26 results about "Erectile function" patented technology

The invention discloses a stem cell exosome based on targeted fusion polypeptide modification, a preparation method and application of the stem cell exosome in treating male erectile dysfunction. According to the exosome, a specific targeting fusion polypeptide (sequence: EPLQLKM-GGGS-DPPV) is anchored on the surface through a chemical coupling technology, so that the targeting property of the exosome on cavernosum smooth muscle cells is enhanced; meanwhile, an anti-TrkA monoclonal antibody (TrkA-2E7-HL) is loaded through an electroporation method, and a fibrosis pathway mediated by a nerve growth factor (NGF) is inhibited. The exosome induces secretion of the umbilical cord mesenchymal stem cells by adopting an anti-oxidation culture medium, so that the anti-oxidation activity of the exosome is remarkably improved. Experiments show that in a diabetes ED rat model, the erectile function (ICP / MAP ratio) of the modified exosome is improved to 0.79 + / -0.05, the fibrosis area is reduced to 9.2 + / -1.6%, and the NO secretion level is improved by 3.5 times compared with that of a common exosome. Through triple mechanisms of polypeptide targeting, antibody synergy and oxidation resistance, effective reversion of the ED pathological process is realized, and the polypeptide has remarkable novelty and clinical transformation potential.

The invention discloses a composition based on an engineered stem cell exosome and application of the composition in treating male sexual dysfunction. The composition comprises a mesenchymal stem cell exosome modified by genetic engineering, and the surface of the mesenchymal stem cell exosome displays a bifunctional fusion polypeptide targeting TbetaR II and LOXL2. According to the fusion polypeptide, TbetaR-PEP and LOXL2-PEP are integrated through a flexible linker, and an HIV-TAT penetrating peptide and a self-assembly motif are introduced, so that nanoparticles are formed, and the half-life period is prolonged. In-vitro experiments show that the inhibition efficiency of the fusion polypeptide on TbetaRII and LOXL2 is obviously superior to that of a single peptide, and the fusion polypeptide can synergistically reverse fibrosis and promote angiogenesis. Animal experiments prove that the exosome loaded with the fusion polypeptide can significantly improve the erectile function of diabetic ED rats. According to the invention, a radical treatment scheme is provided for male sexual dysfunction through double-target cooperation, long-acting delivery and a multi-effect repair mechanism.

The present invention relates to a male erectile function detection device, comprising a silicone shell, an electrode, a control box, a disposable switch and a conductor, wherein the silicone shell is provided with a wearing hole and a shell switch port, the silicone shell is a cavity structure, and an electrode mounting groove, a control box mounting groove and a conductor mounting groove are provided inside; a contact electrode and a control box switch port are provided on the control box, and the control box is installed in the control box mounting groove of the silicone shell; the conductor is installed in the conductor mounting groove, and the electrode is installed in the electrode mounting groove, one end of the electrode contacts the conductor, and the other end contacts the contact electrode in the control box; the disposable switch is set in the switch port of the silicone shell and the switch port of the control box, and is connected to the circuit in the control box; the entire detection device is set on the male genitals through the wearing hole. The detection device provided by the present invention has a simple structure, is convenient and easy to use, adopts wireless data transmission, is comfortable to wear, and does not affect the user's rest at night.

The invention discloses a preparation for treating erectile dysfunction caused by diabetes as well as a preparation method and application of the preparation. The invention firstly finds that a palmitoylation modification site, namely a 282 site, exists beside a 260 site in an Fbp1 functional region, and the site can be modified by the palmitoylation site to cause Fbp1 function damage. Therefore, point mutation modified Fbp1 mRNA of a C282S site is found and synthesized for the first time, namely cysteine of a 282 site is converted into serine, so that the Fbp1 is not subjected to Zdhhc13 palmitoylation modification and further is not subjected to function damage, lipid nanoparticles capable of targeted delivery of the modified Fbp1 mRNA are synthesized, and the C282S-Fbp1 mRNA loaded by the nanoparticles is infiltrated into a mouse cavernous body, so that the number of the Fbp1 is recovered, and the activity of the C282S-Fbp1 is improved. Therefore, the lactic acid concentration of the DMED penis cavernosum is effectively reduced, and the erectile function of a DMED mouse is remarkably improved.

The invention relates to the field of medical instruments, in particular to a comprehensive quantitative assessment system for the circumference diameter and pressure of a male penis erection function. Comprising an underpants body, a flexible cloth pocket, an automatic curling belt, a limiting sleeve and an acquisition control module, the flexible cloth pocket is arranged on the front side of the underpants body and used for containing and wrapping the reproductive organ when a user wears the underpants. A flexible pressure sensor is arranged in the flexible cloth pocket and is used for detecting the pressure of the flexible cloth pocket when the flexible cloth pocket is pressed and sending the pressure to the acquisition control module; the limiting sleeve and the automatic curling belt are arranged outside the flexible cloth pocket in a sleeving manner; the limiting sleeve is used for limiting the outer diameter size of the flexible cloth pocket in the corresponding area; and the automatic curling belt is used for contracting and expanding under the control of the acquisition control module and acquiring the corresponding circumferential diameter. The underpants extension type flexible cloth pocket structure is adopted for measurement, the wearing mode is natural, the comfort is high, and the underpants are more suitable for household self-measurement and long-term monitoring.

The invention discloses a preparation for improving male erectile function and sperm quality. The health-care food is characterized by being prepared from the following raw materials in parts by weight: 30-50 parts of herba epimedii extract, 20-40 parts of herba cistanche extract, 15-30 parts of fructus lycii extract, 18-35 parts of semen cuscutae extract, 10-25 parts of herba cynomorii extract, 8-20 parts of maca powder, 6-18 parts of raspberry extract, 0.5-2 parts of lycopene, 1-3 parts of L-carnitine and 0.3-1 part of vitamin B family (vitamin B1, vitamin B2, vitamin B6 and vitamin B12 are mixed according to the mass ratio of 1: 1: 2: 0.5). The herba epimedii extract is selected as a main component, the content of icariin is regulated to be not lower than 60%, the high-content icariin can more effectively promote sex hormone secretion, enhance sexual desire and improve erectile function, the total content of echinacoside and verbascoside in the herba cistanche extract is not lower than 45%, and the herba epimedii extract and the herba cistanche extract have the effect of promoting sex hormone secretion, enhancing sexual desire and improving erectile function. The two components have the effects of tonifying kidney yang and benefiting essence and blood, and can enhance kidney functions.

A device for measuring penile erectile function and an erectile function test system are provided. The device for measuring penile erectile function may include a body unit having a mesh structure formed of stretchable material and configured to surround at least a portion of a penis, a sensor unit arranged on the mesh structure of the body unit and configured to measure first data representing position information on penis, a storage unit configured to store the first data, and a communication unit configured to communicate the first data with a computing device.

The application of the autologous dendritic cell in preparation of the medicine for treating the nerve injury erectile dysfunction can well promote recovery of the erectile function, perform staged reinfusion, induce immune regulation, repair nerve and blood vessel functions and improve a sex hormone regulation pathway. And the autologous dendritic cells are derived from a user, and have the advantages of safety, effectiveness and convenience in use. The combined immune cell therapy is obviously superior to a single treatment path in efficacy, is also more suitable for chronic, non-structural, subclinical and other ED people which are difficult to intervene by traditional methods, and has stronger individual adaptation ability and long-term controllability at the same time. Compared with a traditional scheme, the cell therapy targeting is better, and the treatment effect is faster.

The present invention relates to a pharmaceutical composition for improving sexual function, comprising a Salvia miltiorrhiza extract as an active ingredient. Specifically, the pharmaceutical composition can improve overall sexual satisfaction through the improvement of one or more selected from the group consisting of erectile function, sexual pleasure, sexual desire, and sexual intercourse satisfaction.

This invention discloses a traditional Chinese medicine composition for erectile dysfunction due to deficiency of both heart and spleen, and its application, belonging to the field of traditional Chinese medicine technology. The composition consists of a basic formula and modified formulas. The basic formula includes a spleen-tonifying and qi-boosting group, a heart-nourishing and blood-nourishing group, and a blood-activating and aphrodisiac group. The modified formulas are adjusted according to different concurrent symptoms. It can be prepared into various dosage forms such as decoctions and granules. This traditional Chinese medicine composition precisely addresses the core pathogenesis of erectile dysfunction due to deficiency of both heart and spleen—namely, "insufficient heart blood, deficiency of spleen qi, and malnourishment of the reproductive organs"—achieving spleen-tonifying and heart-nourishing, qi-boosting and blood-nourishing, and blood-activating and aphrodisiac effects, without causing stagnation or greasiness. Clinical trials have demonstrated definite efficacy, high overall effective rate, few adverse reactions, and low long-term recurrence rate. It can comprehensively improve patients' erectile function and accompanying symptoms, and is suitable for preparing drugs to treat erectile dysfunction due to deficiency of both heart and spleen.

The application discloses a kind of compositions based on engineering stem cell exosome and its application in treating male sexual dysfunction.The composition includes mesenchymal stem cell exosome modified by genetic engineering, which displays bifunctional fusion polypeptide targeting TβRⅡ and LOXL2 on the surface. The fusion polypeptide integrates TβR-PEP with LOXL2-PEP through flexible linker, and introduces HIV-TAT penetrating peptide and self-assembly motif, forms nanoparticles to extend half-life. In vitro experiments show that the inhibition efficiency of the fusion polypeptide on TβRⅡ and LOXL2 is significantly better than that of single polypeptide, and can synergistically reverse fibrosis and promote angiogenesis. Animal experiments confirm that exosome loaded with fusion polypeptide significantly improves the erectile function of diabetic ED rats. The application provides a radical treatment scheme for male sexual dysfunction through double-target synergistic, long-acting delivery and multi-effect repair mechanism.

The invention relates to a composition and a preparation method of a reproduction nursing external preparation with effects of inhibiting bacteria, relieving and improving male functions. The invention discloses an external preparation for male reproduction nursing. The plant essential oil comprises natural plant extracts (clove, herba epimedii, ginseng, dendrobium officinale, tribulus terrestris, radix sophorae flavescentis, fructus cnidii, saw palmetto fruit and aloe vera), nutritional ingredients (arginine, hydrolyzed collagen zinc, nicotinic acid, tocopherol, biotin and B-group vitamin yeast polypeptide) and compound essential oil (tea tree oil, jasmine flower oil, iris oil, cananga odorata flower oil and sandalwood oil). The composition can be prepared into spray, cream, lotion and other dosage forms. The preparation improves erectile function, enhances microcirculation, relieves pressure, improves sexual desire and realizes precise adjustment of male function and protection of gonad axis through mechanisms of inhibiting bacteria, diminishing inflammation, improving testosterone concentration, enhancing nitric oxide synthase activity, promoting vasodilatation, blocking neural signals, delaying ejaculation and the like.

The invention belongs to the technical field of medical instruments, and discloses an erection function detector which comprises an erection detection lantern ring and a sleep monitoring device. The miniature piezoresistive sensors are uniformly mounted in the erection detection lantern ring; the detection ring telescopic assembly is arranged on one side of the erection detection lantern ring; according to the technical scheme, through the arrangement of the detection ring telescopic assembly, the detection ring adjusting assembly and the adjusting locking and fixing assembly, when the top part of the detection ring adjusting assembly is manually rotated, the bottom end part of the detection ring adjusting assembly can synchronously rotate, so that the two side parts of the detection ring telescopic assembly can be smoothly driven to move face to face or back to back; at the moment, the part, connected with the detection ring telescopic assembly, of one side of the erection detection lantern ring can be smoothly driven to stretch and retract oppositely or reversely, finally adjustment can be conducted according to the size of the erected penis of the person to be detected, and the purpose of sleeving penis of different sizes is achieved.

The invention belongs to the technical field of biology, and particularly relates to a human parathyroid hormone 1-34 peptide analogue and a preparation method and application of the human parathyroid hormone 1-34 peptide analogue, and the human parathyroid hormone 1-34 peptide analogue is formed by peptide fragments shown in SEQ ID No.1-SEQ ID No.8 or homologous peptide fragments of the peptide fragments. The human parathyroid hormone 1-34 peptide analogue has osteoporosis treatment activity, is used for relieving parathyroid hypofunction and related symptoms after parathyroid gland resection or extirpation, and also has an erection promoting function, and the preparation method is economical and environment-friendly, is suitable for industrial development and has a wide prospect.

The invention belongs to the technical field of biology, and particularly relates to a preparation for improving male sexual function and a preparation method and application thereof. The preparation is prepared from the following raw materials: a lactobacillus extracellular vesicle solution and a procyanidine microemulsion, the volume ratio of the lactobacillus extracellular vesicle solution to the procyanidine microemulsion is 1: (3-5); the lactobacillus extracellular vesicle solution is derived from fermentation liquor of lactobacillus; the lactobacillus comprises any one of lactobacillus reuteri, lactobacillus jensenii, lactobacillus acidophilus, lactobacillus delbrueckii and lactobacillus gasseri; the procyanidine micro-emulsion is a micro-emulsion prepared by taking procyanidine as a main raw material. The preparation provided by the invention has a better improvement effect on glycolipid metabolism, vascular endothelial function and erectile function of diabetic erectile dysfunction rats, and provides a new direction for treating and / or improving diabetic erectile dysfunction diseases.

The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating diabetes-related erectile dysfunction as well as a preparation method and application of the traditional Chinese medicine composition. The composition consists of a pharmaceutically acceptable carrier and an active ingredient, wherein the active ingredient consists of the following components in parts by weight: 5-15 parts of rhizoma acori graminei; 5-15 parts by weight of ligusticum wallichii; 5-15 parts by weight of radix curcumae; 5-15 parts by weight of polygala tenuifolia; 5-15 parts by weight of Chinese herbaceous peony; 5-15 parts by weight of Chinese angelica; 10-20 parts by weight of Radix Astragali; 5-15 parts by weight of semen cuscutae; 5-15 parts by weight of herba epimedii; 5-15 parts by weight of dens draconis; 5-15 parts by weight of tribulus terrestris; 5-15 parts by weight of radix bupleuri; and 5-15 parts by weight of rhizoma cyperi. The composition is prepared into various oral preparations such as granules, tablets, capsules, pills and the like through the processes of extraction, concentration, drying, granulation and the like. The application can significantly improve the erectile function index, erectile hardness and sexual life quality of DMED patients, improve the serum testosterone level of the patients and reduce blood sugar, and has the advantages of few adverse reactions and good safety.

The invention discloses a traditional Chinese medicine composition for treating diabetic erectile dysfunction and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises medicine powder and a medicament, the medicine powder comprises the following raw materials: stiff silkworm, centipede and pseudo-ginseng powder; the medicament is prepared from the following raw materials: ginseng, rhodiola rosea, rehmannia, astragalus membranaceus, radix puerariae, caulis spatholobi, loofah sponge, peach kernels, safflower carthamus, angelica sinensis, radix paeoniae alba, pubescent holly roots, morinda officinalis, fructus lycii, herba epimedii and radix bupleuri. The traditional Chinese medicine composition disclosed by the invention has a remarkable treatment effect on diabetes mellitus complicated with erectile dysfunction and diabetic erectile dysfunction, and can be used for obviously improving the erectile function and improving the traditional Chinese medicine syndromes such as low sexual desire, fatigue and fatigue. The traditional Chinese medicine composition has a good curative effect and a certain clinical popularization value in the aspect of treating diabetes mellitus erectile dysfunction.

The invention discloses a shock wave generating device for treating male erectile dysfunction, comprising a base, wherein a treatment component for facilitating a patient to lie down for shock wave treatment is installed on the top of the base, a support component for supporting the patient's back after the patient lies down is installed on one side of the treatment component, and the bottom of the support component is connected to the top of the base; the invention starts a first shock wave generator, which generates a certain degree of shock waves, which are diffused through the water inside a shell and the water inside a water bucket, and the patient's buttocks are retracted at the bottom of the water bucket and located above the shell, and the generated shock waves can effectively contact the patient's penis root and sphincter, and low-intensity shock waves are used to stimulate the penis root tissue, thereby promoting blood vessel proliferation and improving blood circulation, thereby improving erectile function; the patient can lie down comfortably during treatment, thereby improving the treatment effect of ED.

A method for determining erectile function of an individual includes obtaining, from a wearable device worn on a penis of the individual during stimulation of the penis, one or more displacement values characterizing a measure of displacement of the wearable device by the penis, determining, using the one or more displacement values, an erection quality score of the penis.

The invention provides a gel, and belongs to the technical field of biological medicine, the gel does not contain dihydric alcohol compounds, and the gel contains 20-40 wt% of glycerin; 30% to 40% by weight of ethanol; 0.1% to 1.5% by weight of a carbomer; and the balance of water, and the gel has the effects of promoting male erectile function and low skin irritation. When the gel is used for preparing a skin preparation, the gel can be used for cooling, improving or treating male erectile dysfunction and cooling, and meanwhile, the occurrence of anaphylactic reaction is reduced.

A method is provided for penile rejuvenation comprising a series of plasma gel and Dysport injections to restore youthful structure and function. Blood is drawn to isolate plasma, which is heated to produce a growth factor-rich gel. The gel is injected into the penis shaft for tissue volumization and into the cavernosa to improve erectile function. Dysport is additionally injected at the penile base to relax ligaments for improved length and into the glans to control prostate secretions. Benefits include enhanced size and fullness, better erectile strength, and reduced leakage. This non-surgical procedure offers a novel approach to aging male aesthetics and sexual dysfunction using the patient's own plasma and targeted chemodenervation with Dysport.

This application belongs to the field of wearable medical device technology, and provides an auxiliary treatment device and control system for improving male sexual function. The auxiliary treatment device includes: a main unit cover, a main unit assembly, a button assembly, a first electrode assembly, and a second electrode assembly. The main unit cover is a flexible, arc-shaped cover. The main unit assembly is located inside the main unit cover. The button assembly is located on the outside of the main unit cover. The first electrode assembly and the second electrode assembly are symmetrically arranged on both sides of the main unit assembly. The main unit cover, the first electrode assembly, and the second electrode assembly elastically cover and clamp the area of ​​the penis to be tested for stimulation of the dorsal nerve of the penis. This auxiliary treatment device for improving male sexual function can provide controllable electrical stimulation of the dorsal nerve of the penis through multiple pairs of electrodes, thereby improving male erectile function and prolonging the duration of intercourse.

The invention relates to the technical field of medical instruments. More specifically, the present invention relates to a stent for vascular erectile dysfunction, comprising: a main stent of an expandable structure for supporting and expanding a main blood vessel to increase the blood flow of the main blood vessel; the branch stent is used for limiting the blood flow of the branch blood vessel; the plastic connecting part is used for connecting the main stent and the branch stent, and the position between the main stent and the branch stent can be freely adjusted through the plastic connecting part. According to the stent, the main blood vessel is expanded through the main stent, meanwhile, the branch blood vessel is subjected to flow limiting through the branch stent, the blood supply amount of the main blood supply artery to the cavernosum of the penis can be ensured, and therefore the problem of vascular erectile dysfunction can be solved. The main support and the split support are connected through the plastic connecting part, the plastic connecting part is of a telescopic structure and can adaptively change along with the installation positions of the main support and the branch support, and adjustment of the positions of the main support and the branch support is guaranteed.

A method for determining erectile function of an individual includes obtaining, from a wearable device worn on a penis of the individual during stimulation of the penis, one or more displacement values characterizing a measure of displacement of the wearable device by the penis, determining, using the one or more displacement values, an erection quality score of the penis.

The invention discloses a multifunctional gender specificity physiological signal monitoring system which comprises a sensing module based on a gender specificity structure, a control module, a battery module and a display module. One side of the sensing module based on the gender specific structure is adhered to the skin surface in different scenes in different composite structure forms, and the other side of the sensing module is connected with the control module; the control module is fixed on the clothes in the form of a flexible circuit board; the battery module is directly connected to the control module to supply power to the control module; the display module is connected with the mobile phone end and the control module by turning on built-in Bluetooth of the mobile phone and then turning on a power switch of the control module, and real-time changes of specific signals monitored by the sensing module are displayed at the mobile phone end. According to the invention, abdominal uterine contraction strain and local temperature change of the pregnant woman are synchronously captured, and dual-mode dynamic evaluation of abnormal uterine activity in the gestation period is realized; meanwhile, the device can also serve as a male penis erection function monitoring ring, and psychological and organic ED are distinguished through radial strain-temperature collaborative analysis.

The application discloses a kind of stem cell exosome based on targeted fusion polypeptide modification, preparation method and its application in treating male erectile dysfunction.The exosome is anchored on the surface by chemical coupling technology with specific targeted fusion polypeptide (sequence: EPLQLKM-GGGGS-DPPV), which enhances its targeting to cavernosal smooth muscle cells;At the same time, by loading anti-TrkA monoclonal antibody (TrkA-2E7-HL) through electroporation method, the fibrosis pathway mediated by nerve growth factor (NGF) is inhibited.The exosome is induced by antioxidant culture medium to induce umbilical cord mesenchymal stem cells to secrete, which significantly improves its antioxidant activity.Experiments show that the erectile function (ICP / MAP ratio) of the exosome after modification is increased to 0.79±0.05 in a diabetic ED rat model, the fibrosis area is reduced to 9.2±1.6%, and the NO secretion level is increased by 3.5 times compared with ordinary exosome.The application realizes effective reversal of ED pathological process through polypeptide targeting, antibody synergy and antioxidant triple mechanism, and has significant novelty and clinical transformation potential.