94 results about "Local anaesthetic" patented technology

The invention comprises a disposable hypodermic syringe with means for passive aspiration. The syringe comprises a barrel (10) of clear synthetic plastics material and a plunger (12) comprising an elastic bung (28) slideable in the barrel (10). Pressure on the plunger elastically deforms the bung (28). If this pressure is released the bung (28) resiles to effect aspiration. This aspiration is passive, requiring no active withdrawal of the plunger by the user. After use the syringe may be disposed of as a whole, with no disassembly, using one hand only. The syringe may be made by adapting cartridges conventionally used for dental local anaesthetic.

Compositions useful for treating inflammatory diseases including arthritis are disclosed which comprise cetyl myristoleate compounds or related compounds and at least one compound useful for treatment of inflammatory disease, such as tetracycline compounds, Cox-2 inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, local anaesthetics, chelating agents, matrix metalloprotease inhibitors, inhibitors of inflammatory cytokines, glucosamine, chondroitin sulfate and collagen hydrolysate. Also disclosed are pharmaceutical compositions and methods of treatment for inflammatory disease and local inflammation and dermal irritation. Also disclosed are compositions including tetracycline and at least one compound useful for treatment of inflammatory disease.

PCT No. PCT/SE97/00566 Sec. 371 Date Aug. 6, 1997 Sec. 102(e) Date Aug. 6, 1997 PCT Filed Apr. 1, 1997 PCT Pub. No. WO97/38675 PCT Pub. Date Oct. 23, 1997The invention is directed to a novel pharmaceutical composition comprising one or more local anaesthetics in oil form, one or more surfactants, water and optionally a taste masking agent. The novel composition is advantageously used as a local anaesthetic for pain relief within the oral cavity.

The invention provides semi-solid or liquid pharmaceutical compositions for topical administration to a finger- or toenail of a human. The compositions are useful for the delivery of active ingredients deep into the nail. Various active ingredients may be incorporated, such as antifungal agents, anti-infectives, anti-inflammatory agents, immunosuppressants, local anaesthetics, and retinoids.

A device for transferring liquid, e.g. local anesthetics, from a reservoir (1) to a hypodermic needle (18) for introduction into tissue. The device comprises a pump chamber (11) in a pump housing (19), which is provided with a manually displaceable pump piston (12), which is pivotably connected to a pump grip (13). The pump housing (19) is fluidly connected to the reservoir (1) through a piercing cannula (3) at an inlet (9), and fluidly connected to the needle (18) at an outlet (20).

The invention discloses a multifunctional microemlusion gel preparation and a preparation process thereof, and belongs to the technical field of medicines. The preparation mainly comprises bulk pharmaceutical chemicals (such as non-steroidal anti-inflammatory drugs-diclofenac sodium, ibuprofen, indometacin, antifungal drugs-ornidazole, antiviral drugs-ganciclovir, hormone drugs-dexamethasone, local anesthesia drugs-lidocaine and irritants-menthol), a cationic polymer and a microemlusion, can further comprise gel or a thickener, and can be used for transdermal drug delivery and local drug delivery. The preparation process is simple, convenient, good in stability and pollution-free. Compared with existing cream and gel, the preparation has the advantages that a novel action mechanism is adopted, the accumulative penetration amount of unit area of drugs is remarkably increased, a certain slow-release effect is achieved, and the drug delivery frequency and the drug delivery amount can be reduced; a chemical penetration enhancer and a conventional preservative are not added, a certain bacterial inhibition effect is achieved, the skin irritation is avoided, and the use safety of the drugs is improved.

The invention relates to compositions and methods for Inducing organ arrest, maintaining arrest and reanimating in a subject that has suffered a life threatening disease or injury; preparing, harvesting, storing organs, tissues and cells; reducing the harmful effects of at least one of anaesthesia, surgery, clinical intervention, and cardiopulmonary bypass on injuring the tissues, organs and cells of a subject; or reducing the harmful effects of surgery or clinical intervention on injuring the organs and brain in the whole body of a subject. The composition comprises (i) a compound selected from at least one of a potassium channel opener, a potassium channel agonist and an adenosine receptor agonist; (ii) an antiarrhythmic agent or a local anaesthetic; and (iii) citrate.

The invention discloses a preparation method of a hydrogel local anesthesia patch. The preparation method comprises the following steps of 1, nanogold dispersion liquid preparation; 2, PDA-PAM hydrogel preparation; 3, PDA-PAM-AuNps hydrogel preparation; 4, hydrogel local anesthesia patch finished product preparation. The hydrogel local anesthesia patch can generate heat under the excitation of near infrared light, and the penetration of local anesthesia medicine in the patch in tissues is promoted; meanwhile, the hydrogel local anesthesia patch also has the following technical advantages that1, a microneedle is used for puncturing the surface of a mucosa or the skin; the aching feeling is weak; 2, some problems and defects such as unprecise anesthesia region, swelling after injection andslow recovery caused by injection anesthesia can be avoided; 3, the process is simple and safe; the operation method is simple; the equipment requirements are low; the hydrogel local anesthesia patchis suitable for large-scale production and industrialization.

The invention discloses a method for preparing chiral alpha- hydroxyl- beta- dicarbonyl compound by taking lappaconitine as catalyst, belonging to the technical field of organic synthesis. The method is characterized in that beta- dicarbonyl compound, the lappaconitine and oxidizing agent are mixed and stirred in inert solvents for thin layer chromatography trace reaction. After the reaction, the chiral alpha- hydroxyl- beta- dicarbonyl compound is obtained by separation. The inert solvents comprise halogenated hydrocarbon, aromatic hydrocarbon, alkane or the like. The dosage mol ratio between organic peroxide which is taken as the oxidizing agent and the beta- dicarbonyl compound is 1-20, the dosage of the lappaconitine taken as catalyst is 0.5-50mol%, and the reaction temperature is -78 DEG C to 25 DEG C. The lappaconitine is extracted from aconitum sinomontanum in the Middle West part of China, is taken as anodyne and local anaesthetics clinically, and has high safety and no addiction. The new method develops the lappaconitine as organic catalyst, so as to prepare the chiral alpha- hydroxyl- beta- dicarbonyl compound by the anisomerous organic catalyst.

Substituted C-furan-2-yl-methylamine and C-thiophen-2-yl-methylamine compounds, processes for their preparation, medicaments and pharmaceutical compositions containing them, and their use in treatment methods and in the preparation of analgesics, in the preparation of a local anaesthetic, an antiarrhythmic, an antiemetic, a nootropic agent and/or a medicament for the treatment and/or prophylaxis of cardiovascular diseases, urinary incontinence, diarrhea, pruritus and/or inflammations, and/or a medicament for the treatment of depression and/or alcohol and/or drug and/or medicament abuse, and/or a medicament for increasing vigilance.

The present invention provides a propofol-containing fat emulsion comprising propofol, an oily component, and an emulsifier, and further comprising a predetermined amount of a stabilizer, such as phosphatidylglycerol in which a specific fatty acid is a constituent fatty acid component. The present invention also provides a pain-relieving propofol-containing fat emulsion, which is obtained by mixing a local anaesthetic in advance with the above-described propofol-containing fat emulsion of the invention.

The invention relates to a medicinal composition for treating canker sore and local infection of body surface and reducing inflammation, a product and application thereof. The medicinal composition comprises aminoglycoside antibiotics, local anaesthetics and glucocorticoids in weight ratio of (0.1-10):(1-10):(0.01-10). Compared with the prior art, the medicinal composition has the advantages that local anaesthetics can alleviate pains of patients in time; antibiotics has the antibiotic effect of treating infection caused by bacteria; and the glucocorticoids has the anti-inflammatory effect of reducing focus hyperemia, reducing permeability of capillary and inhibiting inflammatory cells from transferring to the inflammatory part; and the synergistic action of the three medicaments promotes the healing of canker sore so as to achieve good treatment effect.

The present invention relates to a nanoparticulated anaesthetic composition for topical use in which at least one local anaesthetic agent is encapsulated in polymeric nanoparticles. The present invention also relates to the use of such polymeric nanoparticles comprising at least one local anaesthetic agent in the preparation of an anaesthetic composition for topical application to the skin or mucosa.

The invention discloses a lumbar anesthesia special local anaesthetic-glucose lyophilized powder injection as well as a preparation method and a package method thereof. Corresponding local anaesthetic-glucose is dissolved into water for injection, activated carbon is added for adsorption, then decarburizing filtration and 0.22 mum microporous membrane filtration are carried out, the obtained filtrate is bottled in an aseptic sirin bottle or a pliable ampoule under aseptic condition according to specification, and lyophilized powder is obtained after vacuum freezing and drying; then, plastic aluminium cap sirin bottle seal or portable bottle seal or pliable ampoule process is used for sealing the ampoule which is then marked to obtain the aseptic lumbar anesthesia special local anaesthetic-glucose lyophilized powder injection; the lyophilized powder injection and corresponding solvent adopt pre-filling and sealing injector technology to package and then the lyophilized powder injection and corresponding solvent are sterilized and outer packaged to be a lumbar anesthesia drug utilization unit. The invention is characterized in that the workload of an anaesthetist is reduced to the greatest extent, and the occurrence of accidents of pumping drug errors as well as the oxidation decomposition under high temperature and high pressure and the generation of impurities are avoided.

The invention discloses a clinical anaesthetic-supply anesthesia device for an anesthesiology department. The anesthesia device comprises a bottom plate, a U-shaped fixing frame is welded to two endsof the top of the bottom plate, a slide seat is in slide connection with the top of the bottom plate, an oxygen bottle is arranged on the slide seat, a positioning plate welded to the inner side wallof the fixing frame is clamped on one side of the oxygen bottle, and a limiting plate clamped on the outer wall of the oxygen bottle is hinged to one end of the positioning plate. A supporting frame welded to the top of the bottom plate is arranged on one side of the slide seat, an air pump mounted on the bottom plate is arranged in the supporting frame, and a fixing plate is welded between innerwalls of the supporting frame. Under the joint action of all parts, the oxygen bottle and an anaesthetic tank can be replaced and fixed quickly while a workbench for medicine preparation can be provided, and the workbench is convenient to clean and tidy so as to better meet clinical utilization demands.

The present invention relates to compositions comprising a lipophilic local anaesthetic, preferably bupivacaine or a pharmaceutically active salt thereof, which are formulated for local administration to the mouth or throat of a subject. The compositions are useful in the treatment or alleviation of pain, burning or xerostomia of the oral cavity, pharynx, oral mucosa and pharyngeal mucosa or for use in providing local anesthesia of the oral cavity, pharynx, oral mucosa and pharyngeal mucosa. In particular in the treatment of pain, burning or xerostomia, which is caused by a disease such as oral mucositis, Burning Mouth Syndrome, Sjogren's syndrome, xerostomia, periodontitis, toothache, tonsillectomy, throat infection or mononucleosis, canker sores and aphthous stomatitis.

The invention provides a composite local anesthetic which comprises lidocaine and ropivacaine, wherein the molar concentration ratio of lidocaine to ropivacaine is (1:1) to (1:3). The composite local anesthetic is clinically suitable for various local anesthesia and nerve blocking anesthesia. The invention further provides a preparation method of a composite local anesthetic injection. The composite local anesthetic has the advantages of stable component, convenience in use, quick action, long action time, good postoperative analgesia effect and small toxic and side effects.

A compound isopropylphenol injection containing local anesthetic contains proportionally isopropylphenol, the local anesthetic chosen from procaine, lidocaine, etc, the refined plant oil for injection, emulsifier, isotonic regulator, antioxidant, pH regulator and the water for injection. Its preparing process is also disclosed.