102 results about "Chromone" patented technology

The present invention belongs to the field of agarwood, and in particular to a kind of 2-(2-phenylethyl) chromone and lignan heterocompound and its application. The present invention uses the agarwood produced by thick-leaved agarwood tree as raw material, and after reflux extraction, successively adopts silica gel, Sephadex LH-20 gel, high performance liquid chromatography and other chromatographic techniques to separate and purify to obtain 1 monomer compound, and its structure is identified by spectral methods such as mass spectrometry and nuclear magnetic resonance and combined with physicochemical properties. It is retrieved as a new compound by SciFinder and named as thick-leaved agarwood alcohol (aquicrassnol), which is the first heterocompound formed by 2-(2-phenylethyl) chromone and lignan found in agarwood. It has been verified by experiment that the compound has an inhibitory effect on the production of nitric oxide in mouse mononuclear macrophage RAW264.7 induced by lipopolysaccharide, and its half-maximal inhibitory concentration value is 47.53±2.14μmol / L, which has anti-inflammatory activity.

The invention belongs to the field of biological medicine, and particularly relates to an anti-inflammatory and anti-helicobacter pylori compound separated from agilawood and a preparation method thereof. The method comprises the following steps: by taking the agilawood corasta as a raw material, carrying out reflux extraction with ethanol, extracting with petroleum ether to remove volatile components, separating and purifying by adopting various chromatographic technologies such as silica gel column chromatography, reversed-phase column chromatography and semi-preparative HPLC (High Performance Liquid Chromatography) to obtain a monomeric compound, and identifying the structure of the monomeric compound by adopting spectroscopy methods such as ultraviolet, high-resolution mass spectrometry and nuclear magnetic resonance. The structure of a compound 1 is identified as a new 2-(2-phenethyl) chromone dimer, and the compound 1 is named as aquicrasone V. The invention further discloses a preparation method of the compound 1. A biological activity test verifies that the compound has relatively strong anti-inflammatory activity and anti-helicobacter pylori activity.

The method comprises the following steps: adding o-hydroxyphenyl enaminone as shown in a formula I, aryl sulfonyl chloride as shown in a formula II, a photocatalyst and an additive into a solvent, stirring and reacting under the irradiation of a light source, filtering, washing, and drying to obtain the 3-position sulfonyl substituted chromone derivative. And after the reaction is finished, carrying out post-treatment to obtain the 3-position sulfonyl substituted chromone derivative as shown in a formula III, wherein the reaction formula of the 3-position sulfonyl substituted chromone derivative is as follows: # imgabs0 #. The method has the advantages of simple operation process, cheap and easily available raw materials, mild reaction conditions, high reaction yield and the like, and compared with the traditional process, the method avoids the use of high-temperature conditions and oxidizing agents, and is environment-friendly.

The invention provides a method for leaching chromium in high-chromium tanning sludge, and belongs to the technical field of treatment of heavy metals in leather tanning sludge. The method comprises the following steps: mixing the high-chromium tannery sludge with dilute sulphuric acid, and carrying out acid leaching to obtain a chemical leaching solution and chemical leaching residues; diluting the chemical leaching residues, inoculating domesticated composite thiobacillus species, adjusting the pH value, adding a nutritional agent, and carrying out bioleaching to obtain a bioleaching solution and bioleaching residues; and finally, mixing the chemical leachate, the biological leachate, a sulfuric acid solution, a sodium dichromate solution and a glucose solution, adjusting the alkalinity, and stirring to obtain the chrome tanning agent. According to the method for leaching the chromium in the high-chromium tanning sludge, the removal rate of the chromium can reach 99% or above, the effect is remarkably superior to that of a single process, the method is a feasible and optimal process at the current stage, the chromium leaching solution is further processed and treated and enters a chromium tanning section to serve as a chromium tanning agent, and cyclic utilization is achieved.

The present invention provides an isopsoralen chalcone-curcumin derivative, its preparation method and application, and an antibacterial pharmaceutical preparation, belonging to the field of pharmaceutical chemistry technology. The isopsoralen chalcone-curcumin derivative of the present invention is based on the isopsoralen chalcone and curcumin structural framework. In vitro antibacterial experiments have shown that it has excellent broad-spectrum antibacterial activity, especially against drug-resistant Staphylococcus aureus (MRSA), with antibacterial activity that is more than 1,000 times that of the positive drug ofloxacin. At the same time, the isopsoralen chalcone-curcumin derivative has high biosafety.

The application provides a benzyl chromone compound and a preparation method and application thereof. The application takes dry fruit bodies of Leucangium alectorium as raw materials, carries out ethanol extraction, ethyl acetate extraction, then carries out rough separation on the ethyl acetate phase obtained by extraction with different proportions of dichloromethane-methanol solution, and then carries out elution separation with different proportions of methanol-water to obtain a novel structure benzyl chromone compound. The benzyl chromone compound provided by the application has significant in-vitro inhibition activity on HepG2 cell proliferation, and when the treatment concentration is below 160 muM, the inhibition activity on liver cancer cells is obviously better than that of cisplatin, and the benzyl chromone compound can be used for preparing drugs for treating and preventing liver cancer. Meanwhile, the raw material of the compound is rich in source, low in price, simple in preparation process and convenient for industrial application, so the discovery of the compound is expected to provide a promising treatment scheme for liver cancer patients, and has great significance for breaking through the bottleneck of liver cancer treatment.

The application discloses a chromone dimer with melanin production inhibition, a preparation method and application thereof, and belongs to the technical field of natural products. The chromone dimer with melanin production inhibition has a structure shown in formula I. The chromone dimer with melanin production inhibition is evaluated by taking the melanin production of mouse melanoma (B16) cells as a model. The results show that the chromone dimer with melanin production inhibition can significantly inhibit the production of melanin, and has a good application prospect in the preparation of drugs or skin care products for treating and / or relieving excessive melanin production.

The invention belongs to the technical field of organic synthesis, and specifically relates to a method for preparing a pyridoimidazole nitrogen condensed ring compound, comprising: using a substituted chromone and a substituted 2-aminopyridine as raw materials, adding an oxidant and a catalyst, and reacting in a solvent to obtain a pyridoimidazole nitrogen condensed ring compound; the substituted 2-aminopyridine contains a group R 1 , substituted chromones contain a group R 2 , R 1 is selected from one of an alkyl group, a hydrogen group, a halogen group, an ester group, a methanol group, a trifluoromethyl group and a cyano group, R 2 is selected from one of alkyl, hydrogen, methoxy and halogen, R 1 and R 2 The substitution modes are all single substitution or multiple substitution. The preparation method of the present invention is simple and safe to operate, the cost of raw materials is low, and the scope of application is wide. In addition, the pyridine imidazole nitrogen fused ring compound of the present invention has a novel structure, has anti-MV4-11 cell proliferation activity, and can be used in the preparation of leukemia drugs.

The application discloses a chromone spiro compound, a preparation method and application thereof, and the chromone spiro compound is shown as formula I. The compound has selective CDK4 / 6 inhibitory activity, can relieve and / or treat myelosuppression caused by chemotherapy, improve weight loss caused by chemotherapy and improve survival rate, and has good drug safety. The compound has simple preparation method, is convenient for large-scale production, and has great application prospect.

The invention discloses a method for photocatalytic synthesis of a 2, 3-dihydrobenzopyran-4-ketone compound and application of the 2, 3-dihydrobenzopyran-4-ketone compound, a triplet excitation state with a double-free-radical characteristic is formed after photoexcitation of a chromone compound, and the triplet excitation state can be subjected to hydrogen atom transfer with various substrates such as ethers, esters, alcohols, alkanes, sulfides, amines and aryl phosphine compounds, so that the 2, 3-dihydrobenzopyran-4-ketone compound is obtained. And carrying out Giese addition on the generated free radicals and an unexcited chromone compound to obtain a target product. Further biological activity evaluation shows that part of products obtained in the invention show good inhibitory activity on tobacco mosaic viruses, and the good protective activities of target compounds 3i and 4b are 67.77% and 63.63% respectively when the concentration is 500mg / L, which are equivalent to 63.83% of a control drug ningnanmycin. Therefore, the compound not only is green and efficient in synthesis method, but also has potential application value in the aspects of agricultural disease control and structure protection research.

The invention relates to the technical field of biological medicine, and discloses a non-treatment auxiliary method for improving the application effect of an Angnan active substance, and the method comprises the following steps: carrying out meridian detoxification operation on a user; after the meridian detoxification operation is completed, applying an Angnan active substance; wherein the meridian toxin expelling operation comprises the steps of acupoint opening liquid medicine application, acupoint pot fixing and acupoint sealing application; the Cuinan active substance comprises a chromone compound, a sesquiterpenoids compound, a flavonoid compound and a volatile oil component, and the sesquiterpenoids compound comprises a beta-dihydroagarofuran type compound. According to the invention, main and collateral channels are firstly detoxified, so that garbage and toxins in the body can be removed, the main and collateral channels are cut through, qi and blood are regulated, the internal environment of the human body is improved, and good conditions are created for absorption and action of active substances in Cuinan.

The invention relates to the technical field of drug synthesis, in particular to a 1-(3-chloro-4-fluorobenzyl) piperazine chromone derivative, a preparation method and application of the 1-(3-chloro-4-fluorobenzyl) piperazine chromone derivative as a tyrosinase inhibitor, and the 1-(3-chloro-4-fluorobenzyl) piperazine chromone derivative has a structural formula shown in a formula (I). Wherein R is one or more substituent groups; r is independently selected from one or more of hydrogen, hydroxyl, halogen, alkyl and alkoxy and has a relatively strong tyrosinase inhibition effect, and compared with positive control kojic acid, the tyrosinase inhibition effect is maximally improved by 168 times; the compound has a reversible and mixed inhibition effect on tyrosinase; the influence on melanogenesis and tyrosinase activity of the B16F10 cells in vitro is carried out at the concentration of 3-90 mu M, and no cytotoxicity is caused to the B16F10 cells; under the same test concentration, the compound W2 has higher melanin inhibition activity than kojic acid, has excellent druggability, and has wide application prospects.

The invention discloses a preparation method of a 2-alkyl-3-iodine chromone compound, and belongs to the field of organic synthesis. The preparation method comprises the following steps: taking an o-hydroxyphenylpropargyl ketone compound and an iodination reagent as initial raw materials, and carrying out a tandem cyclization reaction in the presence of halogenosilane and a solvent to obtain the 2-alkyl-3-iodo chromone compound. The preparation method is wide in substrate application range, can be used for synthesizing compounds with different molecular structures, is mild in reaction, good in atom economy, simple and convenient in product post-treatment and high in yield, and is beneficial to industrial production and application of the compounds.

The invention provides a compound for detecting aluminum ions, and particularly provides chromone-3-formaldehyde and 1H-imidazole-5-carbonyl (formula I) or salts thereof, and the compound has strong selectivity to aluminum ions, fast response time, macroscopic obvious fluorescence enhancement after complexation, and low detection limit.

The present invention relates to Compounds (A), pharmaceutically acceptable salts thereof, processes for their preparation and their use, optionally in combination with one or more additional therapeutic agents, for the treatment of disease. # imgabs0 #

The application discloses a thiazole-containing flavonol derivative and a preparation method and application thereof, and belongs to the technical field of pesticide synthesis. A thiazole-containing flavonol derivative is generated by substitution reaction of 3-(bromoalkyloxy)-7-substituent-2-(4-substituent phenyl)-4H-chromone-4-ketone and 5-substituent-2-thiol-1,3,4-thiadiazole, and a structural formula is shown as formula Y: wherein n is 3 or 4; R1 is hydrogen or an amino group; R2 is hydrogen, an alkyl group or an alkoxy group; and R3 is hydrogen, a halogen, an alkyl group or an alkoxy group. The thiazole-containing flavonol derivative has good bacteriostatic activity and can be applied to the preparation of bacteriostatic medicaments.

The invention discloses a chromone-based compound as well as a preparation method and application thereof. The chromone-based compound has a structure as shown in a formula (I), a formula (II) or a formula (III). The compound has an important medicinal value and a wide application prospect in preparation of drugs for treating phosphodiesterase 4 type related diseases including pulmonary fibrosis.

The present invention provides a use of a novel chromone derivative as a preventive and therapeutic agent for fibrosis. The compound can effectively prevent, ameliorate, or treat fibrosis by inhibiting TGF-beta signaling and inducing autophagy, by means of proteasome inhibition.

The invention provides a chromone bisindole derivative as well as a preparation method and application thereof. According to the derivative, a chromone ketone ester compound with different substituted benzene rings is used as a raw material, the 3-site of the compound is structurally modified, and the compound and indole are subjected to an addition reaction to successfully synthesize 21 chromone bis-indole derivatives. The derivative contains chromone and indole dominant skeletons, has various biological activities, and especially has an outstanding anti-tumor effect. The method has the advantages of simple operation, short reaction time, high yield, easily available raw materials, good air stability and wide applicability, can provide a compound source for biological activity screening, and has important application value for drug screening and pharmaceutical industry.

The present invention belongs to the technical field of food chemistry, and particularly relates to a benzo[g]chromone compound having anti-methicillin-resistant Staphylococcus aureus (MRSA) activity, and its preparation method and application. The benzo[g]chromone compound having anti-methicillin-resistant Staphylococcus aureus (MRSA) activity is prepared from the medicinal plant Cassia obtusifolia ( Chamaecrista rotundifolia ) whole plant was used as raw material, and the product was prepared through pretreatment, extract extraction, silica gel column chromatography, and high-performance liquid chromatography separation. The product is named 2-(hydroxymethyl)-6-methoxy-9-methylbenzo[2,3-g]-4H-chromone, and has the following structure: #imgabs0#. The antibacterial benzo[g]chromone compound of the present invention has good activity against drug-resistant bacteria and can be used as a lead compound in the development of drugs against drug-resistant bacteria.

The invention discloses a preparation method for synthesizing trifluoromethyl-substituted chromonoquinoline, comprising the steps of adding a palladium catalyst, a ligand, norbornene, an additive, trifluoroethylimidoyl chloride, and 3-iodochromone to an organic solvent, reacting at 110 to 130° C. for 16 to 30 hours, and after completion of the reaction, post-processing to obtain the trifluoromethyl-substituted chromonoquinoline compound. The preparation method is simple to operate, has inexpensive and readily available starting materials, high reaction efficiency, and a wide substrate range. Trifluoromethyl-substituted chromonoquinoline compounds substituted with different groups can also be synthesized through substrate design, thereby facilitating operation and broadening the practicality of the method.

The invention provides a planting method for increasing chromone content in radix saposhnikoviae, a medium trace element composition and a microbial preparation are jointly applied to planting of radix saposhnikoviae, and the composition is CaCl2, MgSO4, FeCl3, MnCl2, CuCl2 and ZnCl2. The strain in the microbial preparation is bacillus subtilis. The medium trace element composition has significant influence on the contents of cimicifugin, cimicifugin glycoside and 5-O-methylvisammioside in the radix saposhnikoviae.

The invention relates to the field of utilization of marine medicinal biological resources, in particular to a chromone derivative as well as a preparation method and application thereof.The chromone derivative Sonnerachromone A-G (1-7) is obtained by extracting and separating mangrove songarus apetala fruits, the chromone derivative Sonnerachromone A-G belongs to a natural active ingredient, the derivative is a new compound, and the chromone derivative Sonnerachromone A-G is a natural active ingredient and is a natural active ingredient. It is found that the chromone derivatives Sonnerachromone A-G have good activity of delaying senescence of nematodes, the senescence delaying activity of part of compounds is superior to that of a positive control group, and the chromone derivatives Sonnerachromone A-G can be used as medicinal or non-medicinal senescence delaying products independently or in a combined mode and have good medicinal and dietary supplement prospects.

A synthesis method of the tetrapyridine copper oxalate metal complex comprises the following steps: weighing 0.5 g of chromone 2-formic acid (2.6 mmol) and 0.48 g of copper perchlorate hexahydrate (1.3 mmol), putting the weighed chromone 2-formic acid and copper perchlorate hexahydrate into a 250mL round-bottom flask, dissolving the weighed chromone 2-formic acid and copper perchlorate hexahydrate into a 30mL ethanol solution, carrying out ultrasonic uniform dissolution for 3 minutes, and adding equivalent pyridine until the solution is dark blue. Putting the flask on a heating and stirring sleeve, stirring, refluxing and heating, reacting for 28 hours, then taking out, and carrying out hot filtration, so that blue crystals can be separated out in about 30 minutes; the complex shows certain performance in anti-tumor activity of lung cancer. The inhibition rate of the anti-lung cancer activity reaches 43.56%.

The invention belongs to the technical field of food chemistry, and particularly relates to a benzo [g] chromone compound with methicillin-resistant staphylococcus aureus (MRSA) resisting activity as well as a preparation method and application of the benzo [g] chromone compound. The benzo [g] chromone compound with the activity of resisting methicillin-resistant staphylococcus aureus (MRSA) is prepared by taking a whole plant of a medicinal plant chamaecrista rotundifola as a raw material and carrying out pretreatment, extract extraction, silica gel column chromatography and high performance liquid chromatography separation, and is named as 2-(hydroxymethyl)-6-methoxy-9-methylbenzo [2, 3-g]-4H-chromone, and the structural formula of the benzo [g] chromone compound is shown in the specification. The invention relates to a high-molecular polymer, which is characterized in that the English name of the high-molecular polymer is 2-(hydroxy methyl)-6-methylox-9-methylbenz [2, 3-g]-4H-chromone, and the high-molecular polymer has the following structure: # imgabs0 #. The benzo [g] chromone compound with the antibacterial activity, disclosed by the invention, has relatively good activity of resisting drug-resistant bacteria. The compound can be used as a leading compound for research and development of drugs for resisting drug-resistant bacteria.

The invention discloses a tar-reducing, stabbing-reducing and aroma-suppressing compound as well as a preparation method, application and an application method thereof. The tar-reducing, stabbing-reducing and aroma-suppressing compound has the following general formula: # imgabs0 #. According to the technical scheme, 7-hydroxyflavone serves as a raw material, 7-isobutyryloxy-2-phenyl chromone is synthesized through esterification reaction, the precursor-aroma compound is stable in property, can release 7-hydroxyflavone and corresponding organic acid during high-temperature pyrolysis, and can reduce the tar content of cigarettes and reduce smoke irritation when being added into the cigarettes, so that the cigarette quality is improved, and the cigarette quality is improved. Meanwhile, aftertaste comfort is improved, cigarette fragrance is enriched, and potential application value is achieved.

This invention relates to the field of asymmetric catalytic hydrogenation, specifically to a method for preparing chiral chromone or chromane carboxylic acid compounds. The method involves preparing a chiral catalyst from a nickel compound and ligands. By controlling the combination of the nickel compound-ligand-solvent, enantioselective hydrogenation of the conjugated C=C bonds of the substrate chromone carboxylic acid compound is achieved, yielding the semi-reduced product chiral chromone carboxylic acid; or, further, the carbonyl group is reduced, and carbonyl reduction and dehydroxylation reactions are carried out at room temperature under trifluoroacetic acid and triethylsilane conditions to obtain the fully reduced product chiral chromane carboxylic acid. The catalytic system of this invention is simple to construct, and the selectivity can be controlled by the solvent system. It maintains high conversion and excellent enantioselectivity even under high S / C conditions, making it suitable for the efficient preparation of chiral chromone / chromane skeletal carboxylic acid compounds.

The invention discloses a 2-(2-phenethyl) chromone compound with COX-2 and 5-LOX dual-targeting inhibitory activity as well as a preparation method and application of the 2-(2-phenethyl) chromone compound, and belongs to the technical field of natural pharmaceutical chemistry. According to the compound, 2-(2-phenethyl) chromone is taken as a skeleton, and a functional group capable of being specifically combined with COX-2 and 5-LOX enzymes is introduced through chemical modification, so that double-target synergistic inhibition on two inflammatory mediators is realized. The invention also provides a synthesis method of the compound, which comprises the following steps: selecting high-purity 2-(2-phenethyl) chromone as an initial raw material, carrying out structural modification under the action of a catalyst, introducing key functional groups such as acrolein and acrylic acid into specific positions of a chromone ring, synthesizing a target compound through a multi-step reaction, and carrying out purification treatment on a reaction product. An in-vitro experiment result shows that IC50 (half maximal inhibitory concentration) of COX-2 is 1.12 [mu] M, and IC50 of 5-LOX is 1.18 [mu] M; and an acute toxicity experiment LD50 is greater than 2000mg / kg.

The present invention discloses an electrochemical synthesis method of 9a-hydroxy hexahydroxanthone compounds, which is prepared by a one-step method. The preparation route is as follows: #imgabs0# wherein R 1 and R 2 are any of carboxylate, amide or cyano groups, R 3 is any one of an alkyl group, a phenyl group or a heterocyclic group, R 4 is a monosubstituted or polysubstituted group, which may be any of an alkyl, alkoxy, halogen, or aryl group; R is any of an alkyl, aryl, or heterocyclic substituent; and M is any of a metal such as Na, K, or Zn. The present invention provides an electrochemical synthesis method for α-hydroxyhexahydroxanthone compounds. Starting from an alkyl-substituted chromone, 9α-hydroxyhexahydroxanthone compounds are synthesized in one step using electrochemical conditions with a sulfinate. The reaction conditions are mild, the operation is simple, and the yield is excellent, conforming to the concept of green synthesis.

The invention discloses a chromone derivative containing a cyclamine structure as well as a preparation method and application of the chromone derivative. The structures of the compounds are confirmed by structural characterization of 1H NMR (nuclear magnetic resonance), 13C NMR (nuclear magnetic resonance), 19F NMR (nuclear magnetic resonance), HRMS (high resolution mass spectrometry) and other analysis and test methods, and all the compounds are new compounds. The synthesis method of the compound has the advantages of no transition metal catalysis, room temperature, short time, easily available reaction raw materials, simple reaction system, wide substrate application range, high yield and the like, and enriches chromone small molecule libraries. The cyclic amine chromone derivative prepared by the invention has certain inhibitory activity on mouse skin melanoma B16-F10 cells, colon cancer HCT-116 cells and cervical cancer Hela cells, and can be used for further development and application of anti-cancer drugs.