14results about How to "Short steps" patented technology

The application discloses a synthesis method of 7-bromo-2-chloroquinolin-4-ol, which comprises the following steps: taking 7-bromo-2,4-dichloroquinoline as raw material, converting into 7-bromo-4-(tert-butoxy)-2-chloroquinoline, and reacting under the action of p-toluenesulfonic acid to obtain 7-bromo-2-chloroquinolin-4-ol. The synthesis method of 7-bromo-2-chloroquinolin-4-ol is short in steps, relatively mild in reaction condition, and high in product yield, which not only provides a potential route for the process synthesis of 7-bromo-2-chloroquinolin-4-ol, but also helps the development and utilization of quinoline compounds.

A modified tin-silicon molecular sieve, characterized in that it contains tin, silicon, oxygen and an alkali metal element; the modified tin-silicon molecular sieve is characterized by XPS, the center value of the Sn 3d 5 / 2 spectral peak binding energy is located at 487.1±0.4eV, and the ratio of the spectral peak area of six-coordinated tin to four-coordinated tin is greater than 1:1.

This invention relates to mupirocin compounds, specifically to a method for preparing mupirocin derivatives. The method includes the following steps: 1) benzyloxyheptenol reacts with triethyl orthoacetate via a Claisen rearrangement to generate trans-ethyl olefin ester; 2) the trans-ethyl olefin ester undergoes oxidation to remove debenzylic protection, producing an alcohol compound; 3) the alcohol compound undergoes halogenation to generate a key branched iodide; 4) mupirocin reacts with excess trimethyl orthoformate under acidic catalysis for alcohol protection, followed by ester hydrolysis under alkaline conditions to obtain polyol-protected mupirocin acid; 5) the polyol-protected mupirocin acid reacts with the iodide via a nucleophilic substitution reaction to generate a polyalkyl mupirocin ester; 6) the polyalkyl mupirocin ester undergoes alkaline hydrolysis, followed by acid-base adjustment and deprotection to obtain the crude product, which is then neutralized to acid and purified by slurrying with an inorganic base to obtain the target compound. This invention avoids harsh reaction conditions, has readily available raw materials, high yield, simple operation and purification, and can be used for large-scale production of high-quality target compounds.

The invention discloses a synthesis method of a compound 5-bromo-[1, 1 '-biphenyl]-3-alcohol, and belongs to the technical field of organic synthesis. The synthesis method comprises the following steps: mixing a copper catalyst, alkali, a ligand, 1-phenyl-3, 5-dibromobenzene and a solvent, and stirring to react under the protection of inert gas to obtain a reaction solution; and carrying out post-treatment to obtain the 5-bromo-[1, 1 '-biphenyl]-3-alcohol. According to the invention, the compound 1-phenyl-3, 5-dibromobenzene is used as a raw material, the target compound 5-bromine-[1, 1 '-biphenyl]-3-alcohol is obtained through a copper-catalyzed nucleophilic aromatic substitution reaction and a one-step reaction, the steps are simple and short, the reaction conditions are mild, the post-treatment and purification are simple, an expensive catalyst is not needed, and the method is a novel method for preparing the 5-bromine-[1, 1'-biphenyl]-3-alcohol. And a potential route is provided for large-scale production of 1, 1 '-biphenyl]-3-alcohol.

This invention belongs to the field of fetoglobulin B detection technology, and discloses an immunochromatographic test strip for quantitative detection of fetoglobulin B using quantum dot fluorescent microspheres and its preparation method. The immunochromatographic test strip of this invention includes a sample pad, a release pad, and a nitrocellulose membrane; the release pad is coated with a fetoglobulin B monoclonal antibody labeled with quantum dot fluorescent microspheres and a mouse IgG antibody labeled with quantum dot fluorescent microspheres; the nitrocellulose membrane has a detection line and a control line, the detection line is coated with fetoglobulin B monoclonal antibody, and the control line is coated with goat anti-mouse IgG antibody. The immunochromatographic test strip of this invention reduces the detection time to 9-12 minutes, and the total detection time is only 20 minutes, achieving rapid and accurate quantitative detection of fetoglobulin B. It also features high detection sensitivity, a wide detection range, and simple and rapid operation, which is beneficial for the screening and monitoring of atherosclerotic coronary heart disease.

This invention discloses a method for synthesizing an aromatic formate ester compound, comprising: Step S1: adding a photosensitizer, a base, an organic solvent, an aryl alkyne, and an organic bromide as reactants into a reaction vessel; Step S2: placing the reaction vessel under visible light irradiation and stirring the reaction vessel under a preset temperature range and atmospheric conditions; Step S3: monitoring the reaction progress, and after the reaction is completed, concentrating the reaction solution under vacuum to remove volatile solvents, and then purifying the reaction solution using column chromatography to obtain the aromatic formate ester compound. The method for synthesizing an aromatic formate ester compound provided by this invention is more environmentally friendly and economical than traditional esterification reactions, and is also highly efficient and simple to operate.

The application discloses a diflunisal derivative, a preparation method and application thereof, and belongs to the technical field of agricultural fungicides. The preparation method comprises the following steps: mixing 2', 4'-difluoro-4-hydroxy-[1, 1'-biphenyl]-3-carboxylic acid, a condensing agent and an organic base in an ice bath and an inert organic solvent, and activating for 10-30 minutes; then adding an amine compound with a general formula of R-NH2, and stirring and reacting at room temperature for 20-28 hours; after the reaction is completed, extraction, washing, drying, concentration and column chromatography purification are performed, so that the target diflunisal derivative is obtained. The compound disclosed by the application has a novel structure, shows excellent inhibitory activity on cucumber botrytis cinerea, rice pellicularia sasakii, brassica rapa sclerotium, wheat fusarium graminearum and other plant pathogenic fungi, can be used as an active ingredient for preparing an agricultural fungicide or a fungicide composition, and provides a new lead structure for developing a new succinate dehydrogenase inhibitor fungicide.

The invention belongs to the technical field of chemical synthesis of drugs, and particularly discloses a novel synthetic route of an anti-hyperuricemia drug dotinirad (Dotinirad, the CAS number is 1285572-51-1, and the chemical name is 3-(3, 5-dichloro-4-hydroxybenzoyl)-1, 1-dioxo-2, 3-dihydro-1, 3-benzothiazole). The invention further discloses a preparation method of the dotinirad, the CAS number is 1285572-51-1, and the chemical name is 3-(3, 5-dichloro-4-hydroxybenzoyl)-1, 1-dioxo-2, 3-dihydro-1, 3-benzothiazole. According to the route, p-hydroxybenzoic acid which is low in price and easy to obtain serves as a starting raw material, a target product is obtained through four-step reaction of chlorination, acylating chlorination, amide condensation and oxidation, the method has the advantages of being short in step, mild in condition and high in yield, use of 2-aminothiophenol which is odorous and unstable is avoided, benzothiazole which is more stable and low in price is used as a raw material, and the method is suitable for industrial production. The concept of green chemistry is met. The industrial production cost is remarkably reduced, and an efficient and reliable technical scheme is provided for large-scale production of the dotenorad.

The process described in this application uses ethyl N-Cbz-4-oxo-3-pyrrolidinecarboxylate and Wittig reagent ethyltriphenylphosphine iodide as the starting points for synthesis. First, ethyl N-Cbz-4-oxo-3-pyrrolidinecarboxylate undergoes a nucleophilic addition reaction with Wittig reagent ethyltriphenylphosphine iodide to generate an olefin. Then, it undergoes a hydrolysis reaction under alkaline conditions to generate an acid, followed by a double bond reduction reaction under catalytic hydrogen conditions. The process is reasonable, has high yield, is simple to operate, and has low production cost, which is conducive to large-scale industrial production and fills a technological gap in related fields.

The invention provides a synthesis method of asymmetric amino urea (V), which comprises the following steps: directly activating an amine compound (I) by a phenyl chloroformate compound (II) to obtain a carbamate compound (III), and directly reacting the carbamate compound (III) with an amine compound (IV) to obtain the asymmetric amino urea (V). According to the invention, the compound phenyl chloroformate compound (II) is introduced, two molecules of different amine compounds are activated to directly form asymmetric urea, the process adopts a one-pot method, the steps are relatively short, the operation is simple, and the cost is low. R < 1 > and R < 2 > are respectively and independently C1-C6 alkyl groups, aryl groups and heterocyclic rings; r is hydrogen, C1-C6 alkyl, aryl, heterocyclic ring, halogen or nitryl.

An alkali metal-modified titanium-silicon molecular sieve, characterized in that the molecular sieve contains titanium, silicon, oxygen, and alkali metal elements, and is characterized by Raman spectroscopy using a 325 nm light source, showing a value at 990±20 cm⁻¹. ‑1 A titanium species signal peak exists within the range, at 1125±20 cm⁻¹. ‑1 No obvious titanium species signal peak was observed within the range of 800±20 cm⁻¹. ‑1 A molecular sieve framework structure signal peak exists within the range, calculated with peak area as intensity, 990±20 cm⁻¹. ‑1 Signal peak intensity and 800±20cm ‑1 The ratio of signal peak intensity I(990) / I(800) is (0.2-2):1.

The utility model relates to the technical field of new energy automobile main shells, in particular to a main shell for a new energy automobile, which comprises a support frame, a top plate I arranged on one side of the top of the support frame, a clamping plate I arranged on the top plate I, a top plate II arranged on the other side of the top of the support frame, and a flange extending outwards arranged at the bottom of the support frame. A main plate is installed at the front end of the supporting frame, a second clamping plate and a third clamping plate are arranged on the second top plate, a plurality of protruding blocks are arranged at the bottoms of the first top plate and the second top plate, a partition plate is further arranged between the first top plate and the second top plate, a plurality of first reinforcing plates are arranged between the supporting frame and the turned-over edge, and a plurality of second reinforcing plates are arranged between the first top plate and the supporting frame. According to the utility model, the percent of pass of products is improved by reducing air shrinkage holes, the structural strength is high, the safety and durability are strong, the structural design is simple, the battery is convenient to maintain and replace, the maintenance cost is reduced, and the operation steps of disassembly and replacement are fast.

The application discloses a preparation method of cefodizole and an intermediate thereof, and the method comprises the following steps: condensation reaction of 2-chloro-3,4-dihydroxybenzoic acid and 2-(pyrrolidine-1-yl)ethane-1-amine in a mixed solution of polyethylene glycol and water in the presence of a condensing agent and an alkali, then adding an alkali, a halide salt and a hydroxyl protection reagent, and performing a protection group reaction to generate a compound shown in formula (I), wherein R is a hydroxyl protection group; the method can not only synthesize a target product with a better step, but also has a shorter step, less industrial wastewater, and especially can obtain an excellent total yield, is suitable for industrial production, and can be used in a process for preparing cefodizole.

The invention discloses a synthesis method of a key intermediate of a natural product Brasilicardin A, and belongs to the technical field of preparation of raw materials and intermediates in organic synthesis. The Brasilicardins A has relatively strong immunosuppressive activity (IC50 is equal to 0.057 mu g / ml), and has a potential clinical application value. The invention specifically provides a synthesis method of a Brasilicardin A key intermediate as shown in a general formula I. The preparation method comprises the following steps: carrying out reactions of RuBottom oxidation, stereoselective reduction of carbonyl, Eschenmoser-Claisen rearrangement, stereoselective methylation, olefin metathesis, Johnson-Claisen rearrangement and the like on a compound II, so as to prepare the Brasilicardin A key intermediate I. The invention further provides a preparation method of the Brasilicardin A key intermediate. The method has the advantages of easily available raw materials, simple operation, high product yield and purity, and easy industrial mass production.