8 results about "Free-radical addition" patented technology

This invention discloses a method for synthesizing dialkylphosphinates, belonging to the field of organic synthesis technology. The method uses hypophosphite and haloalkanes as starting materials. First, a hypophosphite is generated through a heated and pressurized reaction under the action of a phase transfer catalyst. The obtained hypophosphite does not require complex purification; it is directly reacted with an olefin under heated and pressurized conditions in the presence of a free radical initiator to obtain the target product, dialkylphosphinate. The method of this invention uses inexpensive and readily available raw materials, has a simple process route, includes only two core reactions, operates under mild conditions, is safe and convenient, produces few and easily treatable byproducts, has a high product yield, and is simple to purify. It is very suitable for large-scale industrial production, providing an economical and efficient synthetic route for the preparation of high-performance halogen-free flame retardants.

The invention discloses a perfluoroalkyl-substituted pyrimido [1, 2-b] indazole ketone compound and a preparation method thereof, and belongs to the technical field of compounds containing two or more heterocyclic rings. Comprising the following steps: with enaminone, a perfluoroalkane compound and aminoindazole as raw materials, carrying out a reaction under blue light irradiation in the presence of an organic solvent and alkali to prepare the perfluoroalkyl-substituted pyrimido [1, 2-b] indazole ketone compound; according to the invention, through visible light mediated dehalogenation and cyclization free radical addition, high-yield synthesis of the perfluoroalkyl substituted pyrimido [1, 2-b] indazole ketone compound is realized; the prepared perfluoroalkyl-substituted pyrimido [1, 2-b] indazolone compound has excellent antibacterial activity, can be used for preparing antibacterial drugs, and has outstanding industrial application value.

The present application relates to a kind of fluorine-containing dihydronaphthalenone derivative and its preparation method and application, the fluorine-containing dihydronaphthalenone derivative obtained by visible light induced phosphine catalysis difluoroacetophenone derivative and the radical addition cyclization reaction of a variety of olefins in series compared with prior art, the preparation method of the present application has the advantages of high efficiency, short reaction time, high yield, mild condition etc., its structural motif is important in pharmaceutical and agrochemical products;The synthetic method for preparing fluorine-containing dihydronaphthalenone and its derivative of the present application is completely new, and the fluorine-containing dihydronaphthalenone compound synthesized is used in various organic synthesis reactions.

The present application relates to the field of organic synthesis, specifically a method for synthesizing C3 fluorine alkyl substituted quinoxaline ketone derivatives from olefin derivatives and quinoxaline ketone derivatives under photocatalysis by using [bis(fluoroalkyl acetoxy)iodo] benzene as different fluorine alkyl sources. [Bis(fluoroalkyl acetoxy)iodo] benzene is used as a fluorine alkylating agent to generate fluorine alkyl radicals under photocatalysis, then the radicals add to olefin derivatives to obtain alkyl radicals, the alkyl radicals then add to quinoxaline ketone, and finally, after oxidation and deprotonation, C3 fluorine alkyl substituted quinoxaline ketone derivatives are obtained. The present application uses simple and stable [bis(fluoroalkyl acetoxy)iodo] benzene as a fluorine alkyl source to prepare C3 different fluorine alkyl substituted quinoxaline ketone derivatives from quinoxaline ketone and olefin derivatives in a three-component reaction without the action of photocatalysts. The synthesis method is simple and easy to operate, and different fluorine alkyl group substituted quinoxaline ketone derivatives can be quickly obtained.

The present application relates to the field of photocatalytic organic synthesis, and particularly to a visible light induced tandem radical addition-cyclization reaction for constructing an aromatic heterocycle linked indole ketone compound and a preparation method thereof.By introducing an unsaturated group at the ortho position of a ketoxime ester, a new intramolecular cyclization pathway is generated to realize the construction of a new aromatic heterocycle radical, and a preparation method of the aromatic heterocycle linked indole ketone compound is further provided, and the specific molecular structure is shown in the following formula (I). The present application has the advantages of easy availability of raw materials, simple operation, mild conditions, simple synthesis route, high synthesis efficiency, strong functional group adaptability of the substrate, potential application value in the biological and medical fields due to the particularity and designability of the aromatic heterocycle linked indole ketone structure.

The application discloses a kind of dialkyl hypophosphite-alkyl phosphinic acid composite salt flame retardant and synthesis method thereof, it is related to organic phosphorus compound technical field, scheme is: the composite salt flame retardant is composed of dialkyl hypophosphite, alkyl phosphinic acid root and 2-4 valence metal ions;Its synthesis method includes that phosphine is added with gaseous or liquid olefin to occur radical addition, and the obtained addition product is oxidized, pH is adjusted and is salted with 2-4 valence metal salt, obtains target composite salt flame retardant.The beneficial effect of the application is: by controlling reaction ratio and subsequent conversion process, realizes the structure directional control from single salt to composite salt, so that the obtained product simultaneously has dialkyl hypophosphite and alkyl phosphinic acid root coexistence characteristics, while maintaining high conversion level, has stable preparation and good flame retardant application value.

This invention provides a method for preparing α-BMIDA ester compounds. The method uses α-BMIDA propylene ester and potassium alkyl trifluoroborate as substrates, and generates α-BMIDA esters through intermolecular radical addition-protonation reaction under photocatalytic conditions. This achieves the goal of efficient and versatile synthesis of α-BMIDA esters with different functional groups. The use of α-BMIDA propylene ester as the core reaction unit effectively allows for reaction with various alkyl radicals from different sources or structures, enriching the variety of α-BMIDA esters. Furthermore, the method avoids the use of oxidants and diazo compounds. The yield of most synthesized α-BMIDA ester products is higher than 80%. It has the advantages of mild reaction conditions, simple steps, fast reaction rate, and high yield. The reactants used are readily available, and the catalyst is inexpensive, providing an economical and convenient solution and technical support for the large-scale preparation of α-BMIDA ester compounds.

The application discloses a method for preparing a carborane sulfide compound through a carbon borane sulfhydryl reaction of an olefin, and the method uses a carborane thiol and a non-activated olefin as raw materials, and generates the carborane sulfide through a free radical addition reaction of the carborane thiol and the olefin under the catalysis of a photosensitizer and through light irradiation. The carborane sulfide is prepared through a photo reaction, raw materials are cheap and easy to obtain, operation is simple, the reaction is mild, conditions are safe, the synthesis yield is high, and side reactions are few, so that the method is an economic and environment-friendly synthesis route, provides a new path for synthesizing the carborane sulfide, and can be suitable for industrialized production.