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4 results about "Stereocenter" patented technology

In a molecule, a stereocenter is a particular instance of a stereogenic element that is geometrically a point. A stereocenter or stereogenic center is any point in a molecule, though not necessarily an atom, bearing groups, such that an interchanging of any two groups leads to a stereoisomer. The term stereocenter was introduced in 1984 by Kurt Mislow and Jay Siegel. A chirality center is a stereocenter consisting of an atom holding a set of ligands (atoms or groups of atoms) in a spatial arrangement which is not superimposable on its mirror image. The concept of a chirality center generalizes the concept of an asymmetric carbon atom (a carbon atom bonded to four different entities) such that an interchanging of any two groups gives rise to an enantiomer. In organic chemistry, a chirality center usually refers to a carbon, phosphorus, or sulfur atom, though it is also possible for other atoms to be chirality centers, especially in areas of organometallic and inorganic chemistry.

A method for reconstructing kuroshio front stereo centerline based on attention mechanism correction

The application discloses a kind of based on attention mechanism correction Kuroshio front stereo center line reconstruction method, including the following steps: (1) based on Soble algorithm obtains three-dimensional Kuroshio front area;(2) extract Kuroshio initial stereo center line;(3) using the characteristics of flow field and sea surface height anomaly field to remove outliers;(4) using attention mechanism to adjust correction field weight.The application first uses Soble algorithm to obtain the initial stereo center line of Kuroshio front, then uses the characteristics of flow field and sea surface height anomaly field to correct the stereo center line, and introduces attention mechanism to adjust the correction field weight, realizes the stereo reconstruction of Kuroshio front center line, and effectively describes the vertical swing characteristics of Kuroshio axis, provides an effective tool for the description of Kuroshio front three-dimensional characteristics.
Owner:THE 715TH RES INST OF CHINA SHIPBUILDING IND CORP

Amino nitrile compound with remote chiral center and preparation method and application thereof

PendingCN122325413AOrganic synthesisAmino nitriles
The application belongs to the technical field of organic synthesis, and particularly relates to an amino nitrile compound with a remote chiral center and a preparation method and application thereof. The nickel-hydrogen catalytic asymmetric hydrogenation reaction provided by the application is realized through non-covalent pi-pi interaction between a cyano group in an olefin substrate and a chiral bisoxazoline ligand. The method not only realizes efficient and high-selectivity conversion of various olefin substrates and amine electrophilic reagents, but also is compatible with secondary alkyl amine electrophilic reagents, amide electrophilic reagents and benzisoxazole electrophilic reagents, thereby providing a reliable way for synthesizing chiral amino nitrile compounds (formula I) with a remote (beta-, gamma- and delta-) stereogenic center and various structures.
Owner:TIANJIN NORMAL UNIVERSITY

Synthesis of small molecules inspired by phomoxanthone A

Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane.
Owner:WORCESTER POLYTECHNIC INSTITUTE

A method for synthesizing alpha-substituted arylacetamides

The application discloses a synthesis method of alpha-substituted arylacetamide compounds. The method is based on a light-driven iron-catalyzed decarboxylative arylalkylation reaction system of ligand-metal charge transfer (LMCT) mechanism, can efficiently couple readily available N-arylacrylamide with commercial and various carboxylic acids, and can prepare a series of alpha-substituted arylacetamide compounds containing acyclic quaternary carbon stereogenic centers with high chemical selectivity. The system is suitable for various carboxylic acid substrates, including primary, secondary and tertiary alkyl carboxylic acids and complex biological active carboxylic acid molecules.
Owner:QINGDAO UNIV OF SCI & TECH