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89results about How to "Dissolution rate is fast" patented technology

Method for preparing biodegradable spherical porous starch foam and application

The invention relates to a process for preparing biodegradable spherical porous starch foam and a biodegradable spherical porous starch foam administration system for an insoluble medicament. The process adopts an emulsifying-freeze thawing combined solvent displacement method, and comprises the following steps of: performing high-speed stirring or homogenizing treatment (emulsion homogenizing machine) on starch-melted aqueous solution with certain concentration serving as a water phase, methylbenzene/chloroform mixed solution (or other emulsion oil phase) serving as an oil phase and Span80 (or other W/O emulsifying agent) serving as an emulsifying agent to form uniform W/O emulsion, standing the emulsion for certain time at the temperature of 20 DEG C below zero, demixing the emulsion by gelling, dehydrating the layers in turn by adopting balance of aqueous solution of methanol with different concentrations, separating and removing the methylbenzene/chloroform layer by adopting a separating funnel, balancing the solution by using anhydrous ethanol, filtering the solution, and drying the filtrate with vacuum to obtain the biodegradable spherical porous starch foam. The foam material suitable to be used as an insoluble medicament carrier increases the specific surface area and water solubility of the insoluble medicament, and finally improves the bioavailability of the insoluble medicament.
Owner:SHENYANG PHARMA UNIVERSITY

Echinacea purpurea extract powder and preparation method and application thereof

The invention provides echinacea purpurea extract powder and a preparation method and application thereof, which can solve the problems of large dosage, slow response, low bioavailability, easy moisture absorption and agglomeration and serious waste of medicament resources of the powder which is prepared by a traditional preparation method. The echinacea purpurea extract powder comprises echinacea purpurea extract and micro-powder silica gel serving as a carrier material. The preparation method comprises the steps of crushing the raw medicament material echinacea purpurea, extracting the material by a microwave method, recovering ethanol, performing concentration on the material under reduced pressure, adsorbing the micro-powder silica gel and drying, compounding and packaging the material. The echinacea purpurea extract powder has high dissolution rate and high dissolution capability of the effective ingredient, ensures convenient storage and use of the echinacea purpurea superfine powder by adding the micro-powder silica gel serving as a moisture remover, an anti-caking agent and a flow aid and has a good effect for enhancing the immune function; and the echinacea purpurea extract powder is used for animals of low immune function and improving the immunity effect of vaccine so as to cure various bacterial diseases and viral diseases by matching with other medicaments.
Owner:QINGDAO VLAND BIOTECH INC

Microwave test method for determining content of harmful substances in plastic package material

The invention discloses a microwave test method for determining the content of harmful substances in a plastic package material, which comprises the following steps of cleaning and drying the plastic package material, then jointly placing the plastic package material and extract solvent in a glass bottle, sealing the glass bottle and enabling the glass bottle to serve as a test unit; placing the test unit into a microwave oven, selecting function power and function time of microwave, and then starting a microware function; after a microwave acceleration extracting test is finished, the solvent is concentrated to an appropriate concentration, and determining the content of the harmful substances in the plastic package material through quantifying and nature determination analysis on the harmful substances in extract through a gas chromatograph or a liquid chromatograph. The microwave test method for determining the content of harmful substances in the plastic package material is fast, convenient and short in time duration. After a plastic package material test sample in the test unit is affected by the microwave, the dissolving speed of the harmful substances can be greatly accelerated, and the time duration of the detection can be greatly shortened. The microwave test method for determining the content of harmful substances in the plastic package material is high in flexibility and can fast determine the content of majority types of harmful substances in the plastic package material.
Owner:JINAN UNIVERSITY

Oral disintegrating tablets of microcrystallites of aripiprazole composition and preparation method thereof

The invention relates to orally disintegrating tablets of microcrystallites of an aripiprazole composition and a preparation method thereof, and the orally disintegrating tablets mainly compose the microcrystallites of the aripiprazole lactose composition, a filling agent, a disintegrating agent, a flavor correction agent and a lubricating agent, wherein the particle size of the microcrystallites of the aripiprazole lactose composition is less than 30 mu m. The preparation method comprises the following steps: uniformly mixing all components of the aripiprazole orally disintegrating tablets and then directly tabletting or performing wet-granulation tabletting. The microcrystallites obtained by common micronization of the aripiprazole lactose composition are higher in dissolution rate in comparison with those by independent micronization of aripiprazole; simultaneously, the crystal form of the aripiprazole in the microcrystallites of the composition is not transformed and the uniformity of content of the orally disintegrating tablets is higher; and the hardness of the aripiprazole orally disintegrating tablets is 5-8kg, the disintegration time limit is less than 30 seconds, not only the tablets can be prevented from breaking during transportation, but also the tablets are convenient to take.
Owner:QILU PHARMA
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