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71results about How to "Pharmacologically active" patented technology
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Use of icariin in inducting dry cell body in-vitro directional differentiation
InactiveCN1869204AOpen up new usesResearch helpsNervous disorderNervous system cellsIntellectual propertyDirected differentiation
The invention provides icariin application in inducing stem cell in vitro orientation differentiates to several single type cells. The stem cell said includes embryonic stem cell, nerve stem cell and marrow mesenchyme stem cell. The single type cell includes nerve cell, bone cell, islet cells and endothelial cell. This invention also relates to application of the single type cell in preparing medicine of stem cell transplant curing nerve degenerative diseases, and its application in preparing cell differentiation agent that used to repair recovery injured nerve tissue, and its application in high efficiency drug effect screening model rebuilding and initial screening and estimating by using the model. The new applications of the icariin is extended in this invention, the fact of icariin contains pharmacy activity clarified, so it provides material basis for Chinese traditional medicine prevention and cure effect. The clarifying of drug effect mechanism provides reference for new medicine Chinese metical modern development with self-owned intellectual property right.
Owner:ZHEJIANG UNIV
Pyrazoleoxy acetic acid compounds, preparation method and use
The invention discloses a pyrazolyloxyacetic acid compound, a preparation method and use thereof. In the compound with a structural formula (I), X or Y is respectively hydrogen, C 1-4 alkyl, C 1-4 alkoxyl, substituted or non-substituted phenoxyl, halogen, nitryl or trifluoromethyl; and R is hydrogen or C 1-4 alkyl. The invention also discloses a preparation method for the compound and application thereof in preparing bactericide.
Owner:NANJING UNIV OF TECH
Optical-purity meptazinol orits salts, and preparing method
InactiveCN1850804APharmacologically activeNervous disorderOrganic chemistryAbsolute configurationSingle crystal
This invention belongs to pharmacy field, it relates optical pure mei pu ta fen and its preparation method and application. Racemation mei pu ta fen is splited by optical pure tartaric acid evolving object to get optical pure monomer, enantiomeric excess testing is done through capillary electrophoresis method, their e.e.valude are both excess 99 percent. Laevorotation and dextrorotation mei put a fen absolute configuration is decided by single crystal X-diffraction method as S and R. the R(+)mei pu ta fen has srong activity in analgesia activity testing, but S(-)mei pu ta fen has more stronger activity in acetylcholine esterase restrain activity testing, analgesic medicine and senile dementia medicine can be further prepared.
Owner:FUDAN UNIV
Kit for detecting anti-psychosis drugs in serum and plasma by liquid chromatography tandem mass spectrometry method and application thereof
InactiveCN109085263AReduce matrix effectThe test result is accurateComponent separationPsychosis drug9-Hydroxyrisperidone
The invention provides a kit for detecting anti-psychosis drugs in a serum and plasma by a liquid chromatography tandem mass spectrometry method. The kit comprises drug standards: amsulpiride, aripiprazole, dehydroaripiprazole, chlorpromazine, clozapine, n-desmethylclozapine, risperidone, 9-hydroxyrisperidone, quetiapine, olanzapine, ziprasidone; drug internal standard compounds: amplepiride-d5, aripiprazole-d8, chlorpromazine-d3, clozapine-d8, risperidone-d4, 9-hydroxyrisperidone-d4, quetiapine-d8, olanzapine-d8, ziprasidone-d8; drug extraction compounds: methanol solution 60% (volume ratio),acetonitrile solution 20%, isopropanol solution 10%, purified water 10%; negative plasma; and a diluent: 50% aqueous methanol solution. The kit can be used to simultaneously detect anti-psychosis drugs and active metabolites thereof, the detection time is short and the flux is large.
Owner:HANGZHOU BAICHEN MEDICAL INSTR CO LTD +1
Method for separating and preparation of Gelsemium elegans alkaloid monomer by high speed counter current chromatography
ActiveCN101323618ASimple and fast operationShort separation cycleOrganic chemistrySolid sorbent liquid separationGelsemium elegansGelsemium
The invention discloses a method for separating and preparing a gelsemium alkaloid monomer from gelsemium by adopting high-speed counter current chromatography, which pertains to the separation method of medicinal plant monomers. The invention takes total alkaloids of gelsemium as a raw material and a high-speed counter current chromatograph as a separating device and the method comprises that a solvent system which is composed of stationary phase and mobile phase is prepared; the high-speed counter current chromatograph is filled with the stationary phase and then the mobile phase is pumped in and balanced; and then sampling is conducted by a sample valve; target components are collected according to the map of a detector or in combination of the detection methods of high efficiency liquid chromatography and thin layer chromatography, and distilled under reduced pressure and then recrystallized to obtain the gelsemium alkaloid monomer with high purity. By adjusting the specific proportional parameters of the solvent system, single or multiple target gelsemium alkaloid monomers can be separated by one step or step by step. The method is convenient and efficient, large in preparation amount, less in sample loss, good in separation effect and high in controllability and applicable to automatic production and the obtained gelsemium alkaloid monomer from separation has diverse pharmacological activities and application prospect to be prepared into medicines.
Owner:FUJIAN MEDICAL UNIV
Method for separating and preparation of Gelsemium elegans alkaloid monomer by high speed counter current chromatography
ActiveCN101323618BSimple and fast operationShort separation cycleOrganic chemistrySolid sorbent liquid separationGelsemium elegansGelsemium
Owner:FUJIAN MEDICAL UNIV
Externally applied formulation of cetirizine hydrochloride
InactiveCN1634063APharmacologically activeIncreased free drug concentrationOrganic active ingredientsAerosol deliverySkin sensitizationWhole body
Pharmacological test shows that the externally-used preparation of Cetirizine has ideal allergy resistant and anti-inflammatory action to the rat passive cutaneous anaphylaxis (Rat PCA) model and dimethylbenzene caused mouse otitis model, and also prevents the adverse effect to the central system caused by whole body administration. It is also found in the test, that the externally used preparation of Cetirizine also has very fine inhibitory action to dinitrofluorobenzene caused mouse porphyria hypersensitivity (PTH), the novel pharmacological action of the Cetirizine shows that the Cetirizine external preparation has good therapeutic action to skin inflammations which mainly include porphyria hypersensitivity.
Owner:LUNAN PHARMA GROUP CORPORATION
Use of icariin in inducing external oriented differentiation of embryo stem cells
InactiveCN1425763APharmacologically activeSugar derivativesEmbryonic cellsCell Differentiating AgentDirected differentiation
The present invention provides a new use icariin in inducing external oriented differentiation of embryo stem cells into single type of cells. Icariin may be used as the mitogen in stem cell transplanting cardiac muscle regeneration or cardiac muscle cell reconstruction, and in constructing high-efficiency pharmacodynamic screening model for initial screening and estimation of medicine effect. The present invention demonstrates the medicine effect of icariin in cell level and approaches its plentiful biological information. The present invention determines icariin as pharmacological active componnet and this provides Chinese medicine prevention and treatment with substantil foundation. At the same time, the description of the pharmacodynamic mechanism provides reference for modernized development of Chinese medicine.
Owner:ZHEJIANG UNIV
Cellulosimicrobium cellulans strain and application thereof
ActiveCN104232498AGood effectPharmacologically activeBacteriaMicroorganism based processesAglyconeBacterial strain
The invention relates to a cellulosimicrobium cellulans strain and application thereof. The strain is a Cellulosimicrobium cellulans strain F16 of which the preservation number is CCTCC M2013201 and the preservation date is in may, 2013; the Cellulosimicrobium cellulans strain F16 or a hydrolase generated by virtue of the fermentation of the Cellulosimicrobium cellulans strain F16 are capable of hydrolyzing a compound which contains a xyloside bond and a glucoside bond to obtain a product, namely a corresponding aglycone or an intermediate compound generated in the preparation process of the corresponding aglycone.
Owner:ZHANGJIAGANG IND TECH RES INST CO LTD DALIAN INST OF CHEM PHYSICS CHINESE ACADEMY OF SCI
Kit for determining antianxiety/hypnotic type drugs in serum and plasma through liquid chromatography tandem mass spectrometry and application thereof
InactiveCN109085265AReduce matrix effectThe test result is accurateComponent separationBromazepamTandem mass spectrometry
The invention provides a kit for determining antianxiety / hypnotic type drugs in serum and plasma through liquid chromatography tandem mass spectrometry. The kit comprises the following constituents: drug standards comprising bromazepam, clonazepam, diazepam, lorazepam, midazolam, nitrazepam, oxazepam and Temazepam; drug internal standard compounds comprising alprazolam-d5, clonazepam-d4, diazepam-d5, lorazepam-d4, midazolam-d4, nitrazepam-d5, oxazepam-d5 and Temazepam-d5; drug extraction compositions comprising, by volume, 60% of methanol solution, 20% of acetonitrile solution, 10% of isopropanol solution and 10% of purified water; negative plasma; and diluent: 50% of carbinol water solution. The kit can be used for simultaneously determining antianxiety / hypnotic type drugs and active metabolites thereof, and has the advantages of short determination time and high flux.
Owner:HANGZHOU BAICHEN MEDICAL INSTR CO LTD +1
Application of gentiopicroside in preparation of antiviral medicament
InactiveCN1965853APharmacologically activeOrganic active ingredientsPowder deliveryAntiviral drugViral Myocarditis
The invention relates to the application of gentian in antiviral drug, while its gentian content is more than 50%, wherein the test has proved that gentian has activity resistant to CVB3 and HFRS. Therefore, the gentian can treat viral myocarditis and nephrotic syndrome. And it can be made into tablet, capsule, etc.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Preparation method of volatile oil beta-cyclodextrin inclusion compound
InactiveCN101810864APharmacologically activeEvaporation reductionMacromolecular non-active ingredientsPlant ingredientsTangerine PeelBeta-Cyclodextrins
The invention discloses a preparation method of a volatile oil beta-cyclodextrin inclusion compound, which is characterized in that volatile oil is extracted from capillary artemisia, cabline patchouli, rhizoma atractylodis macrocephaiae, tangerine peel and rhizoma alismatis, and the inclusion compound is prepared through inclusion of beta-cyclodextrin. The volatile oil beta-cyclodextrin inclusion compound prepared in the method has a high inclusion rate.
Owner:北京卓越同舟药物研究院有限公司
Use of neurocyte differentiated from stem cell induced by isobavachin
InactiveCN101273983AResearch helpsPharmacologically activeOrganic active ingredientsNervous disorderNeural stem cellNervous tissue
The invention provides a single type nerve cell which is formed by in vitro directed differentiation of sobavachin-induced stem cells (comprising embryonic stem cells, neural stem cells and bone marrow mesenchymal stem cells). The single type nerve cell is applied in the preparation of drugs used for stem cell transplantation therapy of neurodegenerative diseases, in the preparation of cell differentiation agents used for repairing and reconstructing of damaged nerve cells and is also applied in the construction of a efficacy screening and evaluation model. The invention develops a new usage of the isobavachin, provides a physical basis for the prevention and treatment functions of the isobavachin traditional Chinese medicine and also provides a basis for the drug regulation and control regenerative medicine or the tissue engineering.
Owner:ZHEJIANG UNIV
Tegafur derivative containing 1,3,4-thiadiazole heterocyclic ring and amide group
InactiveCN103864776AIncrease elimination timeLong duration of actionOrganic active ingredientsOrganic chemistryDitazoleStructural formula
The invention provides a tegafur derivative containing a 1,3,4-thiadiazole heterocyclic ring and an amide group. The structural formula of the tegafur derivative is as shown in the specification. A preparation method of the tegafur derivative comprises the steps of (1) dissolving a 3-(methoxycarbonylmethyl)tegafur in methanol, dropwise adding a sodium hydroxide solution, extracting by using ethyl acetate and distilled water and separating out an organic layer and a water layer, next, extracting by using ethyl acetate and blending the organic layers, and adding anhydrous sodium sulfate to obtain 1-(tetrahydro-2-furyl)-3-carbethoxy-5-fluoro-2,4-pyrimidinedione; (2) blending 1-(tetrahydro-2-furyl)-3-carbethoxy-5-fluoro-2,4-pyrimidinedione with dioxane, then adding sulfoxide chloride to obtain a 1-(tetrahydro-2-furyl)-3-chloracetyl-5-fluoro-2,4-pyrimidinedione solution, and then adding dioxane, evenly mixing and then sealing for later use; (3) taking 2-amino-5-p-nitrophenyl-1,3,4-thiadiazole, dioxane and triethylamine, and dropwise adding the 1-(tetrahydro-2-furyl)-3-chloracetyl-5-fluoro-2,4-pyrimidinedione solution obtained in the step (2) to obtain a pure product 1-(tetrahydro-2-furyl)-3-acetamido-[5-p-nitrophenyl-(1,3,4-thiadiazole-2-yl)]-5-fluoro-2,4-pyrimidinedione. The tegafur derivative has anti-tumor effect and no obvious toxicity, and is used for clinically treating malignant tumors.
Owner:INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI
Alpha, beta-unsaturated carbonyl tetralone derivative and application thereof
InactiveCN106278857AHas anti-Alzheimer's disease-related pharmacological activityPharmacologically activeNervous disorderOrganic chemistryDiseaseTetralone
The invention discloses an alpha, beta-unsaturated carbonyl tetralone derivative and application thereof. The alpha, beta-unsaturated carbonyl tetralone derivative has the following structural formula, wherein R1 represents methylene or -HC-CH3; R2 represents hydrogen atoms or methoxyl; R3 represents hydrogen atoms, chlorine atoms, methoxyl, bromine atoms, fluorine atoms or nitryl; R4 represents hydrogen atoms or methoxyl; R5 represents hydrogen atoms, hydroxyl or methoxyl; R'3 and R'4 respectively represent hydrogen atoms or methoxyl; R'6 represents chlorine atoms or bromine atoms. The synthetic compound has pharmacological activities associated with anti-Alzheimer's disease, and is suitable for serving as a drug that can prevent, treat and diagnose Alzheimer's disease, and has a good potential application prospect. (Please see the formula in the description).
Owner:WUHAN UNIV OF TECH
Flute diaphragm glue and manufacturing method thereof
InactiveCN105086878AWith gelling functionLong storage timeProtein waste adhesivesMacromolecular adhesive additivesGellan gumTear lysozyme
The invention discloses flute diaphragm glue and a manufacturing method thereof. The flute diaphragm glue comprises, by weight, 5-10 parts of donkey-hide gelatin powder, 3-6 parts of gellan gum, 14-32 parts of mucopolysaccharide, 0.2-2.2 parts of mucoprotein, 30-55 parts of deionized water and 10-20 parts of lysozyme. The manufacturing method of the flute diaphragm glue comprises 1, weighing 5-10 parts by weight of donkey-hide gelatin powder, 3-6 parts by weight of gellan gum, 14-32 parts by weight of mucopolysaccharide and 0.2-2.2 parts by weight of mucoprotein, crushing the above materials to obtain granules, pouring the granules into 30-55 parts by weight of deionized water and 10-20 parts by weight of lysozyme, putting all the raw materials into a container, and carrying out stirring at a rate of 800-900rpm to obtain a uniform mixture, and 2, covering the container with a cover, steaming the raw materials in the container for 2-3h until the raw materials form threads, pouring the melt raw material threads into a mold, carrying out cooling curing and packaging the finished product.
Owner:姚晓明
Method for detecting active ingredients of salviae miltiorrhizae and products
The invention relates to a method for detecting active ingredients of salviae miltiorrhizae and products. The method comprises the following steps: preparation of a test solution, preparation of a reference solution and sample detection. In the method provided by the invention, index ingredients such as sodium danshensu, rosmarinic acid, alkannic acid, danshinolic acid B, dihydrotanshinone I, cryptotanshinone, tanshinone I and tanshinone II contained in salviae miltiorrhizae and preparations thereof are simultaneously detected for the first time to realize more comprehensive evaluation and control of the quality of salviae miltiorrhizae and preparations thereofs. The detection time is shortened, the detection cost is reduced, the method is not only accurate, but also is simple and feasible. The method provided by the invention has good stability, good repeatability, high recovery rate and relatively high specificity.
Owner:YUNNAN CHUXIONG TIANLI PHARMA
Immune cell culture medium
InactiveCN105936891AHigh speedImprove cell functionBlood/immune system cellsCell culture active agentsInterleukin 5Cell culture media
The invention discloses an immune cell culture medium. The immune cell culture medium comprises a serum-free basal culture medium, plasma, cytokines and cistanchis glycosides. The content of cistanchis glycosides is 5-15 mg / mL, and the volume ratio of plasma to serum-free basal culture medium is (1:15)-(1:25). The cytokines include interleukin, monoclonal antibodies and interferon, the interleukin is one or more of interleukin-1, interleukin-4, interleukin-5, interleukin-12, interleukin-15 and interleukin-23, the monoclonal antibodies are anti-CD3 antibodies or anti-CD28 antibodies or both, and the interferon is gamma-interferon. By the adoption of the immune cell culture medium, different types of immune cells can be cultured, the amplification speed of immune cells is increased greatly, and a good cell function is maintained.
Owner:GUANGZHOU ZISHENG BIOLOGICAL TECH CO LTD
Medicinal application of chicoric acid
InactiveCN103877071APharmacologically activeOrganic active ingredientsAntineoplastic agentsCichoriumHistone deacetylase
The invention relates to a medicinal application of chicoric acid and application of anti-tumor medicaments and health products formed by chicoric acid. In-vitro tests prove that chicoric acid has the effect of a histone deacetylase (HDAC) inhibitor.
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
Nepenthes extract mosquito-repellent liquid and preparation method thereof
InactiveCN106212519AEasy to prepareRaw materials are easy to obtainBiocideNervous disorderBacteriaLavender extract
The invention belongs to the field of mosquito-repellent incenses, and in particular relates to a nepenthes extract mosquito-repellent liquid and a preparation method thereof. The nepenthes extract mosquito-repellent liquid is prepared from the following raw materials in parts by weight: 110-160 parts of a nepenthes extracting solution, 67-94 parts of a wormwood extracting solution, 33-51 parts of a lantana camara extract solution, 8-20 parts of a lavender extract solution, 40-60 parts of deionized water and 30-55 parts of ethanol. The preparation method comprises the following steps: performing ultrasonic treatment, eccentric treatment, concentration treatment and the like so as to prepare the nepenthes extracting solution, the wormwood extracting solution, the lantana camara extracting solution and the lavender extracting solution, mixing the nepenthes extracting solution, the wormwood extracting solution, the lantana camara extracting solution, the lavender extracting solution, deionized water and ethanol, and performing sealed stirring for 3-6 hours at 53-70 DEG C to obtain the nepenthes extract mosquito-repellent liquid. Effective components of the nepenthes extract mosquito-repellent liquid are all extracted from natural traditional Chinese herbal medicines which are relatively low in cost, so that the prepared product is safe and non-toxic and has the effects of killing bacteria, repelling mosquitoes and helping sleep.
Owner:郑耀相
Method for preparing 2-triazole-quinoline-4-carboxylic acid compound
InactiveCN103992303ARaw materials are easy to getEasy to operateOrganic chemistryQuinolineCarboxylic acid
The invention discloses a method for preparing a 2-triazole-quinoline-4-carboxylic acid compound. The method comprises the steps of using benzyl halide, sodium azide, a 1-3-dicarbonyl compound and isatin as raw materials, and performing one-pot synthesis under the catalysis of diethylamine and strong alkali to obtain a 1,2,3-triazole substituted quinoline-4-carboxylic acid compound. The method is easily-available in raw material, simple in operation and high in yield, and has good application prospects.
Owner:GUANGXI NORMAL UNIV
Substituded acza nember 5/nember 6 ring compound and its preparation process
A process for one-step synthesizing 3-dialkylthiomethylene azapentacycle / hexacycle-2,4-dione from alpha-acyl-alpha-amine / ammonia formacyl dithioketene, and the compound (polysubstitutent pyrrolidone or polysubstitutent hydropyridone) prepared by said process are disclosed.
Owner:YANBIAN UNIV +1
Quantitative fingerprint spectrum analysis method for components in ginger ginger pinellia percolate
ActiveCN114563496ARealize quality controlDetect and evaluate qualityComponent separationBiologyHplc mass spectrometry
The invention discloses a quantitative fingerprint spectrum analysis method for components in ginger and ginger pinellia percolate. The method comprises the following steps: (1) preparing a test solution and a reference substance mixed solution; and (2) analyzing the reference substance mixed solution and the test solution by adopting a high performance liquid chromatograph to obtain the quantitative fingerprint spectrum of the components in the ginger and pinellia percolate. Wherein the chromatographic conditions are as follows: a high performance liquid chromatography system is selected as an instrument, and a Waters Atlants T3 chromatographic column (100mm * 2.1 mm, 3.0 [mu] m) is selected as a chromatographic column; a DAD detector is adopted; the flow rate is 0.30 mL / min, the column temperature is 25 DEG C, and the sample injection volume is 3-5 [mu] L; taking pure water and acetonitrile as mobile phases; and (3) selecting chromatographic peaks existing in chromatograms of different batches of ginger and ginger pinellia percolates as common peaks, calculating component contents of different batches of percolates, and calculating similarity, thereby providing scientific basis and technical support for quality control of the ginger and ginger pinellia percolates. The method provided by the invention makes up for the deficiency of a method for detecting chemical components of a common goldenrop capsule production intermediate.
Owner:浙江赞生药业有限公司
Alpha, beta-unsaturated cyclohexanone derivatives and application thereof
InactiveCN106083557ADemonstrated pharmacological activityConfirm that the compound synthesized by the present invention has pharmacological activityNervous disorderOrganic chemistryDiseaseCyclohexanone
The invention discloses an alpha, beta-unsaturated cyclohexanone derivatives and application thereof as medicaments for preventing, treating or dignozing Alzheimer's disease. The alpha, beta-unsaturated cyclohexanone derivatives comprise 2,6-bis(2-chloro-3- methoxybenzylidene)cyclohexnone, 2,6-bis(2-chloro-3,4-dimethoxybenzylidene)cyclohexnone, 2,6-bis(2-bromo-3,4,5-trimethoxybenzylidene)cyclohexnone, 2,6-bis(2-chloro-3-methoxybenzylidene)-4-methylcyclohexnone, 2,6-bis(2-chloro-3,4-dimethoxybenzylidene)-4-methylcyclohexnone and the like. Through bioactivity determination, the alpha, beta-unsaturated cyclohexanone derivatives are proved to possess pharmacological activity related to resistance to Alzheimer's disease, is applicable as medicaments to prevent, treat and diagnose Alzheimer's disease, and possesses relatively good potential application prospect.
Owner:WUHAN UNIV OF TECH
Natural medicament with cancer prevention effect and preparation method and application thereof
InactiveCN108815463ANo pathological damageBlock cancer-causing mutationsOrganic active ingredientsFungi medical ingredientsCancer preventionOncology
The invention relates to a natural medicament with the cancer prevention effect and a preparation method and application thereof. The natural medicament with the cancer prevention effect is prepared from the following raw materials (by weight): 30-70 parts of turmeric, 5-20 parts of broccoli, 10-50 parts of Trametes versicolor, 5-20 parts of yeast beta-glucan and 5-20 parts of pepper. According tothe natural medicament, by reducing formation of cancerogenic substances in body, cancerogenic mutation induced by harmful compounds is prevented, thus forming primary prevention of cancers; by activating immune cells such as lymphocyte, macrophage, etc., tumor inflammation of patients with cancer at an early stage is reduced, and clinical symptoms of cancer patients are improved, thus forming secondary prevention of cancers; and through synergism with other chemotherapeutic drugs, drug resistance of tumor is inhibited, thus forming tertiary prevention of cancers. Then, incidence rate and mortality of cancers are finally reduced, thus achieving the purpose of cancer prevention.
Owner:李军
Preparation method and medical application of traditional Chinese medicine composition capable of treating gout
The invention relates to a traditional Chinese medicine composition capable of treating gout. The traditional Chinese medicine composition is prepared from the following traditional Chinese herbal medicines by mass: 12-20 parts of herba taxilli, 12-18 parts of ramulus mori, 25-35 parts of honeysuckle stem, 8-13 parts of radix angelicae pubescentis, 8-13 parts of angelica sinensis, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of radix salviae miltiorrhizae, 8-12 parts of rhizoma corydalis, 12-18 parts of siegsbeckia orientalis, 12-18 parts of radix cynanchi paniculati and 25-35 parts of rhizoma polygonati odorati. The traditional Chinese medicine composition can tonify kidney and activate blood, unblock meridians to relieve pains, and has a significant curative effect and low toxic and side effect.
Owner:FUJIAN PROVINCIAL HOSPITAL
Traditional Chinese medicine compound preparation for treating cancers
ActiveCN104127684ACompletely curedTo promote metabolismKetone active ingredientsAntineoplastic agentsSide effectPatient compliance
The invention provides a traditional Chinese medicine compound preparation for treating cancers. The preparation is prepared from the following raw medicinal materials in parts by weight: 110-130 parts of curcumin, 10-30 parts of subprostrate sophora extracts, 30-50 parts of sealwort extracts, 10-30 parts of fructus forsythiae extracts, 10-30 parts of radix bupleuri extracts, 10-30 parts of ligusticum wallichii extracts and 10-30 parts of pinellia ternate extracts. The preparation provided by the invention is high in curative effect, low in cost, convenient and efficient to use, free from toxic and side effects and high in patient compliance.
Owner:杨全江
Application of Cellulomonadaceae as industrial biocatalyst
InactiveCN106148471APharmacologically activeMicroorganism based processesFermentationAstragalosideHydrolysate
The invention provides application of Cellulomonadaceae as an industrial biocatalyst, belonging to the field of biochemical engineering. The Cellulomonadaceae provided by the invention is used for hydrolysis of xyloside and glucoside bonds of glucoside compounds so as to prepare corresponding aglycones or semi-hydrolysates. The Cellulomonadaceae is applicable to the field of biological medicine for preparation of drug intermediates and also applicable to the fields of food, agriculture and food for preparation of monosaccharides or corresponding aglycones. The invention provides application of the Cellulomonadaceae as the industrial biocatalyst; and good effect is obtained when the Cellulomonadaceae is applied to hydrolysis of a mixture of taxane xyloside and astragaloside extracted from plant materials.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Optical-purity meptazinol orits salts, and preparing method
InactiveCN1850804BPharmacologically activeNervous disorderOrganic chemistryAbsolute configurationSingle crystal
Owner:FUDAN UNIV
New method for synthesis of substituted furo-piperidine derivatives
The invention discloses a new method for synthesis of substituted furo-piperidine derivatives. The substituted furo-piperidine derivatives are synthesized based on furfural compound raw material which is cheap and easy to get and after a series of simple and practicable unit operations of condensation, reduction, Pictet-spengler reaction and the like.
Owner:JIANGSU SIMCERE PHARMA
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