40 results about "Chromone" patented technology

The invention belongs to the field of biological medicine, and particularly relates to an anti-inflammatory and anti-helicobacter pylori compound separated from agilawood and a preparation method thereof. The method comprises the following steps: by taking the agilawood corasta as a raw material, carrying out reflux extraction with ethanol, extracting with petroleum ether to remove volatile components, separating and purifying by adopting various chromatographic technologies such as silica gel column chromatography, reversed-phase column chromatography and semi-preparative HPLC (High Performance Liquid Chromatography) to obtain a monomeric compound, and identifying the structure of the monomeric compound by adopting spectroscopy methods such as ultraviolet, high-resolution mass spectrometry and nuclear magnetic resonance. The structure of a compound 1 is identified as a new 2-(2-phenethyl) chromone dimer, and the compound 1 is named as aquicrasone V. The invention further discloses a preparation method of the compound 1. A biological activity test verifies that the compound has relatively strong anti-inflammatory activity and anti-helicobacter pylori activity.

The application discloses a chromone dimer with melanin production inhibition, a preparation method and application thereof, and belongs to the technical field of natural products. The chromone dimer with melanin production inhibition has a structure shown in formula I. The chromone dimer with melanin production inhibition is evaluated by taking the melanin production of mouse melanoma (B16) cells as a model. The results show that the chromone dimer with melanin production inhibition can significantly inhibit the production of melanin, and has a good application prospect in the preparation of drugs or skin care products for treating and / or relieving excessive melanin production.

The application discloses a chromone spiro compound, a preparation method and application thereof, and the chromone spiro compound is shown as formula I. The compound has selective CDK4 / 6 inhibitory activity, can relieve and / or treat myelosuppression caused by chemotherapy, improve weight loss caused by chemotherapy and improve survival rate, and has good drug safety. The compound has simple preparation method, is convenient for large-scale production, and has great application prospect.

The invention discloses a method for photocatalytic synthesis of a 2, 3-dihydrobenzopyran-4-ketone compound and application of the 2, 3-dihydrobenzopyran-4-ketone compound, a triplet excitation state with a double-free-radical characteristic is formed after photoexcitation of a chromone compound, and the triplet excitation state can be subjected to hydrogen atom transfer with various substrates such as ethers, esters, alcohols, alkanes, sulfides, amines and aryl phosphine compounds, so that the 2, 3-dihydrobenzopyran-4-ketone compound is obtained. And carrying out Giese addition on the generated free radicals and an unexcited chromone compound to obtain a target product. Further biological activity evaluation shows that part of products obtained in the invention show good inhibitory activity on tobacco mosaic viruses, and the good protective activities of target compounds 3i and 4b are 67.77% and 63.63% respectively when the concentration is 500mg / L, which are equivalent to 63.83% of a control drug ningnanmycin. Therefore, the compound not only is green and efficient in synthesis method, but also has potential application value in the aspects of agricultural disease control and structure protection research.

The invention relates to the technical field of drug synthesis, in particular to a 1-(3-chloro-4-fluorobenzyl) piperazine chromone derivative, a preparation method and application of the 1-(3-chloro-4-fluorobenzyl) piperazine chromone derivative as a tyrosinase inhibitor, and the 1-(3-chloro-4-fluorobenzyl) piperazine chromone derivative has a structural formula shown in a formula (I). Wherein R is one or more substituent groups; r is independently selected from one or more of hydrogen, hydroxyl, halogen, alkyl and alkoxy and has a relatively strong tyrosinase inhibition effect, and compared with positive control kojic acid, the tyrosinase inhibition effect is maximally improved by 168 times; the compound has a reversible and mixed inhibition effect on tyrosinase; the influence on melanogenesis and tyrosinase activity of the B16F10 cells in vitro is carried out at the concentration of 3-90 mu M, and no cytotoxicity is caused to the B16F10 cells; under the same test concentration, the compound W2 has higher melanin inhibition activity than kojic acid, has excellent druggability, and has wide application prospects.

The invention provides a compound for detecting aluminum ions, and particularly provides chromone-3-formaldehyde and 1H-imidazole-5-carbonyl (formula I) or salts thereof, and the compound has strong selectivity to aluminum ions, fast response time, macroscopic obvious fluorescence enhancement after complexation, and low detection limit.

The application discloses a thiazole-containing flavonol derivative and a preparation method and application thereof, and belongs to the technical field of pesticide synthesis. A thiazole-containing flavonol derivative is generated by substitution reaction of 3-(bromoalkyloxy)-7-substituent-2-(4-substituent phenyl)-4H-chromone-4-ketone and 5-substituent-2-thiol-1,3,4-thiadiazole, and a structural formula is shown as formula Y: wherein n is 3 or 4; R1 is hydrogen or an amino group; R2 is hydrogen, an alkyl group or an alkoxy group; and R3 is hydrogen, a halogen, an alkyl group or an alkoxy group. The thiazole-containing flavonol derivative has good bacteriostatic activity and can be applied to the preparation of bacteriostatic medicaments.

The invention discloses a chromone-based compound as well as a preparation method and application thereof. The chromone-based compound has a structure as shown in a formula (I), a formula (II) or a formula (III). The compound has an important medicinal value and a wide application prospect in preparation of drugs for treating phosphodiesterase 4 type related diseases including pulmonary fibrosis.

The present invention provides a use of a novel chromone derivative as a preventive and therapeutic agent for fibrosis. The compound can effectively prevent, ameliorate, or treat fibrosis by inhibiting TGF-beta signaling and inducing autophagy, by means of proteasome inhibition.

The invention provides a chromone bisindole derivative as well as a preparation method and application thereof. According to the derivative, a chromone ketone ester compound with different substituted benzene rings is used as a raw material, the 3-site of the compound is structurally modified, and the compound and indole are subjected to an addition reaction to successfully synthesize 21 chromone bis-indole derivatives. The derivative contains chromone and indole dominant skeletons, has various biological activities, and especially has an outstanding anti-tumor effect. The method has the advantages of simple operation, short reaction time, high yield, easily available raw materials, good air stability and wide applicability, can provide a compound source for biological activity screening, and has important application value for drug screening and pharmaceutical industry.

The invention relates to the field of utilization of marine medicinal biological resources, in particular to a chromone derivative as well as a preparation method and application thereof.The chromone derivative Sonnerachromone A-G (1-7) is obtained by extracting and separating mangrove songarus apetala fruits, the chromone derivative Sonnerachromone A-G belongs to a natural active ingredient, the derivative is a new compound, and the chromone derivative Sonnerachromone A-G is a natural active ingredient and is a natural active ingredient. It is found that the chromone derivatives Sonnerachromone A-G have good activity of delaying senescence of nematodes, the senescence delaying activity of part of compounds is superior to that of a positive control group, and the chromone derivatives Sonnerachromone A-G can be used as medicinal or non-medicinal senescence delaying products independently or in a combined mode and have good medicinal and dietary supplement prospects.

This invention relates to the field of asymmetric catalytic hydrogenation, specifically to a method for preparing chiral chromone or chromane carboxylic acid compounds. The method involves preparing a chiral catalyst from a nickel compound and ligands. By controlling the combination of the nickel compound-ligand-solvent, enantioselective hydrogenation of the conjugated C=C bonds of the substrate chromone carboxylic acid compound is achieved, yielding the semi-reduced product chiral chromone carboxylic acid; or, further, the carbonyl group is reduced, and carbonyl reduction and dehydroxylation reactions are carried out at room temperature under trifluoroacetic acid and triethylsilane conditions to obtain the fully reduced product chiral chromane carboxylic acid. The catalytic system of this invention is simple to construct, and the selectivity can be controlled by the solvent system. It maintains high conversion and excellent enantioselectivity even under high S / C conditions, making it suitable for the efficient preparation of chiral chromone / chromane skeletal carboxylic acid compounds.

The invention discloses a 2-(2-phenethyl) chromone compound with COX-2 and 5-LOX dual-targeting inhibitory activity as well as a preparation method and application of the 2-(2-phenethyl) chromone compound, and belongs to the technical field of natural pharmaceutical chemistry. According to the compound, 2-(2-phenethyl) chromone is taken as a skeleton, and a functional group capable of being specifically combined with COX-2 and 5-LOX enzymes is introduced through chemical modification, so that double-target synergistic inhibition on two inflammatory mediators is realized. The invention also provides a synthesis method of the compound, which comprises the following steps: selecting high-purity 2-(2-phenethyl) chromone as an initial raw material, carrying out structural modification under the action of a catalyst, introducing key functional groups such as acrolein and acrylic acid into specific positions of a chromone ring, synthesizing a target compound through a multi-step reaction, and carrying out purification treatment on a reaction product. An in-vitro experiment result shows that IC50 (half maximal inhibitory concentration) of COX-2 is 1.12 [mu] M, and IC50 of 5-LOX is 1.18 [mu] M; and an acute toxicity experiment LD50 is greater than 2000mg / kg.

The invention discloses a chromone derivative containing a cyclamine structure as well as a preparation method and application of the chromone derivative. The structures of the compounds are confirmed by structural characterization of 1H NMR (nuclear magnetic resonance), 13C NMR (nuclear magnetic resonance), 19F NMR (nuclear magnetic resonance), HRMS (high resolution mass spectrometry) and other analysis and test methods, and all the compounds are new compounds. The synthesis method of the compound has the advantages of no transition metal catalysis, room temperature, short time, easily available reaction raw materials, simple reaction system, wide substrate application range, high yield and the like, and enriches chromone small molecule libraries. The cyclic amine chromone derivative prepared by the invention has certain inhibitory activity on mouse skin melanoma B16-F10 cells, colon cancer HCT-116 cells and cervical cancer Hela cells, and can be used for further development and application of anti-cancer drugs.

The invention discloses a preparation method and application of a hypochlorite photoelectrochemical sensing platform, and belongs to the technical field of analytical chemistry. According to the preparation process, adopted raw materials are easy to obtain, and reaction conditions are mild and easy to control. The sensing platform is designed and synthesized based on phenothiazine-chromone photosensitive micromolecules as a photosensitizer, and photoelectrochemical (PEC) sensing is realized. The sensing platform has the characteristics of high specificity, high sensitivity and easiness in preparation, quantitative photoelectrochemical signals of pypocholoride can be realized, and the PEC detection electrode is 1.64 nM.

The application provides a chromone-modified o-phenanthroline polypyridine Ru(II) series compound and a preparation method and application thereof, the preparation method synthesizes an intermediate A by taking 1,10-o-phenanthroline-5,6-diketone and 6-substituted-4-oxo-4H-benzopyran-3-formaldehyde as raw materials, then the intermediate A is heated to reflux in ethylene glycol solvent and cis-[Ru(2,2'-dipyridine)2Cl2]·2H2O at 120 DEG C for 6h, after the system is cooled to room temperature, an excess amount of a saturated aqueous solution of potassium hexafluorophosphate is added, after a precipitate is separated out, the filter cake is washed with clean water, and the final product is obtained after drying. The synthesis method is simple and easy to operate without steps such as column chromatography.

This invention pertains to organic synthesis and medicinal chemistry, specifically relating to a 4-chromone-cyclohexane spirocyclic trimer compound, its preparation method, and its applications. The 4-chromone-cyclohexane spirocyclic trimer compound has the structure shown in Formula I, II, III, or IV, or stereoisomers of the structures shown in Formulas I to IV. This invention also provides a method for preparing this compound, using 2-hydroxyacetophenone or its derivatives as a starting material, reacting it with dihalomethane in the presence of a base and additives to construct a spirocyclic trimer skeleton in one step. The compound of this invention can inhibit PPM1E and PPM1F protein phosphatases with high activity and high selectivity, achieving nanomolar inhibitory activity against PPM1E and sub-enzyme selectivity exceeding 100-fold. The compound of this invention can be used to prepare drugs for cancers associated with PPM1E / PPM1F overexpression.

This invention discloses a MYB transcriptional repressor, AsMYB054, related to the synthesis of 2-(2-phenylethyl) chromones in Aquilaria sinensis and its applications. Targeting the weak links in the synthesis and regulation of 2-(2-phenylethyl) chromone compounds, this invention clones for the first time the AsMYB054 gene, a transcriptional repressor related to the regulation of 2-(2-phenylethyl) chromone synthesis in Aquilaria sinensis. AsMYB054 is located in the cell nucleus and possesses transcriptional repressive activity, capable of binding to and inhibiting the activity of the promoters of enzyme genes AsPKS02 and AsPKS09, which are related to the biosynthesis of 2-(2-phenylethyl) chromone compounds. Inhibiting the expression of AsMYB054 using gene editing or RNA interference techniques can promote the accumulation of 2-(2-phenylethyl) chromone compounds in Aquilaria sinensis, showing broad application prospects and significant economic value.

The invention discloses a preparation method of a 3-deuterated chromone compound, which comprises the following steps of: carrying out cyclic isomerization reaction on an o-hydroxyphenylpropargyl ketone compound as shown in a formula (I) in the presence of a catalyst and a deuterated organic solvent as a deuterium source and a reaction solvent by taking the o-hydroxyphenylpropargyl ketone compound as a starting raw material, thereby obtaining the 3-deuterated chromone compound. The 3-deuterated chromone compound shown in the formula (II) is obtained. The preparation method is wide in substrate application range, can be used for synthesizing compounds with different molecular structures, and is mild in reaction, good in atom economy, high in deuterization rate, simple and convenient in product post-treatment and high in yield, and industrial production and application of the compounds are facilitated.

The application discloses a preparation method of 2-hydrocarbon-3-iodine chromone compounds and belongs to the field of organic synthesis. The preparation method comprises the following steps: taking o-hydroxyphenyl propargyl ketone compounds and iodine reagent as starting materials, and performing a tandem cyclization reaction in the presence of halosilane and a solvent to obtain the 2-hydrocarbon-3-iodine chromone compounds. The substrate of the preparation method has a wide application range and can be used for synthesizing compounds with different molecular structures. The reaction of the preparation method is mild, the atomic economy is good, the product post-treatment is simple, and the yield is high, so that the industrialized production and application of the compounds are facilitated.

This invention discloses a photocatalytic method for synthesizing 3-sulfonyl-substituted chromone derivatives. The method involves adding o-hydroxyphenylenamine ketone (Formula I), arylsulfonyl chloride (Formula II), a photocatalyst, and additives to a solvent, stirring the mixture under light irradiation, and then post-processing to obtain the 3-sulfonyl-substituted chromone derivative as shown in Formula III. The reaction formula is as follows: This invention has advantages such as simple operation, readily available and inexpensive raw materials, mild reaction conditions, and high reaction yield. Compared with traditional processes, it avoids high-temperature conditions and the use of oxidants, making it environmentally friendly.

The application discloses a class of aurone oxime ester photoinitiators, a preparation method and application thereof. The photoinitiator has ultraviolet absorption in the wavelength range of 250-450 nm, has a large molar extinction coefficient under common LED light wavelengths, has high photosensitive activity, can be well matched with an LED light source, can quickly and efficiently initiate double bond polymerization of a free radical monomer, and solves the problem that a traditional photoinitiator cannot initiate double bond polymerization of a monomer under an LED light source or has low initiation efficiency. The photoinitiator takes an aurone compound as a matrix, has simple synthesis, is easy to prepare, has low cytotoxicity, and has certain application potential in the fields of biological medicines, photocuring coatings, inks, 3D printing materials and UV-LED curing systems.

A method may comprise: exposing a substituted chromone dissolved in a solvent to a sample; taking a fluorescence measurement of the sample after exposure to the substituted chromone; and determining a presence or absence of one or more ions in the sample, a concentration of the one or more ions in the sample, or both based on the fluorescence measurement.

The present invention relates to organoleptic chromanones and furochromanones and their effects on aroma characteristics.

The application provides a chromone-3-carboxylic acid equipment wastewater treatment device, and belongs to the technical field of wastewater treatment. The device comprises a box body, a driving assembly, a cleaning assembly, a flexible filter layer and a winding assembly. A water inlet is formed in the top of the box body. Two groups of winding assemblies are arranged inside the box body, and the two groups of winding assemblies are symmetrically distributed about the water inlet. The two ends of the flexible filter layer are respectively wound outside the two groups of winding assemblies, and are used for filtering wastewater entering the inside of the box body from the water inlet. The driving assembly is installed inside the box body, and is used for driving the two groups of winding assemblies to reciprocatingly rotate in the same direction, so as to reciprocatingly move the flexible filter layer. Compared with the prior art, the embodiment of the application can automatically filter the working wastewater of the chromone-3-carboxylic acid equipment, and can also automatically clean the filtered sundries, thereby improving the filtering effect of the wastewater.

The application discloses a chromone compound prepared from a natural active product and application thereof, and the chromone compound is a thiazolidinedione derivative, and the thiazolidinedione derivative has the following structure: wherein R represents a substituted or unsubstituted aromatic hydrocarbon group, and the substitution is optional substitution. The application designs and synthesizes a series of thiazolidinedione compounds by taking thiazolidinedione as a mother nucleus, and the thiazolidinedione compounds have good alpha-glucosidase inhibiting effect and can be used as alpha-glucosidase inhibitors to treat or prevent diabetes.

The application provides dichloro-chromone compounds with Helicobacter pylori inhibiting activity and a preparation method and application thereof, and belongs to the field of natural medicines. Compound 1 and compound 2 are separated from 'Reke 1' white agilawood, wherein the compound 1 is (5R, 6R, 7S, 8R)-5, 8-dichloro-6, 7-dihydroxy-2-[2-(4-methoxy) ethyl]-5, 6, 7, 8-tetrahydrochromone; the compound 2 is (5R, 6R, 7S, 8R)-5, 8-dichloro-6, 7-dihydroxy-2-(2-phenylethyl)-5, 6, 7, 8-tetrahydrochromone; the two compounds can effectively inhibit the activity of Helicobacter pylori, and have wide development and application prospects in preparation of medicines or health products for inhibiting excessive production of Helicobacter pylori.

The invention discloses an alpha, beta unsaturated ketone substituted chromone derivative of which the structure is shown as a formula I or pharmaceutically acceptable salt and isomer I thereof. The compound can realize efficient selective inhibition on a BLT1 receptor through a specific molecular action mechanism, shows nanomole-level BLT1 inhibition activity and excellent selectivity, and meanwhile, shows a remarkable treatment effect in acute lung injury, chronic obstructive pulmonary disease and sepsis models. The invention discloses an application of the alpha, beta unsaturated ketone substituted chromone derivative or the pharmaceutically acceptable salt and isomer thereof in preparation of a BLT1 inhibitor, and also discloses an application of the alpha, beta unsaturated ketone substituted chromone derivative or the pharmaceutically acceptable salt and isomer thereof in preparation of the BLT1 inhibitor. The invention discloses an application of the alpha, beta unsaturated ketone substituted chromone derivative or the pharmaceutically acceptable salt and isomer thereof in preparation of medicines for treating acute lung injury, chronic obstructive pulmonary disease and sepsis, and also discloses an application of the alpha, beta unsaturated ketone substituted chromone derivative or the pharmaceutically acceptable salt and isomer thereof in preparation of medicines for treating acute lung injury, chronic obstructive pulmonary disease and sepsis.

The application discloses a flavonol fluorescent probe for detecting biological amine, a preparation method thereof and a fluorescent spin coating film application thereof. The application takes 3'-hydroxy-4'-acetyl.[1,1'-biphenyl]-4-carboxylic acid as a starting material, and performs a hydroxy aldehyde condensation reaction with 2,4,6-trimethoxybenzaldehyde to prepare 3'-hydroxy-4'-(3-(2,4,6-trimethoxyphenyl) acryloyloxy)-[1,1'-biphenyl]-4-carboxylic acid (HTC); the HTC is subjected to oxidative cyclization under alkaline conditions to obtain 4-(2-(2,4,6-trimethoxyphenyl)-3-hydroxy-chromone-7-yl) benzoic acid (HTBA); the HTBA is further subjected to esterification with 4-cyanobenzoyl chloride to prepare 4-(2-(2,4,6-trimethoxyphenyl)-3-((4-cyanobenzoyl)oxy)-chromone-7-yl) benzoic acid (CTBA). Under the irradiation of 365nm ultraviolet light, after a DMF / 10mM PBS buffer (v / v=1 / 9) solution of the CTBA is added with biological amine cadaverine, the fluorescence color of the solution changes from light blue to bright yellow, and the detection limit of the biological amine reaches 3.6*10 ‑7 M, and the CTBA has a good application prospect as a fluorescent probe for detecting biological amine.

The application belongs to the technical field of pharmaceutical chemistry synthesis, and particularly relates to a phenanthroimidazole terpyridine ruthenium compound and a preparation method and application thereof. The core structure of the phenanthroimidazole terpyridine ruthenium compound is [Ru(L1)(L2)Cl]PF6, wherein L1 is a 4'-substituted-2,2':6',2"-terpyridine ligand, and L2 is a 6-substituted-3-(1H-imidazo[4,5-f][1,10]phenanthroline-2-yl)-4-oxo-4H-benzopyran. The application provides a chromone-modified phenanthroimidazole terpyridine Ru(II) series compound and a preparation method thereof. The method is simple and easy to implement, and does not need steps such as column chromatography. According to the data results of the embodiments of the application, the compound provided by the application has a good inhibitory effect on Staphylococcus aureus.