32results about How to "Improve cell function" patented technology

The present invention aims to activate neural cells in brain, and further provide a useful composition having an action to protect intracerebral neural cells from external and internal stresses.An agent for improving a neural cell function containing reduced coenzyme Q as an active ingredient, more specifically, an agent for activating neural cells and an agent for protecting neural cells, is useful, and can be used for the improvement or prophylaxis of central neurological diseases or neuropathy symptoms derived from or associated with a neurodegenerative disease, promotion of cognitive function or improvement of learning and memory disorders.

The invention relates to the technical field of regenerative medicine and discloses a method for adjusting and controlling in vitro three-dimensional directed differentiation of stem cells. The method includes following steps: embedding Stem cells into calcium alginate micro gel beads containing chondroitin sulfate, adding an inductive differentiation culture liquid, adjusting and controlling the in vitro directed differentiation of the stem cells by changing a mass ratio between the sodium alginate and the chondroitin sulfate during the preparation of the micro gel beads, dissolving the calcium alginate micro gel beads in a sodium citrate solution after the differentiation process being finished, and then obtaining pure differentiation cells. The method is simple in operation and low in cost, the calcium alginate micro gel beads containing chondroitin sulfate can simulate an in vivo three-dimensional extracellular matrix so that a three-dimensional directed differentiating microenvironment which approximates an in vivo microenvironment is supplied for the stem cells, thereby improving directed differentiation efficiency and a biological function of the stem cells. The method plays an important role in applications of regenerative medicine.

Disclosed is a particle-containing cell aggregate composed of cells and hydrogel particles, which are obtained by forming chemical crosslinks between one or more water-soluble synthetic polymers selected from among water-soluble synthetic polymers, polysaccharides and proteins. Also disclosed is a method for producing said cell aggregate.

Compounds such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol which have an activity for improving pancreatic function are used as an active ingredient of a pancreas function improving drug and food or drink.

The present invention provides combinations of (a) an immunoconjugate comprising at least one antigen-binding moiety and an effector moiety, and (b) an antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them.

Compounds having a cyclolanostane skeleton such as 9,19-cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol are used as an active ingredient of a drug and food or drink for improving pancreatic functions.

A supplement for administering to a human, or other mammals, includes a carotenoid material, a nicotinamide material, a zinc source material, and a water soluble extract material of an Uncaria species. The supplement can be in a form for oral administration, particularly in a form of nutritional drink, or in a formulation for parenteral administration. Also disclosed is a method of treating a human including administering to an individual the supplement daily in amounts effective, in combination, to improve the individual's resistance to DNA damage, enhance DNA repair capacity, stimulate immune cell function, and inhibit tumor cell growth.

The present invention is directed to recombinant fibronectin peptide mimetics and wound healing compositions containing the same. Other aspects of the present invention include wound healing dressings that comprise the wound healing composition of the present invention and a wound dressing material and methods of treating wounds using these compositions.

The invention discloses a composition for preventing and treating radioactive intestinal injuries. The composition comprises ferulic acid converted according to dosage 10-9mg / kg of an experiment mouse. The composition can be prepared into a clinically acceptable dosage form. The composition has an effect of preventing and treating the radioactive intestinal injuries, and the prevention and treatment of the radioactive intestinal injuries refer to improvement of capillary vessel injuries in intestinal villi, promotion of intestinal crypt stem cell proliferation and differentiation, promotion ofmucous epithelial cell regeneration, improvement of a cell state and a function of a hemopoietic system of the irradiated mouse by influencing a Thbd-aPC signal pathway and adjustment of an inflammatory factor HMGB1 (high mobility group box 1).

The invention provides a construction method of a bionic intestinal model based on a micro-fluidic technology, applied to the construction of an in-vitro intestinal model. The micro-fluidic chip prepared by adopting the preparation method is mainly composed of an upper-layer chip, a porous filter membrane and a lower-layer chip, wherein the upper-layer chip is inoculated with intestinal cells, fluid moving forwards and backwards alternatively is applied, peristaltic flow is formed in a micro-channel inoculated with the intestinal cells, the actual fluid condition in the intestinal tract in thebody is simulated by utilizing the peristaltic flow, and a good promotion effect is achieved on the intestinal function. The method has great significance for realizing the intestinal chip of an in-vitro simulation environment, realizing the application of medicine evaluation and the like.

The invention discloses an immune cell culture medium. The immune cell culture medium comprises a serum-free basal culture medium, plasma, cytokines and cistanchis glycosides. The content of cistanchis glycosides is 5-15 mg / mL, and the volume ratio of plasma to serum-free basal culture medium is (1:15)-(1:25). The cytokines include interleukin, monoclonal antibodies and interferon, the interleukin is one or more of interleukin-1, interleukin-4, interleukin-5, interleukin-12, interleukin-15 and interleukin-23, the monoclonal antibodies are anti-CD3 antibodies or anti-CD28 antibodies or both, and the interferon is gamma-interferon. By the adoption of the immune cell culture medium, different types of immune cells can be cultured, the amplification speed of immune cells is increased greatly, and a good cell function is maintained.

A pharmaceutical composition, and methods for using a pharmaceutical composition, for treating osteoarthritis in a subject in need thereof, the pharmaceutical composition including cannabidiol or a pharmaceutically acceptable salt thereof; and especially wherein administration of the cannabidiol is by a transdermal pharmaceutical gel composition. A method is disclosed for treating one or more symptoms of osteoarthritis in a patient. The method includes transdermally administering an effective amount of cannabidiol (CBD) to the patient wherein one or more symptoms of osteoarthritis are treated in the patient.

The present invention relates to a health-care food with the functions of improving female immunological function and nourishing face. It is made up by using ( by weight portion) 10-70 portions of Chinese Xinjiang jujube powdered extract, 20-90 portions of leonurus powdered extract and 1-10 portions of sheep's placenta powder of Xinjiang sheep through a certain preparation process.

The invention provides a micro-fluid driving method applied to an organ chip, and belongs to the technical field of micro-fluidics. According to the method, motion modes, namely alternated moving forwards and backwards, of fluid on the organ chip are controlled by virtue of a control pump; a peristaltic flow is formed in a micro-channel of the organ chip; and through the peristaltic flow, bidirectional shear force of the fluid is presented, the retention duration of the fluid in the micro-channel is prolonged and a fluid contact area is increased, so that a better fluid mixing effect is achieved. The driving method is stable in effect; fluid, in a peristaltic mode, in an organ can be simulated, so that micro-fluid functions are enriched; construction of the organ chip and a micro-reactor in an in-vitro simulation environment can be achieved; and the method has an important significance for application to drug evaluation and the like.

The invention provides a preparation method of primary-color lycium barbarum fiber. The preparation method comprises the following steps of (1) preparing a lycium barbarum compound solution; (2) spraying a penetrant; (3) performing tanning; (4) spraying the lycium barbarum compound solution; (5) performing tanning; (6) performing washing with water; (7) performing softening treatment; and (8) performing drying. According to the lycium barbarum fiber prepared by adopting the novel preparation method, the lycium barbarum contains a large amount of strong antioxidant and is also rich in vitamin e and trace elements, so that the fiber can effectively prevent skin aging; polysaccharides in the lycium barbarum can effectively improve the cell function and reduce serum cholesterol, so that the fiber can effectively control hyperglycemia, hypertension and hyperlipidemia; the lycium barbarum contains crude fat, crude protein and various trace elements, so that the fiber can effectively improve the hematopoietic function; and the ultraviolet ray shielding rate of the fiber is high.

The present invention provides combinations of (a) an immunoconjugate comprising at least one antigen-binding moiety and an effector moiety, and (b) an antibody engineered to have increased effector function, for use in treating a disease in an individual in need thereof. Further provided are pharmaceutical compositions comprising the combinations, and methods of using them.

The invention provides an application of fig polysaccharide in preparing immune modulators for fishes. The invention also provides an immune modulator for fishes, which is prepared by taking an effective amount of fig polysaccharide as an active component and adding acceptable auxiliary materials or auxiliary components. The experiment proves that the fig polysaccharide has a capacity of non-specific immune modulation for scale fishes; the consumption of the fig polysaccharide accounts for 0.1-0.8%w / w of the weight of auxiliary materials, and the fig polysaccharide has stronger efficacy of immune modulation; and the effect is optimal when the consumption of the fig polysaccharide is 0.4% of the weight of auxiliary materials. In addition, the immune modulator for fishes of the invention is a polysaccharide substance which has good safety, simultaneously is a carbohydrate which can save the consumption of carbohydrates in feed; especially, being a feed additive for fishes, the immune modulator for fishes has good effect and easy acquisition of materials, is safe and effective, and can save the cost.

The present invention provides a method for enhancing immune cell function by activating various immune cells ex vivo and provides immune cells with enhanced function. The invention further provides an immune-related cell multifunctionality evaluation method. A biguanide antidiabetic drug selected from metformin, phenformin, and buformin is capable of enhancing immune cell multifunctionality by increasing CD8+T cells having a high ability to produce IL-2, INFα, and IFNγ. The immune-related cell multifunctionality may be evaluated by comparing immune cells treated with a biguanide antidiabetic drug selected from metformin, phenformin, and buformin, with control immune cells untreated with the biguanide antidiabetic drug. When the multifunctionality of immune cells treated with the biguanide antidiabetic drug selected from metformin, phenformin, and buformin is determined to be significantly increased compared with the control, it can be evaluated that the sensitivity of the immune cells to the therapeutic agent is improved.

Wnt-inducible signalling protein 1 (WISP1) or a fragment or variant thereof for use in maintaining or increasing muscle function and / or mass in a subject, and / or substantially preventing or reducing muscle wasting in a subject.

Wnt-inducible signalling protein 1 (WISP1) or a fragment or variant thereof for use in maintaining or increasing muscle function and / or mass in a subject, and / or substantially preventing or reducing muscle wasting in a subject.

Compositions and methods of use are provided for improving β cell function and promoting pancreatic β cell proliferation in vitro, in vivo and ex vivo. The active agents of the pending invention comprise Serpin family peptides (e.g., SerpinB1), functional and structural analogs of Serpin family peptides and nucleic acids encoding Serpin family peptides, as well as active fragments thereof.

The invention relates to a device for treating the male erectile dysfunction, in particular to a luminous body assembly and device for treating the male erectile dysfunction based on laser irradiation, and solves the problems that inconvenience is brought to a patient due to the fact that an existing treatment device needs to be held by hand for treatment and a treatment head is hard, and it is impossible that deep tissue is treated without thermal damage to organs. The luminous body assembly is characterized by comprising a first flexible luminous body and N scattering optical fibers arrangedon the first flexible luminous body, wherein N is greater than or equal to 1; and the first flexible luminous body is of a tubular structure with at least one end open. The device is characterized bycomprising at least one optical fiber coupled semiconductor laser generator, M energy transfer input optical fibers, at least one flexible luminous body and N scattering optical fibers arranged on the flexible luminous body in total; N is greater than or equal to M, and N plus M are greater than or equal to 1; the output end of the at least one semiconductor laser generator is connected with theinput ends of the energy transfer input optical fibers; and the output ends of the energy transfer input optical fibers are connected with the input ends of the scattering optical fibers.

The invention provides a plaster for treatment of scapulohumeral periarthritis and a preparation method thereof. The plaster for treatment of scapulohumeral periarthritis comprises, by weight, 80-120 parts of longpeduncle kadsura roots, 100-180 parts of radix curcuma, 100-200 parts of geranium wilfordii maxim, 80-200 parts of semen strychni, 10-15 parts of resina draconis, 400-800 parts of yellow lead, 1-8 parts of olibanum and 2-7 parts of myrrh. The plaster for treatment of scapulohumeral periarthritis is good in permeability, low in price and obvious in efficacy.

The invention discloses a preparation method of a cortex phellodendri face-cleaning traditional Chinese medicine for treating whelks, and relates to a formula and a preparation method of the cortex phellodendri face-cleaning traditional Chinese medicine. The cortex phellodendri face-cleaning traditional Chinese medicine is characterized in that the formula of the cortex phellodendri face-cleaning traditional Chinese medicine comprises cortex phellodendri, radix scutellariae, radix et rhizoma rhei, radix salviae miltiorrhizae and sulfur. The preparation method comprises the following steps: step 1, grinding sulfur; step 2, decocting traditional Chinese medicines; step 3, mixing a preparation; and step 4, performing discharging and filling. The cortex phellodendri, radix scutellariae, radix et rhizoma rhei, radix salviae miltiorrhizae and sulfur are adopted to form a sulfur compound, the cortex phellodendri, radix scutellariae, radix et rhizoma rhei are used for killing insects, inhibiting bacteria and detoxifying to improve the cell function of skin and promote the mite killing effect of sulfur, and the characteristics of quickly taking effect, being reliable in curative effect, killing insects, inhibiting bacteria, detoxifying, dehumidifying, treating both symptoms and root causes and being difficulty in relapse and short treatment course are realized. The defects in the prior art are overcome.

The present invention is based on the discovery that certain small molecules can relieve ER stress, leading to increased insulin production in beta cells and improved insulin secretion. Methods of treating a disease or disorder in a subject, wherein the disease or disorder is characterized by intracellular endoplasmic reticulum (ER) stress, by administering to the subject, an effective amount of a compound that is an ER stress reliever, are provided herein.

The invention discloses a plant enzyme nutrition mask. The mask is prepared from fermentation products of raw materials including, by mass, 5-10 parts of apples, 5-10 parts of cucumbers, 5-10 parts of lemons, 5-10 parts of pineapples, 5-10 parts of citrus peel, 5-10 parts of cladosiphon okamuranus, 5-10 parts of radix sophorae, 5-10 parts of dry roots and rhizomes glycyrrhiza inflata Batal., 5-10 parts of radix scutellariae, 5-10 parts of herb of medicago sativa L., 5-10 parts of aloe and 5-10 parts of beet roots. The plant enzyme nutrition mask can obviously improve the cell functions, repair injured cells in a human body, help the skin to resist oxidation, scavenge free radicals, help the human body skin to remove speckles and eliminate acne and improve the skin elasticity; enzymes have the activating effect on the human body cells and can exclude dead cells and promote healthy cell regeneration division, and therefore the human body health can reach a new level. Compared with a conventional moisture and nutrition supplementing type mask, the plant enzyme nutrition mask can fundamentally solve the problems such as skin premature senility, skin dullness and color spots.

The invention discloses a stepped fine adjustment method for the in-situ over-expression of a long-chain non-coding RNA-LINC00842. According to the method, LINC00842 specific sgRNA is used to positiondCas9 to a promoter region of an LINC00842 gene on a genome DNA, a transcription initiation complex is recruited in different degrees at a positioning site through the binding of MS2-P65-HSF1 with dCas9-fused VP64, and thereby the gradient adjustment of the in-situ over-expression of the LINC00842 gene is effectively realized. Moreover, a lentivirus system can integrate over-expression required elements (LINC00842-sgRNA, dCAS-VP64 and MS2-P65-HSF1) into a genome DNA of cells, the stable over-expression of LINC00842 in a cell strain is realized along with cell division and replication, and finally a cell strain series for stably over-expressing the LINC00842 gene with different amplitudes is obtained.