / or evaluating circulatory parameters, retinal function, retina morphology and / or visual relating quality of life (QOL).

The invention provides a tripeptide for promoting bone growth, the tripeptide is VPF, the amino acid sequence of the tripeptide is Val-Pro-Phe, the molecular weight of the tripeptide is 361.44 Da, and the tripeptide belongs to the technical field of functional bioactive peptides. The tripeptide can be prepared from egg yolk protein through enzymolysis separation and purification, can also be obtained through chemical solid-phase synthesis, has a good effect of promoting bone growth, can remarkably improve the growth and proliferation level of osteoblasts in a body, promotes synthesis and secretion of bone matrixes, and has a good application prospect. Meanwhile, the secretion of insulin-like growth factors (IGF-1), transforming growth factors (TGF-beta1) and I-type procollagen amino-terminal peptide (PINP) in the body is efficiently promoted, and good market prospects are achieved.

The invention provides a preparation method of a mixed pilatory of active peptide and stem cell exosome, and belongs to the technical field of pilatory preparation. The preparation method comprises the following steps: extracting the stem cell exosome; extracting an active extract; preparing an exosome entrapped active extract; preparing the liposome loaded active peptide; preparing the liposome loaded active peptide modified by the gallic acid modified chitosan; and preparing the mixed hair restorer. The prepared mixed hair restorer can provide a suitable growth environment for hair follicles and promote hair growth, the synergistic effect of the active peptide and the exosome can provide abundant signal molecules and enhance the stimulation effect on hair follicle cells, and the active peptide and the exosome can promote angiogenesis and increase the blood flow volume of scalp, so that the hair follicle can be effectively promoted. More nutrition and oxygen are provided for hair follicles, and the growth of hair is effectively promoted.

Provided herein are compositions that are useful in healing wounds and / or treating inflammatory skin conditions comprising (a) a copper-containing peptide; (b) an antioxidant; and (c) a cyclic oligosaccharide-based polymer, where the copper-containing peptide and the antioxidant form a complex. Further provided herein are methods for healing wounds and / or treating inflammatory skin conditions using the compositions of the disclosure.

The invention relates to an anti-aging oligopeptide for beauty and skin care, the oligopeptide has an amino acid sequence as shown in (X1) (R or K or H) G (D or E) # (X2), X1 represents one amino acid of G, A, V, L, I and P or represents that no amino acid exists, # represents one amino acid selected from A, V, D, E, N and Q, and X2 represents G and P or represents that no amino acid exists. The oligopeptide is a functional fragment of XVII type collagen, can induce in-vivo collagen synthesis or simulate a protein regulation function, has the effects of promoting cell self-cleaning, helping to remove aged skin cells, reconstructing skin rhythm, maintaining a good skin structure, resisting initial aging, promoting skin repair and regeneration, reducing fine wrinkles and the like, and is mild in action, free of side effects and free of toxic and side effects. The product has no obvious adverse reaction on human body, and is a good beautifying and anti-aging product.

The invention relates to the technical field of biology, and discloses a stem cell exosome anti-hair loss and hair growth complex and a preparation method thereof.A hair growth agent is wrapped and loaded in adipose-derived mesenchymal stem cell exosome to form a drug-loaded stem cell exosome; the medicine-carrying stem cell exosome is loaded in cross-linked hydrogel composed of a gentisic acid-cyclodextrin complex and epsilon-polylysine modified hyaluronic acid to form the stem cell exosome anti-hair loss and hair growth complex, and the stem cell exosome anti-hair loss and hair growth complex is directly smeared and externally applied to the scalp surface and acts on the hair follicle infection part in a targeted mode, so that the hair loss prevention and hair growth promotion effect is achieved. The stem cell exosome anti-hair-loss and hair-growth-promoting compound can inhibit bacterial growth, relieve and treat hair follicle inflammation caused by bacterial infection and improve the scalp environment, so that under the condition that inflammation is effectively controlled, the drug-loaded stem cell exosome in the stem cell exosome anti-hair-loss and hair-growth-promoting compound is stably released, damaged hair follicle cells are repaired, hair regeneration is promoted, the exosome treatment effect is prolonged, and the anti-hair-loss and hair-growth-promoting effect is achieved. The purpose of treating alopecia is achieved.

The invention discloses application of an anti-CD20 antibody drug conjugate or a drug combination thereof in preparation of a drug for treating diffuse large B-cell lymphoma. The drug combination comprises the anti-CD20 antibody drug conjugate, gemcitabine and oxaliplatin, the anti-CD20 antibody drug conjugate or the drug combination therapy containing the anti-CD20 antibody drug conjugate has a better curative effect compared with the existing clinical second-line standard therapy.

The invention discloses a tripeptide LAF with uric acid reducing activity and application thereof, and belongs to the technical field of biological medicine. The amino acid sequence of the tripeptide LAF is Leu-Ala-Phe (Leu-Ala-Phe). The tripeptide LAF disclosed by the invention has uric acid reducing activity for the first time, and the generation of uric acid can be reduced by reducing the activity of xanthine oxidase in the liver; meanwhile, uric acid discharge is increased by reducing kidney uric acid reabsorption. The invention provides an active substance for reducing uric acid through multi-target action, and the active substance can be applied to preparation of medicines for preventing or treating hyperuricemia or preparation of foods for assisting in reducing the uric acid level, and has a good application prospect.

The present invention belongs to the field of biotechnology, and discloses an antimicrobial peptide and a preparation method and use thereof. The antimicrobial peptide of the present invention is a mixture of any one or more of the polypeptides of RcASScGAK, RcASScGAKS, TGMRcASScGAK, and TGMRcASScGAKS. The present invention also provides a method for preparing the antimicrobial peptide by heterologous co-expression of a whole enzyme and a substrate, as well as a purification process of the antimicrobial peptide, which can successfully obtain high-yield and high-purity antimicrobial peptides, the required reagents are low-priced, the operation steps are simple and easy, and it is suitable for large-scale cultivation and purification; the antimicrobial peptide prepared by the present invention has excellent antimicrobial activity, and provides a new choice for the development of antimicrobial and anti-infective drugs.

A method of treating or inhibiting a viral infection in a human subject, such as a SARS-CoV-2 infection, involves inhibiting in vivo the expression or activity of one or a combination of the subject's genes required for viral infection. Single genes or subsets of genes for inhibition of activity or expression are selected from certain identified genes. Methods of administration of certain known small molecules or other therapeutics which mimic loss of function of the identified genes are provided. Similar methods for conducting screens of host genes required for viral infection are shown.

The invention discloses a novel compound as well as a pharmaceutical composition and application thereof, the novel compound is represented by formula I or pharmaceutically acceptable salt, tautomer, isotope substitute or solvate, the definition of substituent groups is detailed in the specification, and the novel compound can prevent and / or treat thyroid hormone receptor related diseases. # imgabs0 #

The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

The invention discloses a wheat peptide with a hypoglycemic effect as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The invention provides a bioactive peptide LPQ or LPQF with a hypoglycemic effect, and animal model experiments prove that the bioactive peptide can effectively reduce the blood sugar level and improve related metabolic indexes, and has no obvious side effects. The invention also provides a wheat peptide rich in oligopeptide containing the peptide fragment LPQ, and animal model experiments prove that the wheat peptide has a remarkable effect in the aspect of reducing blood sugar. The invention provides a safe and effective alternative scheme for development of diabetes treatment drugs, and has good market prospects and application potential.

The invention discloses a yolk protein source tripeptide with a function of improving osteoporosis and application of the yolk protein source tripeptide, and belongs to the technical field of biological medicines. The tripeptide is a tripeptide APW of which the amino acid sequence is Ala-Pro-Trp. The peptide fragment can be obtained through artificial synthesis or directional enzymolysis of defatted yolk powder. Functional verification shows that the tripeptide APW and the egg yolk protein hydrolysate containing the peptide fragment have the function of improving the bone mineral density, and in a zebra fish osteoporosis model, when the egg yolk protein hydrolysate is 20 mu g / mL, the bone mineral density is improved by 58%; when the tripeptide APW is 0.5 mu g / mL, the bone mineral density is increased by 23.4%; in a rat osteoporosis model, the bone mineral density of thighbone is increased by 3.39% after 10 mg / kg. D of egg yolk protein enzymatic hydrolysate is eaten. Moreover, the food-borne bioactive peptide is high in biological safety, so that the tripeptide APW and a yolk protein enzymolysis product containing the peptide fragment can be applied to preparation of medicines for treating osteoporosis or health-care foods for improving bone mineral density, and the tripeptide APW has a good market prospect and application potential.

The disclosure relates to methods, compositions, and combinations for detoxification in a patient comprising performing therapeutic plasma exchange (TPE) on the patient. The disclosure also relates to methods, compositions, and combinations for removing toxins in a patient as a result of chronic exposure to the toxins, comprising performing one or more TPE sessions on the patient and administering an oral composition to the patient. The methods, compositions, and combinations of the disclosure may also be used to replenish biomarkers indicative of a healthy state of the body in order to improve immune system function or patient longevity, and / or reduce oxidative stress or inflammation. The methods, compositions, and combinations of the disclosure may also be used to reduce the level of atherosclerosis, improve cognitive function, prevent early cancer development, promote immune health, and / or treat health conditions or diseases such as autoimmune diseases, cancers, Alzheimer's disease, Parkinson's disease, chronic fatigue syndromes, or fibromyalgia. Additionally, the methods, compositions, and combinations of the disclosure may comprise an intravenous supplementation, wherein each TPE session is followed by administration to the patient of an IV composition. The disclosure further relates to oral compositions and IV compositions for use in the methods, compositions, and combinations of the disclosure.

The invention relates to the technical field of bioactive peptides, in particular to a novel multifunctional collagen-like tripeptide and application thereof, an amino acid sequence contains multiple combinations, X can be selected from multiple components, 3-methoxy-4-hydroxyphenylalanine and the like are added, and the novel multifunctional collagen-like tripeptide can interact with specific proteins, activate related pathways and play multiple physiological functions and is applied to multiple fields. The collagen-like tripeptide has obvious advantages, innovates component expansion functions, improves the preparation method, improves the efficiency, reduces the cost, is matched with other components in the fields of beauty, health care and medicine, enhances the efficacy, realizes targeted delivery, and brings a new opportunity to related industries.

The invention discloses a medicinal and edible anti-alcoholism composition and a preparation method thereof, and relates to the crossing field of biotechnology and food and medicine, the composition comprises the following components: dried orange peel powder, vitamin C, glutathione, phellinus igniarius extract, polygonatum sibiricum extract, oriental wormwood extract, isatis root extract, schisandra chinensis extract, ginseng powder, lucid ganoderma extract and licorice extract. Silymarin, puerarin, white tomato powder, watermelon powder, fucoidin, tomato powder, mung bean powder, celery powder, turmeric powder, hawthorn fruit powder, honey powder, corn peptide, soybean peptide powder, xanthan gum and stevioside are added. The composition provided by the invention has the effect of increasing the content of ethanol dehydrogenase and acetaldehyde dehydrogenase in blood after drinking, and has the capability of promoting alcohol metabolism.

The invention relates to application of a combination of an anti-B7H3 antibody-drug conjugate and selulimab in preparation of a drug for treating cancer. The invention also relates to application of a pharmaceutical composition and a pharmaceutical kit comprising the combination in treatment of cancer.

The invention provides an NSD protein degradation agent and application thereof, and particularly provides a compound with a structure as shown in a formula (I) or pharmaceutically acceptable salt thereof, or a stereoisomer or a prodrug molecule thereof. The compound can degrade proteins such as NSD2, NSD1, NSD3, c-MYC, KLK3 / PSA, AR, NKX3.1, GSPT1 and the like in a targeted ubiquitination manner, so that the compound can be used for treating indications related to abnormal expression of the proteins such as NSD2, NSD1, NSD3, c-MYC, KLK3 / PSA, AR, NKX3.1, GSPT1 and the like. # imgabs0 #

A method of providing a slow, controlled or sustained release of a compound of interest such as biomolecules or drugs is provided. The method involves incubating the compound of interest with mercerized decellularized cellulose particles for a predetermined amount of incubation time to allow the mercerized decellularized cellulose particles to absorb the compound of interest. Thereafter, the method involves adjusting a physical or chemical property of the decellularized particles to trigger, alter, enable or affect the slow, controlled or sustained release of the compound of interest. Mercerized decellularized particles and formulations for slow, controlled or sustained release of compounds of interest are also provided.

The invention provides a whey protein deep hydrolysate with low sensitization and an allergy relieving effect as well as a preparation method and application of the whey protein deep hydrolysate. According to the method, the alkaline protease, the neutral protease and the glutamyltransferase are sequentially used for carrying out first enzymolysis, second enzymolysis and third enzymolysis on the whey protein raw material, and the whey protein hydrolysate which is low in molecular weight, good in taste, good in digestion and absorption performance, low in sensitization and capable of effectively relieving allergic reaction of the organism is obtained.

A group of polypeptides, which can be used as a tyrosinase inhibitor. The polypeptides have the effects of inhibiting tyrosinase activity, reducing melanin secretion, resisting oxidation, skin-whitening, spot-removing, etc. The polypeptides can be widely used in antioxidant drugs and in the preparation of skin-whitening cosmetics for resisting melanogenesis and lightening spots as a new raw material, and has good application scenarios.

The invention relates to the technical field of biology, in particular to an ACE inhibitory peptide, a preparation method and application, the ACE inhibitory peptide has the amino acid sequence of Trp-Pro-Phe (WPF) or Phe-Pro-Trp (FPW) or Phe-Gly-Trp (FGW) or Leu-Pro-Val-Pro-Ala-Phe-Asn (LPVPAFN) or Leu-Trp-Trp-Leu (LWWL), the ACE inhibitory peptide WPF, FPW, FGW, LPVPAFN and LWWL have outstanding antihypertensive activity, the IC50 values of the WPF, FPW, FGW, LPVPAFN and LWWL are 0.264 mg / mL, 0.800 mg / mL, 0.106 mg A variety of aquatic product peptide powder sources are separated and purified by an affinity ultrafiltration screening method, an ultrafiltrate component is selected for amino acid sequence identification, and a new amino acid sequence with ACE inhibitory activity is screened out; the ACE inhibitory peptides WFP, FPW, FGW, LPVPAFN and LWWL prepared by the invention have outstanding antihypertensive activity.

The invention relates to the technical field of biological products, and discloses a mesenchymal stem cell hair growth liquid and a preparation method thereof, and the mesenchymal stem cell hair growth liquid comprises the following components: hair follicle mesenchymal stem cells; a hair follicle mesenchymal stem cell exosome; growth factors: a vascular endothelial growth factor (VEGF), a fibroblast growth factor (FGFs), a keratinocyte growth factor (KGF-7) and interleukin-10 (IL-10); vitamins: vitamin E, vitamin B5, vitamin B2, vitamin B6, vitamin C and biotin; the plant extracts comprise a cacumen biotae extract, a polygonum multiflorum extract, a ginseng extract, a peppermint extract, a purslane extract and a rhodiola rosea extract; other active ingredients: tripeptide and digoxin; the auxiliary material is a hyaluronic acid-collagen peptide graft copolymer; and the balance of a phosphate buffer solution.

The invention discloses a fish by-product active peptide, a preparation and application, and belongs to the technical field of biological active peptides. The amino acid sequences of the fish by-product active peptide are shown as SEQ ID NO: 1 to SEQ ID NO: 3. Both the single peptide fragment and the compound peptide fragment of the fish by-product active peptide can obviously inhibit NO secretion of a lipopolysaccharide (LPS)-induced macrophage (RAW264.7) inflammation model, so that the fish by-product active peptide has a relatively good application prospect in preparation of a product with an anti-inflammatory effect; and a foundation is laid for high-added-value utilization of salmon byproducts and promotion of research, development and application of functional active peptides.

The invention relates to the technical field of foods and medicines, and discloses a composition of medicinal and edible food extracts for treating insomnia, which comprises the following components in percentage by weight: 8.92%-9.9% of gamma-aminobutyric acid (GABA), 2.97%-3.96% of phosphatidylserine, 29.7%-39.64% of spina date seed extract, 29.7%-39.64% of poria cocos extract, 0.59%-0.79% of tea leaf theanine extract and 5.95%-6.94% of fish collagen peptide. The mask comprises the following components in percentage by weight: 5.95%-6.94% of honey, 0.59%-0.79% of collagen tripeptide, 0.59%-0.79% of sodium hyaluronate, 0.59%-0.79% of rice bran oil powder, 0.59%-0.79% of haematococcus pluvialis, 0.59%-0.79% of acerola cherry extract, 0.01% of nicotinamide and 0.59%-0.79% of grape seed extract. The composition for treating insomnia based on the concept of homology of medicine and food not only overcomes the limitation of the existing therapy, but also has higher safety, wide adaptability and good user acceptability, and has positive significance for improving the life quality of insomnia people, improving the overall health level and improving the skin elasticity and luster.

The invention relates to the field of polypeptides, in particular to a red camellia polypeptide as well as a preparation method and application thereof. Red camellia is used as a raw material, high-pressure homogenization wall breaking and pepsase enzymolysis are performed, and separation and purification are performed to obtain the red camellia polypeptide with repairing, moisturizing, oxidation resisting and nourishing functions. The polypeptide prepared by the invention is more efficient, safer and more environment-friendly, and has a wide application prospect in the fields of cosmetics, functional foods and biological medicines.

The submicron sized particle is substantially spherical, comprising an oily core containing the peptide active and a wax shell that is solid at room temperature The particle is stabilized by an outer layer of a high-HLB non-ionic surfactant. The invention provides a method for obtaining an aqueous suspension of said particles with a satisfactory degree of encapsulation and improved long-term stability, for use in particular in the cosmetics industry. Peptide active associations can be considered, incorporated into the particles and adsorbed on the outside of the particles.

Described herein are compositions and methods comprising high molecular weight hyaluronic acid (high MW HA). In some embodiments, the high MW HA is formulated in combination with one or more peptides. In some embodiments, the peptide comprises an octapeptide having amino acid sequences characteristic of those found in collagen and / or elastin.