95 results about "Free-radical addition" patented technology

The invention discloses an alpha, omega-diiodo perfluoroalkane derivative, an alpha, omega-diiodo ethyl perfluoroalkane derivative as well as a preparation method and application of the alpha, omega-diiodo perfluoroalkane derivative and the alpha, omega-diiodo ethyl perfluoroalkane derivative. According to the method, alpha, omega-diiodo perfluoroalkane is taken as a raw material, and the alpha, omega-diiodo perfluoroalkane and ethylene are subjected to free radical addition reaction under the action of an initiator and a solvent to prepare the alpha, omega-diiodo ethyl perfluoroalkane. The alpha, omega-diiodoethyl perfluoroalkane and alkali are subjected to a one-molecule and / or two-molecule hydrogen iodide hydride elimination reaction, and alpha, omega-iodoethyl vinyl perfluoroalkane and / or alpha, omega-divinyl perfluoroalkane are / is generated. The method is simple and convenient to operate, the raw material utilization rate and the target product yield are high, the preparation cost is effectively reduced, and the industrial production requirement is met. The alpha, omega-diiodo perfluoroalkane derivative or alpha, omega-diiodo ethyl perfluoroalkane derivative prepared by the method disclosed by the invention can be used as a vulcanization point monomer for preparing peroxide vulcanized fluororubber, and compared with common rubber, the rubber has more excellent compression deformation performance, strength and medium resistance and has a wide application prospect.

The invention discloses a synthesis method of a 6-trifluoromethylthio phenanthridine compound, and belongs to the technical field of organic synthesis. The phenanthridine compound containing the trifluoromethylthio group is prepared in one step by taking phenanthridine thione as a raw material and taking bromotrifluoromethane which is low in price and easy to obtain as a fluorinating reagent through a C = S free radical addition reaction under the action of visible light induction and a photocatalyst and alkali. The method has the characteristics of being green and safe, cheap and easily available in raw materials, high in atom economy, good in reaction regioselectivity, mild in reaction condition, wide in substrate application range, high in yield, easy in product purification and the like, and belongs to green synthesis.

The invention discloses a novel method for synthesizing 1, 3-diketone organic matters, which comprises the following steps: by taking acyl chloride and silyl enol ether as raw materials, generating acyl free radicals through photo-induced copper catalysis, and carrying out free radical addition reaction on the acyl free radicals and silyl enol ether, thereby efficiently constructing 1, 3-diketone compounds. Compared with strong base, oxidant, high temperature and expensive metal catalyst required by the existing method, the method provided by the invention adopts the cheap and high-yield copper catalyst, so that the production cost is reduced, and the economic benefit is improved. In addition, the method has mild reaction conditions, easily available catalysts and raw materials, utilizes clean and sustainable light energy as driving force, is simple and convenient to operate, and is suitable for large-scale production. The invention provides an economic and environment-friendly innovative way for synthesizing the 1, 3-diketone compound, and has a wide application prospect.

This invention discloses a method for synthesizing dialkylphosphinates, belonging to the field of organic synthesis technology. The method uses hypophosphite and haloalkanes as starting materials. First, a hypophosphite is generated through a heated and pressurized reaction under the action of a phase transfer catalyst. The obtained hypophosphite does not require complex purification; it is directly reacted with an olefin under heated and pressurized conditions in the presence of a free radical initiator to obtain the target product, dialkylphosphinate. The method of this invention uses inexpensive and readily available raw materials, has a simple process route, includes only two core reactions, operates under mild conditions, is safe and convenient, produces few and easily treatable byproducts, has a high product yield, and is simple to purify. It is very suitable for large-scale industrial production, providing an economical and efficient synthetic route for the preparation of high-performance halogen-free flame retardants.

The invention discloses an anti-yellowing automotive interior composite material and a preparation method thereof, belongs to the technical field of composite material preparation, and aims to solve the technical problem that the anti-yellowing performance and flame retardant performance of an automotive interior material in the prior art need to be further improved. The material specifically comprises the following components in parts by weight: 50-60 parts of modified polystyrene, 20-30 parts of elastic silicon foam and 16-25 parts of auxiliary materials, according to the invention, fluorine group-inlaid and double-bond-terminated long-chain polysiloxane is constructed, the long-chain polysiloxane can participate in a free radical addition reaction so as to obtain modified polystyrene, on the other hand, modified polysiloxane is obtained through phosphorus-hydrogen addition and in-situ generation, and further, the modified polysiloxane and tetramethyl orthosilicate are subjected to a demethanation reaction so as to obtain the modified polystyrene. And melting and extruding the modified polystyrene, the elastic silicon foam and auxiliary materials into a mold to obtain the composite material.

The invention discloses a deuterium-containing alkyl reagent as well as a synthesis method and application thereof. The structural formula of the deuterium-containing alkyl reagent is shown as a formula I or a formula II. Alkyl triphenyl phosphine iodide is used as a raw material, hydrogen-deuterium exchange is carried out in deuterium water through heating, and the deuterium band alkylation reagent is prepared. The method is simple and convenient in process, high in yield and capable of realizing 10-gram-level large-scale preparation, more importantly, the deuterium band alkylation reagent can be used as a free radical reagent to be applied to free radical addition reaction to prepare different types of deuterium band alkylation products, and the deuterium band alkylation reagent has important application value. # imgabs0 #

The present invention relates to a novel method for cyanoalkylation of C-3 position of 2-amino-1,4-naphthoquinone compounds under visible light induction without the participation of photosensitizer, specifically, in an argon environment, under visible light irradiation, a substrate 2-amino-1,4-naphthoquinone compound is excited, and then a cyclobutanone oxime ester compound is subjected to single electron reduction, and then N-O bond cleavage occurs, β The desired 3-position cyanoalkylated 2-amino-1,4-naphthoquinone compounds are obtained by cleavage, free radical addition and deprotonation. The raw materials of this method are easily available, the steps are simple, no photosensitizer and oxidant are required, the reaction conditions are mild, and it is environmentally friendly. It is a new green method for synthesizing 2-amino-1,4-naphthoquinone derivatives.

The invention discloses a perfluoroalkyl-substituted pyrimido [1, 2-b] indazole ketone compound and a preparation method thereof, and belongs to the technical field of compounds containing two or more heterocyclic rings. Comprising the following steps: with enaminone, a perfluoroalkane compound and aminoindazole as raw materials, carrying out a reaction under blue light irradiation in the presence of an organic solvent and alkali to prepare the perfluoroalkyl-substituted pyrimido [1, 2-b] indazole ketone compound; according to the invention, through visible light mediated dehalogenation and cyclization free radical addition, high-yield synthesis of the perfluoroalkyl substituted pyrimido [1, 2-b] indazole ketone compound is realized; the prepared perfluoroalkyl-substituted pyrimido [1, 2-b] indazolone compound has excellent antibacterial activity, can be used for preparing antibacterial drugs, and has outstanding industrial application value.

The invention belongs to the technical field of photoresist, and particularly relates to a triazinyl negative photoresist composition for an organic insulating film, which comprises the following components in parts by mass: 30-100 parts of a polymer containing a triazine structure; 5-65 parts of an unsaturated compound containing an olefinic bond; 0.005 to 10 parts of a surface active agent; 0.005 to 10 parts of an adhesion promoter; 0.005 to 30 parts of a free radical polymerization initiator; and 100 to 2000 parts of a solvent. According to the invention, a polyfunctional group triazine derivative participates in a free radical addition reaction, a poly (methyl) acrylate polymer containing a triazine structure is synthesized, and by regulating and controlling the type and number of functional groups of monomers participating in the reaction and the alkyl chain length and introducing aryl or naphthenic base, the polyfunctional group-containing poly (methyl) acrylate polymer is obtained. The hydrophilic-hydrophobic property, the temperature resistance and the chemical resistance of the polymer can be accurately adjusted.

The invention discloses a preparation method of a visible light / copper dual-catalysis 1-aryl-3-alkynyl bicyclo [1.1. 1] pentane compound, which comprises the following steps: taking trifluoromethanesulfonic acid aryl sulfonium salt, [1.1. 1] propeller alkane and terminal alkyne as initial raw materials, taking tris (2-phenylpyridine) iridium and the like as photocatalysts, taking copper acetylacetonate and the like as metal catalysts, taking 2, 2 '-bis (dicyclohexylphosphino)-1, 1'-pentane as a catalyst, and taking 2, 2 '-bis (dicyclohexylphosphino)-1, 1'-pentane as a catalyst to prepare the visible light / copper dual-catalysis 1-aryl-3-alkynyl bicyclo [1.1. 1] pentane compound. The method comprises the following steps: under the conditions that 1, 1 '-biphenyl and the like are used as ligands, 1, 8-diazabicyclo [5.4. 0] undec-7-alkene and the like are used as alkali, and acetonitrile and the like are used as solvents, reducing aryl hexane salt into aryl free radicals, and then carrying out ring tension released free radical addition with [1.1. 1] propeller alkane, so as to obtain the aryl hexane compound. And finally, capturing by an alkynyl copper intermediate generated in situ, and carrying out reduction elimination to obtain the 1-aryl-3-alkynyl bicyclo [1.1. 1] pentane compound. After the method is optimized, the reaction condition is mild, the substrate universality is good, the problem that synthesis needs multiple steps in the prior art is solved, and the method is a novel method for preparing the 1-aryl-3-alkynyl bicyclo [1, 1, 1] pentane compound.

The invention belongs to the technical field of water-based curing agents in the textile industry, and provides a water-based closed isocyanate curing agent, a preparation method thereof and application of the water-based closed isocyanate curing agent in fabric waterproof finishing. The preparation method comprises the following steps: mixing polyisocyanate, hydroxyl acrylate and a solvent, carrying out a polymerization reaction, adding a sealing agent into the obtained polymerization reaction system, and carrying out an end-capping reaction to obtain blocked isocyanate; the preparation method comprises the following steps: mixing blocked isocyanate, long-chain alkyl acrylate, a POSS (polyhedral oligomeric silsesquioxane) hydrophobic modifier, a chain transfer agent, an initiator and a solvent, and carrying out free radical addition reaction to obtain hydrophobic modified blocked isocyanate; and mixing the hydrophobic modified blocked isocyanate, an emulsifier, a pH regulator, water and a cosolvent, and carrying out high-pressure homogenization to obtain the water-based blocked isocyanate curing agent. The water-based closed isocyanate curing agent disclosed by the invention has waterproof synergism, and is compounded with a fluoride-free waterproof agent, so that the waterproofness and washability of the fluoride-free waterproof agent can be improved.

The invention provides a method for preparing sodium diisobutyl dithiophosphinate by using a microreactor, and belongs to the technical field of organic synthesis. The method comprises the following steps: sequentially carrying out impurity removal pretreatment, precooling drying and deep cooling on phosphine gas to obtain high-purity liquid phosphine, the method comprises the following steps: by taking liquid phosphine and isobutene as raw materials, adding an initiator, and carrying out photo-thermal synergistic initiated free radical addition reaction in a microreactor to synthesize diisobutyl phosphorus; the micro-reactor comprises a straight-through pre-activation zone, a transition reaction zone and a main reaction zone; rectifying and separating the diisobutyl phosphorus; the preparation method comprises the following steps: adding diisobutyl phosphorus and a sodium hydroxide solution into a sulfur source solution under the conditions of pressurization and heating, carrying out nucleophilic substitution reaction, and carrying out heat preservation reaction to obtain the sodium diisobutyl dithiophosphinate. The free radical addition reaction is carried out in the microreactor, and step-by-step operation initiated by photo-thermal synergy is adopted, so that the yield of the target product diisobutyl phosphorus of the reaction is effectively improved, the generation of by-products is inhibited, and the blockage of the microreactor is avoided.

The invention discloses a free radical addition tandem cyclization reaction of N-aryl acryloylbenzamide or 2-aryl-N-acryloyl indole or N-methacryloyl-2-phenylbenzimidazole with potassium selenocyanate under visible light conditions, using cheap KSeCN as a selenocyanation reagent, potassium persulfate and the like as an oxidant, 2,4,6-triphenyl tetrafluoroborate and the like as a phase transfer catalysis and photocatalytic bifunctional catalyst to carry out a selenocyanation cyclization reaction. The reaction synthesizes selenocyanide isoquinoline-1,3 (2H, 4H)-diketone, indole [2,1-a] isoquinolinone and benzimidazole [2,1-a] isoquinoline-6 ​​(5H)-one in moderate to excellent yields under room temperature and visible light. The method has the advantages of mild reaction conditions, good substrate compatibility, large-scale synthesis, simple operation, cheap and easily available raw materials, simple preparation, and stable structure.

The present application relates to a kind of fluorine-containing dihydronaphthalenone derivative and its preparation method and application, the fluorine-containing dihydronaphthalenone derivative obtained by visible light induced phosphine catalysis difluoroacetophenone derivative and the radical addition cyclization reaction of a variety of olefins in series compared with prior art, the preparation method of the present application has the advantages of high efficiency, short reaction time, high yield, mild condition etc., its structural motif is important in pharmaceutical and agrochemical products;The synthetic method for preparing fluorine-containing dihydronaphthalenone and its derivative of the present application is completely new, and the fluorine-containing dihydronaphthalenone compound synthesized is used in various organic synthesis reactions.

This invention discloses a method for preparing organic sulfates, comprising the following steps: using persulfate as the sulfate source, and achieving the functional group transformation of a free radical precursor compound through the free radical anion of the sulfate ion, thereby preparing the organic sulfate. This invention uses persulfate as the source and, through a free radical addition mechanism, acts on the free radical precursor substrate. Persulfate, as a sulfate free radical anion, participates in the functional group transformation of the organic compound, resulting in the efficient synthesis of organic sulfates.

The invention discloses a synthesis method of novel alpha, beta-unsaturated ketone, which comprises the following steps: by taking aryl acyl chloride and olefin as raw materials, catalyzing the aryl acyl chloride through light-induced copper to generate acyl free radicals, and then carrying out free radical addition reaction and elimination on the acyl free radicals and the olefin, so as to efficiently construct an alpha, beta-unsaturated ketone compound. Compared with an existing method depending on an expensive iridium catalyst or organic dye, the method has the advantages that the cheap and high-yield copper catalyst is directly adopted, the production cost is remarkably reduced, and the economic benefit is improved. The method has the characteristics of mild reaction conditions, easily available catalyst and raw materials, use of clean and sustainable light energy as driving force, simplicity and convenience in operation and the like. The invention provides a new way which is economical, environment-friendly and easy for large-scale production for the synthesis of the alpha, beta-unsaturated ketone compound.

The application relates to the technical field of pet dry food packaging materials, and discloses a high-barrier puncture-resistant soft packaging film, a preparation process and application, which specifically are as follows: isocyanate functional groups obtained by deblocking of a multifunctional linking agent are subjected to nucleophilic addition reaction with hydroxyl functional groups enriched on the surface of zinc-aluminum hydrotalcite nanosheets, the multifunctional linking agent molecules are anchored to the surface of the hydrotalcite, and methacrylic acid functionalized stable hydrotalcite is prepared; under the action of a melt state and a free radical initiator, the methacrylic acid functionalized stable hydrotalcite is grafted to a polyethylene resin main chain through a free radical addition reaction, and hydrotalcite modified polyethylene masterbatch is prepared; the hydrotalcite modified polyethylene masterbatch is used as raw material of a functional layer in a three-layer co-extrusion film, a three-layer co-extrusion blow molding process is adopted, and the high-barrier puncture-resistant soft packaging film is prepared, which meets the technical requirements of pet dry food product packaging materials in barrier properties and mechanical properties and can be used as pet dry food packaging materials.

The present invention relates to a bifunctionalized graphene oxide nonlinear optical nanohybrid material and its preparation and application. First, the carbonyl group at the edge of the graphene oxide is converted into dicyanomethylene through a Knoevenagel condensation reaction, and then porphyrin molecules are covalently grafted on the surface of the graphene oxide through a free radical addition reaction, thereby achieving bicovalent functionalization of the graphene oxide. By chemically bonding the electron-donating porphyrin and the dicyanomethylene with strong electron-pulling properties to the graphene surface, the electron and energy transfer process between the porphyrin and the graphene oxide is strengthened, thereby enhancing the third-order nonlinear optical properties of the organic-inorganic hybrid material. The present invention enriches the chemical modification methods of graphene oxide, and the obtained materials have broad application prospects in optoelectronic fields such as nonlinear optical devices.

The invention relates to the technical field of bag-in-box BIB flexible packaging materials, and discloses a single-material flexible packaging film for manufacturing a cubic BIB liquid bag and a preparation method of the single-material flexible packaging film for manufacturing the cubic BIB liquid bag. Specifically, based on a hydroxyl-epoxy ring-opening reaction mechanism, hydroxyphenyl long-chain fatty amine monomers are modified on the surface of graphene rich in epoxy functional groups, and phenylated long-fatty-chain graphene is prepared; on the basis of a free radical addition reaction mechanism, octavinyl-POSS is grafted to a polyethylene main chain to prepare octavinyl-POSS functionalized polyethylene, and the octavinyl-POSS functionalized polyethylene is compounded with phenylated long aliphatic chain type graphene through a Friedel-Crafts reaction to prepare the high-performance polyethylene master batch. The high-performance polyethylene master batch is used as a modification component of single polyethylene resin, the single-material flexible packaging film is prepared through a nine-layer co-extrusion blow molding process, and the film product has excellent mechanical performance, oxygen resistance and recoverability, can be used as a cubic BIB liquid bag material and is used for manufacturing bag-in-box BIB.

This invention belongs to the field of photoresist technology, specifically relating to a compound containing a multifunctional polysiloxane structure and its applications. The structural formula is selected from general formula I or general formula II. Based on an organosiloxane polymer, this invention introduces multifunctional reactive functional groups into the polymer structure through transesterification and free radical addition reactions. The hydrophilic / hydrophobic properties, temperature resistance, and chemical resistance can be improved by adjusting the types of monomers introduced. This compound is used to prepare a photoresist composition with a solvent, a monomer with ethylene unsaturated bonds, a photosensitizer, and other additives. This photoresist exhibits advantages such as low dielectric constant, good adhesion, high residual film rate, good UV transmittance, good patterning, and good chemical resistance.

The application provides a synthesis method of 1,4-butanediol sulfonic acid lactone, and aims to provide a synthesis method of 1,4-butanediol sulfonic acid lactone which uses tetrahydrofuran as a raw material, is low in price and easy to obtain, reduces a chlorination reaction, reduces the generation of by-products, is simple in reaction, easy to operate and high in industrial value, and the technical scheme is that sulfite and tetrahydrofuran are subjected to a free radical addition reaction under the action of a free radical initiator to obtain 4-hydroxybutane sulfonate in one step, and the 4-hydroxybutane sulfonate is acidified and ring-closed to obtain 1,4-butanediol sulfonic acid lactone; and the application relates to the technical field of chemical industry.

The invention discloses a preparation method of a high-hardness wear-resistant coating coated with MS resin, and belongs to the technical field of preparation of MS resin protective coatings. The preparation method comprises the following steps: mixing and stirring a double-bond-terminated pre-polymerized organic silicon-oxygen emulsion, an organic solvent, a high-temperature alkyl initiator and bisphenol A polycarbonate to form a coating solution; the MS resin is completely immersed in the coating liquid, and then a pulling process of 20 cm / min to 25 cm / min and a thermocuring process of treating for 2 h to 3 h at the temperature of 120 DEG C to 150 DEG C are sequentially carried out, so that the high-hardness wear-resistant coating coated with the MS resin is obtained. The preparation method comprises the following steps: carrying out ultrasonic pre-polymerization on an organic silicon oxygen compound monomer to obtain a double-bond-terminated pre-polymerized organic silicon oxygen emulsion, then mixing the pre-polymerized organic silicon oxygen emulsion with bisphenol A polycarbonate, and carrying out free radical addition with double bonds on MS resin under the catalytic action of a high-temperature alkyl initiator. And a coating coated with the MS resin has good adhesive force, hardness and wear resistance.

The invention belongs to the technical field of compound synthesis, and particularly relates to a one-step synthesis method of a phenanthrene cyclic aromatic hydrocarbon derivative, which comprises the following steps of: reacting 2-iodobiphenyl shown in a general formula (1) and alkyne shown in a general formula (2) in the presence of a transition metal Pd catalyst, a ligand, an alkaline substance and a solvent in a nitrogen atmosphere under the irradiation of visible light with the wavelength of 420-500nm to obtain the phenanthrene cyclic aromatic hydrocarbon derivative. The phenanthrene ring compound is generated. According to the reaction, aryl free radicals are generated through single electron transfer and then are subjected to free radical addition with alkyne, and then cyclization is carried out. A series of complex phenanthrene ring derivatives are synthesized under mild conditions. The reaction mode of the method for synthesizing the phenanthrene ring derivative is extremely rare.

The present invention relates to an agent for initiating a free radical addition reaction, comprising or consisting of a persulfate and one or more transition metals in elemental or oxidized form, and to a process for the preparation of a compound of formula (I) by a free radical addition reaction in the presence of such an agent; wherein X is selected from S, Se and O. # imgabs0 #

The application relates to the technical field of bag-in-box (BIB) flexible packaging materials, and discloses a single-material flexible packaging film for manufacturing a cubic BIB liquid bag and a preparation method, which is characterized by the following steps: based on a hydroxyl-epoxy ring-opening reaction mechanism, a hydroxyl phenyl long-chain aliphatic amine monomer is modified on a graphene surface rich in epoxy functional groups to prepare phenylated long aliphatic chain graphene; based on a free radical addition reaction mechanism, octavinyl-POSS is grafted to a polyethylene main chain to prepare octavinyl-POSS functionalized polyethylene, and the high-performance polyethylene master batch is prepared by compounding the octavinyl-POSS functionalized polyethylene and the phenylated long aliphatic chain graphene through a Friedel-Crafts reaction; the high-performance polyethylene master batch is used as a modified component of single polyethylene resin, and a single-material flexible packaging film is prepared through a nine-layer co-extrusion blowing process; the film product has excellent mechanical properties, oxygen barrier properties and recyclability, can be used as a cubic BIB liquid bag material, and can be used for manufacturing a bag-in-box (BIB).

The present application relates to the field of organic synthesis, specifically a method for synthesizing C3 fluorine alkyl substituted quinoxaline ketone derivatives from olefin derivatives and quinoxaline ketone derivatives under photocatalysis by using [bis(fluoroalkyl acetoxy)iodo] benzene as different fluorine alkyl sources. [Bis(fluoroalkyl acetoxy)iodo] benzene is used as a fluorine alkylating agent to generate fluorine alkyl radicals under photocatalysis, then the radicals add to olefin derivatives to obtain alkyl radicals, the alkyl radicals then add to quinoxaline ketone, and finally, after oxidation and deprotonation, C3 fluorine alkyl substituted quinoxaline ketone derivatives are obtained. The present application uses simple and stable [bis(fluoroalkyl acetoxy)iodo] benzene as a fluorine alkyl source to prepare C3 different fluorine alkyl substituted quinoxaline ketone derivatives from quinoxaline ketone and olefin derivatives in a three-component reaction without the action of photocatalysts. The synthesis method is simple and easy to operate, and different fluorine alkyl group substituted quinoxaline ketone derivatives can be quickly obtained.

The invention discloses a method for synthesizing functional pyrrole through photocatalysis of N-arylglycine and 1, 3-eneyne. According to the method, N-arylglycine is decarboxylated through photocatalysis to form an alpha-amino alkyl free radical, and the free radical and 1, 3-eneyne are subjected to free radical addition, cyclization and oxidative aromatization reaction to construct polysubstituted pyrrole. Pyrrole serves as a heterocyclic compound with great importance, widely exists in numerous drug compounds and bioactive molecules, shows electronic characteristics with great prospects in organic photovoltaic devices (OPVs) and organic field effect transistors (OFETs), is also a key structural unit in synthesis of pesticides, natural products and dyes, and has a broad application prospect. Powerful support is provided for multi-industry development, and the application prospect is wide. The polysubstituted pyrrole compound is synthesized through a one-pot method, and a new method is provided for preparing the novel polysubstituted pyrrole compound.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of 1-pentafluorothio-2-arylacetylene. The 1-pentafluorothio-2-arylacetylene is prepared according to the following steps: under an inert atmosphere, a monovalent or divalent copper salt is used as an initiator, mixed with a ligand in a solvent, so that the initiator is coordinated with the ligand, then mixed with an arylacetylene compound and an SF5Cl hexane solution, and subjected to a free radical addition reaction to obtain 1-pentafluorothio-2-chloro-2-arylvinyl; and the 1-pentafluorothio-2-chloro-2-arylvinyl is subjected to HCl removal by using LiOH.H2O to obtain the 1-pentafluorothio-2-arylacetylene. The application realizes the preparation of 1-pentafluorothio-2-chloro-2-arylvinyl with a high yield, and then uses LiOH.H2O as an alkali to generate a target product by removing HCl. The application overcomes the technical defects existing in the prior art of the preparation of 1-pentafluorothio-2-arylacetylene.

The invention relates to a synthesis method of ternary spiro gamma-lactam, which comprises the following steps: by taking benzaldehyde, aniline and methyl 4-chloro-2-methylene butyrate as raw materials, carrying out formate oxidation / HAT process under a photocatalytic condition to generate a carbon dioxide free radical anion CO2 <.->; reducing the imine intermediate into corresponding free radical anions by the carbon dioxide free radical anions; carrying out free radical addition / cyclization reaction on the free radical anion and 4-chloro-2-methylene methyl butyrate to generate a three-membered ring intermediate; then, nitrogen anions in the three-membered ring intermediate serve as a nucleophilic reagent, nucleophilic attack is conducted on molecular lactone carbonyl, a molecular lactone amination reaction is conducted, a three-membered spiro gamma-lactam product is obtained in a closed loop mode, a one-step cyclization strategy is adopted, raw materials easy to obtain are directly started, and multi-step protection and deprotection are avoided.

The invention belongs to the technical field of photoresists, and particularly relates to a negative photoresist based on POSS (polyhedral oligomeric silsesquioxane) hyperbranched structure acrylate resin, which comprises the POSS hyperbranched structure acrylate resin, a free radical polymerization initiator, an ethylenic bond-containing unsaturated compound, a surfactant and an adhesion promoter, the POSS hyperbranched structure acrylate resin has a structure as shown in a general formula II, wherein n is greater than or equal to 1. According to the invention, POSS is taken as a core, acrylate resin with a POSS hyperbranched structure is prepared through free radical addition reaction, the acrylate resin is used as matrix resin of negative photoresist, and an organic insulating film with high process yield, low manufacturing cost, good light transmission, high flatness, excellent pattern stability, low dielectric constant and good adhesion with a matrix layer can be formed.