14 results about "Local anaesthetic" patented technology

This invention belongs to the field of biomedical materials technology, and particularly relates to an analgesic microneedle patch, its preparation method, and its application. The analgesic microneedle patch of this invention uses extracted mesenchymal stem cell exosomes and ginger exosomes as analgesic active substances, and by combining them with microneedle patch technology, it provides a new technical approach for surface anesthesia. The analgesic microneedle patch of this invention combines microneedle technology and photopolymerization 3D printing technology to develop a customizable hydrogel microneedle patch, achieving minimally invasive and precise percutaneous delivery of local anesthetics, providing a new technical approach for surface anesthesia.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The application relates to the technical field of tracheal catheters, and discloses a medical tracheal catheter with double coatings of local anesthetic and antibacterial drugs, which comprises a catheter main body and a cuff main body connected to the outer wall of the catheter main body, the catheter main body comprises a catheter base material layer, a first transition bonding layer, a first nano local anesthetic coating and a first antibacterial coating; the cuff main body comprises a cuff base material layer, a second transition bonding layer, a second nano local anesthetic coating and a second antibacterial coating; a tracheal tube is mounted on the catheter main body; and a head tube is connected to the bottom end of the catheter main body. The first nano local anesthetic coating, the first antibacterial coating, the second nano local anesthetic coating and the second antibacterial coating are arranged, so that the catheter main body and the cuff main body can realize a synergistic protection mechanism of analgesia and antibiosis; during the process of leaving the catheter, the local anesthetic drug acts on the mucosa of the tracheal wall through slow release, and the antibacterial component effectively reduces bacterial adhesion and biofilm formation.

The utility model discloses a disposable visual laryngoscope capable of preventing fog and realizing surface anesthesia, which comprises a visual display screen, a laryngoscope handle, a laryngoscope lens and an injector, the visual display screen is arranged at one end of the laryngoscope handle, the laryngoscope lens is arranged at the other end of the laryngoscope handle, a camera is arranged at the front end of the laryngoscope lens, and the camera is connected with the visual display screen through a cable. The injector is detachably arranged on the laryngoscope handle and connected with one end of the spray pipe, the other end of the spray pipe extends into the laryngoscope blade from the rear end of the laryngoscope blade and extends out of the front end of the laryngoscope blade, the atomization nozzle is arranged at the front end of the spray pipe and supported and fixed through an adjusting support arranged in the laryngoscope blade, and the fixing plate is arranged on the side wall of the laryngoscope handle. A positioning plate is arranged at one end of the fixing plate, a positioning hole is formed in the positioning plate, and the positioning plate is fixedly connected with a laryngoscope handle through a positioning screw arranged in the positioning hole. The laryngoscope can effectively infiltrate local anesthesia medicine on the throat, and the visual laryngoscope cannot fog when entering the oropharynx.

This invention relates to the field of fluorescent carbon nanomaterials, specifically to highly efficient water-soluble carbon dots for loading local anesthetic drugs, their preparation method, and applications. Using water-soluble amino acids and carboxylic acid compounds that readily aggregate and carbonize to form six-membered rings as precursors, the precursors are sonicated to dissolve them in an organic solvent to form a homogeneous solution. This solution is then transferred to a reaction vessel and subjected to a solvothermal reaction at 180-240°C for 4-10 hours. The reaction vessel is then allowed to cool naturally to room temperature, directly obtaining a carbon dot solution. The obtained carbon dot solution is filtered, eluted, and dried to obtain a solid carbon dot powder. The functionalized carbon dots prepared by this invention possess both good water solubility and high efficiency in loading local anesthetic drugs, showing broad application prospects in the field of sustained-release analgesia of local anesthetic drug formulations.

The invention discloses a preparation method of an amide local anesthetic key intermediate, which comprises the step of carrying out hydrogenation reaction on N-(2, 6-dimethylphenyl) pyridine-2-formamide and hydrogen in a continuous flow fixed bed reactor to generate N-(2, 6-dimethylphenyl) piperidine-2-formamide. The method has the beneficial effects that the danger of a kettle type hydrogenation process is avoided, the process is stable, the operation is simple, the raw material conversion is complete, alkylation impurities are extremely few, excessive hydrogenation impurities are avoided, the atom economy is higher, and the method is greener and more efficient; the HPLC purity of N-(2, 6-dimethylphenyl) piperidine-2-formamide obtained through the hydrogenation process is larger than 99.5%, alkylation impurities are smaller than 0.2%, excessive hydrogenation impurities are smaller than 0.1%, next-step reaction can be directly carried out without purification, the preparation yield can be greatly improved, and the method is especially suitable for industrial production and has the cost competitive advantage.

The invention relates to a local anesthesia dosage control system based on CFD (Computational Fluid Dynamics) and PC-MRI (Personal Computer-Magnetic Resonance Imaging) coupling and a working method thereof, and the system comprises an information collection unit which is used for collecting physical examination and medical evaluation information of a patient; the geometric unit is used for acquiring a T2 weighted MRI image sequence; the calculation model unit is used for determining the range of a lumbar, thoracic and vertebral segment calculation domain; a measurement unit for phase encoding using PC-MRI; the cerebrospinal fluid dynamic unit is used for acquiring an initial flow field of cerebrospinal fluid flow of the spinal canal of the patient; the dosage selection unit is used for selecting the injection dosage of the local anesthetic; the intrathecal administration calculation unit is used for establishing coupling analysis to obtain a local anesthetic concentration value of a blocking plane; and the dose evaluation unit is used for quantitatively evaluating the concentration value of the local anesthetic. The system is beneficial for improving the accuracy and safety of local anesthesia medication.

This invention relates to the field of needle-free injector technology, and in particular to an apparatus and method for needle-free injection of local anesthetics into the dermis for infiltration anesthesia. The apparatus includes a receiving space for containing the anesthetic solution; the injection pressure is 14-21 MPa. This invention allows for the design of different needle-free injectors to address the physiological differences in the dermis between men and women, ensuring precise intradermal injection of the anesthetic solution and avoiding entry into the muscle layer. Furthermore, it results in less pain during injection and a longer duration of effect from the onset and exhaustion of the local anesthetic.

The utility model discloses a chest drainage tube capable of assisting in analgesia, and relates to the technical field of drainage tubes, the chest drainage tube comprises an analgesia pipeline and a drainage pipeline, the drainage pipeline is arranged in the analgesia pipeline, analgesia micropores are formed in the tube wall of the other end of the analgesia pipeline in the circumferential direction of the analgesia pipeline, and the drainage pipeline is connected with the analgesia pipeline. And the other end of the drainage pipeline is annularly sleeved with a supporting rib for supporting the analgesia micropore. According to the thoracic cavity drainage tube, the drainage pipeline can be connected with a conventional drainage bag or a drainage bottle to execute drainage work under the internal support of the supporting ribs based on the internal and external integrated combination of the analgesia pipeline and the drainage pipeline, meanwhile, the analgesia pipeline can be connected with a self-control analgesia pump, and the pipeline part from the skin to the thoracic cavity is provided with a large number of analgesia micropores; local anesthetic can be continuously pumped through the self-control analgesia pump, the local anesthetic can flow out of the analgesia micropores on the contact surfaces of subcutaneous, ribs and pleura, the local anesthetic effect is generated locally, and the drainage and analgesia dual-synchronization effect is achieved.

The invention relates to the technical field of medical instruments, in particular to a local anesthetic airway spraying device which comprises a shell, a built-in cavity formed in the inner wall of the shell, a liquid medicine bin arranged on the inner wall of the built-in cavity, a liquid supply device arranged at the end of the liquid medicine bin and a battery. The liquid supply device is of a swash plate type piston conveying structure, speed and quantity control and accurate quantitative conveying of liquid medicine are achieved through control over the rotating speed and start and stop of a driving motor, dosage misalignment caused by liquid medicine backflow and liquid suction idling is eradicated, and the poisoning risk caused by excessive administration of local anesthetics is reduced. High-pressure drive conveying of liquid medicine is achieved through the liquid supply device, the liquid medicine is primarily atomized through the atomizing piece, and then the liquid medicine enters the mixing cavity with the air inlet to be secondarily atomized to form fine spray. A heating structure is arranged in the liquid medicine bin to realize constant-temperature control of liquid medicine; a wide-angle spray head or an auxiliary catheter with a spray head is integrally formed at the end of the diffusion tube, the auxiliary catheter has plasticity and rigid supporting performance, the tip end of the auxiliary catheter is designed to be spherical, a micropore mist outlet structure is adopted, the auxiliary catheter can be matched with a bronchofiberscope-free scene, and accurate dosing of a target area at the far end of an airway is achieved.

The invention discloses an abdominal wall local anesthetic diffusion visual analysis system based on infrared temperature image features, and relates to the technical field of medical monitoring. The thermal imaging acquisition and processing module is used for performing sequence scanning at preset time points set before and after retardation operation to obtain original temperature image data; the target region feature extraction module is used for determining a target analysis region according to the retardation type and determining feature parameters according to the temperature data of the target analysis region; and the effect prediction and evaluation module takes the characteristic parameter set as the input of a time sequence prediction model, and outputs and obtains the corresponding predicted low-temperature area and predicted retardation effect level. Through the infrared thermal imaging technology, the temperature change caused by diffusion of the local anesthetic in the abdominal wall tissue after injection can be continuously captured in a non-contact and non-radiation mode, so that the two-dimensional diffusion profile and the dynamic migration process of the local anesthetic can be visually presented in real time, and then corresponding visual information can be provided.

The invention belongs to the field of pharmaceutics, and particularly relates to a depot type local anesthetic sustained-release composition as well as a preparation method and application thereof, and the depot type local anesthetic sustained-release composition comprises the following components: a, active pharmaceutical ingredients; b, a slow-release carrier material; c. A phospholipid; d. A pharmaceutically acceptable oil; and e. A pharmaceutically acceptable solvent, the new composition not only can maintain the long-acting slow-release effect of the preparation composition, but also accelerates the corrosion absorption of the preparation composition in the body, on one hand, promotes the complete release of the medicine, on the other hand, accelerates the absorption of the preparation, obviously improves the medication safety and bioavailability, and has the advantages of good slow-release effect, good physical and chemical stability and no toxic or side effect. An in-vivo animal experiment shows that no inflammatory reaction occurs at the administration part, the safety is good, and a wide clinical application prospect is achieved.

The present application relates to the technical field of catheter, and discloses a kind of comfortable dual-function medical catheter with nano coating antibacterial, including tube body, the tube head is connected to the top of the tube body, the water bag is connected to the outer wall of the top of the tube body, and the segment below water bag of the tube body is set as local anesthesia section;The outer wall of the local anesthesia section is covered with nano local anesthetic coating, and the outer wall of the tube body and nano local anesthetic coating is covered with antibacterial coating.The setting of nano local anesthetic coating and antibacterial coating makes the nano local anesthetic coating release the drug by slow-release principle and pass through the antibacterial coating, finally contacts with urethral mucosa, and then plays the effect of local anesthesia, avoids the friction irritation and pain in the process of intubation, indwelling and removal, and the antibacterial coating covers the outer side of the tube body and nano local anesthetic coating, forming a comprehensive infection protection barrier.

The utility model relates to the technical field of medical auxiliary instrument especially is a nerve block needle single person injection administration auxiliary device, its with nerve block needle connection is connected to medicine discharge structure, under the ultrasonic probe, the nerve block needle is pricked into the designated position, then through the piston structure carries out the back -and -forth drawing, detects whether there is blood, after confirming that there is no blood, through the piston structure absorbs the local anaesthetic in the storage structure, and through the medicine discharge structure is arranged into the patient's body with local anaesthetic, thereby improving the practicality of nerve block needle single person injection administration auxiliary device, including storage structure, still including piston structure and medicine discharge structure, and the storage structure and medicine discharge structure all install on the piston structure, the storage structure carries out the storage to local anaesthetic, and the piston structure cooperates medicine discharge structure and carries out back -and -forth drawing detection and local anaesthetic injection.