8 results about "Chromane" patented technology

The invention belongs to the technical field of biological medicines, and particularly relates to a synthetic method and application of a cyclobutane and chroman skeleton molecular compound, which is a method for synthesizing a cyclobutane and chroman skeleton molecular compound through a triplet-triplet energy transfer mechanism by using a blue light excitation photocatalyst under a mild condition. The invention discloses a method for constructing a cyclobutane and chroman skeleton molecular compound by efficiently, highly regionally and stereoselectively catalyzing intramolecular [2 + 2] cycloaddition of a 2H-chromene compound, and further explores the application potential of the cyclobutane and chroman skeleton molecular compound in research and development of anti-glioma drugs. The obtained compound can specifically and effectively kill glioma stem cells, and a new lead compound and thought are provided for research and development of anti-glioma drugs.

Described herein are compounds of Formula (I) and pharmaceutically acceptable salts, solvates, or stereoisomers thereof, as well as their uses (e.g., as estrogen receptor degraders).

This invention relates to the field of asymmetric catalytic hydrogenation, specifically to a method for preparing chiral chromone or chromane carboxylic acid compounds. The method involves preparing a chiral catalyst from a nickel compound and ligands. By controlling the combination of the nickel compound-ligand-solvent, enantioselective hydrogenation of the conjugated C=C bonds of the substrate chromone carboxylic acid compound is achieved, yielding the semi-reduced product chiral chromone carboxylic acid; or, further, the carbonyl group is reduced, and carbonyl reduction and dehydroxylation reactions are carried out at room temperature under trifluoroacetic acid and triethylsilane conditions to obtain the fully reduced product chiral chromane carboxylic acid. The catalytic system of this invention is simple to construct, and the selectivity can be controlled by the solvent system. It maintains high conversion and excellent enantioselectivity even under high S / C conditions, making it suitable for the efficient preparation of chiral chromone / chromane skeletal carboxylic acid compounds.

This invention pertains to organic synthesis and medicinal chemistry, specifically relating to a 4-chromone-cyclohexane spirocyclic trimer compound, its preparation method, and its applications. The 4-chromone-cyclohexane spirocyclic trimer compound has the structure shown in Formula I, II, III, or IV, or stereoisomers of the structures shown in Formulas I to IV. This invention also provides a method for preparing this compound, using 2-hydroxyacetophenone or its derivatives as a starting material, reacting it with dihalomethane in the presence of a base and additives to construct a spirocyclic trimer skeleton in one step. The compound of this invention can inhibit PPM1E and PPM1F protein phosphatases with high activity and high selectivity, achieving nanomolar inhibitory activity against PPM1E and sub-enzyme selectivity exceeding 100-fold. The compound of this invention can be used to prepare drugs for cancers associated with PPM1E / PPM1F overexpression.

Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane.

Provided are monobactam compounds of Formula (I), and pharmaceutically acceptable salts thereof. Also provided are compositions which comprise a monobactam compound of Formula (I) or a pharmaceutically acceptable salt therof, and a pharmaceutically acceptable carrier. Further provided are methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of Formula (I), either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

The invention belongs to the technical field of organic synthesis, and relates to a synthetic method of chroman-5-amine. The molecular structural formula of the chroman-5-amine is shown as a formula 1. The synthesis method of the chroman-5-amine comprises the following steps: by taking methyl 4-bromo-3-hydroxybenzoate as a raw material, carrying out six-step reaction of substitution, cyclization, elimination, hydrolysis, amination and Boc group removal to synthesize the compound chroman-5-amine. The synthesis method is mild in condition, simple and efficient.

Provided are a compound of Formula 1 having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.: