38 results about "Local anaesthetic" patented technology

The invention belongs to the technical field of pharmaceutical preparations, and relates to an external gel emplastrum containing local anesthetics as well as a preparation method and application of the external gel emplastrum. The gel emplastrum comprises a backing layer, an emplastrum body layer and an anti-sticking film from bottom to top, wherein the pasty fluid layer adopts organic water-retaining resin as a framework structure, and contains local anesthetics accounting for 1-20% of the weight of the pasty fluid layer. The external gel emplastrum containing the local anesthetic can have a higher transdermal release rate, and can improve the stability of a supply chain of the added part of neutralized polyacrylic acid.

The invention discloses oral multi-effect analgesic and anti-inflammatory gel and a preparation method thereof, and belongs to the technical field of medical gel. The gel is prepared from mussel mucin grafted hydroxypropyl chitosan, a poly (N-isopropylacrylamide)-co-acrylic acid copolymer, quercetin-zinc coordination nanoparticles, a local anesthetic compound wrapped by temperature-sensitive lipidosome, a gamma-polyglutamic acid-catechin gel matrix, aloe polysaccharide, dipotassium glycyrrhizinate, and sodium hyaluronate and potassium sorbate which can be selectively added, wherein the local anesthetic compound is prepared from the mussel mucin grafted hydroxypropyl chitosan, the poly (N-isopropylacrylamide)-co-acrylic acid copolymer, the quercetin-zinc coordination nanoparticles, the temperature-sensitive lipidosome, the gamma-polyglutamic acid-catechin gel matrix, the aloe polysaccharide and the dipotassium glycyrrhizinate. During preparation, part of the components and water are stirred to obtain a mixed solution, and then the other components are added and stirred into gel. According to the gel, the leakage rate of local anesthetics is reduced by stabilizing the liposome through the zinc ions, the quercetin adjusts the phase transition temperature of the liposome to realize preferential drug release at the pain part, the mussel mucin and the copolymer form a reversible hydrogen bond network to enhance the mucous membrane adhesive force, and the inflammatory environment triggers the gel permeation drug release, so that the gel has the advantages of multiple-effect synergy, strong adhesion and the like; the problems that existing oral gel is short in analgesia time and insufficient in anti-inflammation can be effectively solved.

This invention belongs to the field of biomedical materials technology, and particularly relates to an analgesic microneedle patch, its preparation method, and its application. The analgesic microneedle patch of this invention uses extracted mesenchymal stem cell exosomes and ginger exosomes as analgesic active substances, and by combining them with microneedle patch technology, it provides a new technical approach for surface anesthesia. The analgesic microneedle patch of this invention combines microneedle technology and photopolymerization 3D printing technology to develop a customizable hydrogel microneedle patch, achieving minimally invasive and precise percutaneous delivery of local anesthetics, providing a new technical approach for surface anesthesia.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The present application belongs to the field of biological medicine, and relates to an in-situ spraying particle-gel composite as well as a preparation method and application thereof. The present application prepares a drug-loaded particle-gel composite material, which can be rapidly gelled in-situ in the form of spraying. In a wound infection model of diabetic rats, the composite material exhibits good photothermal activation TRPV1 channel-mediated local analgesia, as well as anti-inflammatory, antibacterial, antioxidant, hemostatic and wound healing-promoting multifunctional therapeutic effects. Through in-vitro and in-vivo material characterization, as well as histopathological examination of animal experiments, it is confirmed that the composite gel material has good biological safety and degradability, and is a local anesthetic biomaterial preparation which is expected to be clinically transformed for chronic wound analgesia and healing-promoting therapeutic effects.

The application relates to the technical field of tracheal catheters, and discloses a medical tracheal catheter with double coatings of local anesthetic and antibacterial drugs, which comprises a catheter main body and a cuff main body connected to the outer wall of the catheter main body, the catheter main body comprises a catheter base material layer, a first transition bonding layer, a first nano local anesthetic coating and a first antibacterial coating; the cuff main body comprises a cuff base material layer, a second transition bonding layer, a second nano local anesthetic coating and a second antibacterial coating; a tracheal tube is mounted on the catheter main body; and a head tube is connected to the bottom end of the catheter main body. The first nano local anesthetic coating, the first antibacterial coating, the second nano local anesthetic coating and the second antibacterial coating are arranged, so that the catheter main body and the cuff main body can realize a synergistic protection mechanism of analgesia and antibiosis; during the process of leaving the catheter, the local anesthetic drug acts on the mucosa of the tracheal wall through slow release, and the antibacterial component effectively reduces bacterial adhesion and biofilm formation.

This invention relates to topical drug delivery formulations, formulated to carry at least one drug, be applied to an open wound, and enable systemic absorption of the at least one drug via the open wound to provide a systemic therapeutic effect for a predetermined period of time. In some embodiments, the invention concerns a topical drug delivery composition comprising a rapid onset local anaesthetic agent and / or an analgesic agent, and a drug delivery formulation, for providing both local and systemic anaesthesia and / or analgesia.

The utility model discloses a disposable visual laryngoscope capable of preventing fog and realizing surface anesthesia, which comprises a visual display screen, a laryngoscope handle, a laryngoscope lens and an injector, the visual display screen is arranged at one end of the laryngoscope handle, the laryngoscope lens is arranged at the other end of the laryngoscope handle, a camera is arranged at the front end of the laryngoscope lens, and the camera is connected with the visual display screen through a cable. The injector is detachably arranged on the laryngoscope handle and connected with one end of the spray pipe, the other end of the spray pipe extends into the laryngoscope blade from the rear end of the laryngoscope blade and extends out of the front end of the laryngoscope blade, the atomization nozzle is arranged at the front end of the spray pipe and supported and fixed through an adjusting support arranged in the laryngoscope blade, and the fixing plate is arranged on the side wall of the laryngoscope handle. A positioning plate is arranged at one end of the fixing plate, a positioning hole is formed in the positioning plate, and the positioning plate is fixedly connected with a laryngoscope handle through a positioning screw arranged in the positioning hole. The laryngoscope can effectively infiltrate local anesthesia medicine on the throat, and the visual laryngoscope cannot fog when entering the oropharynx.

The present invention provides a method and application for identifying the plane tissue structure of the transverse abdominal muscle based on RMSD-Net, and relates to the field of image processing technology. The method comprises the following steps: performing data preprocessing on an acquired ultrasound image with a plane structure of the transverse abdominal muscle to establish an abdominal ultrasound image dataset; wherein the ultrasound image with the plane structure of the transverse abdominal muscle includes key abdominal tissue structure information that can be observed during TAP block; constructing an RMSD-Net model with a U-shaped network structure; the RMSD-Net model comprises an encoder, a jump connection structure, and a decoder; a multi-scale residual feature extraction module RMDC module is added to each layer of the encoder; the jump connection structure uses a feature fusion module SFF module layer by layer; an attention mechanism GAM module is added to the last layer of the decoder; a segmentation task is performed on the aforementioned key abdominal tissue structure information, the aforementioned abdominal ultrasound image dataset is divided into a training set and a test set, and the aforementioned RMSD-Net model is used for training and testing respectively; the tested RMSD-Net model is used to segment and identify the key abdominal tissue structure information of the newly acquired ultrasound image with the plane structure of the transverse abdominal muscle. The present invention can help clinicians to quickly and accurately interpret ultrasound images with the transverse abdominal muscle plane structure, so as to assist them in accurately locating the blocking area and injecting local anesthetics.

The invention discloses a preparation method of an anesthetic taking effect quickly and lasting for a long time. The preparation method comprises the following steps: S1, heating and dissolving a slow-release local anesthetic and an oil phase matrix, cooling, and adding an antioxidant and an emulsifier to form an oil phase; s2, heating the water-phase matrix, adding the bacteriostatic agent, dissolving, cooling, respectively adding the quick-release local anesthetic, the pH regulator, the chelating agent and the film-forming agent, and dissolving to obtain a water phase; s3, under high-speed shearing, the water phase is slowly added into the oil phase, after high-speed shearing and mixing, the thickening agent is added, and filling is carried out, so that the anesthetic is obtained.The prepared anesthetic can form a film for administration during use, no residual medicine adheres to the anesthetic after the film is removed, meanwhile, the anesthetic takes effect quickly and lasts for a long time, the controllability of the anesthetic effect is enhanced, and the experience feeling and satisfaction degree of a user are improved; and the product can be stored at room temperature for more than 12 months.

This invention relates to the field of fluorescent carbon nanomaterials, specifically to highly efficient water-soluble carbon dots for loading local anesthetic drugs, their preparation method, and applications. Using water-soluble amino acids and carboxylic acid compounds that readily aggregate and carbonize to form six-membered rings as precursors, the precursors are sonicated to dissolve them in an organic solvent to form a homogeneous solution. This solution is then transferred to a reaction vessel and subjected to a solvothermal reaction at 180-240°C for 4-10 hours. The reaction vessel is then allowed to cool naturally to room temperature, directly obtaining a carbon dot solution. The obtained carbon dot solution is filtered, eluted, and dried to obtain a solid carbon dot powder. The functionalized carbon dots prepared by this invention possess both good water solubility and high efficiency in loading local anesthetic drugs, showing broad application prospects in the field of sustained-release analgesia of local anesthetic drug formulations.

The application discloses a long-acting local anesthetic compound, a preparation method, application and a pharmaceutical composition thereof. The long-acting local anesthetic compound is prepared by the following steps: reacting a local anesthetic with bromoethanol to generate a quaternary ammonium salt intermediate, and then condensing the quaternary ammonium salt intermediate with a non-steroidal anti-inflammatory drug. The preparation method is simple and suitable for large-scale production. The prepared long-acting local anesthetic compound has a long duration and an anesthetic time of more than 24 hours, and has nerve block selectivity. The long-acting local anesthetic compound can reduce the frequency of administration, increase the compliance of patients, greatly reduce the risk of anesthesia, and has a very good application prospect.

The present invention discloses a low-molecular-weight local anesthetic gel, liposomes, and preparation methods thereof. The raw materials of the low-molecular-weight local anesthetic gel include: a local anesthetic, a bile salt, an aqueous solvent, or a buffer; the local anesthetic is selected from an amide local anesthetic; and the bile salt is selected from at least one of sodium cholate, sodium deoxycholate, sodium chenodeoxycholate, sodium lithocholic acid, sodium ursocholic acid, sodium ursodeoxycholate, sodium glycodeoxycholate, sodium taurolithocholic acid, sodium glycotaurocholate, sodium glycochenodeoxycholate, sodium phenylpropanecholate, sodium casocholic acid, sodium leukocholic acid, bile acid dimer, bile acid side chain amino acid conjugate, bile acid side chain PEG conjugate, and bile acid side chain glucose conjugate. The preparation process of the gel and liposome of the present invention is simple and controllable, and can achieve the purpose of postoperative pain management after a single administration.

The invention discloses a preparation method of an amide local anesthetic key intermediate, which comprises the step of carrying out hydrogenation reaction on N-(2, 6-dimethylphenyl) pyridine-2-formamide and hydrogen in a continuous flow fixed bed reactor to generate N-(2, 6-dimethylphenyl) piperidine-2-formamide. The method has the beneficial effects that the danger of a kettle type hydrogenation process is avoided, the process is stable, the operation is simple, the raw material conversion is complete, alkylation impurities are extremely few, excessive hydrogenation impurities are avoided, the atom economy is higher, and the method is greener and more efficient; the HPLC purity of N-(2, 6-dimethylphenyl) piperidine-2-formamide obtained through the hydrogenation process is larger than 99.5%, alkylation impurities are smaller than 0.2%, excessive hydrogenation impurities are smaller than 0.1%, next-step reaction can be directly carried out without purification, the preparation yield can be greatly improved, and the method is especially suitable for industrial production and has the cost competitive advantage.

The invention relates to the technical field of machine vision, and provides a thoracic trunk nerve block auxiliary system, which comprises a wireless ultrasonic probe device used for collecting an ultrasonic image of a thoracic trunk nerve block area of a patient based on a thoracic trunk nerve block scheme of the patient; the thoracic trunk nerve block scheme is generated by the mobile terminal device based on multi-dimensional individual feature information of the patient; the mobile terminal device is used for determining an anatomical structure and a target retardation area based on the ultrasonic image; generating a blocking path based on the thoracic trunk nerve blocking scheme, the anatomical structure and the target blocking area; the target retardation area is an injection area of local anesthetics; and the augmented reality glasses device is used for displaying the ultrasonic image, the anatomical structure, the target retardation area and the retardation path on the real view image of the patient in an overlapping manner. According to the method, individualized retardation scheme recommendation, real-time ultrasonic visual guidance and dynamic retardation path planning are realized, the retardation success rate is improved, and the operation difficulty is reduced.

The invention relates to a local anesthesia dosage control system based on CFD (Computational Fluid Dynamics) and PC-MRI (Personal Computer-Magnetic Resonance Imaging) coupling and a working method thereof, and the system comprises an information collection unit which is used for collecting physical examination and medical evaluation information of a patient; the geometric unit is used for acquiring a T2 weighted MRI image sequence; the calculation model unit is used for determining the range of a lumbar, thoracic and vertebral segment calculation domain; a measurement unit for phase encoding using PC-MRI; the cerebrospinal fluid dynamic unit is used for acquiring an initial flow field of cerebrospinal fluid flow of the spinal canal of the patient; the dosage selection unit is used for selecting the injection dosage of the local anesthetic; the intrathecal administration calculation unit is used for establishing coupling analysis to obtain a local anesthetic concentration value of a blocking plane; and the dose evaluation unit is used for quantitatively evaluating the concentration value of the local anesthetic. The system is beneficial for improving the accuracy and safety of local anesthesia medication.

The invention provides a ripdicaine emulsifiable paste and a preparation process thereof. According to the invention, a new cream formula is selected, the transdermal absorption is faster than that of a preparation without a penetration enhancer, the anesthesia time is shortened, and the waiting time of a patient is reduced. Compared with the prior art, the new penetration enhancer has the advantages that the irritation of damaged skin is greatly reduced, the sensitivity of sensitive skin to products can be reduced, and for local anesthesia application of small surgeries such as puncture on subsequent patients, the irritation feeling of the skin after being damaged to the applied local anesthesia medicine is reduced, and better compliance is achieved. The preparation process of the cream provided by the invention is simple and stable to operate, and can meet the requirements of industrial large-scale production.

The invention relates to a capsaicin and local anesthetic liquid eutectic and a composition thereof, and more specifically, the capsaicin and local anesthetic liquid eutectic comprises (a) capsaicin; (b) local anesthetics; (c) water; wherein the molar ratio of the component (a) capsaicin to the component (b) local anesthetic is (1: 0.5)-(1: 10), preferably (1: 0.6)-(1: 6), and more preferably (1: 0.75)-(1: 5); the component (c) accounts for at least 1%, preferably at least 3%, preferably at least 5% and more preferably at least 6% of the mass percent of the eutectic; the invention also discloses a pharmaceutical composition containing the eutectic, the eutectic is stable at room temperature, and the further prepared pharmaceutical composition is free of drug crystal precipitation after being placed for a long time, and is stable and controllable in quality.

The present invention belongs to the field of biomedicine and relates to an injectable, long-acting, selective analgesic complex, its preparation method, and application. The complex of the present invention has the properties of temperature sensitivity, injectability, and high drug loading rate. In a rat sciatic nerve block model, complete selective pain blockade can be achieved without affecting lower limb movement, and the sensory block duration is 10 times that of free local anesthetic blockade. Local tissue pathology and gross anatomy show that the complex of the present invention has good biocompatibility and degradability, and is a long-acting, sustained-release, selective pain-blocking local anesthetic biomaterial preparation with potential for clinical translation.

This invention relates to the field of needle-free injector technology, and in particular to an apparatus and method for needle-free injection of local anesthetics into the dermis for infiltration anesthesia. The apparatus includes a receiving space for containing the anesthetic solution; the injection pressure is 14-21 MPa. This invention allows for the design of different needle-free injectors to address the physiological differences in the dermis between men and women, ensuring precise intradermal injection of the anesthetic solution and avoiding entry into the muscle layer. Furthermore, it results in less pain during injection and a longer duration of effect from the onset and exhaustion of the local anesthetic.

The utility model discloses a chest drainage tube capable of assisting in analgesia, and relates to the technical field of drainage tubes, the chest drainage tube comprises an analgesia pipeline and a drainage pipeline, the drainage pipeline is arranged in the analgesia pipeline, analgesia micropores are formed in the tube wall of the other end of the analgesia pipeline in the circumferential direction of the analgesia pipeline, and the drainage pipeline is connected with the analgesia pipeline. And the other end of the drainage pipeline is annularly sleeved with a supporting rib for supporting the analgesia micropore. According to the thoracic cavity drainage tube, the drainage pipeline can be connected with a conventional drainage bag or a drainage bottle to execute drainage work under the internal support of the supporting ribs based on the internal and external integrated combination of the analgesia pipeline and the drainage pipeline, meanwhile, the analgesia pipeline can be connected with a self-control analgesia pump, and the pipeline part from the skin to the thoracic cavity is provided with a large number of analgesia micropores; local anesthetic can be continuously pumped through the self-control analgesia pump, the local anesthetic can flow out of the analgesia micropores on the contact surfaces of subcutaneous, ribs and pleura, the local anesthetic effect is generated locally, and the drainage and analgesia dual-synchronization effect is achieved.

The invention relates to the technical field of medical instruments, in particular to a local anesthetic airway spraying device which comprises a shell, a built-in cavity formed in the inner wall of the shell, a liquid medicine bin arranged on the inner wall of the built-in cavity, a liquid supply device arranged at the end of the liquid medicine bin and a battery. The liquid supply device is of a swash plate type piston conveying structure, speed and quantity control and accurate quantitative conveying of liquid medicine are achieved through control over the rotating speed and start and stop of a driving motor, dosage misalignment caused by liquid medicine backflow and liquid suction idling is eradicated, and the poisoning risk caused by excessive administration of local anesthetics is reduced. High-pressure drive conveying of liquid medicine is achieved through the liquid supply device, the liquid medicine is primarily atomized through the atomizing piece, and then the liquid medicine enters the mixing cavity with the air inlet to be secondarily atomized to form fine spray. A heating structure is arranged in the liquid medicine bin to realize constant-temperature control of liquid medicine; a wide-angle spray head or an auxiliary catheter with a spray head is integrally formed at the end of the diffusion tube, the auxiliary catheter has plasticity and rigid supporting performance, the tip end of the auxiliary catheter is designed to be spherical, a micropore mist outlet structure is adopted, the auxiliary catheter can be matched with a bronchofiberscope-free scene, and accurate dosing of a target area at the far end of an airway is achieved.

The invention discloses a PIEB epidural delivery analgesia pump capable of regulating and controlling local anesthetic concentration, which comprises a main shell, a mounting mechanism is arranged on the outer side wall of the main shell, a liquid storage mechanism for storing liquid medicine is arranged in the main shell, and the liquid storage mechanism comprises an anesthetic bag filled with anesthetic and a normal saline bag for reducing the anesthetic concentration. According to the invention, the collision mechanism and the extrusion mechanism are arranged, the extrusion mechanism adopts two extrusion rollers to extrude the medicine mixing bag, and in the extrusion process, the two extrusion rollers tend to rise, and at the moment, liquid medicine in the medicine mixing bag moves upwards after being pressed; the middle part of the medicine mixing bag is accumulated due to the upward liquid medicine, and the collision mechanism can impact the middle part of the medicine mixing bag through oppositely arranged collision heads, so that the liquid medicine is mixed by virtue of rapid impact force, and the homogenization of the liquid medicine is realized.

The invention discloses an abdominal wall local anesthetic diffusion visual analysis system based on infrared temperature image features, and relates to the technical field of medical monitoring. The thermal imaging acquisition and processing module is used for performing sequence scanning at preset time points set before and after retardation operation to obtain original temperature image data; the target region feature extraction module is used for determining a target analysis region according to the retardation type and determining feature parameters according to the temperature data of the target analysis region; and the effect prediction and evaluation module takes the characteristic parameter set as the input of a time sequence prediction model, and outputs and obtains the corresponding predicted low-temperature area and predicted retardation effect level. Through the infrared thermal imaging technology, the temperature change caused by diffusion of the local anesthetic in the abdominal wall tissue after injection can be continuously captured in a non-contact and non-radiation mode, so that the two-dimensional diffusion profile and the dynamic migration process of the local anesthetic can be visually presented in real time, and then corresponding visual information can be provided.

The invention relates to a visual nasopharynx-imbedded airway / tracheal catheter system which comprises an airway catheter internally provided with an oxygen supply airway and a laryngeal anesthesia tube imbedded in the pharynx of a patient through the oxygen supply airway, a jacking air bag is arranged on one side of the front end of the laryngeal anesthesia tube, a local anesthetic administration channel is arranged in the laryngeal anesthesia tube, and the local anesthetic administration channel is communicated with the airway catheter. A camera is arranged at the front end of the ventilation catheter, an inclined plane is arranged at the front end of the ventilation catheter, the normal direction of the inclined plane is opposite to the epiglottis direction, and an air bag is arranged at the front end of the ventilation catheter. The ventilation catheter is matched with the laryngeal anesthesia tube with the jacking cuff to penetrate into the epiglottis from the nasal cavity of a patient, the tip is guided by the camera to accurately reach and be maintained below the epiglottis and above the glottis, the soft palate, the tongue and the epiglottis can be supported, upper respiratory tract obstruction caused by collapse of the three structures due to sedation or diseases is effectively avoided, and the operation is simple and convenient. The respiratory tract smoothness is maintained.

The invention belongs to the field of pharmaceutics, and particularly relates to a depot type local anesthetic sustained-release composition as well as a preparation method and application thereof, and the depot type local anesthetic sustained-release composition comprises the following components: a, active pharmaceutical ingredients; b, a slow-release carrier material; c. A phospholipid; d. A pharmaceutically acceptable oil; and e. A pharmaceutically acceptable solvent, the new composition not only can maintain the long-acting slow-release effect of the preparation composition, but also accelerates the corrosion absorption of the preparation composition in the body, on one hand, promotes the complete release of the medicine, on the other hand, accelerates the absorption of the preparation, obviously improves the medication safety and bioavailability, and has the advantages of good slow-release effect, good physical and chemical stability and no toxic or side effect. An in-vivo animal experiment shows that no inflammatory reaction occurs at the administration part, the safety is good, and a wide clinical application prospect is achieved.

The application provides a lumbar plexus nerve ultrasound segmentation and recognition method based on U-Net and application, and relates to the technical field of medical auxiliary diagnosis. The method comprises the following steps: constructing a lumbar ultrasound image dataset; constructing a U-Net model capable of recognizing the psoas major muscle, the quadratus lumborum muscle, the erector spinae muscle, the transverse process and the lumbar plexus nerve, and training the U-Net model; the U-Net model comprises an encoder, a jump connection and a decoder; the encoder uses a multi-layer dynamic context perception expansion residual module (DCDR) to perform a downsampling operation; the decoder uses a multi-layer attention enhancement hybrid module (AEH) to perform an upsampling operation; the trained U-Net model is configured in an ultrasound device; an image recognition is performed on the collected ultrasound image, and a recognition result is obtained. The application can help clinicians to quickly and accurately interpret the cloverleaf view ultrasound image containing the lumbar plexus nerve tissue, so as to assist them in accurately positioning the block area and injecting local anesthetic.

The present application relates to a kind of local anesthesia intervention preoperative diet planning system, belong to preoperative diet management technical field.The system includes: fluorescence measuring unit is configured to be used to determine the gastric emptying trend line of patient using fluorescence indication method in preoperative planning stage;Diet planning unit is configured to generate the feeding time and feeding category planning of patient according to the gastric emptying trend line of patient and predetermined operation time;Blood glucose detection unit is configured to monitor the blood glucose of patient in real time.Optimally, diet planning unit is further configured to individualize revision the gastric emptying rate of patient according to the real-time monitoring value of blood glucose of patient, and adjust the feeding time and feeding category planning of patient according to the gastric emptying rate after revision.

The present application relates to the technical field of catheter, and discloses a kind of comfortable dual-function medical catheter with nano coating antibacterial, including tube body, the tube head is connected to the top of the tube body, the water bag is connected to the outer wall of the top of the tube body, and the segment below water bag of the tube body is set as local anesthesia section;The outer wall of the local anesthesia section is covered with nano local anesthetic coating, and the outer wall of the tube body and nano local anesthetic coating is covered with antibacterial coating.The setting of nano local anesthetic coating and antibacterial coating makes the nano local anesthetic coating release the drug by slow-release principle and pass through the antibacterial coating, finally contacts with urethral mucosa, and then plays the effect of local anesthesia, avoids the friction irritation and pain in the process of intubation, indwelling and removal, and the antibacterial coating covers the outer side of the tube body and nano local anesthetic coating, forming a comprehensive infection protection barrier.

The invention disclosed herein describes a polyherbal local anaesthetic formulation and a method of preparation. The polyherbal anaesthetic formulation was formulated using the hydroalcoholic extract of herbs, viz., Syzygium aromaticum, Aconitum heterophyllum, Myristica fragrans, Aconitum ferox and Acmella ciliate along with the essential oil of Syzygium aromaticum and Nigella sativa. Alginate was used as the emulsifying agent (extracted from brown algae). The invention also discloses method of preparing the polyherbal formulation.