15 results about "Ylide" patented technology

The invention relates to the technical field of chemical synthesis, and particularly discloses a compound with a peculiar smell removing function as well as a preparation method and application thereof. The chemical name of the compound is 2-ethoxy-3-((E)-methoxy-3-oxopropyl-1-alkene-1-yl) phenyl cinnamate, the smell of the compound is extremely light, sulfur-containing and nitrogen-containing compounds causing stink can be captured through a Michael addition reaction, and efficient peculiar smell removal is achieved. The preparation method comprises the following steps: (1) taking cinnamic acid as an initial raw material, and reacting with diethylamino sulfur trifluoride to prepare cinnamic acid acyl fluoride; (2) carrying out an esterification reaction on the cinnamic acid acyl fluoride and 2-methoxy-3-hydroxybenzaldehyde in the presence of 4-dimethylaminopyridine, so as to obtain 2-methoxy-3-formyl phenyl cinnamate; and (3) carrying out Wittig reaction on the 2-methoxy-3-formyl phenyl cinnamate and a phosphorus ylide reagent, so as to obtain the target compound.

This invention discloses a chiral [oxyindole-pyrrolidine-β-lactam] bispirocyclic compound containing trifluoromethyl groups, with the following structural formula: The preparation includes the following steps: 1. Sequentially adding a metal catalyst, a chiral ligand, a base, indigo-derived trifluoromethylimine ylide, and 3-methylene β-lactam, followed by the addition of an organic solvent to obtain a mixture. The mixture is stirred at a reaction temperature of 0℃ to 50℃. 2. After the reaction is complete, the chiral [oxyindole-pyrrolidine-β-lactam] bispirocyclic compound containing trifluoromethyl groups is obtained through post-processing. The chiral [oxyindole-pyrrolidine-β-lactam] bispirocyclic compound containing trifluoromethyl groups prepared in this application lays a material foundation for in-depth drug activity research based on new drug development.

The present invention relates to sulfur ylide diazo compounds, their synthesis and their use for the transfer of a carbon atom or a CN2 group into an organic substrate comprising a pi electron system, in particular for C(sp3)-atom transfer to create carbon spiro centers. The invention further relates to related processes and the compounds thus obtained.

The application provides application of phosphorus ylide organophosphine as Lewis base in catalysis of polar vinyl monomer polymerization, and belongs to the technical field of polymer synthesis. The application utilizes phosphorus ylide organophosphine as Lewis base, and through Lewis base and Lewis acid synergistic catalysis of polar vinyl monomer polymerization under the cooperation of Lewis acid, realizes active controllable polymerization of polar vinyl monomer by changing steric hindrance and electronic effect of Lewis acid and Lewis base, and can realize active controllable homopolymerization and copolymerization (random copolymerization and block copolymerization) of different polar vinyl monomers. The molecular weight of the obtained polymer increases with the increase of the monomer to catalyst ratio, so that the system can realize the molecular weight of the polymer reaching more than 10 6 g / mol, the measured value of the molecular weight of the obtained polymer is basically consistent with the theoretical value, the monomer conversion rate is 100%, and the initiation efficiency is close to 100%.

The present invention provides methods of generating diverse chemical structures on DNA through Wittig olefination of novel on-DNA phosphorane ylides and Homer-Wadsworth-Emmons reaction of on-DNA β-keto phosphonates. The methods of this invention provide access to DNA-encode libraries (DELs) of diverse peptides, peptidomimetics, chalcone-based molecules, and the like.

This invention discloses a method for preparing a trifluoromethyl-substituted dihydroquinoxaline compound, comprising the following steps: adding diisopropylethylamine, trifluoroacetylimine ylide, and azo ester to an organic solvent in an air atmosphere, reacting at 60–100°C for 20–30 hours, and after complete reaction, post-treatment to obtain the trifluoromethyl-substituted dihydroquinoxaline compound. This preparation method is simple to operate, uses inexpensive and readily available starting materials, can be carried out in an air atmosphere, utilizes inexpensive and non-toxic diisopropylethylamine, and eliminates the need for heavy metal catalysts. The reaction can also be scaled up to the gram level, facilitating operation and broadening the applicability of the method.

The application discloses a synthetic method of natural product Moracin N and belongs to the technical field of organic synthesis. The application takes an aldehyde containing a benzene ring as a starting raw material, introduces an isopentenyl group on the benzene ring through a Friedel-Crafts reaction, connects a hydroxyl protecting group to a No. 4 position hydroxyl group of the benzene ring to obtain an intermediate II, then uses a phosphorus ylide reagent to prepare the intermediate II into gem-dibromo olefin to obtain an intermediate III, then under the catalysis of a base and a copper catalyst, the gem-dibromo vinyl group is coupled with an ortho hydroxyl group to form a benzofuran ring to obtain an intermediate IV, then 3,5-dihydroxy bromobenzene is introduced to the right side of the benzofuran ring of the intermediate IV through a Suzuki-Miyaura reaction to obtain an intermediate VI, and finally the hydroxyl protecting group of the intermediate VI is removed to obtain Moracin N. The synthetic route of the application is simple, the reaction condition is mild, the safety is high, the required raw material is cheap and easy to obtain, the total cost is low, and the application is suitable for industrialized preparation.

The invention belongs to the technical field of pesticide processing, and discloses a preparation method of metconazole. The preparation method of metconazole provided by the invention comprises the following steps: S1, mixing N-methyl pyrrolidone, 2, 2-dimethyl-5-(4-chlorobenzyl) cyclopentanone, triazole alkali metal salt and organic strong alkali, and adding an oxygen-sulfur ylide reagent in batches for reaction; s2, after the reaction, adding an organic weak acid and a liquid-liquid extraction system, and layering to obtain an organic phase; s3, adding mixed inorganic strong acid into the organic phase, and performing suction filtration to obtain a filter cake; and S4, mixing the filter cake with water, removing the organic solvent, adding liquid caustic soda, and carrying out solid-liquid separation to obtain metconazole. According to the method, the organic acid quenching agent is adopted to prevent side reaction during solvent removal through distillation, purification is carried out in a mixed inorganic strong acid salifying mode, mixed inorganic strong acid salt is sheared and then fully reacts with alkali, pure metconazole powder is obtained, the purification process is simplified, and meanwhile the yield of a target product is increased.

The invention discloses a synthesis method of an intermediate precursor of a low-deposition-temperature precursor ligand, which comprises the following steps: reacting halogenated salt of trimethyl sulfoxide or trimethyl sulfide with alkali in a solvent to obtain a dimethyl sulfoxide methylene ylide solution; the preparation method comprises the following steps: reacting ketone with a dimethyl sulfoxide methylene ylide solution to obtain an epoxy compound of ketone, namely an intermediate precursor of a precursor ligand; sodium tert-butoxide with the same strong alkalinity and relatively stable chemical properties is selected to replace sodium hydride, the tert-butyl steric hindrance of the sodium tert-butoxide is large, side reactions can be reduced, the method is suitable for reactions needing high selectivity, meanwhile, the danger of reaction operation can be greatly reduced, the flammable and explosive hidden danger caused by the use of sodium hydride is eliminated, the production safety is improved, and the method is suitable for industrial production. And the reaction yield is improved.

This invention discloses a chiral pyran ring compound, its synthesis method, and its application. Using thioyl ylide (I) and vinyl-containing carbonate compounds (II) as reactants, molecular sieves are added under the action of a catalyst and chiral phosphoric acid, and the reaction is carried out in an organic solvent. Post-reaction processing yields a chiral pyran ring compound as shown in formula (III). The reaction formula is as follows: Wherein, when substituted, R is selected from a benzene ring, a substituted phenyl group, furan, thiophene, or a naphthalene ring; the substituent for the substituted phenyl group is tert-butyl, halogen, or trifluoromethyl; when substituted, R... 1 The reactants are selected from benzene rings, substituted phenyl groups, or thiophene, where the substituents of the substituted phenyl groups are methyl, methoxy, halogen, or trifluoromethyl. This invention features high yield and high selectivity; mild reaction conditions; readily available and stable reactants with no irritating odor, making it environmentally friendly.

The invention relates to compounds of the substance class of cumulated S-ylides of the general formula R1R2S=CN2. The compound proves to be a broadly applicable reagent that, depending on the substrate and the reaction conditions, can be used as a carbon atom transfer reagent or a CN2 atom group transfer reagent, thus enabling rapid synthetic access to rigid sp3-rich, for example, spirocyclic compounds.

The invention discloses a method for synthesizing a 2-aryl-(hetero) ring 1, 3-dicarbonyl compound from aryl iodine ylide. According to the invention, copper bromide is used as a catalyst, at least one of carbonate and phosphate is used as alkali, at least one of dichloroethane and acetonitrile is used as a solvent, the reaction can be rapidly carried out under mild conditions to obtain the required target product, and the yield is relatively high. The method is suitable for most aryl iodine ylide compounds to react to generate the 2-aryl-(hetero) ring 1, 3-dicarbonyl compound, and the application range is wide.

The invention discloses a method for synthesizing an aryl formyl methyl-triazole skeleton compound under catalysis of trivalent rhodium. According to the method, aryl triazole and a benzoyloxy sulfur ylide compound are subjected to ortho-position C (sp)-H bond aryl formyl methylation reaction under catalysis of trivalent rhodium to synthesize the aryl formyl methyl-triazole skeleton compound. The method not only has good to excellent product yield, but also shows a wide substrate application range and excellent functional group tolerance. The obvious advantages lay a solid foundation for large-scale popularization in practical application, and meanwhile, a new strategy is provided for subsequent reasonable utilization of a guiding group in the C (sp2)-H bond activation process catalyzed by trivalent rhodium.

The application discloses a preparation method of a trans-4,5-di-substituted oxazolidinone compound, a [4+1] cyclization reaction of an aldimine and an oxysulfur ylide catalyzed by an iron salt, a product configuration is trans, and the product has high diastereoselectivity (d.r.>20:1). The application provides a new synthesis route of the trans-4,5-di-substituted oxazolidinone compound, which has the advantages of high efficiency, relatively mild reaction conditions, cheap and easily obtained raw materials, wide substrate application range, excellent functional group tolerance, high atom and step economy and the like, and has a potential application prospect in the field of drug synthesis.

This invention discloses a method for preparing and applying the fullerene pyrrolidine phenyl ether derivative shown in formula (I). First, methylimine ylides are generated from amino acids and p-alkoxybenzaldehyde, and then subjected to a [1,3] cycloaddition reaction with fullerene to obtain the fullerene pyrrolidine phenyl ether derivative. When this fullerene pyrrolidine phenyl ether derivative is used alone as a light stabilizer in polystyrene, its light stability is significantly better than that of fullerene. Where: R 1 =-CH3,-C2H5,R 2 =‑H,‑CH2‑C6H5,‑CH2‑C6H5‑OCH3.