11 results about "Stereocenter" patented technology

The present invention relates to the technical field of circularly polarized luminescent material preparation, and in particular to a spirochiral tetradentate platinum(II) complex-based circularly polarized luminescent material based on pyridine-carbazole-phenylcarbene and a derivative structure thereof, and an application thereof. The provided complex molecule autonomously induces, by means of a remote stereocenter-containing fragment in chirally substituted pyridine, an entire tetradentate ligand to coordinate with a metal ion in a less sterically hindered manner, so as to form an optically pure spirochiral metal complex-based circularly polarized luminescent material. Such spirochiral metal complex-based circularly polarized luminescent material does not require chiral resolution, has high molecular thermodynamic stability, and has important applications in circularly polarized light-emitting components.

The invention discloses a three-dimensional covalent organic framework material based on an adamantane three-dimensional center, a preparation method of the three-dimensional covalent organic framework material and application of the three-dimensional covalent organic framework material in hydrogen storage, and belongs to the technical field of hydrogen storage materials and preparation of the hydrogen storage materials. The hydrogen storage performance of the COF hydrogen storage material is further improved. According to the invention, TFPA and diamino monomers containing different numbers of benzene rings are taken as raw materials, covalent organic framework materials with different chain link lengths and a three-dimensional space network structure are constructed, the material has a dia topological structure, the three-dimensional structure enables pore channels to be complex, and the material has obvious advantages in gas adsorption. Test results show that when adamantane is taken as the three-dimensional center of the three-dimensional covalent organic framework material, the interpenetration degree is increased along with the increase of the length of the chain link, and different interpenetration structures have different hydrogen adsorption effects. When an organic chain link is short, a non-interspersed structure is more likely to be formed, at the moment, a higher specific surface area and more exposed active sites are achieved, and hydrogen storage is more facilitated.

The invention relates to the field of chemical synthesis, and discloses a method for constructing a full-alkyl quaternary carbon stereocenter through stereospecific conversion of chiral tertiary alcohol. The method successfully solves the industrial problem that the peralkyl quaternary carbon center is difficult to construct with high stereoselectivity due to huge steric hindrance and lack of electron difference, the process shows excellent stereospecificity and chemical selectivity, the ee value of the product is as high as 98%, the dr value is superior to 20: 1, and meanwhile, the excellent yield of 90% or above is kept; besides, according to the scheme, the substrate is wide in universality and can be compatible with various chemical small molecule substrates of different structures, the used reagents such as triethyl aluminum and KHMDS are cheap and easy to obtain, operation is easy and convenient, and a simple and efficient stereospecific conversion strategy with industrial application potential is provided for synthesis of complex drug intermediates.

The present application belongs to the technical field of tumor targeted therapy, and particularly relates to a small-molecule compound targeting EGFR and application thereof. The present application provides a small-molecule compound targeting EGFR or a pharmaceutically acceptable salt thereof. The spiro alkaloid compound provided by the present application contains an arylated four-membered stereocenter heterocyclic framework, including a helical heterocycle, a distributed heterocycle, a fused heterocycle and a bridged heterocycle, which can be applied to preparation of an EGFR-targeted inhibitory drug.

The invention relates to silicon-containing three-dimensional center silacyclohexenone skeleton borane as well as a preparation method and application thereof, the silicon-containing three-dimensional center silacyclohexenone skeleton borane has a structural formula as shown in a formula (I), and substituent groups R1 and R2 are respectively aryl or alkyl. According to the synthesis method of the compound, metal copper is used as a catalyst, and under the combined action of a chiral phosphine ligand and alkali, silacyclohexenone and a diborane compound are subjected to a hydroboration reaction to synthesize the compound. The synthesis method provided by the invention is simple to operate, mild in reaction condition, high in substrate universality, high in product yield and high in enantioselectivity. The synthesized compound is an important silicon-containing stereo center heterocyclic compound and can be widely applied to various fields of organic synthesis, medicine, material chemistry and fine chemical engineering.

The present invention relates to stereoisomeric phosphatidyl oligoglycerols having a predetermined configuration in at least three stereocenters, in particular to phosphatidyl oligoglycerols as a single stereoisomer. The present invention also relates to a stereospecific method for providing a stereospecific phosphatidyl oligoglycerol having a predetermined configuration in at least three stereocenters, in particular for providing a phosphatidyl oligoglycerol as a single stereoisomer, and to a liposome comprising the novel stereoisomeric phosphatidyl oligoglycerol, in particular, liposomes comprising novel stereoisomeric phosphatidyl oligoglycerols as a single stereoisomer.

The application discloses a kind of based on attention mechanism correction Kuroshio front stereo center line reconstruction method, including the following steps: (1) based on Soble algorithm obtains three-dimensional Kuroshio front area;(2) extract Kuroshio initial stereo center line;(3) using the characteristics of flow field and sea surface height anomaly field to remove outliers;(4) using attention mechanism to adjust correction field weight.The application first uses Soble algorithm to obtain the initial stereo center line of Kuroshio front, then uses the characteristics of flow field and sea surface height anomaly field to correct the stereo center line, and introduces attention mechanism to adjust the correction field weight, realizes the stereo reconstruction of Kuroshio front center line, and effectively describes the vertical swing characteristics of Kuroshio axis, provides an effective tool for the description of Kuroshio front three-dimensional characteristics.

The application belongs to the technical field of organic synthesis, and particularly relates to an amino nitrile compound with a remote chiral center and a preparation method and application thereof. The nickel-hydrogen catalytic asymmetric hydrogenation reaction provided by the application is realized through non-covalent pi-pi interaction between a cyano group in an olefin substrate and a chiral bisoxazoline ligand. The method not only realizes efficient and high-selectivity conversion of various olefin substrates and amine electrophilic reagents, but also is compatible with secondary alkyl amine electrophilic reagents, amide electrophilic reagents and benzisoxazole electrophilic reagents, thereby providing a reliable way for synthesizing chiral amino nitrile compounds (formula I) with a remote (beta-, gamma- and delta-) stereogenic center and various structures.

Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane.

The application discloses a synthesis method of alpha-substituted arylacetamide compounds. The method is based on a light-driven iron-catalyzed decarboxylative arylalkylation reaction system of ligand-metal charge transfer (LMCT) mechanism, can efficiently couple readily available N-arylacrylamide with commercial and various carboxylic acids, and can prepare a series of alpha-substituted arylacetamide compounds containing acyclic quaternary carbon stereogenic centers with high chemical selectivity. The system is suitable for various carboxylic acid substrates, including primary, secondary and tertiary alkyl carboxylic acids and complex biological active carboxylic acid molecules.

The invention discloses a three-dimensional covalent organic framework material based on double three-dimensional centers, a preparation method of the three-dimensional covalent organic framework material and application of the three-dimensional covalent organic framework material in hydrogen storage, and belongs to the technical field of hydrogen storage materials and preparation of the hydrogen storage materials. The invention aims to further improve the gas adsorptivity of the existing COF hydrogen storage material. According to the invention, two tetrahedron construction base blocks are directly condensed to construct the three-dimensional covalent organic framework material with the non-interpenetrating dia topological structure, and the COF shows good crystallinity and high BET specific surface area. By utilizing a higher specific surface area brought by a non-interpenetrating structure and fully exposed high-energy adsorption sites as well as high-density three-dimensional central units and high-energy adsorption sites provided by imine bond nitrogen atoms in a framework, the hydrogen adsorption performance is excellent, and a contribution is made for improving the hydrogen adsorption capacity.