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The present invention relates to, in part, methods, reagents and apparatuses for the detection of agents. The present invention also relates, in part, to compositions including, but not limited to, flow cells, assay chambers, reagent reservoir delivery units and devices for holding an assay chamber. The present invention also provides various components and combinations of components for various detection apparatuses. The present invention also relates to a portable agent detection apparatus that can be used in the field or at a point of care and is not limited to specialized laboratories or limited to use by highly skilled users.

The invention relates to a prediction device and a prediction method for the state of an emergency topic. The prediction device and the prediction method are provided based on the research of a microblog topic production mechanism and the influence of opinion leaders of emergency on the state of the emergency topic. The prediction device is provided with four components of a text acquisition unit, a topic clustering unit, a topic state recognition unit and a topic state prediction unit, and the topic state is predicted through the participation state of the opinion leaders, so that the prediction method of the topic state is simplified, the prediction accuracy is higher, and a basis can be provided for monitoring the tendency of the emergency topic. Through the calculation method of topic attention provided by the invention, the computation complexity of a traditional topic attention method is reduced. Moreover, the numerical value prediction of the topic attention is replaced by adopting the prediction of the state of the topic, so that the prediction content is more reasonable, and the prediction accuracy is higher. Furthermore, a prediction method of a hidden Markov model is provided, the set of the opinion leaders and the model of topic prediction are constructed through incremental iteration, so that the prediction operation can be obviously simplified, and the prediction efficiency is improved.

The invention discloses a method for synthesizing cabazitaxel, and belongs to the field of medicine synthesis. In the method, oppolzer reagent is used as a chiral source, and (3R,4S)-beta-lactam with optical purity ee of 98 percent is obtained by five steps. Under the action of a proper alkali, hydroxyls on C-7 and C-10 in 10-baccatine III are methylated selectively to form 7,10-dimethoxy-10-baccatine III in one step. Then beta-lactam is used to esterify the 7,10-dimethoxy-10-baccatine III under an alkaline condition, and then cabazitaxel with a purity of 99 percent can be obtained by a step of removing protective groups. In the synthesis method, the steps are short and the conditions are mild.

The number of releasable licenses is registered in a first entity, the resource to be used being attributed and/or having withdrawn from it, by a second entity, a releasable license for use which is registered in the second entity and/or a license. In a synchronization step the difference between the number of licenses allocated for use since a previous synchronization step and the licenses released again in this time is repeatedly reported from the second entities to the first entity respectively, this difference being taken as a basis for reducing or increasing the number of releasable licenses registered in the first entity, and conversely the resultant number of releasable licenses is reported from the first entity to the second entity and is registered there as the number of releasable licenses.

The invention relates to a method for separating and purifying human immunoglobulin from a component I+III of blood plasma, and aims to provide a high-efficiency method for recovering high-purity human immunoglobulin. According to the technical scheme provided by the invention, the method comprises the following steps of: a, fully dissolving component I+III precipitate; b, precipitating with octylic acid and removing lipid and a part of impurity protein to prepare IgG (Immunoglobulin G); c, purifying through anion exchange column chromatography; and d, collecting flow-through liquid, performing membrane nanofiltration, ultrafiltration and concentration, preparing the human immunoglobulin, sterilizing and packaging. The method has the beneficial effects of capability of being operated at the room temperature, simple and short steps, high yield, low energy consumption and high output and is suitable for mass production; comprehensive utilization of the blood plasma is fully realized; the time of the entire production process is shortened; the cost is reduced; extremely considerable economic benefit can be produced; the safety of a product is guaranteed by using two virus inactivation/elimination methods of different mechanisms; the environmental pollution is avoided; and the method has high economic and social values.

The invention provides preparation of an LCZ696 key intermediate and relates to a preparation method of the LCZ696 key intermediate (4S,2R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride. Two chiral centers of the (4S,2R)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride prepared by adopting the preparation method provided by the invention are respectively from chiral fragments, usage of expensive metal catalysts and chiral ligands which are difficult to commercially purchase in bulk is avoided, and commercialized production can be easily realized.

A web of a polymer film (1) is coated with an oxide layer, in particular with an SiO_x barrier layer, by transporting the web with the aid of a rotatable drum (12) through a plurality of flame bands, which are directed in a radial direction from above against the circumferential surface of the drum, which extend at a distance from each other across the width of the web being supported and transported on this circumferential surface, and which are fed with a gas mixture including a combustible gas, an oxidant, and a silicon containing compound. Therein the circumferential surface of the rotatable drum is cooled to a predetermined temperature and the web is transported through the area of the tip of the inner flame region. Polymer films with barrier layers produced in the named way have at small layer thicknesses of less than 10 nm very good barrier properties.

The invention discloses a method for measuring the fish freshness index value K in an online way based on multi-spectral imaging. The method comprises the steps of firstly, measuring the freshness index values K of fish samples which are refrigerated for different days by the traditional high performance liquid chromatography, and then scanning the corresponding fish samples by using a visible near-infrared multi-spectral imaging system to obtain corresponding multi-spectral images; preprocessing the multi-spectral images, extracting average reflected spectrum value at the parts with the central wavelengths of 425nm, 560nm, 660nm, 795nm and 960nm, and establishing a prediction model by a least squares support vector machine based on the obtained values K and the average spectrum value; predicting a fish sample to be measured. According to the method, the fish freshness is evaluated by the multi-spectral imaging technology, so that the prediction accuracy is improved, the time needed by the traditional method is shortened, and the aim of rapid, nondestructive and non-contact online detection can be effectively realized.

The invention offers 2-amphi capryl phenethyl-2-amino group propylene glycol hydrochloride preparation method. It includes the following steps: doing Friedel-Crafts reaction for styrene and capryl chloride to produce amphi capryl styrene; doing Michael addition reaction with kharophen diethyl malonate under alkali action to produce 2-amphi capryl phenethyl-2-kharophen diethyl malonate; reacting with triethyl silane to produce 2-amphi capryl phenethyl-2-kharophen diethyl malonate; reducing and hydrolyzing to produce 2-amphi capryl phenethyl-2-amino group propylene glycol; acidifying with hydrochloric acid to produce salt. It has the advantages of simple line, low cost, short period, little pollution, and high yield. It also offers the intermediate compound preparation method.

Color filters can each be fabricated by printing a pixel pattern for the color filter on a flexible plastic film by a central impression cylinder press. The pixel pattern is formed of pixels of three primary colors consisting of red, green and blue or pixels of three primary colors consisting of yellow, magenta and cyan. Also disclosed are inks, color filters, and image displays using the color filters.

The invention discloses a method for preparing improved decitabine (formula I), comprising: using 1-alpha-chlorine-3,5-two pairs of halo-benzoyl-2-deoxidation-D-ribose (formula II) as materials, concentrating with 2-4-bi-(trimethyl silicane)-5-azacytosine (formula III) to obtain I by de-protecting group. Materials used in the invention are easy to obtain at a low price. The invention also has the advantages of convenient operation and a high reaction yield, and is suitable for industrialized production.

The invention provides a preparation method for vismodegib, and in other words, a preparation method for 2-chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(methylsulfonyl)benzamide. The method comprises: firstly preparing an intermediate 2-(3-nitrophenyl)pyridine, and then performing chlorination reaction, reduction reaction and acylation reaction to prepare 2-chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(methylsulfonyl)benzamide. The related preparation method has the characteristics of being brief in steps, simple in operation, basically free of waterless requirement on reaction conditions, relatively low in oxygen-free requirement and the like, and is capable of effectively reducing production cost.

The invention relates to a preparation method of flurbiprofen axetil. The method comprises the following steps: condensing 2-(4-nitro-3-fluorophenyl) propionic and 1-chloroethyl acetate so as to generate 1-acetoxyl ethyl 2-(4-nitro-3-fluorophenyl) propionate, carrying out hydrogenation reduction on 1-acetoxyl ethyl 2-(4-nitro-3-fluorophenyl) propionate under the catalysis of palladium-carbon so as to generate 1-acetoxyl ethyl 2-(4-amino-3-fluorophenyl) propionate, carrying out diazotization and iodination on 1-acetoxyl ethyl 2-(4-amino-3-fluorophenyl) propionate so as to obtain 1-acetoxyl ethyl 2-(3-fluoro-4-iodophenyl) propionate, carrying out Suzuki coupling reaction on the intermediate and a phenylboronic acid in water by taking palladium-carbon as a catalyst so as to obtain a target product flurbiprofen axetil crude product, carrying out silica gel column chromatography on the crude product so as to obtain a flurbiprofen axetil finished product. The method disclosed by the invention enriches the synthesis methods of flurbiprofen axetil, a synthetic process is simple in operation, environment-friendly and low in cost, and the purity of obtained flurbiprofen axetil is over 99.3%, therefore, the method has a good industrial application prospect.

The invention discloses a preparation method of an intermediate of an anti-new crown drug Paxlovid. According to the preparation method, cheap and easily available N-Boc-trans-4-hydroxy-L-proline methyl ester (compound II) is taken as an initial raw material, the Paxlovid intermediate can be obtained through a plurality of steps of reactions, and the structural formula of the anti-new crown drug Paxlovid intermediate is as shown in the formula I. The method has the advantages of simple process, low production cost, easiness in industrial production and the like.

An anti-surge system capable of anticipating a surge event in a compressor for readying the actuator to quickly actuate the anti-surge valve from the closed position to the open position. The control system includes a compressor surge controller configured to transmit a signal to the valve positioner when the operating point of the valve is approaching the surge control line. The compressor surge controller may monitor an operating margin equal to the difference between the operating point and the surge control line, and when the operating margin falls below a prescribed threshold, the compressor surge controller may send a signal to the positioner. In turn, the positioner may vent some pressure from the actuator. In this way, the dead time of the anti-surge valve on the valve seat is minimized and the valve will react more promptly to an opening signal.

The invention discloses an acid-base bifunctional catalyst for synthesis of methyl methacrylate by methyl propionate and formaldehyde. Active components of the catalyst are Cs and P, an auxiliary agent of the catalyst is one selected from the group consisting of Zr, Fe, Cu, La, Ce, Zn, Co, W and Mo, and a carrier of the catalyst is Al2O3 or Al2O3 treated by phosphoric acid, wherein Al2O3 is one selected from alpha-Al2O3, beta-Al2O3 and gamma-Al2O3. Based on the carrier, the loading capacity of the active components Cs and P is 5-20 wt% based on oxides, the loading capacity of the auxiliary agent is 0.1-1 wt% based on an oxide, and the concentration of a phosphoric acid treatment solution of the carrier is 1-5 wt%. The catalyst provided by the invention has better activity, selectivity andstability, and a simple preparation process, and is suitable for large-scale industrial application.

A process for preparing astaxanthin from phylloxanthinextracted from marigold includes such steps as preparing high-purity phylloxanthin crystal, preparing kryptoxanthin, and preparing astaxanthin.