7 results about "Local anaesthetic" patented technology

This invention belongs to the field of biomedical materials technology, and particularly relates to an analgesic microneedle patch, its preparation method, and its application. The analgesic microneedle patch of this invention uses extracted mesenchymal stem cell exosomes and ginger exosomes as analgesic active substances, and by combining them with microneedle patch technology, it provides a new technical approach for surface anesthesia. The analgesic microneedle patch of this invention combines microneedle technology and photopolymerization 3D printing technology to develop a customizable hydrogel microneedle patch, achieving minimally invasive and precise percutaneous delivery of local anesthetics, providing a new technical approach for surface anesthesia.

The application belongs to the technical field of biological medicine, and particularly relates to a composite material containing a local anesthetic and a preparation method thereof. The composite material containing the local anesthetic comprises the following raw materials in parts by weight: bupivacaine hydrochloride 10-15 parts, a light-heat conversion agent 4-8 parts, delta-cadinene 0.5-1 part, a penetration enhancer 1-3 parts, and glycerol 2-5 parts. The light-heat conversion agent and the bupivacaine hydrochloride are added in combination, so that the discomfort caused by photothermal therapy is relieved. The delta-cadinene and the bupivacaine hydrochloride are combined, so that the analgesic effect is improved, the analgesic time is prolonged, the pain caused by frequent dressing change is avoided, and the toxic side effects caused by the accumulation of blood drug concentration are avoided. In addition, the penetration enhancer composed of egg membrane protein peptide and polylysine is introduced, so that the absorption of the effective components by the skin is further promoted, and the analgesic effect is quickly exerted.

The application relates to the technical field of tracheal catheters, and discloses a medical tracheal catheter with double coatings of local anesthetic and antibacterial drugs, which comprises a catheter main body and a cuff main body connected to the outer wall of the catheter main body, the catheter main body comprises a catheter base material layer, a first transition bonding layer, a first nano local anesthetic coating and a first antibacterial coating; the cuff main body comprises a cuff base material layer, a second transition bonding layer, a second nano local anesthetic coating and a second antibacterial coating; a tracheal tube is mounted on the catheter main body; and a head tube is connected to the bottom end of the catheter main body. The first nano local anesthetic coating, the first antibacterial coating, the second nano local anesthetic coating and the second antibacterial coating are arranged, so that the catheter main body and the cuff main body can realize a synergistic protection mechanism of analgesia and antibiosis; during the process of leaving the catheter, the local anesthetic drug acts on the mucosa of the tracheal wall through slow release, and the antibacterial component effectively reduces bacterial adhesion and biofilm formation.

This invention relates to the field of fluorescent carbon nanomaterials, specifically to highly efficient water-soluble carbon dots for loading local anesthetic drugs, their preparation method, and applications. Using water-soluble amino acids and carboxylic acid compounds that readily aggregate and carbonize to form six-membered rings as precursors, the precursors are sonicated to dissolve them in an organic solvent to form a homogeneous solution. This solution is then transferred to a reaction vessel and subjected to a solvothermal reaction at 180-240°C for 4-10 hours. The reaction vessel is then allowed to cool naturally to room temperature, directly obtaining a carbon dot solution. The obtained carbon dot solution is filtered, eluted, and dried to obtain a solid carbon dot powder. The functionalized carbon dots prepared by this invention possess both good water solubility and high efficiency in loading local anesthetic drugs, showing broad application prospects in the field of sustained-release analgesia of local anesthetic drug formulations.

This invention relates to the field of needle-free injector technology, and in particular to an apparatus and method for needle-free injection of local anesthetics into the dermis for infiltration anesthesia. The apparatus includes a receiving space for containing the anesthetic solution; the injection pressure is 14-21 MPa. This invention allows for the design of different needle-free injectors to address the physiological differences in the dermis between men and women, ensuring precise intradermal injection of the anesthetic solution and avoiding entry into the muscle layer. Furthermore, it results in less pain during injection and a longer duration of effect from the onset and exhaustion of the local anesthetic.

The present application relates to the technical field of catheter, and discloses a kind of comfortable dual-function medical catheter with nano coating antibacterial, including tube body, the tube head is connected to the top of the tube body, the water bag is connected to the outer wall of the top of the tube body, and the segment below water bag of the tube body is set as local anesthesia section;The outer wall of the local anesthesia section is covered with nano local anesthetic coating, and the outer wall of the tube body and nano local anesthetic coating is covered with antibacterial coating.The setting of nano local anesthetic coating and antibacterial coating makes the nano local anesthetic coating release the drug by slow-release principle and pass through the antibacterial coating, finally contacts with urethral mucosa, and then plays the effect of local anesthesia, avoids the friction irritation and pain in the process of intubation, indwelling and removal, and the antibacterial coating covers the outer side of the tube body and nano local anesthetic coating, forming a comprehensive infection protection barrier.

The utility model relates to the technical field of medical auxiliary instrument especially is a nerve block needle single person injection administration auxiliary device, its with nerve block needle connection is connected to medicine discharge structure, under the ultrasonic probe, the nerve block needle is pricked into the designated position, then through the piston structure carries out the back -and -forth drawing, detects whether there is blood, after confirming that there is no blood, through the piston structure absorbs the local anaesthetic in the storage structure, and through the medicine discharge structure is arranged into the patient's body with local anaesthetic, thereby improving the practicality of nerve block needle single person injection administration auxiliary device, including storage structure, still including piston structure and medicine discharge structure, and the storage structure and medicine discharge structure all install on the piston structure, the storage structure carries out the storage to local anaesthetic, and the piston structure cooperates medicine discharge structure and carries out back -and -forth drawing detection and local anaesthetic injection.