13 results about "Male erectile dysfunction" patented technology

The application belongs to the field of regenerative medicine and nano drug delivery system, and particularly relates to a drug-loaded exosome for improving the testosterone secretion capacity of testicular interstitial cells and a preparation method and application thereof. The application links a targeting FATE1 polypeptide to the surface of MSC-derived exosomes by a chemical coupling method, and loads a small molecule compound in the exosomes by electroporation, so as to obtain modified MSC-derived exosomes. The obtained exosomes can obtain the targeting capacity in testicular interstitial cells, and the natural repair capacity of MSC-derived exosomes and the release of small molecule drugs promote the repair of damaged cells, improve the testosterone secretion capacity of testicular interstitial cells, and relieve male erectile dysfunction caused by diseases or aging.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to external nano-emulsion gel for treating male erectile dysfunction and application of the external nano-emulsion gel. The invention provides external nano-emulsion gel for treating male erectile dysfunction. The external nano-emulsion gel is prepared from lidocaine, carbomer, a surfactant, a cosolvent and water, the particle size of the nanoemulsion gel is 80 nm to 120 nm, and the pH value of the nanoemulsion gel is 6.0 to 7.0; according to the nano-emulsion gel, the solubility and the skin penetrability of a hydrophobic drug lidocaine are remarkably improved through a micro-emulsion / nano-emulsion technology, so that the transdermal absorption efficiency is improved by 3.3-4.0 times, and quick effect taking and long-acting effects are realized. The carbomer gel matrix also provides good smearing performance and retention performance, the smearing area is increased by 5-6 times compared with that of common gel, and the use experience is remarkably improved.

The invention provides a traditional Chinese medicine composition for tonifying kidney, strengthening yang and tonifying deficiency for treating male erectile dysfunction and oligospermia and asthenospermia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 220 to 500 parts of semen cuscutae, 350 to 650 parts of bull penis, 230 to 480 parts of herba epimedii, 210 to 470 parts of herba cistanche, 190 to 450 parts of fructus corni, 180 to 420 parts of tortoise shell, 170 to 400 parts of antler, 160 to 350 parts of hippocampus, 160 to 280 parts of ginseng, 170 to 300 parts of rhizoma polygoni cuspidati, 210 to 380 parts of cortex eucommiae, 160 to 310 parts of okra seed, 130 to 250 parts of pericarpium citri reticulatae, 210 to 450 parts of caulis spatholobi, 250 to 360 parts of caulis sargentodoxae and 180 to 380 parts of rhizoma chuanxiong. The traditional Chinese medicine composition is used for treating male erectile dysfunction and insufficiency of kidney yang, impotence, spermatorrhea, premature ejaculation and sexual dysfunction in oligospermia and asthenospermia, can be used for symptomatically improving the weakness of male middle-aged and elderly people, has a long-term effect and stability after treatment, is superior to other treatment medicines and treatment technologies in modern medicine, and has a wide application prospect. Wide clinical value and commercial value are realized.

The present application relates to the technical field of medical devices, in particular to a kind of external device for treating male erectile dysfunction, including outer tube, and the negative pressure pump and internal inner tube of the internal inside being arranged at the front end of outer tube,It also includes ball hinge seat, movably connected at the rear end of outer tube, and there is silica gel sealing ring at the opening of its rear end;Control center, installed at the front end inside outer tube, and installed at the output end of negative pressure pump, control center is connected with temperature control sensing device, temperature control sensing device is installed on the I-shaped connecting seat at the rear end of inner tube, solve the single negative pressure control mode of existing device, manually cannot be accurate control pressure and cause tissue damage or affect erection effect, the pressure program of automatic version is fixed, complex structure, poor portability, and cannot be adapted to the angle change after penis erection, easily cause compression pain, air leakage pressure loss;Lack of auxiliary physical stimulation, limited efficacy;In addition, local hypothermia under negative pressure causes body discomfort, also can contract blood vessels, hinder blood perfusion and erection maintenance problem.

The application belongs to the field of traditional Chinese medicine, and particularly relates to a time-delay spray containing dry toad extract and toad oil and a preparation method thereof. The time-delay spray provided by the application can significantly treat male erectile dysfunction. The time-delay spray prepared by the application has the advantages of direct action, quantitative drug delivery, and no contact to avoid drug pollution. The application realizes the transformation of waste into treasure of toad oil, fully excavates the medicinal value of toad oil, further improves the rational utilization system of toad resources, and provides a practical scheme for efficient development of toad medicinal resources.

The invention provides a composition for treating male erectile dysfunction by combining human prepuce mesenchymal stem cell exosome with human placenta mesenchymal stem cells and application, and relates to the technical field of biological medicine. The composition comprises human prepuce mesenchymal stem cell exosome particles and human placenta mesenchymal stem cells. The human prepuce mesenchymal stem cell exosome particles and the human placenta mesenchymal stem cells are core components and have the repairing effects of revascularization, nerve repairing, fibrosis resistance and the like. The composition also comprises glutathione, L-arginine, icariin, ginseng stem and leaf total saponins, mecobalamin and human serum albumin, can provide functional support and antioxidant protection, ensures the instant effect, and creates an environment for restoration. According to the invention, multi-target and fundamental treatment of male erectile dysfunction is realized through an action mode of quick effect taking, synergistic repair and long-acting reconstruction, and symptoms of male erectile dysfunction are remarkably improved.

Provided are stable, concentrated, and palatable solutions suitable for sublingual and / or transurethral administration containing tadalafil, with or without other active ingredients to address comorbidities, in a liquid vehicle or solvent selected from propylene carbonate, 2-pyrrolidone, dimethyl isosorbide, dimethyl acetamide, n-methyl-2-pyrrolidone, ethanol, water, oleic acid, and isopropyl myristate. The solutions have low irritancy for sublingual tissues and a-are compatible with commercial atomizers. The invention is further directed to methods of treating male erectile dysfunction and / or comorbidities by administering an effective amount of the pharmaceutical formulations comprising tadalafil, with or without other active ingredients, to a patient in need of such treatments.

The invention relates to the technical field of traditional Chinese medicine compositions, and provides a composition for treating male erectile dysfunction by using a super nano coating technology and a preparation method thereof. The preparation method comprises the following steps: mixing a tribulus terrestris extract, a South African drunken solanum extract, L-arginine, an eurycoma longifolia extract, a ganoderma lucidum extract, a caraway extract, a radix puerariae extract, a burdock root extract and fructus cannabis peptide with ultrapure water and ethanol to obtain a mixture; gelatin and chitosan are dissolved with ultrapure water, and a wall material solution is obtained; the mixture and the wall material solution are mixed, a surfactant is added, stirring and drying are conducted, and nanometer wrapped particles are obtained; and filling the nano-coated particles with a capsule filling machine to obtain the composition. According to the composition prepared by a nano coating technology, the stability and the bioavailability of the medicine can be improved; meanwhile, the traditional Chinese medicine components in the composition are compatible with one another, so that the sperm motility and the kidney motility are improved, the anti-fatigue ability of the body is enhanced, and the effect of treating the sexual dysfunction is further achieved.

The invention provides an application of an active peptide in treating male erectile dysfunction. Specifically, the invention provides a PDE-5 inhibitory active peptide P-C-5, and the active peptide can well inhibit the activity of PDE-5 in human primary cavernous smooth muscle cells and increase the concentration of cGMP in the smooth muscle cells. Mouse experiments prove that the polypeptide can well improve the sexual capacity of mice. And the polypeptide can overcome the common side effects of common erectile dysfunction medicines, such as headache, flushing, stomach discomfort, muscular pain, back pain and nausea. The polypeptide can also be combined with other drugs for ED treatment, and the application prospect is wide.

The present application provides a polypeptide composition and its use in treating male erectile dysfunction. Specifically, the polypeptide composition contains an erectile peptide screened and identified by the present application, which has good anti-oxidation and anti-fatigue properties, can effectively promote penile erection, increase testosterone level, effectively treat erectile dysfunction, and has a wide application prospect.

The present application provides a kind of stem cell composition for treating male erectile dysfunction and its preparation method, belong to medical technology field.Magnetic particles loaded with platelet-derived growth factor and matrix metalloproteinase are added to culture medium, amniotic membrane mesenchymal stem cells are activated, and activated amniotic membrane mesenchymal stem cells, paracrine composition and magnetic nutrient particles are obtained by separation, mixed with intercalated sustained-release drug compound and penetration activator and added to temperature-sensitive hydrogel sustained-release system to prepare stem cell composition for treating male erectile dysfunction.The stem cell composition for treating male erectile dysfunction prepared by the present application plays a role through multiple pathways, promotes angiogenesis, improves penile hemodynamics, inhibits smooth muscle cell apoptosis, regulates nerve function, enhances endothelial progenitor cell recruitment, etc., thereby more comprehensively repairing and regenerating damaged penile tissue, and has broad application prospects.

The present application belongs to the technical field of biological medicine, and particularly relates to a composition for treating male erectile dysfunction and application thereof. The oyster polypeptide is prepared by oyster protease hydrolysis, and the oyster polypeptide can effectively promote the proliferation of testicular interstitial cells, enhance and improve sexual desire and sexual behavior, has certain clinical application value, and has the advantages of simple preparation, easy absorption and the like, and is easy to popularize and apply.

The application discloses a kind of stem cell exosome based on targeted fusion polypeptide modification, preparation method and its application in treating male erectile dysfunction.The exosome is anchored on the surface by chemical coupling technology with specific targeted fusion polypeptide (sequence: EPLQLKM-GGGGS-DPPV), which enhances its targeting to cavernosal smooth muscle cells;At the same time, by loading anti-TrkA monoclonal antibody (TrkA-2E7-HL) through electroporation method, the fibrosis pathway mediated by nerve growth factor (NGF) is inhibited.The exosome is induced by antioxidant culture medium to induce umbilical cord mesenchymal stem cells to secrete, which significantly improves its antioxidant activity.Experiments show that the erectile function (ICP / MAP ratio) of the exosome after modification is increased to 0.79±0.05 in a diabetic ED rat model, the fibrosis area is reduced to 9.2±1.6%, and the NO secretion level is increased by 3.5 times compared with ordinary exosome.The application realizes effective reversal of ED pathological process through polypeptide targeting, antibody synergy and antioxidant triple mechanism, and has significant novelty and clinical transformation potential.