68 results about "Chromone" patented technology

The present invention belongs to the field of agarwood, and in particular to a kind of 2-(2-phenylethyl) chromone and lignan heterocompound and its application. The present invention uses the agarwood produced by thick-leaved agarwood tree as raw material, and after reflux extraction, successively adopts silica gel, Sephadex LH-20 gel, high performance liquid chromatography and other chromatographic techniques to separate and purify to obtain 1 monomer compound, and its structure is identified by spectral methods such as mass spectrometry and nuclear magnetic resonance and combined with physicochemical properties. It is retrieved as a new compound by SciFinder and named as thick-leaved agarwood alcohol (aquicrassnol), which is the first heterocompound formed by 2-(2-phenylethyl) chromone and lignan found in agarwood. It has been verified by experiment that the compound has an inhibitory effect on the production of nitric oxide in mouse mononuclear macrophage RAW264.7 induced by lipopolysaccharide, and its half-maximal inhibitory concentration value is 47.53±2.14μmol / L, which has anti-inflammatory activity.

The invention belongs to the field of biological medicine, and particularly relates to an anti-inflammatory and anti-helicobacter pylori compound separated from agilawood and a preparation method thereof. The method comprises the following steps: by taking the agilawood corasta as a raw material, carrying out reflux extraction with ethanol, extracting with petroleum ether to remove volatile components, separating and purifying by adopting various chromatographic technologies such as silica gel column chromatography, reversed-phase column chromatography and semi-preparative HPLC (High Performance Liquid Chromatography) to obtain a monomeric compound, and identifying the structure of the monomeric compound by adopting spectroscopy methods such as ultraviolet, high-resolution mass spectrometry and nuclear magnetic resonance. The structure of a compound 1 is identified as a new 2-(2-phenethyl) chromone dimer, and the compound 1 is named as aquicrasone V. The invention further discloses a preparation method of the compound 1. A biological activity test verifies that the compound has relatively strong anti-inflammatory activity and anti-helicobacter pylori activity.

The present invention provides an isopsoralen chalcone-curcumin derivative, its preparation method and application, and an antibacterial pharmaceutical preparation, belonging to the field of pharmaceutical chemistry technology. The isopsoralen chalcone-curcumin derivative of the present invention is based on the isopsoralen chalcone and curcumin structural framework. In vitro antibacterial experiments have shown that it has excellent broad-spectrum antibacterial activity, especially against drug-resistant Staphylococcus aureus (MRSA), with antibacterial activity that is more than 1,000 times that of the positive drug ofloxacin. At the same time, the isopsoralen chalcone-curcumin derivative has high biosafety.

The application provides a benzyl chromone compound and a preparation method and application thereof. The application takes dry fruit bodies of Leucangium alectorium as raw materials, carries out ethanol extraction, ethyl acetate extraction, then carries out rough separation on the ethyl acetate phase obtained by extraction with different proportions of dichloromethane-methanol solution, and then carries out elution separation with different proportions of methanol-water to obtain a novel structure benzyl chromone compound. The benzyl chromone compound provided by the application has significant in-vitro inhibition activity on HepG2 cell proliferation, and when the treatment concentration is below 160 muM, the inhibition activity on liver cancer cells is obviously better than that of cisplatin, and the benzyl chromone compound can be used for preparing drugs for treating and preventing liver cancer. Meanwhile, the raw material of the compound is rich in source, low in price, simple in preparation process and convenient for industrial application, so the discovery of the compound is expected to provide a promising treatment scheme for liver cancer patients, and has great significance for breaking through the bottleneck of liver cancer treatment.

The application discloses a chromone dimer with melanin production inhibition, a preparation method and application thereof, and belongs to the technical field of natural products. The chromone dimer with melanin production inhibition has a structure shown in formula I. The chromone dimer with melanin production inhibition is evaluated by taking the melanin production of mouse melanoma (B16) cells as a model. The results show that the chromone dimer with melanin production inhibition can significantly inhibit the production of melanin, and has a good application prospect in the preparation of drugs or skin care products for treating and / or relieving excessive melanin production.

The application discloses a chromone spiro compound, a preparation method and application thereof, and the chromone spiro compound is shown as formula I. The compound has selective CDK4 / 6 inhibitory activity, can relieve and / or treat myelosuppression caused by chemotherapy, improve weight loss caused by chemotherapy and improve survival rate, and has good drug safety. The compound has simple preparation method, is convenient for large-scale production, and has great application prospect.

The invention discloses a method for photocatalytic synthesis of a 2, 3-dihydrobenzopyran-4-ketone compound and application of the 2, 3-dihydrobenzopyran-4-ketone compound, a triplet excitation state with a double-free-radical characteristic is formed after photoexcitation of a chromone compound, and the triplet excitation state can be subjected to hydrogen atom transfer with various substrates such as ethers, esters, alcohols, alkanes, sulfides, amines and aryl phosphine compounds, so that the 2, 3-dihydrobenzopyran-4-ketone compound is obtained. And carrying out Giese addition on the generated free radicals and an unexcited chromone compound to obtain a target product. Further biological activity evaluation shows that part of products obtained in the invention show good inhibitory activity on tobacco mosaic viruses, and the good protective activities of target compounds 3i and 4b are 67.77% and 63.63% respectively when the concentration is 500mg / L, which are equivalent to 63.83% of a control drug ningnanmycin. Therefore, the compound not only is green and efficient in synthesis method, but also has potential application value in the aspects of agricultural disease control and structure protection research.

The invention relates to the technical field of biological medicine, and discloses a non-treatment auxiliary method for improving the application effect of an Angnan active substance, and the method comprises the following steps: carrying out meridian detoxification operation on a user; after the meridian detoxification operation is completed, applying an Angnan active substance; wherein the meridian toxin expelling operation comprises the steps of acupoint opening liquid medicine application, acupoint pot fixing and acupoint sealing application; the Cuinan active substance comprises a chromone compound, a sesquiterpenoids compound, a flavonoid compound and a volatile oil component, and the sesquiterpenoids compound comprises a beta-dihydroagarofuran type compound. According to the invention, main and collateral channels are firstly detoxified, so that garbage and toxins in the body can be removed, the main and collateral channels are cut through, qi and blood are regulated, the internal environment of the human body is improved, and good conditions are created for absorption and action of active substances in Cuinan.

The invention relates to the technical field of drug synthesis, in particular to a 1-(3-chloro-4-fluorobenzyl) piperazine chromone derivative, a preparation method and application of the 1-(3-chloro-4-fluorobenzyl) piperazine chromone derivative as a tyrosinase inhibitor, and the 1-(3-chloro-4-fluorobenzyl) piperazine chromone derivative has a structural formula shown in a formula (I). Wherein R is one or more substituent groups; r is independently selected from one or more of hydrogen, hydroxyl, halogen, alkyl and alkoxy and has a relatively strong tyrosinase inhibition effect, and compared with positive control kojic acid, the tyrosinase inhibition effect is maximally improved by 168 times; the compound has a reversible and mixed inhibition effect on tyrosinase; the influence on melanogenesis and tyrosinase activity of the B16F10 cells in vitro is carried out at the concentration of 3-90 mu M, and no cytotoxicity is caused to the B16F10 cells; under the same test concentration, the compound W2 has higher melanin inhibition activity than kojic acid, has excellent druggability, and has wide application prospects.

The invention discloses a preparation method of a 2-alkyl-3-iodine chromone compound, and belongs to the field of organic synthesis. The preparation method comprises the following steps: taking an o-hydroxyphenylpropargyl ketone compound and an iodination reagent as initial raw materials, and carrying out a tandem cyclization reaction in the presence of halogenosilane and a solvent to obtain the 2-alkyl-3-iodo chromone compound. The preparation method is wide in substrate application range, can be used for synthesizing compounds with different molecular structures, is mild in reaction, good in atom economy, simple and convenient in product post-treatment and high in yield, and is beneficial to industrial production and application of the compounds.

The invention provides a compound for detecting aluminum ions, and particularly provides chromone-3-formaldehyde and 1H-imidazole-5-carbonyl (formula I) or salts thereof, and the compound has strong selectivity to aluminum ions, fast response time, macroscopic obvious fluorescence enhancement after complexation, and low detection limit.

The application discloses a thiazole-containing flavonol derivative and a preparation method and application thereof, and belongs to the technical field of pesticide synthesis. A thiazole-containing flavonol derivative is generated by substitution reaction of 3-(bromoalkyloxy)-7-substituent-2-(4-substituent phenyl)-4H-chromone-4-ketone and 5-substituent-2-thiol-1,3,4-thiadiazole, and a structural formula is shown as formula Y: wherein n is 3 or 4; R1 is hydrogen or an amino group; R2 is hydrogen, an alkyl group or an alkoxy group; and R3 is hydrogen, a halogen, an alkyl group or an alkoxy group. The thiazole-containing flavonol derivative has good bacteriostatic activity and can be applied to the preparation of bacteriostatic medicaments.

The invention discloses a chromone-based compound as well as a preparation method and application thereof. The chromone-based compound has a structure as shown in a formula (I), a formula (II) or a formula (III). The compound has an important medicinal value and a wide application prospect in preparation of drugs for treating phosphodiesterase 4 type related diseases including pulmonary fibrosis.

The present invention provides a use of a novel chromone derivative as a preventive and therapeutic agent for fibrosis. The compound can effectively prevent, ameliorate, or treat fibrosis by inhibiting TGF-beta signaling and inducing autophagy, by means of proteasome inhibition.

The invention provides a chromone bisindole derivative as well as a preparation method and application thereof. According to the derivative, a chromone ketone ester compound with different substituted benzene rings is used as a raw material, the 3-site of the compound is structurally modified, and the compound and indole are subjected to an addition reaction to successfully synthesize 21 chromone bis-indole derivatives. The derivative contains chromone and indole dominant skeletons, has various biological activities, and especially has an outstanding anti-tumor effect. The method has the advantages of simple operation, short reaction time, high yield, easily available raw materials, good air stability and wide applicability, can provide a compound source for biological activity screening, and has important application value for drug screening and pharmaceutical industry.

The invention discloses a preparation method for synthesizing trifluoromethyl-substituted chromonoquinoline, comprising the steps of adding a palladium catalyst, a ligand, norbornene, an additive, trifluoroethylimidoyl chloride, and 3-iodochromone to an organic solvent, reacting at 110 to 130° C. for 16 to 30 hours, and after completion of the reaction, post-processing to obtain the trifluoromethyl-substituted chromonoquinoline compound. The preparation method is simple to operate, has inexpensive and readily available starting materials, high reaction efficiency, and a wide substrate range. Trifluoromethyl-substituted chromonoquinoline compounds substituted with different groups can also be synthesized through substrate design, thereby facilitating operation and broadening the practicality of the method.

The invention relates to the field of utilization of marine medicinal biological resources, in particular to a chromone derivative as well as a preparation method and application thereof.The chromone derivative Sonnerachromone A-G (1-7) is obtained by extracting and separating mangrove songarus apetala fruits, the chromone derivative Sonnerachromone A-G belongs to a natural active ingredient, the derivative is a new compound, and the chromone derivative Sonnerachromone A-G is a natural active ingredient and is a natural active ingredient. It is found that the chromone derivatives Sonnerachromone A-G have good activity of delaying senescence of nematodes, the senescence delaying activity of part of compounds is superior to that of a positive control group, and the chromone derivatives Sonnerachromone A-G can be used as medicinal or non-medicinal senescence delaying products independently or in a combined mode and have good medicinal and dietary supplement prospects.

This invention relates to the field of asymmetric catalytic hydrogenation, specifically to a method for preparing chiral chromone or chromane carboxylic acid compounds. The method involves preparing a chiral catalyst from a nickel compound and ligands. By controlling the combination of the nickel compound-ligand-solvent, enantioselective hydrogenation of the conjugated C=C bonds of the substrate chromone carboxylic acid compound is achieved, yielding the semi-reduced product chiral chromone carboxylic acid; or, further, the carbonyl group is reduced, and carbonyl reduction and dehydroxylation reactions are carried out at room temperature under trifluoroacetic acid and triethylsilane conditions to obtain the fully reduced product chiral chromane carboxylic acid. The catalytic system of this invention is simple to construct, and the selectivity can be controlled by the solvent system. It maintains high conversion and excellent enantioselectivity even under high S / C conditions, making it suitable for the efficient preparation of chiral chromone / chromane skeletal carboxylic acid compounds.

The invention discloses a 2-(2-phenethyl) chromone compound with COX-2 and 5-LOX dual-targeting inhibitory activity as well as a preparation method and application of the 2-(2-phenethyl) chromone compound, and belongs to the technical field of natural pharmaceutical chemistry. According to the compound, 2-(2-phenethyl) chromone is taken as a skeleton, and a functional group capable of being specifically combined with COX-2 and 5-LOX enzymes is introduced through chemical modification, so that double-target synergistic inhibition on two inflammatory mediators is realized. The invention also provides a synthesis method of the compound, which comprises the following steps: selecting high-purity 2-(2-phenethyl) chromone as an initial raw material, carrying out structural modification under the action of a catalyst, introducing key functional groups such as acrolein and acrylic acid into specific positions of a chromone ring, synthesizing a target compound through a multi-step reaction, and carrying out purification treatment on a reaction product. An in-vitro experiment result shows that IC50 (half maximal inhibitory concentration) of COX-2 is 1.12 [mu] M, and IC50 of 5-LOX is 1.18 [mu] M; and an acute toxicity experiment LD50 is greater than 2000mg / kg.

The present invention discloses an electrochemical synthesis method of 9a-hydroxy hexahydroxanthone compounds, which is prepared by a one-step method. The preparation route is as follows: #imgabs0# wherein R 1 and R 2 are any of carboxylate, amide or cyano groups, R 3 is any one of an alkyl group, a phenyl group or a heterocyclic group, R 4 is a monosubstituted or polysubstituted group, which may be any of an alkyl, alkoxy, halogen, or aryl group; R is any of an alkyl, aryl, or heterocyclic substituent; and M is any of a metal such as Na, K, or Zn. The present invention provides an electrochemical synthesis method for α-hydroxyhexahydroxanthone compounds. Starting from an alkyl-substituted chromone, 9α-hydroxyhexahydroxanthone compounds are synthesized in one step using electrochemical conditions with a sulfinate. The reaction conditions are mild, the operation is simple, and the yield is excellent, conforming to the concept of green synthesis.

The invention discloses a chromone derivative containing a cyclamine structure as well as a preparation method and application of the chromone derivative. The structures of the compounds are confirmed by structural characterization of 1H NMR (nuclear magnetic resonance), 13C NMR (nuclear magnetic resonance), 19F NMR (nuclear magnetic resonance), HRMS (high resolution mass spectrometry) and other analysis and test methods, and all the compounds are new compounds. The synthesis method of the compound has the advantages of no transition metal catalysis, room temperature, short time, easily available reaction raw materials, simple reaction system, wide substrate application range, high yield and the like, and enriches chromone small molecule libraries. The cyclic amine chromone derivative prepared by the invention has certain inhibitory activity on mouse skin melanoma B16-F10 cells, colon cancer HCT-116 cells and cervical cancer Hela cells, and can be used for further development and application of anti-cancer drugs.

The present invention relates to a non-aqueous electrolyte for a lithium secondary battery, which contains a first additive containing a chromone compound, and a lithium secondary battery containing the same.

The invention discloses a chromone compound with anti-MTV activity and a preparation method and application thereof.The chromone compound with the anti-MTV activity is prepared from stems and leaves of desmodium caudatum through the steps of pretreatment, extract extraction, silica gel column chromatography and separation and purification, the molecular formula of the chromone compound with the anti-MTV activity is C13H14O5, and the structural formula of the chromone compound with the anti-MTV activity is shown in the description. The compound is named as (S)-5-hydroxy-7-(hydroxymethyl)-2-(2-hydroxypropyl)-4H-chromene-4-ketone, and the structural formula of the compound is shown in the description. The structural formula of the compound is shown in the specification, and the English name of the compound is (S)-5-hydroxy-7-(hydroxymethyl)-2-(2-hydroxymethyl)-4H-chromen-4-one. The solid substance is a light yellow solid substance; the present invention has the following structure. Activity tests show that the compound has a certain inhibition effect on MTV. The novel compound disclosed by the invention is novel in structure, has certain anti-MTV activity, can be used as an anti-MTV lead compound, and can be used for research and development of anti-MTV prevention and treatment drugs.

The invention discloses a preparation method and application of a hypochlorite photoelectrochemical sensing platform, and belongs to the technical field of analytical chemistry. According to the preparation process, adopted raw materials are easy to obtain, and reaction conditions are mild and easy to control. The sensing platform is designed and synthesized based on phenothiazine-chromone photosensitive micromolecules as a photosensitizer, and photoelectrochemical (PEC) sensing is realized. The sensing platform has the characteristics of high specificity, high sensitivity and easiness in preparation, quantitative photoelectrochemical signals of pypocholoride can be realized, and the PEC detection electrode is 1.64 nM.

The application discloses a Phaeoacremonium scolyti strain and application thereof. A laccar symbiotic bacterium is screened from laccar, and is identified as a strain of the Phaeoacremonium genus through morphology and molecular biology, and is named as Phaeoacremonium scolyti CX-2. The bacterium can utilize laccar powder after laccar is combined to carry out fermentation, and active substances are produced, and with the increase of the fermentation time, the laccar alcohol extract content, the laccar characteristic substance content and the laccar alcohol extraction antioxidant activity are significantly improved, so that the bacterium can produce sesquiterpenes and chromones by taking wood as raw material, and has a wide application prospect in the industrial production of laccar.

The application discloses a 7-sulfur-substituted chromone-3-formaldehyde compound shown in a formula I or a derivative thereof shown in a formula II and a preparation method and application thereof, wherein R is selected from a methylthio group, a thiazole-2-yl group, a pyrimidine-2-yl group, a pyridine-2-yl group, an imidazole-2-yl group, a (1-methyl-pyridine-4) group-4-thiazole-2-yl group, a benzothiazole-2-yl group, a quinoline-2-yl group, a benzothiophene-2-yl group, a (4-carboxylpropyl)-5-thiophene-2-yl group, and n represents the number of S; when R is selected from a thiophene-2-yl group, n is selected from 0, 1 or 2; when R is selected from groups other than the thiophene-2-yl group, n is selected from 0. The compound and the derivative thereof have a better inhibiting effect on NDM-1, can enhance the antibacterial effect in combination with imipenem and meropenem, and in addition, the synthesis route is simple and easy to operate.

The present invention relates to the field of utilization of marine medicinal biological resources, and in particular to a class of chromone derivatives, a preparation method and an application thereof. The present invention obtains chromone derivatives SonnerachromoneA-G (1-7) by extracting and separating the fruit of Sonneratia apetala, a mangrove tree. The chromone derivatives SonnerachromoneA-G are natural active ingredients and are new compounds. It is found that the chromone derivatives SonnerachromoneA-G all have good nematode aging activity, and some compounds have better aging activity than a positive control group. The chromone derivatives can be used alone or in combination as medicinal or non-medicinal anti-aging products, and have good medicinal and dietary supplement prospects.

As racemic modifications, novel cannabinoids cannabinoid phenols (CBC, 1), cannabinoid phenolic acids (CBCA, 2), hypocannabinoids (CBCV, 3), hypochromene phenolic acids (CBCVA, 4), and other chromene cannabinoids 7, as single enantiomers (S)-7 or (R)-7 or proportional mixtures of (S)-7 and (R)-7, are analogues of cannabinoids cannabinoid phenols (CBC, 1), cannabinoid phenolic acids (CBCA, 2), hypocannabinoids (CBCV, 3), and hypochromene phenolic acids (CBCVA, 4), all the compounds are racemic compounds, single enantiomers and proportionally mixed compounds. In addition, the invention also relates to novel key intermediates of the formula 9 to the formula 15 for synthesizing the cannabinoids.

The application provides a chromone-modified o-phenanthroline polypyridine Ru(II) series compound and a preparation method and application thereof, the preparation method synthesizes an intermediate A by taking 1,10-o-phenanthroline-5,6-diketone and 6-substituted-4-oxo-4H-benzopyran-3-formaldehyde as raw materials, then the intermediate A is heated to reflux in ethylene glycol solvent and cis-[Ru(2,2'-dipyridine)2Cl2]·2H2O at 120 DEG C for 6h, after the system is cooled to room temperature, an excess amount of a saturated aqueous solution of potassium hexafluorophosphate is added, after a precipitate is separated out, the filter cake is washed with clean water, and the final product is obtained after drying. The synthesis method is simple and easy to operate without steps such as column chromatography.

The invention discloses an application of eleusine indica isopeucedanone-7-methyl ether and a derivative thereof in preparation of medicines and functional foods for delaying senescence or regulating immunity. The isopeucedanum praeruptorum chromonone-7-methyl ether monomer from gooseberry and the derivative of the isopeucedanum praeruptorum chromonone-7-methyl ether monomer can effectively delay replicative senescence of mesenchymal stem cells by improving the activity of cell telomerase and reducing the expression of senescence-related genes, inhibit the expression of adriamycin-induced senescence-related markers of mouse livers and lungs, and can be used for preparing the senescence-related markers for the mouse livers and lungs. The mouse grasping strength is improved, the muscle function is enhanced, the proliferation of T cells separated from human peripheral blood mononuclear cells can be promoted, and the immunomodulatory effect is achieved. Therefore, the eleusine indica fruit isopeucedanone-7-methyl ether and the derivative thereof have good effects of improving telomerase activity and resisting aging or immunoregulation, and are expected to be developed into anti-aging or immunoregulation products.