77 results about "Erectile function" patented technology

A compound having the structureuseful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.

We have found a consistent pattern of hormonal abnormalities in patients with ERECTILE DYSFUNCTION. Our study group included men from age 21 to 88 years old. By helping to correct the hormonal imbalance of progesterone and testosterone towards normal values, most of the men in our study were able to obtain normal erectile function. By using a progesterone / testosterone cream we were able to help correct the hormonal imbalance commonly found in men with ERECTILE DYSFUNCTION.

The application of L-arginine and its derivatives to the skin causes beneficial effects of wound healing, increasing erectile function and increased growth of hair when applied in sufficient quantity to the skin. A hostile biophysical agent may be combined with the L-arginine to increase its absorption into the skin. The desired concentrations of the hostile biophysical agent is increased when concentration of L-arginine is less than 20% of the concentration of the substance applied to maximize its effect.

Surgical implants and procedures for restoring erectile function are described. One method includes the steps of providing an inflatable prosthesis system with a pump, a cylinder, a septum, and a reservoir, the system having sufficient fluid to inflate the cylinder and reservoir, implanting the system in an inflated condition and leaving the system in this condition in the post-operative period, then inserting a needle through the septum and withdrawing some fluid from the system. The systems of the invention may include the insertion of a needle through the septum for the injection of an antimicrobial or antibiotic.

Compositions for treating erectile dysfunction (“ED”), including age related erectile dysfunction (ARED), comprise in a preferred embodiment ginger and an amino acid. Preferably the amino acid is L-arginine and / or L-citrulline. Additionally, the compositions may comprise guarana (Paullinia cupana), Muira puama cortex magnoliae officinalis (CMO) and / or fructus aurantil immaturus (FAI). The compositions of the present inventions are administered in a pharmaceutically effective amount to treat erectile dysfunction. Essential ingredients in formulations of the present inventions for treatment of ED and ARED are ginger (or ginger derivative) and L-citrulline or L-arginine. A daily dosage of at least about 250 mg ginger and at least about 400 mg L-citrulline or L-arginine for a sufficient period of time will result in improved IIEF scores in a substantial number of patients.

The invention relates to compounds having the structure of Formula (I) and pharmaceutically acceptable salts thereof, which are soluble guanylate cyclase activators. The compounds are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

The invention discloses a medicine combination for treating impotence and premature ejaculation and a preparation method thereof. The medicine combination is a preparation prepared by the following main raw materials: fried caltrop, acanthopanax, hypericum perforatum, rhodiola and black ants. The medicine combination disclosed by the invention has the effects of soothing liver and tonifying kidney, and tonifying qi and promoting blood circulation and removing obstruction in channels, and has the advantages that the curative effect is exact, the price is cheap, no side effects are produced, the erectile function of a patient can be quickly improved, the hardness of the erection is increased, the erection duration and the ejaculatory latency are prolonged, the total effective rate is 88%, the total effectual rate is 68%, and the clinical curative rate is 28%. The invention also discloses a preparation method of the medicine combination. In the preparation method, according to the different characteristics of traditional Chinese medicines, the traditional Chinese medicines are preprocessed respectively through grinding or solvent extraction, and other methods, and are then proportioned to be prepared into the product.

Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

The present invention is directed to the compounds of Formula I which are inhibitors of tropomyosin-related kinase A (TrkA): Formula (I) or steroisomers, tautomers or a pharmaceutically acceptable salts, metabolites, isotopes, solvates or prodrugs thereof, wherein, Ra, Rb, Rc, Rd, R1, R2, L and Het-Ar are as defined herein. These compounds can be used for the preventive and / or therapeutic treatment of diseases or disorders associated with abnormal activities of nerve growth factor (NGF) receptor TrkA such as Pain, inflammation or an inflammatory diseases, Cancer, atherosclerosis, restenosis, thrombosis, Neurodegenerative diseases, Erectile Dysfunction (ED), Skin disorders, Autoimmune disease like Multiple sclerosis, Sj gren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, Infectious diseases, diseases related to an imbalance of the regulation of bone remodeling, endometriosis, pelvic pain syndrome and diseases resulting from abnormal tissue remodelling and fibrotic disorders; or a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination.

L-citrulline for treatment of endothelial dysfunction and in particular of erectile dysfunction and a pharmaceutical composition comprising L-citrulline in combination with one or more substances selected from the group consisting of pycnogenol, aqueous extract of Viscum album, NADPH, tetrahydrobiopterin, folic acid and mixtures thereof.

A device, system and method for improving sexual erectile functions in males that includes an electromyography (EMG) sensor, which is set up in the perineum area over the bulbospongiosus and ischiocavernosus muscles. A cable connects the EMG sensor to an amplifier, the output of which is connected to an analog-to-digital converter. The converter transforms the EMG signal into a form that is accepted by a computer or a smartphone, which contains software that is able to display the EMG signal in a visual-auditory form that can be accepted by the sensory organs of a user. The training of the perineum muscles restricts the blood outflow from the cavernous bodies of a penis and reinforcement of erectile function.

The invention provides an extracellular vesicle-containing injectable hydrogel for treating an erectile dysfunction. The extracellular vesicle-containing injectable hydrogel for treating the erectiledysfunction comprises an injectable hydrogel and ex vivo human mesenchymal stem cell-derived extracellular vesicles, of which the density is 5*10<10> particles / ml. The invention also provides a methodfor preparing the extracellular vesicle-containing injectable hydrogel for treating the erectile dysfunction. The human mesenchymal stem cell-derived extracellular vesicles can carry bioactivators such as growth factors and nucleic acids to promote vascular repair and nerve regeneration, thereby restoring the erectile function. The invention solves the technical problem of penile vascular endothelium and nerve damage in patients with refractory erectile dysfunction by injecting the human mesenchymal stem cell-derived extracellular vesicles into the corpus cavernosum. The extracellular vesicle-containing injectable hydrogel provided by the invention utilizes the injectable hydrogel to encapsulate the human mesenchymal stem cell-derived extracellular vesicles to provide a safe, effective and convenient therapeutic pharmaceutical preparation for treating the erectile dysfunction.

The invention provides a rehabilitation ring for male erectile dysfunction. The rehabilitation ring is made of a latex material, and comprises a ring body, wherein two lugs which can be held by hands to stretch the ring body are arranged on two sides of the ring body oppositely; and a recessed gap I which does not influence arterial blood supply when the ring body is sleeved on the root of penis and a recessed gap II which makes the ring body not press a urethral canal at the root of the penis to facilitate ejaculation when the ring body is sleeved on the root of the penis are formed on an inner ring of the ring body. After patients who suffer from erectile dysfunction (ED) are treated by a negative pressure erection-assistant tool, the rehabilitation ring is sleeved on the root of the erected penis, and the recessed gap I of the rehabilitation ring ensures full arterial blood supply, so that the penis is in the erected state safely and continuously; and a spermiation canal (the urethral canal) is smooth by the recessed gap II of the rehabilitation ring. By using the rehabilitation ring, high-price medicines are not needed to be bought repeatedly, the side effect caused by the medicines is avoided, and the satisfaction degree is high during long-term use; and the rehabilitation ring can be used as a tool for training an erection function, so that the normal sexual life of husbands and wives is ensured.

Particles are provided for use in restorative procedures to treat erectile dysfunction. The particles include poly[bis(trifluoroethoxy)phosphazene] and / or derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles may also include a core having a hydrogel formed from an acrylic-based polymer. Such particles may be loaded to provide localized treatment with an active agent directed at restoration of normal penile erectile function and the treatment of erectile dysfunction. Moreover, such particles may be provided to a user with customized coloration or in various coded colors to indicate differing doses of active agent contained therein.

A device, system and method for improving sexual erectile functions in males that includes an electromyography (EMG) sensor, which is set up in the perineum area over the bulbospongiosus and ischiocavernosus muscles. A cable connects the EMG sensor to an amplifier, the output of which is connected to an analog-to-digital converter. The converter transforms the EMG signal into a form that is accepted by a computer or a smartphone, which contains software that is able to display the EMG signal in a visual-auditory form that can be accepted by the sensory organs of a user. The training of the perineum muscles restricts the blood outflow from the cavernous bodies of a penis and reinforcement of erectile function.

Provided herein are substituted PDE5 inhibitors of Formula 1, and processes of preparation and pharmaceutical compositions thereof. Also provided are methods of their use for the treatment and / or management of hypertension, erectile dysfunction, and / or the inability to maintain improved erectile function.

An intelligent monitor of erectile function, including a pair of underpants equipped with a mechanical device operating to monitor a penile axial length, a penile radial length, and a penile volume; a temperature detector operating to detect a penile temperature; an oxygen saturation measuring device operating to measure a penile oxygen saturation; an integrated circuit chip operating to receive and process output signals from the mechanical device, the temperature detector, and the oxygen saturation measuring device; and a data storage device. The mechanical device, the temperature detector, and the oxygen saturation measuring device are electrically or electronically connected to the integrated circuit chip. The data storage device is electrically or electronically connected to the integrated circuit chip.

The invention relates to a medicine for increasing male sexual function and treating erectile dysfunction and a preparation method thereof. The medicine comprises the following raw materials in partsby weight: 3-18 parts of poria cocos, 3-18 parts of coix seeds, 3-18 parts of citron, 5-30 parts of longan pulp, 3-18 parts of donkey-hide gelatin, 5-30 parts of penis cervi, 3-18 parts of cinnamon, 12 parts of wolfberry, 3-18 parts of clove, 5-30 parts of raspberry, 2-12 parts of fennel, 2-12 parts of fructus amomi, 3-18 parts of Chinese yam, 2-12 parts of polygala root, 2-12 parts of peach kernel, 3-18 parts of lumbricus, 2-12 parts of ginseng, 4-24 parts of male flower of eucommia ulmoides, and 5-30 parts of oyster peptide. The medicine is suitable for male population, increases energy, enhances male sexual function, and improves erectile dysfunction symptom.

Surgical implants and procedures for restoring erectile function are described.

An apparatus for enhancing erection of a penis includes an expandable first member that partially encircles an upper portion of the penis and partially constricts at least a first vein of the penis to reduce the volume of blood carried away from the penis via the first vein. A second member is mounted to the first member includes left and right shoulder sections configured to contact the penis shaft along the left and right sides the urethra. A contoured section is formed between and extends outwards away from the shoulders so that, when the shoulder sections contact the penis shaft and the first member encircles at least partially encircles the upper portion of the penis, the contoured section extends over and does not constrict the urethra.

A sexual aid useful for men that have some degree of erectile dysfunction. The device inflates to provide rigidity for sexual intercourse, or to assist in maintaining an erection. Inflation of the device according to the invention results from the reaction of non-toxic chemicals. The gas inflates a condom and supports the condom in a posture that is sufficiently rigid to facilitate sexual intercourse or inflates a constriction ring and holds blood in the penis that may maintain sufficient erectile function to facilitate sexual intercourse.

The invention discloses an ultra-light and thin and soft type penile erection detector, and relates to the field of medical detection equipment. The detector includes a top silica gel encapsulation layer, a PCB board detection layer and a disposable silica gel patch layer. The PCB board detection includes a flexible PCB panel. A micro pressure sensor, a single-chip microcomputer, a rechargeable lithium battery and a bluetooth module are mounted on a component bearing surface of the flexible PCB panel. According to the invention, a three-layer structure consisting of the top silica gel encapsulation layer, the PCB board detection layer and the disposable silica gel patch layer is provided, and the micro pressure sensor and the bluetooth module are mounted on the PCB board detection layer. The detection of erection times, longitudinal erection hardness and other indicators of an erectile function is completed by attaching a disposable silica gel patch to the head of a penis for pressuresensing and recording and transmitting recorded information to a user mobile phone through the bluetooth module. Therefore, the problem that detection data is inaccurate caused by psychological factors, detection environment and detection equipment structure is avoided, and the detection is accurate and efficient.

The insertion assisting device allows a penis, though having a decreased erectile function, to be inserted smoothly into a vagina and dissolves within a few minutes of insertion, so that the penis can be kept inserted in the vagina in a natural state of insertion. Thus, a good physical contact between spouses and hence a desirable marital relationship can be maintained. The insertion assisting device includes a cylindrical member for covering a penis, the cylindrical member including a front portion having a round tip at which the front portion closes and tapering in a curve toward the round tip and a cylindrical portion having a circular opening end. The cylindrical member is a hard capsule formed from a soluble material that dissolves in body fluid existing inside the vagina.

This invention relates to the use of cyclic guanosine 3′,5′-monophosphate phosphodiesterase type five inhibitors, including in particular the compound sildenafil, for the treatment of premature ejaculation in patients with normal erectile function.