7 results about "Absolute configuration" patented technology

Chiral isomeric sulfite compounds, and preparative separation and application of chiral structures thereof are disclosed,. which belong to the technical field of agriculture. The present disclosure has found that the chiral isomeric sulfite compounds having the structure of general formula (A) have excellent inhibitory activities against pest eggs, especially have strong inhibitory activities against eggs of thrips, mites, Lepidoptera moths, Aleyrodidae and Harmonia axyridis, and meanwhile have germicidal activity, and their absolute configuration are obtained through preparative separation. The compounds with such structures can be used for killing pest eggs and germs, and have high research value of agrochemical, having broad application prospects in the field of agricultural pharmacy. 20 25 20 23 00 31 M ar 2 02 5 2 0 2 5 2 0 2 3 0 0 3 1 M a r 2 0 2 5

Chiral isomeric sulfite compounds, and preparative separation and application of chiral structures thereof are disclosed, which belong to the technical field of agriculture. The present disclosure has found that the chiral isomeric sulfite compounds having the structure of general formula (A) have excellent inhibitory activities against pest eggs, especially have strong inhibitory activities against eggs of thrips, mites, Lepidoptera moths, Aleyrodidae and Harmonia axyridis, and meanwhile have germicidal activity, and their absolute configuration are obtained through preparative separation. The compounds with such structures can be used for killing pest eggs and germs, and have high research value of agrochemical, having broad application prospects in the field of agricultural pharmacy.

This invention discloses a method for preparing the natural product mycenolide A, comprising the following steps: mixing compound 2, IBX oxidant, and solvent to carry out an oxidation reaction to obtain the natural product mycenolide A; the structural formulas of compound 2 and the natural product mycenolide A are as follows: This invention proposes and realizes for the first time an efficient total synthesis strategy for all possible chiral isomers of mycenolide A, not only solving the scientific problem of the scarcity of natural mycenolide A and its unknown absolute configuration, but also providing solid technical support and material guarantee for subsequent evaluation of neuroprotective activity and development of related original drugs due to its excellent synthetic efficiency and comprehensive coverage of chiral isomers.

The invention relates to a synthetic method of an azabicyclo [3.2. 1] octyl-2-ene derivative, and belongs to the technical field of organic synthesis. The synthetic method of the azabicyclo [3.2. 1] octyl-2-ene derivative comprises the following steps: S1, in an inert atmosphere and at a low temperature, carrying out an addition reaction on N-Boc-nortropinone as a raw material and an aryl lithium reagent to obtain an intermediate IM1; s2, removing a Boc protecting group under an acidic condition to obtain an intermediate IM2; and S3, salifying the intermediate IM2 and chiral mandelic acid, performing fractional crystallization and alkali dissociation to obtain a target enantiomer with high optical purity, culturing an S-mandelate single crystal of a compound (1S, 5R)-(+)-3-(4-chlorphenyl)-8-azabicyclo [3.2. 1] oct-2-ene, and determining the absolute configuration of the compound through single crystal diffraction. The synthesis method disclosed by the invention has the characteristics of simple reaction operation in each step, mild conditions, high yield, good repeatability and suitability for industrial large-scale production.

This invention relates to a tomographic gamma-ray scanning method for transmission imaging and a method for solving the track matrix, including: establishing a voxel model of a rectangular container of nuclear waste; performing layer-by-layer scanning measurements on the voxel model to acquire scanning data; solving the track matrix of TGS transmission imaging using the above method: dividing the two-dimensional plane into 9 regions using the four sides of a rectangular clipping window; denoting the codes at both ends of the line segment to be clipped as code1 and code2 respectively, and determining the relationship between code1 and code2 and the clipping window: if code1=code2=0, the line segment is completely visible and is selected; if code1&code2≠0, & is a bitwise AND operation, the line segment is completely invisible and is discarded; if neither code1=code2=0 nor code1&code2≠0 is satisfied, a perpendicular line is drawn from the vertex of the clipping window to the line segment; if the foot of the perpendicular is within the clipping window, an intersection operation is performed on the line segment; if the foot of the perpendicular is outside the clipping window, it is discarded; and reconstructing the linear attenuation coefficient. This invention effectively avoids the shortcomings of the traditional Cohen-Sutherland algorithm and improves the efficiency of track matrix solving.

Chiral isomeric sulfite compounds, and preparative separation and application of chiral structures thereof are disclosed,.which belong to the technical field of agriculture. The present disclosure has found that the chiral isomeric sulfite compounds having the structure of general formula (A) have excellent inhibitory activities against pest eggs, especially have strong inhibitory activities against eggs of thrips, mites, Lepidoptera moths, Aleyrodidae and Harmonia axyridis, and meanwhile have germicidal activity, and their absolute configuration are obtained through preparative separation. The compounds with such structures can be used for killing pest eggs and germs, and have high research value of agrochemical, having broad application prospects in the field of agricultural pharmacy.

The invention relates to a nemorubicin co-crystal and a preparation method thereof. The absolute configuration of a chiral center in a molecule of the nemorubicin co-crystal is {C17 (S), C19 (S), C22 (R), C23 (S), C24 (S), C25 (S) and C30 (S)}. The problem of structure confirmation of the compound in the development process is solved, and a powerful support basis is provided for absolute configuration confirmation of a terminal product PNU-159682. Moreover, the preparation method of the nemorubicin crystal form provided by the invention is simple to operate, the prepared crystal form is high in purity and uniform in particle size distribution, the production cost is reduced, and the purity of the nemorubicin is improved.