89results about How to "Dissolution rate is fast" patented technology

The invention provides a crystal form, preparing method and application of Olaparib. According to the Olaparib with the new crystal form, CuKa radiation is adopted, powder X-ray diffraction represented by 2 theta angle has diffraction peaks at 22.9+/-0.5, 23.4+/-0.5, 21.0+/-0.5, 17.1+/-0.5, 17.3+/-0.5, 14.2+/-0.5, 15.0+/-0.5, 13.5+/-0.5, 18.6+/-0.5, 20.6+/-0.5, 10.2+/-0.5, 20.3+/-0.5, 21.9+/-0.5, 25.8+/-0.5 and 26.5+/-0.5. The granularity D50 of the Olaparib with the crystal form is 2.45 microns which is quite small, so that dissolving-out speed is high when the Olaparib serves as a preparation, and drug efficacy of a product is improved. Furthermore, the preparing method is simple, and the performance of the obtained Olaparib with the crystal form is stable.

The invention relates to an ellagic acid supramolecular combination and a preparation method. The substance is an anti-oxidant and has the anti-cancer effect, and the ellagic acid supramolecular combination belongs to the technical field of drugs and health care products. The ellagic acid supramolecular combination is composed of raw materials according to the following weight ratio that ellagic acid: cyclodextrin: emulsifier is equal to 1: (1-50): (0-10). The ellagic acid, the cyclodextrin and the emulsifier are added into a colloid mill, and the ellagic acid supramolecular combination is prepared by grinding and drying. The combination has the advantages of higher solubility, high dissolution rate, good stability and higher relative bioavailability.

The invention relates to an Azilsartan tablet and a preparation method thereof. The Azilsartan tablet contains micronized Azilsartan, lactose anhydrous 21AN, lactose anhydrous 24AN, a disintegrating agent, and a lubricant, and is prepared by pressing through adopting tabletting technology. Compared with the prior art, the Azilsartan tablet is fast in dissolving speed, simple in technology, and an acceleration test result shows that the prepared Azilsartan tablet has good stability.

A provided (-)-pantoprazole sodium enteric coated tablet consists of a tablet core containing (-)-pantoprazole sodium, a separation layer and an enteric layer, the increased weight of the separation layer accounts for 2-9%, and the increased weight of the enteric layer accounts for 7-15%. In dissolution tests using a system with pH of 5.5 or more, 85% or more of the main drug is dissolved in 30 min. The prepared (-)-pantoprazole sodium enteric coated tablet is an oral preparation with stable quality and high bioavailability.

The invention provides a protopanaxadiol solid dispersion and its preparing method, wherein the weight ratio of the protopanaxadiol and carrier material is 1:1-50, and protopanaxadiol solid dispersion can be prepared through melting method, solvent method, solvent-melting method, grinding method, spray-drying method or freeze drying method. The preparation can be made into the dosage forms of capsules, tablets, suppositories and drop pills.

The invention belongs to the technical field of drugs and in particular relates to a rivaroxaban tablet. The rivaroxaban tablet contains rivaroxaban, hydroxypropyl cellulose and fumed silica and is prepared by dissolving rivaroxaban and hydroxypropyl cellulose in diethylene glycol monoethyl ether, adding fumed silica for adsorption, then mixing the materials with pharmaceutically acceptable auxiliary materials uniformly and pressing the mixture by adopting a direct tabletting process. Compared with the prior art, the rivaroxaban tablet is high in drug dissolution speed and simple in process and dispenses with addition of surfactants and micronization treatment.

The invention discloses a nimodipine capsule with high dissolution and semi-solid composition as content and a preparation method thereof, and belongs to the pharmaceutical preparation field. The method comprises the following steps of mixing micronized nimodipine and a hydrophilic carrier, preparing into solid dispersion by melting extrusion method, cooling, pulverizing, mixing with semi-solid matrix, surfactant, melting point regulator under heating, and filling the content into hard capsule with a capsule filling machine. The invention combines the melting extrusion technique and semi-solid filling hard capsule technique, and after the prepared novel nimodipine capsule is administered into human body, the nimodipine quickly diffuses in molecular form and saturates metabolic enzymes, so as to improve bioavailability. The inventive nimodipine capsule solves the low dissolution and low utilization ratio problems of prior nimodipine preparation; and has the advantages of high dissolution, good stability, simple preparation method, and applicability to industrial production.

The invention relates to a process for preparing gelatin, in particular to a process for producing high-viscosity cowhide alkaline gelatin by a batch and alkaline (BATALK) method. The process comprises pretreatment, rubber extraction, filtration, ion exchange, concentration, high temperature sterilization, drying, crushing, mixing, metal detection and formation of a finished product. The process is characterized in that: the pretreatment process is the BATALK method. By the process, the consumption of water and the consumption of sulfur acid can be reduced; and the gelatin obtained by the process has high viscosity.

The present invention relates to a compound 9-nitrocamptothecine solid dispersion and its preparation method. Said invention adopts 9-nitrocamptothecine as medicine active componnet, and adds carrier material, and separately adopts grinding method, freeze-drying method, melting method and solvent method to prepare the invented product which can be made into capsule, table and drip pill. It can raise solubility of medicine, as compared with raw material medicine its resolution speed can be raised by 4-80 times, it can promote absorption, can reduce irritation of medicine to stomach and intestine and can raise stability of the medicine.

The invention discloses a preparation method of sodium carboxymethyl starch. The preparation method comprises the following steps of: (1) performing cross-linking reaction; (2) performing etherification reaction; (3) performing neutralization reaction; (4) centrifuging; (5) drying; and (6) sieving and packaging. The preparation method has the technical effects that: the sodium content of the sodium carboxymethyl starch prepared by the preparation method is greater than 2.9; strong water absorbing expansion is guaranteed; the dissolution rate of a medicament is promoted; and the bioavailability of the medicament is greatly improved.

The invention relates to a process for preparing biodegradable spherical porous starch foam and a biodegradable spherical porous starch foam administration system for an insoluble medicament. The process adopts an emulsifying-freeze thawing combined solvent displacement method, and comprises the following steps of: performing high-speed stirring or homogenizing treatment (emulsion homogenizing machine) on starch-melted aqueous solution with certain concentration serving as a water phase, methylbenzene/chloroform mixed solution (or other emulsion oil phase) serving as an oil phase and Span80 (or other W/O emulsifying agent) serving as an emulsifying agent to form uniform W/O emulsion, standing the emulsion for certain time at the temperature of 20 DEG C below zero, demixing the emulsion by gelling, dehydrating the layers in turn by adopting balance of aqueous solution of methanol with different concentrations, separating and removing the methylbenzene/chloroform layer by adopting a separating funnel, balancing the solution by using anhydrous ethanol, filtering the solution, and drying the filtrate with vacuum to obtain the biodegradable spherical porous starch foam. The foam material suitable to be used as an insoluble medicament carrier increases the specific surface area and water solubility of the insoluble medicament, and finally improves the bioavailability of the insoluble medicament.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition containing Iloperidone and a preparation method thereof. In the invention, Iloperidone and lactose are prepared into solid dispersion, and a hydrophilic gel material is added to the prescription at the same time, thus improving the water insolubility of Iloperidone. The pharmaceutical composition containing Iloperidone provided by the invention has the characteristics that the water insolubility of Iloperidone is improved, the in-vitro dissolution is different from the characteristic that the traditional common preparation rapidly releases at the early stage, and the in-vitro dissolution is mild at the early stage, but is completed within 30 minutes.

A microemulsion of matrine with high biologic utilization rate and stability is proportionally prepared from matrine, emulsifier, emulsifying aid, oil phase and water phase. Its preparing process is also disclosed.

The invention provides an imidafenacin pharmaceutical composition which is high in content uniformity, quick to dissolve and excellent in stability and a preparation method of the imidafenacin pharmaceutical composition. The preparation method of the imidafenacin pharmaceutical composition comprises the following steps: (A) dissolving imidafenacin by using an appropriate inert non-volatile solvent; (B) selecting a porous auxiliary material for absorbing a medicine solution A to obtain flowable powder; and (C) mixing the powder prepared by the step B with a disintegrating agent and an excipient and carrying out compression molding.

The invention provides echinacea purpurea extract powder and a preparation method and application thereof, which can solve the problems of large dosage, slow response, low bioavailability, easy moisture absorption and agglomeration and serious waste of medicament resources of the powder which is prepared by a traditional preparation method. The echinacea purpurea extract powder comprises echinacea purpurea extract and micro-powder silica gel serving as a carrier material. The preparation method comprises the steps of crushing the raw medicament material echinacea purpurea, extracting the material by a microwave method, recovering ethanol, performing concentration on the material under reduced pressure, adsorbing the micro-powder silica gel and drying, compounding and packaging the material. The echinacea purpurea extract powder has high dissolution rate and high dissolution capability of the effective ingredient, ensures convenient storage and use of the echinacea purpurea superfine powder by adding the micro-powder silica gel serving as a moisture remover, an anti-caking agent and a flow aid and has a good effect for enhancing the immune function; and the echinacea purpurea extract powder is used for animals of low immune function and improving the immunity effect of vaccine so as to cure various bacterial diseases and viral diseases by matching with other medicaments.

The invention provides a medical composite containing pirfenidone, which is characterized by containing 20-90% of pirfenidone, 10-50% of filler, 1-10% of disintegrating agent, 0.1-8% of adhesive and 0.2-3% of lubricant.

The invention provides a preparation method of a high stability aprepitant composition. The preparation method comprises the following steps: grinding aprepitant and an auxiliary material between -170DEG C and -100 DEG C for 0.5-3h, and then performing granulating. The preparation method can improve solubility of an insoluble medicine, namely aprepitant, and increase dissolving-out speed of a preparation. Compared with the existing aprepitant capsule, the prepared aprepitant capsule can ensure physical stability of active ingredients, and a preparation technology of the preparation is simple,appropriate in cost and applicable to industrial mass production.

The invention discloses a microwave test method for determining the content of harmful substances in a plastic package material, which comprises the following steps of cleaning and drying the plastic package material, then jointly placing the plastic package material and extract solvent in a glass bottle, sealing the glass bottle and enabling the glass bottle to serve as a test unit; placing the test unit into a microwave oven, selecting function power and function time of microwave, and then starting a microware function; after a microwave acceleration extracting test is finished, the solvent is concentrated to an appropriate concentration, and determining the content of the harmful substances in the plastic package material through quantifying and nature determination analysis on the harmful substances in extract through a gas chromatograph or a liquid chromatograph. The microwave test method for determining the content of harmful substances in the plastic package material is fast, convenient and short in time duration. After a plastic package material test sample in the test unit is affected by the microwave, the dissolving speed of the harmful substances can be greatly accelerated, and the time duration of the detection can be greatly shortened. The microwave test method for determining the content of harmful substances in the plastic package material is high in flexibility and can fast determine the content of majority types of harmful substances in the plastic package material.

The invention relates to orally disintegrating tablets of microcrystallites of an aripiprazole composition and a preparation method thereof, and the orally disintegrating tablets mainly compose the microcrystallites of the aripiprazole lactose composition, a filling agent, a disintegrating agent, a flavor correction agent and a lubricating agent, wherein the particle size of the microcrystallites of the aripiprazole lactose composition is less than 30 mu m. The preparation method comprises the following steps: uniformly mixing all components of the aripiprazole orally disintegrating tablets and then directly tabletting or performing wet-granulation tabletting. The microcrystallites obtained by common micronization of the aripiprazole lactose composition are higher in dissolution rate in comparison with those by independent micronization of aripiprazole; simultaneously, the crystal form of the aripiprazole in the microcrystallites of the composition is not transformed and the uniformity of content of the orally disintegrating tablets is higher; and the hardness of the aripiprazole orally disintegrating tablets is 5-8kg, the disintegration time limit is less than 30 seconds, not only the tablets can be prevented from breaking during transportation, but also the tablets are convenient to take.

The invention discloses a letrozole troche and a preparation method of the letrozole troche. The letrozole troche disclosed by the invention is prepared from the following original auxiliary materials in parts by weight: 1-5 parts of letrozole, 0-56.5 parts of microcrystalline cellulose, 30-70 parts of lactose, 0-50 parts of pregelatinized starch, 0-10 parts of croscarmellose sodium, 0-10 parts of polyvinylpolypyrrolidone, and 0.5-2.0 parts of stearic acid, wherein coating powder is a film coating premixed agent. The preparation method of the letrozole troche comprises the following steps of taking letrozole bulk drug, and putting the letrozole bulk drug in crushing equipment to crush; uniformly mixing the crushed letrozole bulk drug with a filling agent and a disintegrating agent according to the amount; adding magnesium stearate according to the amount, and uniformly mixing; pressing mixed powder on a tablet press to prepare the troche, thereby obtaining streptomycin; and coating streptomycin on a high-efficiency coating machine, and packaging after the coated troche is qualified. The letrozole troche disclosed by the invention has the advantages of high dissolution rate, simple process, low production cost and the like.

The invention discloses a preparation method of a lung-soothing concentration pill. The preparation method comprises the following steps: taking hempleaf groundsel herb as raw materials, adding water to soak the hempleaf groundsel herb, performing extraction through an ultrasonic extraction tank, and merging the extracts for decoction, filtering and concentration to obtain an extractum; drying and crushing extractum to sieve by a 100-mesh sieve, so as to obtain hempleaf groundsel herb extractum powder; mixing with starch, microcrystalline cellulose and sodium carboxymethyl starch to form mixture powder; preparing the concentration pill by a centrifugal coating palletizing machine. The concentration pill has the benefits of reducing fever, eliminating phlegm, relieving cough and relieving asthma, can be used for lungs infection, chronic bronchitis, asthmatoid bronchitis, acute respiratory tract infection and the like. According to the invention, as ultrasonic extraction is adopted, the dissolving-out amount of effective component of materials to be extracted can be improved in unit time, and the prepared concentration pill is high in effective component content, small in taking dose and small in local irritation.

The present invention relates to compositions comprising compound (I) and processes for the preparation thereof.

The invention discloses a high-dissolution oral bifendate capsule and a preparation method thereof, which belong to the technical field of medicines. The high-dissolution oral bifendate capsule is prepared by 10 of bifendate, 20-80 of hydrophilic carrier auxiliary material, 10-20 of flow aid, 0-50 of filling agent, and the like according to the weight percentage. The preparation method of the high-dissolution oral bifendate capsule comprises the following steps: a bifendate bulk drug is mixed with a hydrophilic carrier, and the high-dissolution solid dispersion is prepared by a melt-extrusion technology; and the obtained solid dispersion is crushed and sieved and then is mixed with a proper mount of the auxiliary material and then is filled in capsules to be prepared into high-dissolution oral bifendate capsules. The drug in the solid dispersion exists in the polymeric carrier in an abnormal crystal form, the dissolution rate is remarkably improved compared with that of the bulk drug, and the bioavailability of the drug can be improved, therefore, the dosage of administration and the untoward reaction of the drug can be reduced.

The prevent invention discloses a vitamin C Yinqiao dispersion tablet and its preparation method. It is made up by using Chinese medicinal materials of lonicera flower, forsythia fruit, schizonepeta, bamboo leaf, arctium seed, phragmites root, platycodon root, licorice and menthanol, chlorphenamine maleate, paracetamol and vitamin C as raw material and adding proper auxiliary material through a certain preparation process. Said invention also provides the concrete steps of its preparation method.

The present invention discloses a method for preparing desloratadine particles by using a solvent drying method, wherein the method is characterized in that the drug and an acrylic acid resin are prepared into a clathrate through a solvent drying method, and then the particle and an appropriate auxiliary material (such as a filler, a flavoring agent, a disintegrating agent, a suspending aid and the like) are completely mixed to granulate. With the process, the taste can be significantly improved, and the drug stability can be increased.

The invention provides a freeze-dried oral preparation containing agomelatine and a preparation method thereof and belongs to the field of medicinal preparations. The freeze-dried oral preparation is prepared from agomelatine in medicine dosage and freeze-dried preparation auxiliary materials. According to the preparation method, agomelatine and the auxiliary materials are prepared into the freeze-dried oral preparation through a freeze-drying method. Agomelatine and the freeze-dried preparation auxiliary materials are dissolved in purified water and then subjected to freeze drying, and then the freeze-dried oral preparation containing agomelatine is prepared. Due to the fact that the freeze-dried oral preparation can be quickly disintegrated in the oral cavity or the stomach, the dissolving-out speed of medicine is increased, absorption before the stomach and taking without water of agomelatine are achieved through mucous membrane transfer, the disintegration and absorption time of agomelatine is shortened, and therefore bioavailability and the compliance of clinic patients are improved.

The present invention relates to a fresh flower spice extraction, and a preparation technology of a black tea and an extract thereof. The preparation technology successively comprises the following steps: flower-fragrant concentrate extracting, instant black tea powder producing, fragrance enhancing, mixing, and packaging. The preparation technology of the flower-fragrant black tea fully takes the combined advantages of both traditional tea and instant tea, especially improves the dissolution rate of a first tea brewing, and improves product quality. The preparation technology of the flower-fragrant black tea fully uses the physical properties of strong suction force of the tea leaves and is beneficial to increase natural fresh flower fragrance absorption, and the fragrance enhancing method is safe and healthy.

The invention provides a blueberry flower scented tea product and a making technology thereof. The making technology comprises putting various teas in the upper layer of an enclosed container, uniformly spreading the teas, arranging a flower fragrance concentrated solution obtained through conventional extraction in the lower layer, heating the blueberry flower concentrated solution to a temperature of 50-70 DEG C, wherein in heating, the tea is turned over 2-5 times, standing the tea at a temperature of 60-80 DEG C for 0.5-10h to obtain an aroma-improved scented tea, wherein in the whole aroma improvement process, the pressure is kept in 2-5atm, taking 80-100 parts of the aroma-improved scented tea and 8-15 parts of instant tea powder, carrying out mixing, drying the mixture until water content is 7% or less and carrying out packaging. The making technology fully utilizes advantages of the traditional tea and instant tea making technologies, especially improves a tea primary dissolution rate and improves teabag quality.

The invention belongs to the technical field of medicines, and in particular relates to cefditoren pivoxil tablets. The cefditoren pivoxil tablets comprise cefditoren pivoxil, hydroxy propyl cellulose and gas phase silicon dioxide. A preparation method comprises the following steps: dissolving cefditoren pivoxil and hydroxy propyl cellulose into diethylene glycol monoethyl ether, adding gas phase silicon dioxide for performing adsorption, then uniformly mixing with pharmaceutically acceptable auxiliary materials, and pressing a mixture by using a direct tabletting process. Compared with the prior art, the cefditoren pivoxil tablets disclosed by the invention are high in medicine dissolution speed and simple in process, do not need to add surfactants, and also do not need micronization treatment.

The invention discloses a method for extracting hesperidin from pericarpium citri reticulatae, which belongs to the technical field of hesperidin extraction. The method comprises the following steps: taking pericarpium citri reticulatae powder, and adding an ethanol solution, so that a mixture is obtained, wherein 40-90 ml of ethanol solution is added into 1 g of pericarpium citri reticulatae powder; and putting the mixture into an airtight container, carrying out extraction for 15-75 min at a temperature of 90-135 DEG C, cooling to room temperature, taking out liquid supernatant, and carrying out centrifugal separation on the liquid supernatant, so that a hesperidin extracting solution is obtained. Hesperidin is extracted from pericarpium citri reticulatae by using an ethanol solution, so that the extraction yield is high, and up to 6.1%. The method for extracting hesperidin from pericarpium citri reticulatae has the advantages of cheap and easily-obtained equipment, simplicity in operation, rapidness, high extraction yield, and the like, and is conducive to mass production.