11 results about "Absolute configuration" patented technology

Chiral isomeric sulfite compounds, and preparative separation and application of chiral structures thereof are disclosed,. which belong to the technical field of agriculture. The present disclosure has found that the chiral isomeric sulfite compounds having the structure of general formula (A) have excellent inhibitory activities against pest eggs, especially have strong inhibitory activities against eggs of thrips, mites, Lepidoptera moths, Aleyrodidae and Harmonia axyridis, and meanwhile have germicidal activity, and their absolute configuration are obtained through preparative separation. The compounds with such structures can be used for killing pest eggs and germs, and have high research value of agrochemical, having broad application prospects in the field of agricultural pharmacy. 20 25 20 23 00 31 M ar 2 02 5 2 0 2 5 2 0 2 3 0 0 3 1 M a r 2 0 2 5

Chiral isomeric sulfite compounds, and preparative separation and application of chiral structures thereof are disclosed, which belong to the technical field of agriculture. The present disclosure has found that the chiral isomeric sulfite compounds having the structure of general formula (A) have excellent inhibitory activities against pest eggs, especially have strong inhibitory activities against eggs of thrips, mites, Lepidoptera moths, Aleyrodidae and Harmonia axyridis, and meanwhile have germicidal activity, and their absolute configuration are obtained through preparative separation. The compounds with such structures can be used for killing pest eggs and germs, and have high research value of agrochemical, having broad application prospects in the field of agricultural pharmacy.

The present disclosure is directed to an analytical method for determining the concentration of a chiral alcohol in a sample and one or both of (i) the absolute configuration of the chiral alcohol in the sample, and (ii) the enantiomeric and / or the diastereomeric composition of the chiral alcohol in the sample. The present disclosure is also directed to an aryl or heteroaryl sulfonamide probe having the structure according to formula (I): Formula (I), where Ar, R1, R2, and n are as described herein, as well as to a kit for carrying out the analytical method described herein.

This invention discloses a method for preparing the natural product mycenolide A, comprising the following steps: mixing compound 2, IBX oxidant, and solvent to carry out an oxidation reaction to obtain the natural product mycenolide A; the structural formulas of compound 2 and the natural product mycenolide A are as follows: This invention proposes and realizes for the first time an efficient total synthesis strategy for all possible chiral isomers of mycenolide A, not only solving the scientific problem of the scarcity of natural mycenolide A and its unknown absolute configuration, but also providing solid technical support and material guarantee for subsequent evaluation of neuroprotective activity and development of related original drugs due to its excellent synthetic efficiency and comprehensive coverage of chiral isomers.

The application provides a method for synthesizing an R-10-hydroxy-10-(1H-indol-3-)-9-phenanthrenone compound, which comprises the following steps: mixing a 9,10-phenanthrenequinone compound shown in formula 2, an indole compound shown in formula 3 and a chiral catalyst in an organic solvent, and performing reaction to obtain an R-10-hydroxy-10-(1H-indol-3-)-9-phenanthrenone compound shown in formula 4. The application can obtain the R-10-hydroxy-10-(1H-indol-3-)-9-phenanthrenone compound as a main product, the enantiomeric excess value of which is up to 97%, the yield is good (75%-95%), and the absolute configuration of the target compound is determined as R through X-single crystal diffraction experiment. It is found through cell experiment that a series of synthesized compounds have good antitumor activity, and the application provides a basis for the research of chiral drugs.

The invention relates to a synthetic method of an azabicyclo [3.2. 1] octyl-2-ene derivative, and belongs to the technical field of organic synthesis. The synthetic method of the azabicyclo [3.2. 1] octyl-2-ene derivative comprises the following steps: S1, in an inert atmosphere and at a low temperature, carrying out an addition reaction on N-Boc-nortropinone as a raw material and an aryl lithium reagent to obtain an intermediate IM1; s2, removing a Boc protecting group under an acidic condition to obtain an intermediate IM2; and S3, salifying the intermediate IM2 and chiral mandelic acid, performing fractional crystallization and alkali dissociation to obtain a target enantiomer with high optical purity, culturing an S-mandelate single crystal of a compound (1S, 5R)-(+)-3-(4-chlorphenyl)-8-azabicyclo [3.2. 1] oct-2-ene, and determining the absolute configuration of the compound through single crystal diffraction. The synthesis method disclosed by the invention has the characteristics of simple reaction operation in each step, mild conditions, high yield, good repeatability and suitability for industrial large-scale production.

This invention relates to a tomographic gamma-ray scanning method for transmission imaging and a method for solving the track matrix, including: establishing a voxel model of a rectangular container of nuclear waste; performing layer-by-layer scanning measurements on the voxel model to acquire scanning data; solving the track matrix of TGS transmission imaging using the above method: dividing the two-dimensional plane into 9 regions using the four sides of a rectangular clipping window; denoting the codes at both ends of the line segment to be clipped as code1 and code2 respectively, and determining the relationship between code1 and code2 and the clipping window: if code1=code2=0, the line segment is completely visible and is selected; if code1&code2≠0, & is a bitwise AND operation, the line segment is completely invisible and is discarded; if neither code1=code2=0 nor code1&code2≠0 is satisfied, a perpendicular line is drawn from the vertex of the clipping window to the line segment; if the foot of the perpendicular is within the clipping window, an intersection operation is performed on the line segment; if the foot of the perpendicular is outside the clipping window, it is discarded; and reconstructing the linear attenuation coefficient. This invention effectively avoids the shortcomings of the traditional Cohen-Sutherland algorithm and improves the efficiency of track matrix solving.

The present invention relates to an analytical method that includes providing a sample potentially containing a chiral analyte that can exist in stereoisomeric forms, and providing a probe selected from the group consisting of coumarin-derived Michael acceptors, dinitrofluoroarenes and analogs thereof, arylsulfonyl chlorides and analogs thereof, arylchlorophosphines and analogs thereof, aryl halophosphites, and halodiazaphosphites. The sample is contacted with the probe under conditions to permit covalent binding of the probe to the analyte, if present in the sample; and, based on any binding that occurs, the absolute configuration of the analyte in the sample, and / or the concentration of the analyte in the sample, and / or the enantiomeric composition of the analyte in the sample is / are determined. The probe may be a coumarin-derived Michael acceptor, a di nitrofluoroarene or analog thereof, an arylsulfonyl chloride or analog thereof, an arylchlorophosphine or analog thereof, an aryl halophosphite, or a halodiazaphosphite.

The application discloses a chiral, isomeric sulfite compound and preparation, separation and application of a chiral structure of the chiral, isomeric sulfite compound, and belongs to the field of agricultural technology. The application finds that the chiral, isomeric sulfite compound with the structure of a general formula (A) has excellent inhibitory activity on insect eggs, especially has a strong inhibitory effect on insect eggs of plant bugs, mites, lepidoptera, whiteflies and ladybugs, and has fungicidal activity, and absolute configurations of the chiral, isomeric sulfite compound are obtained through preparation and separation; the compound with the structure can be used for killing insect eggs and killing fungi, and has high pesticide research value and wide application prospects in the field of pesticide science.

Chiral isomeric sulfite compounds, and preparative separation and application of chiral structures thereof are disclosed,.which belong to the technical field of agriculture. The present disclosure has found that the chiral isomeric sulfite compounds having the structure of general formula (A) have excellent inhibitory activities against pest eggs, especially have strong inhibitory activities against eggs of thrips, mites, Lepidoptera moths, Aleyrodidae and Harmonia axyridis, and meanwhile have germicidal activity, and their absolute configuration are obtained through preparative separation. The compounds with such structures can be used for killing pest eggs and germs, and have high research value of agrochemical, having broad application prospects in the field of agricultural pharmacy.

The invention relates to a nemorubicin co-crystal and a preparation method thereof. The absolute configuration of a chiral center in a molecule of the nemorubicin co-crystal is {C17 (S), C19 (S), C22 (R), C23 (S), C24 (S), C25 (S) and C30 (S)}. The problem of structure confirmation of the compound in the development process is solved, and a powerful support basis is provided for absolute configuration confirmation of a terminal product PNU-159682. Moreover, the preparation method of the nemorubicin crystal form provided by the invention is simple to operate, the prepared crystal form is high in purity and uniform in particle size distribution, the production cost is reduced, and the purity of the nemorubicin is improved.