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Ellagic acid supermolecule composition and preparation method

A technology of ellagic acid and composition, applied in the field of ellagic acid supramolecular composition and preparation, can solve the problems of not belonging to the prototype drug, low bioavailability, etc., and achieve good water solubility, high bioavailability, and improved stability sexual effect

Active Publication Date: 2009-03-04
宿迁医美科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ellagic acid is difficult to dissolve in water and lipid media, and the bioavailability of oral administration is low
The previous patents or documents rarely involved in improving the water solubility of ellagic acid. Among them, US patent US3576007 / US3657453 involved the preparation of water-soluble salts of ellagic acid to improve water solubility. However, due to the change of the structure of the natural compound, it is no longer a prototype drug.

Method used

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  • Ellagic acid supermolecule composition and preparation method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0015] The ellagic acid composition of the present invention is composed of the following raw materials in weight ratio: ellagic acid: gamma cyclodextrin: decaglycerol monooleate = 1:1:0.1.

[0016] According to the above weight ratio, take 50g of ellagic acid, 50g of gamma cyclodextrin and 5g of decaglycerol monooleate, add 10 times of water equivalent to cyclodextrin, put it into the colloid mill, wet mill for 60-100 minutes, put material, vacuum dried.

[0017] The γ-cyclodextrin can be replaced by any one or combination of β-cyclodextrin, hydroxypropyl β-cyclodextrin, SBE-β-cyclodextrin.

Embodiment 2

[0019] The ellagic acid composition of the present invention is composed of the following raw materials in weight ratio: ellagic acid: β-cyclodextrin: ten polyglycerol monolaurate = 1:50:10.

[0020] According to the above weight ratio, take 1g of ellagic acid, 50g of β-cyclodextrin and 10g of decaglycerol monolaurate, add 2-5 times of water equivalent to cyclodextrin, put it into the colloid mill, and wet mill for 10-60 minutes , discharging, spray drying.

[0021] The β-cyclodextrin can be replaced by any one or combination of γ-cyclodextrin, hydroxypropyl β-cyclodextrin and SBE-β-cyclodextrin.

Embodiment 3

[0023] The ellagic acid composition of the present invention is composed of the following raw materials in weight ratio: ellagic acid:γ-cyclodextrin=1:5.

[0024] Take 10 g of ellagic acid and 50 g of gamma cyclodextrin according to the above weight ratio, and the preparation is the same as in Example 1.

[0025] γ-cyclodextrin can be replaced by any one of β-cyclodextrin, hydroxypropyl β-cyclodextrin, SBE-β-cyclodextrin.

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PUM

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Abstract

The invention relates to an ellagic acid supramolecular combination and a preparation method. The substance is an anti-oxidant and has the anti-cancer effect, and the ellagic acid supramolecular combination belongs to the technical field of drugs and health care products. The ellagic acid supramolecular combination is composed of raw materials according to the following weight ratio that ellagic acid: cyclodextrin: emulsifier is equal to 1: (1-50): (0-10). The ellagic acid, the cyclodextrin and the emulsifier are added into a colloid mill, and the ellagic acid supramolecular combination is prepared by grinding and drying. The combination has the advantages of higher solubility, high dissolution rate, good stability and higher relative bioavailability.

Description

technical field [0001] The invention relates to an ellagic acid supramolecular composition and a preparation method. The substance is an antioxidant, has anticancer and antiviral effects, and belongs to the technical field of medicines and health care products. Background technique [0002] Ellagic acid, English name, ellagic acid, molecular formula C 14 h 6 o 8 , which is widely found in plant nuts and soft fruits in nature, and is a polyphenolic substance. It is a dimeric derivative of gallic acid, a polyphenolic dilactone. It can exist not only in free form, but more in condensed form (such as ellagitannin, glycoside, etc.). Ellagic acid is a strong antioxidant with anti-mutation and anti-carcinogenic effects. In the in vivo and in vitro experiments on mouse and human tissue transplantation, ellagic acid showed resistance to chemical substances-induced carcinogenesis and other carcinogenesis. It has obvious inhibitory effect, especially on colon cancer, esophageal ca...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61K47/40A61P31/12A61P35/00
Inventor 董英杰艾莉
Owner 宿迁医美科技有限公司
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