855 results about "Pyrrolidine" patented technology

The present invention relates to crystalline forms of salts of the KRas G12C inhibitor 2-[(2b)-4- [7-(8-chloro-1-naphthyl)-2-[[(25)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H -pyrido [3,4- d]pyrimidin-4-yl]-1-(2-fluoroprop-2-enoyl)piperazin-2-yl]acetonitrile, pharmaceutical compositions comprising the crystalline forms, processes for preparing the crystalline forms and methods of use thereof.

The present invention provides a compound as shown in formula (I), and a pharmaceutically acceptable salt of the compound. The compound in the present invention exhibits a strong inhibitory effect on Lp(a) assembly, and can be used for treating cardiovascular diseases (CVD).

The invention discloses a polysubstituted pyrrolidine derivative represented by a general formula (I), a stereoisomer, a tautomer, a deuterated derivative or a pharmaceutically acceptable salt thereof, and a preparation method and application of the compound. The invention also relates to pharmaceutical compositions comprising these compounds, stereoisomers, tautomers, deuterated derivatives or pharmaceutically acceptable salts thereof, uses of the compounds as sodium channel subtype Nav1.8 inhibitors, and uses thereof in the treatment and prevention of pain-related diseases. # imgabs0 #

Herein is provided a novel process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylate by a Suzuki coupling of compound (3), wherein LG represents a leaving group, with an organoboron reagent:Compound (3) is obtained by activation of compound (4) with a leaving group LG, and compound (4) is obtained by alpha-arylation of methyl 5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-carboxylate with 1-LG′-2,4-dichlorobenzene, wherein LG′ represents a leaving group:

The invention discloses an indole-benzothiadiazole derivative as well as a preparation method and application thereof. The general structural formula of the indole-benzothiadiazole derivative provided by the invention is shown in the specification, wherein R is selected from one of methyl piperazinyl, diethylamino, azetidinyl and pyrrolidinyl. The derivative can be specifically combined and fluorescently labeled with mitochondrial RNA in cells, and has good selectivity, high fluorescence signal-to-noise ratio and excellent anti-interference capability in a complex biological system. Meanwhile, the indole-benzothiadiazole derivative provided by the invention is simple in synthetic route, easily available in raw materials, good in stability and convenient to store and use, can be specifically combined with RNA and generate strong fluorescence response, is suitable for real-time detection and imaging of in-vitro and in-vivo mitochondrial RNA, and is an efficient mitochondrial RNA micromolecular fluorescent probe.

Described herein are lithium-metal rechargeable electrochemical cells comprising a lithium-metal negative electrode, a positive electrode, and a liquid electrolyte. The liquid electrolyte comprises a core mixture and a diluent. The diluent comprises a fluorinated ether. The core mixture comprises a set of salts and a set of solvents. The set of solvents comprises a pyrrolidinium-containing ionic liquid and a molecular solvent. The molecular solvent is a non-fluorinated ether, for example including but not limited to 1,2-dimethoxyethane. In some examples, the electrolyte further comprises an electrolyte additive, for example including but not limited to tris(trimethylsilyl)phosphate. In some examples, the set of salts comprises one or more imide-containing lithium salts. In some examples, the set of salts comprises lithium bis(fluorosulfonyl)imide and an additional salt and the mole fraction of lithium bis(fluorosulfonyl)imide in the set of salts is 0.5 or greater.

The invention discloses an omega-transaminase progenitor enzyme mutant for efficient catalytic synthesis of (R)-chiral amine compounds and application, and relates to the technical field of molecular biology. The omega-transaminase mutant is obtained by mutating an ancestor enzyme Ancaa-101 of omega-transaminase from Aspergillus terreus, and the amino acid sequence of the omega-transaminase mutant is as shown in SEQ ID NO. 6. The invention also discloses a preparation method of the omega-transaminase mutant. Compared with an ancestor enzyme, the activity of the omega-transaminase ancestor enzyme mutant on a non-natural substrate, namely 1-acetyl naphthalene, N-tert-butyloxycarboryl-3-piperidone or 3-oxopyrrolidine-1-carboxylic acid tert-butyl ester, is remarkably improved.

The invention discloses an ionic liquid-based electrolyte, a wide-temperature-range high-voltage supercapacitor and application of the wide-temperature-range high-voltage supercapacitor. The wide-temperature-range high-voltage supercapacitor comprises a eutectic ionic liquid system and an organic solvent, the eutectic ionic liquid system comprises at least two ionic liquids; the ionic liquid comprises cations and anions; the positive ions are selected from at least one of pyrrolidinyl positive ions, piperidinyl positive ions, imidazolyl positive ions and quaternary ammonium positive ions containing different side chains; the anion is selected from at least one of tetrafluoroborate, hexafluorophosphate, bis (trifluoromethylsulfonyl imine), bis (fluorosulfonyl imine) and tetracyanoborate; the organic solvent comprises at least one of fluorinated carbonic ester, fluorinated carboxylic ester, sulfones, ethers and nitriles. The supercapacitor based on the ionic liquid-based electrolyte can stably operate in a wide temperature range, so that the wide-temperature-range high-voltage supercapacitor can be suitable for an extreme working environment, and high energy density and power density are achieved.

The invention discloses a fullerene pyrrolidine derivative as well as a preparation method and application thereof, and relates to the field of photoelectric functional materials. The structural general formula of the fullerene pyrrolidine derivative is # imgabs0, and fullerene, amino acids with different carbon chain lengths and aromatic aldehyde are subjected to Prato reaction to generate the fullerene pyrrolidine derivative. The fullerene pyrrolidine derivative provided by the invention is used as an electron transport layer material, can significantly improve the performance of a photoelectric device, has excellent chemical stability and environmental adaptability, and greatly enhances the stability of the device. In addition, the preparation method of the fullerene pyrrolidine derivative is simple, convenient and efficient, the operation condition is mild, and the manufacturing cost of a device is reduced.

The present invention relates to compounds of formula (I)processes for their production and their use as pharmaceuticals. The compounds are inhibitors of Casein kinase 1 alpha and / or delta (CSNK1α and / or β) useful for the treatment of proliferative disorders.

An electrolyte membrane for a battery that cycles lithium ions includes a sulfide-based solid electrolyte, a polymer binder, an inorganic filler, an inorganic lithium salt, and an ionic liquid. The sulfide-based solid electrolyte includes lithium sulfide (Li2S) and at least one element selected from the group consisting of phosphorus (P), tin (Sn), silicon (Si), germanium (Ge), boron (B), gallium (Ga), and aluminum (Al). The ionic liquid includes substantially equimolar amounts of a cation and an anion. The cation includes a complex of lithium (Li+) and an ethylene glycol dimethyl ether, an imidazolium ion, a piperidinium ion, a pyrrolidinium ion, an ammonium ion, a phosphonium ion, or a combination thereof. The anion includes an arsenate ion, a phosphate ion, a sulfonylimide ion, a borate ion, a chlorate ion, or a combination thereof.

The disclosure relates to a pharmaceutical composition comprising a salt of Formula II. The pharmaceutical composition comprises granules and is suitable for preparing an oral medicinal capsule or tablet.

The present invention provides a modifier for solid electrolytes that comprises: an ionic compound which comprises a pyrrolidinium cation and an anion including fluorine or a cyano group; a borate ester which has a polymerizable functional group; and a lithium salt.

The invention provides an anti-hair-loss and hair-growing product containing plant extract components and a preparation method thereof, and relates to the field of wash supplies, the anti-hair-loss and hair-growing product is prepared from the following raw materials by weight: 50-80 parts of water, 5-10 parts of propylene glycol, 1-5 parts of 1, 3-propylene glycol, 1-5 parts of 1, 3-propylene glycol, and 1-5 parts of 1, 3-propylene glycol. The composition is prepared from the following components in parts by weight: 0.1 to 1 part of 1, 2-pentanediol, 0.1 to 1 part of pyrrolidinyl diaminopyrimidine oxide, 0.1 to 0.5 part of diaminopyrimidine oxide, 0.01 to 0.02 part of caffeine, 0.01 to 0.1 part of adenosine, 0.05 to 0.2 part of vitamin B6, 0.01 to 0.5 part of biotin tripeptide-1, 0.1 to 1 part of dipotassium glycyrrhizinate, 0.02 to 0.05 part of ethylenediamine tetraacetic acid, 0.1 to 1 part of D panthenol, 0.2 to 1 part of p-hydroxyacetophenone, 0.01 to 1 part of 1, 2-pentanediol, 0.1 to 1 part of 1, 2-pentanediol, 0.1 to 1 part of 2, 2-pentanediol, 0.1 to 1 part of 2, 2-pentanediol, 0.1 to 1 part of 2, 2- The composition comprises the following components in parts by weight: 1-2 parts of 1, 2-hexanediol, 0.1-0.5 part of citric acid, 1-2 parts of 1, 3-butanediol, 0.01-1 part of NMN and 3-5 parts of a plant extract. According to the present invention, the extraction method of the plant extract in the raw materials is specifically adjusted so as to significantly reduce the content of the pigment and the odor substance in the extract, such that the obtained hair growing liquid has characteristics of good hair growing effect, light color and light drug taste, can be easily accepted by consumers, and is suitable for large-scale promotion and application.

The invention belongs to the technical field of polyoxyethylene ether production, and particularly relates to a pyrrolidine compound polyoxyethylene ether composition and a preparation method thereof.The reaction speed is further increased and N-hydroxyethyl pyrrolidine is prevented from being oxidized and discolored by adopting a negative-pressure feeding mode in a reactor, so that the yield of N-hydroxyethyl pyrrolidine is increased, and the production cost is reduced. The pyrrolidine polyoxyethylene ether composition is prepared by mixing pyrrolidine polyoxyethylene ether with different polymerization numbers, pyrrolidine polyoxyethylene ether sodium sulfate and pyrrolidine polyoxyethylene ether sodium carboxylate according to a certain mass ratio, and the proportion of pyrrolidine polyoxyethylene ether with different lengths can be adjusted in the composition. The balance of hydrophilicity and hydrophobicity is changed, so that excellent hydrophobic-hydrophilic, dispersion and wettability properties are realized.

The invention belongs to the technical field of polyether polyol preparation, and discloses a synthesis method of propylene glycol polyether. The synthesis method comprises the following steps: mixing propylene glycol, an organic boron catalyst and a cocatalyst, then introducing alkylene oxide at 10-80 DEG C for reaction, adding a solvent into a reaction system after the reaction is finished, and carrying out reduced pressure distillation, washing and drying to obtain propylene glycol polyether, the cocatalyst is selected from one or a combination of at least two of trimethylphosphine, triethylphosphine, triphenylphosphine, tris (dimethylamino) phosphine and tripyrrolidine phosphine. According to the invention, the organic boron catalyst and the cocatalyst phosphine salt are matched for use, and the cocatalyst is selected, so that the reaction can be carried out under a relatively wide temperature condition, and the propylene glycol polyether with controllable molecular weight and narrow distribution is prepared.

Pharmaceutical compositions suitable for oral administration (such as a tablet or a capsule) are provided, which comprise a therapeutically effective amount of an amorphous solid dispersion of cabozantinib, e.g., for treating a proliferative disorder. Preferably, the amorphous solid dispersion consists of (a) cabozantinib or a pharmaceutically acceptable salt thereof (such as cabozantinib(S)-malate); (b) at least one pharmaceutically acceptable carrier selected from the group consisting of hydroxypropyl methyl cellulose acetate succinate (HPMC-AS), polyvinyl pyrrolidine and vinyl acetate (PVP / VA) copolymer, hydroxypropyl methylcellulose phthalate (HPMCP), and mixtures thereof; (c) a pore-forming agent; and (d) a plasticizer.

The present invention is directed to pyrrolidine compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

The invention discloses a polyion liquid-based solid electrolyte, a preparation method thereof and a lithium ion battery, and belongs to the technical field of lithium ion batteries. The preparation method provided by the invention comprises the following steps: dispersing LLZTO nanoparticles into a polyacrylonitrile solution to obtain a spinning solution; performing electrostatic spinning on the spinning solution to obtain a composite fiber membrane; the preparation method comprises the following steps: mixing poly (diallyldimethylammonium) bis (fluorosulfonyl) imide, lithium bis (fluorosulfonyl) imide and 1-methyl-1-propyl pyrrolidinium bis (fluorosulfonyl) imide in a solvent to obtain a polyion liquid electrolyte solution; and immersing the composite fiber membrane into the polyion liquid electrolyte solution, taking out, standing and drying to obtain the composite fiber membrane. The solid electrolyte prepared by the invention has relatively high ionic conductivity and mechanical strength, and good flexibility and flame retardance, and a battery prepared from the solid electrolyte can circulate for more than 200 circles under high-rate current density.

The present disclosure relates to solid-state forms and corresponding pharmaceutical compositions of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, and methods of treatment, including treatment of rheumatoid arthritis and juvenile idiopathic arthritis using the same. The treatment methods generally comprise administering to a patient (e.g., a pediatric patient) a therapeutically effective amount of upadacitinib as a stable liquid pharmaceutical composition or a solid dosage form, at a dose based on patient body weight.

Described herein are compounds of Formula (I): I and their pharmaceutically acceptable salts, wherein R1, R2, R3, Rp, A1, L1, L2, T1, T2, T3, T4, n1, t1, t2, and t3 are defined herein; their use as GIPR antagonists; pharmaceutical compositions containing such compounds and salts; and the use of such compounds and salts to treat or prevent, for example, obesity, weight gain, and / or T2DM.

An subject of the present invention is (S)-2-Methyl-5-(1-methyl-2-pyrrolidinyl)pyridine for use in in a method for the treatment of nicotine dependence in an amount of 0.1-5% by weight, a pharmaceutical composition comprising (S)-2-Methyl-5-(1-methyl-2-pyrrolidinyl)pyridine for use in a method for the treatment of nicotine addiction in an amount of 0.1-5% by weight per composition of oral, inhalation and dermal products for humans. It is also an subject of the present invention to use a composition comprising (S)-2-Methyl-5-(1-methyl-2-pyrrolidinyl)pyridine in an amount of 0.1-5% by weight as a substitute for a nicotine composition in food products, inhalation and dermal products for humans, the composition being in liquid or solid form and selected from such as e-cigarettes, e-cigarette liquids, chewing tobaccos, oral pouches, chewing gums, candies, lollipops, strips, dragees, jelly beans, lozenges, tablets, snuffs, shisha-type smoking mixtures, toothpastes, inhalation mixtures, inhalers or skin patches.

The invention discloses an application of a novel miscellaneous [3] aromatic hydrocarbon crystal material in adsorptive separation of a pyrrolidine and tetrahydrofuran mixture and / or capture of iodine vapor, and relates to the technical field of adsorption.Firstly, the novel miscellaneous [3] aromatic hydrocarbon crystal material capable of adsorptive separation of pyrrolidine and tetrahydrofuran so as to realize iodine capture is synthesized; the application method comprises the following steps: selectively adsorbing pyrrolidine in a mixture of pyrrolidine and tetrahydrofuran by adopting the novel miscellaneous [3] aromatic hydrocarbon crystal material to obtain a pyrrolidine-miscellaneous [3] aromatic hydrocarbon crystal material, realizing separation of tetrahydrofuran and pyrrolidine, and capturing iodine vapor by adopting the pyrrolidine-miscellaneous [3] aromatic hydrocarbon crystal material. Compared with other macrocyclic aromatic hydrocarbons, the method provided by the invention not only can realize separation of tetrahydrofuran and pyrrolidine, but also has the advantages of high iodine adsorption capacity, good thermal stability and the like; meanwhile, the synthesis method has the advantages of simplicity in operation, high yield, simplicity in post-treatment, easiness in separation and purification of products and the like.

Crosslinking aromatic compounds are described which have structure (I). Also described, are compositions including these crosslinking compounds, for instance ones which also comprising a photoacid generator. Also, described are methods of using such compositions to coat a substrate and by exposing it to radiation producing an image which may be used as a mask in the manufacture of microelectronics. Also disclosed is a selective iodination method for multiphenolic compounds at the ortho position to the phenol functionality, employing a 1-iodopyrrolidine-2,5-dione moiety in the presence of an arylsulfonic acid which produces the phenolic precursors of crosslinking aromatic compounds with selective iodination.

The invention discloses a non-aqueous electrolyte, an electrochemical device and an electronic device. The non-aqueous electrolyte comprises a compound shown as a formula I, and M < + > in the compound shown as the formula I is selected from lithium ions, sodium ions, potassium ions, silver ions, cesium ions, ammonium cations, piperidinium cations, pyrrolidine cations or imidazolium ions; based on the total mass of the non-aqueous electrolyte, the mass ratio of the compound in the formula I is a%, and a is greater than or equal to 0.01 and less than or equal to 1. The electrochemical device provided by the invention has relatively excellent electrochemical performance, and particularly has relatively excellent high-temperature discharge performance. # imgabs0 #

The invention relates to a wafer cutting protection liquid and a preparation method thereof. The wafer cutting protection liquid comprises the following raw materials: modified water-soluble resin, an organic solvent, a wetting agent, a pH regulator, an ultraviolet light absorber and water. The modified water-soluble resin is prepared by the following steps: carrying out free radical polymerization reaction on vinyl acetate, ethyl-3-(1-pyrrolidinyl) ethyl acrylate and 3, 3-dimethyl acrylate to obtain a copolymer, and then carrying out alcoholysis on the copolymer to obtain modified polyvinyl alcohol. The invention has the following beneficial effects: by using the modified water-soluble resin composed of the vinyl acetate, the ethyl-3-(1-pyrrolidinyl) ethyl acrylate and the 3, 3-dimethyl acrylate copolymer, a protective film can be rapidly formed on the surface of a wafer; and meanwhile, the protective film layer formed by the wafer cutting protective liquid can be completely removed by using pure water. According to the wafer cutting protection liquid disclosed by the invention, a cutting line can be straight without edge breakage during wafer laser cutting, and sintering can be effectively avoided.

The invention discloses a carvacrol / thymol derivative with a structure as shown in the following formula (I), and pharmaceutically acceptable salts of the derivative: # imgabs0 #, wherein R is selected from 1-piperidyl or 1-pyrrolidinyl. The carvacrol / thymol derivative has remarkable inhibitory activity and high selectivity on butyrylcholine esterase, has good anti-neuroinflammation activity, can be used as a selective butyrylcholine esterase inhibitor with the anti-neuroinflammation activity, can be used for preparing medicines for preventing or treating Alzheimer's disease, and has wide application prospects. The compound has a good application prospect in treatment of Alzheimer's disease.

The invention relates to the technical field of bio-based high polymer materials, in particular to a vanillin-based diepoxy monomer compound as well as a preparation method and application thereof. The invention provides a brand new vanillin-based diepoxy monomer compound. A preparation method of the compound comprises the following steps: 1, synthesizing a bio-based bisphenol intermediate from bio-based platform compounds such as vanillin and vanillin under the catalysis of pyrrolidine acetate; 2, adding epichlorohydrin to synthesize a diepoxy monomer under the catalytic action of a phase transfer catalyst and base; and the epoxy resin can be reacted with a commercial curing agent to prepare high-performance bio-based epoxy resin. The glass transition temperature of the prepared high-performance bio-based epoxy resin is 170-220 DEG C, the initial decomposition index in nitrogen is 300-380 DEG C, the tensile strength is 85-120 MPa, and the high-performance bio-based epoxy resin has good mechanical properties and thermal stability.