159 results about "Gamma-cyclodextrin" patented technology

The invention relates to a preparation method for a muscle relaxing antagonistic agent sugammadex sodium. The preparation method comprises the following steps: preparing sulfydryl gamma-cyclodextrin by taking halogenated gamma-cyclodextrin and thiourea as reactants; then, initiating sulfydryl-alkene click reaction by illuminating or using an initiator on sulfydryl gamma-cyclodextrin with acrylic acid or acrylic esters or sodium acrylate so as to prepare high-purity sugammadex sodium in a water phase. According to the preparation method for the sugammadex sodium, the the operation environment is gentle, the yield is increased, and the purifying process for the final product sugammadex sodium is simpler.

The invention discloses a method for preparing high-purity sugammadex. The product purity is greater than 98%, the method comprises the following steps: 1) 6-deoxy-6-perhalogeno-gamma-cyclodextrin, mercaptopropionic acid and an alkalescence reagent are reacted at a certain reaction temperature in a reaction solvent to obtain a crude product sugammadex; and 2) re-crystallizing the crude product in the above step and purifying to obtain the sugammadex with purity greater than more than 98%. The method has the advantages of short synthesis step, simple technology and high security , high product quality, and large scale production.

A method is provided for producing a coenzyme Q10 / γ-cyclodextrin complex. This method provides that a mixture of γ-cyclodextrin and coenzyme Q10 is treated by homogenisation and inputting energy.

The polycyclodextrin preparing process is that alpha-, beta, gamma-cyclodextrin or their derivative monomer is first polymerized through reaction under the action of crosslinking agent and template agent inside solvent to produce polymer, which is then pelletized, washed and dried to obtain polycyclodextrin product. It features that solvent dimethyl methane amide or dimethyl sulfoxide in the amount of making a molar concentration of cyclodextrin monomer of 0.05-0.15 mol / l; the crosslinking agent diisocyanate in the amount of 7-9 molar times cyclodextrin monomer; template agent cholesterin, benzyl phenol or hydroxyazobenzene in the amount of 0.25-0.4 molar times cyclodextrin monomer and the polymerization temperature 60-80 deg.c. Polycyclodextrin has high adsorption capacity to organic in water and can be used to lower the organic matter concentratino in water to ppb level. It is easy to regenerate and has good filming property.

The invention aims to provide an active oxygen free radical sensitive cyclodextrin material as a drug delivery carrier. The chemical structure of the cyclodextrin material is disclosed in the specification, wherein n is equal to 6, 7 or 8 which are respectively corresponding to active oxygen free radical sensitive alpha-cyclodextrin, beta-cyclodextrin or gamma-cyclodextrin material; R is -H or disclosed in the specification; and the glucose unit of each cyclodextrin molecule at least has one R group disclosed in the specification. The invention also provides a preparation method of the cyclodextrin material.

A water-soluble coenzyme Q10 composition for treating cardiovascular disease, hepatitis and hypoimmunocompetence is proportionally prepared from coenzyme Q10, gamma-cyclodextrin, alditol and disintegrant through high-speed stirring in water or ultrasonic oscillating, high-pressure homogenizing, freeze-drying, and granulating.

A novel process for the preparation of 6-perdeoxy-6-per-halo Gamma cyclodextrin which is a useful intermediate in the synthesis of Sugammadex is disclosed in the invention. The process involves reacting Gamma cyclodextrin with phosphorous halide in the presence of organic solvent.

The present invention relates to a novel treatment composition for use in treating food products and food intermediates. The treatment composition may be used in single, home use settings as well as commercial applications for larger scale treatment of food products in the course of manufacture. The treatment composition of the present invention uses at least one of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin or combinations and modified derivatives thereof along with a suitable carrier such as in an aerosol, liquefied mister and the like.

The invention, which belongs to the field of biochemistry, relates to a tumor-targeting functionalized quantum dot and a preparation method thereof. The functionalized quantum dot consists of folic acid, cyclodextrin and quantum dot, and part of folic acid molecules are contained in the hydrophobic cavity of the cyclodextrin to form folic acid-cyclodextrin inclusion compound, which is then combined with the surface of the quantum dot. In the process of preparing the functionalized quantum dot, the folic acid is first combined with the Gamma-cyclodextrin to form the inclusion compound, and the Gamma-cyclodextrin-folic acid inclusion compound is then modified on the surface of the quantum dot, so that the dual-function nano material with excellent fluorescent characteristic and tumor-targeting property is produced. Since the Gamma-cyclodextrin is used to include the folic acid, the water-solubility and dispersibility of the folic acid are improved. The folic acid and the quantum dot are connected together by an effective method, and the produced fluorescent probe can be used for biological research on tumor cells. The preparation method is simple, the cost is low, and the screening of a variety of tumor cells and an in-vivo experiment on mice indicate that the material is characterized by low toxicity, high selectivity and the like.

The invention belongs to the technical field of medicines, and in particular relates to a curcumin and mixed-cyclodextrin inclusion compound and a preparation method thereof. The technical scheme provided by the invention is as follows: an alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin mixture and curcumin are adducted in a low-concentration ethanol-water solution, the inclusion rate is improved, and the dissolvability and the stability are enhanced.

The invention relates to the technical field of health care food, in particular to a krill oil microcapsule with an antioxidation effect and a preparation process thereof. Antarctic krill oil, DHA algal oil and haematococcus pluvialis are used as core materials; a proper amount carrageenan is added into an oil phase; chitosan oligosaccharide and gamma-cyclodextrin are used as wall materials, and are proportionally mixed with an oil phase antioxidant, a water phase antioxidant, an emulsifying agent, a dispersing agent and the like to be prepared into microemulsion; through freeze drying, powder grinding, sieving and the like, the krill oil microcapsule is prepared. The krill oil microcapsule obtained by the process has the advantages that the stability of the krill oil on the factors such as light, temperature and humidity is improved; the content of bioactive substances such as astaxanthin and DHA in the microcapsule is high; the antioxidation performance of the krill oil is greatly improved.

A composition comprising a water-soluble and stable complex formed by an alkyl ether derivative of gamma-cyclodextrin and curcumin and optionally comprising non-complexed cyclodextrin, the molar ratio of curcumin to cyclodextrin being between 1:1 and 1:6, and a method of manufacturing such a composition. The water-soluble and stable complex of curcumin is useful in therapy, e.g. for treatment of cancer, leukemia, myocardial infarction, stroke, sepsis, acute lung injury, acute liver failure, acute tubular necrosis, acute pancreatitis, radiation injury and other life-threatening conditions in a human or animal subject, as well as for preserving human or animal organs, tissues or cells at a hypothermic temperature.

The present invention provides a process for the preparation of sugammadex sodium involving the step of: reacting 6-perdeoxy-6-per-halo-gamma-cyclodextrin with 3-mercapto propionic acid in the presence of alkali metal alkoxide in an organic solvents. The invention also provides a process for purifying the sugammadex or its pharmaceutically acceptable salts using water and organic solvents.

The invention belongs to the field of pharmacy, and especially relates to a preparation method for green and environmentally friendly sugammadex sodium. The preparation method obtains a crude productof sugammadex sodium through preparation for the first time by taking 3-mercaptopropionic acid, alkali and 6-deoxy-6-perhalogeno-gamma-cyclodextrin as raw materials; and high purity sugammadex sodiumcan be obtained after desolvation through recrystallization and column chromatography purification. Compared with the prior art, a reaction solvent of the preparation method can replace organic solvents like N,N-dimethylformamide used by traditional methods by only using water, so that disadvantages of hard recovery and large pollution caused by large amount of high boiling organic solvents can beimproved; and the sugammadex sodium is clean and environmentally friendly, green and efficient, has advantages of being mild in reaction condition, high in product purity, simple in post-treatment step, high in product yield, low in cost and convenient for industrialization, and has good application prospects.

The invention provides preparation of a cyclodextrin metal organic framework carbon material and application of the cyclodextrin metal organic framework carbon material to water treatment. The preparation method comprises the following steps: firstly, enabling gamma-cyclodextrin and potassium hydroxide to react, so as to obtain a gamma-cyclodextrin metal organic framework (gamma-CD MOF); then carrying out high-temperature firing on the gamma-cyclodextrin metal organic framework under the protection, so as to obtain the cyclodextrin metal organic framework carbon material. According to the material provided by the invention, firstly, the problem that the gamma-CD MOF is not stable in water can be solved; secondly, the material can inherit porous properties of the gamma-CD MOF and the surface has abundant oxygen-containing functional groups, so that the material can be used as a novel water body heavy metal ion repairing material.

The invention provides a preparation method of a pesticide emulsion, which comprises the steps of preparing an avermectin molecular capsule system; preparing a water phase; preparing an oil phase; adding the oil phase into the water phase, adding the avermectin molecular capsule system after shear emulsion and carrying out the shear emulsion again, wherein, the avermectin molecular capsule systemis prepared by evenly mixing a capsule wall material, a cosolvent and the first part of water under the heating condition, adding avermectin and a first emulsifier for evenly mixing and cooling to the room temperature, the capsule wall material is beta-cyclodextrin and / or gamma-cyclodextrin, the first emulsifier is one or a plurality of fatty alcohol polyoxyethylene ether, sorbitan monooleate andpolyoxyethylene sorbitan monolaurate. Avermectin molecules in the pesticide emulsion containing avermectin molecular capsules prepared by the method greatly enhance the resistance of the avermectin molecules to oxygen, light, heat, acid, alkali and the like and simultaneously have the effects of sustained-release and solubilization, thereby solving the problem that the avermectin is instable to the light and further prolonging the effective period for prevention and treatment of the avermectin.

The invention provides an aqueous solution containing coenzyme Q10 nano-particles, and a preparation method thereof, which belongs to the technical field of inclusion compounds and preparation thereof. The aqueous solution consists of coenzyme Q10, HP-beta cyclodextrin, gamma cyclodextrin and an emulsifier of which the weight ratio is 1:1-100:1-100:0.5-2. The preparation method adopts a process that the HP-beta cyclodextrin and the gamma cyclodextrin are weighed according to that the weight ratio of the coenzyme Q10 to the HP-beta cyclodextrin to the gamma cyclodextrin to the emulsifier is 1:1-100:1-100:0.5-2, are dissolved in water 3 to 10 times the weight of cyclodextrin and heated to be between 40 and 80 DEG C; an oil-phase matrix of the coenzyme Q10 is completely melted, added to an dissolved aqueous phase in a shearing state and shorn for 5 to 30 minutes at a speed of between 5,000 and 20,000 rpm; a solution obtained after shearing is sent into a high-pressure homogenizer and circulated twice to ten times under the pressure of between 50 and 200 MPa, so the liquid is obtained; and the liquid is diluted to a needed concentration under shearing conditions and continues to be homogenized and circulated once to ten times under the high pressure of between 50 and 220 MPa, so that a finished product is obtained. The preparation method has the advantages of greatly increasing the solubility of the coenzyme Q10 and improving the stability of the solution.

The present invention relates to a process for preparation of 6-perdeoxy-6-per-chloro gamma-cyclodextrin which is a key intermediate useful in the synthesis of Sugammadex sodium. The present invention further relates to a process for preparation and purification of Sugammadex sodium.

The invention discloses a stainless steel oxidizing layer cleaning agent and a preparation method and application thereof. The stainless steel oxidizing layer cleaning agent comprises the following raw materials: 30% to 50% of cyclodextrin, 10% to 20% of organic acid, 10% to 20% of a composite surface active agent, and the balance of water, wherein the cyclodextrin is a mixture of one or more than two of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, hydroxypropyl beta-cyclodextrin and methylase beta-cyclodextrin; the organic acid is a mixture of one or more than two of methane acid, ethane acid, propionic acid, lemon acid, oxalic acid, maleic acid and lauric acid; the composite surface active agent is a mixture of one or more than two of sodium oleate, alkyl glycoside, lauryl sodium sulfate, coconut fatty acid diethanol amide, fatty alcohol-polyoxyethylene ether and polyethylene glycol. The stainless steel oxidizing layer cleaning agent has the advantages that the preparation method is simple, the use and operation are convenient, the service life is long, the generation amount of wastewater is small, the components can be easily and biologically degraded, the green and environment-friendly effects are realized, and the cost is low. The stainless steel oxidizing layer cleaning agent has the potentiality of replacing the existing stainless steel oxidizing layer cleaning agent using inorganic acid as the main component.

The invention relates to a reduced glutathione percutaneous absorption preparation and a preparation method thereof, and belongs to the field of medicinal preparations. In the technical problem, the invention provides a reduced glutathione percutaneous absorption preparation which has the sustained-release effect. The reduced glutathione percutaneous absorption preparation is prepared from an auxiliary material bag and reduced glutathione, wherein an auxiliary material is at least one of gamma-cyclodextrin, a derivative of the gamma-cyclodextrin, alpha-cyclodextrin and a derivative of the alpha-cyclodextrin. The reduced glutathione percutaneous absorption preparation has the advantages of quick response, long half-life period and high bioavailability, is convenient to use and does not have pain. The reduced glutathione provides a new preparation, and has a wide application prospect.

The invention relates to a synthesis method of natural high-molecular acrylate products. The method comprises the steps of: adding a polysaccharide taken from one of chitosan, hyaluronic acid or alpha, beta, gamma-cyclodextrin into a mixed solution of an acid binding agent and chloralkane in a volume ratio of 1-2:1, stirring and placing the mixed solution under room temperature for 48h; cooling and stirring the mixed solution in an ice bath at a temperature of 0-5DEG C for 2h; adding dropwisely a chloralkane solution of 20-40 wt% of unsaturated acyl chloride for 2-4h, controlling the added unsaturated acyl chloride of 2-4 times the weight of the polysaccharide; raising the temperature to 25-30DEG C for a reaction of 8h, and washing the filtered precipitate with acetone for 3 times, thus obtaining a natural biological polysaccharide derivative. The natural biomaterial acrylate product of the method provided in the invention can be used for tissue engineering scaffold materials, drug controlled slow release materials, and UV (ultraviolet)-curing paint materials.

Provided are an injectable tissue adhesive hydrogel including gamma-cyclodextrin (γ-CD). When such an injectable tissue adhesive hydrogel including the γ-CD is used as a skin glue, based on a fact that the γ-CD has a bigger hydrophobic cavity than that of α- and β-CDs, the injectable tissue adhesive hydrogel including the γ-CD has stronger interactions than host-guest interactions. In addition, hydrogen bonding in the injectable tissue adhesive hydrogel including the γ-CD can improve both cohesiveness and adhesiveness of gelatin. The injectable tissue adhesive hydrogel including the γ-CD having excellent cell viability is used for adhesion of a skin incision, to thereby effectively promote tissue regeneration.

The invention discloses a preparation method of a resistant starch nutritional carrier based on a metal-organic framework as well as a product thereof. The preparation method of the resistant starch nutritional carrier comprises the step of adsorbing metal-organic framework structured gamma-cyclodextrin on the surface of octenyl succinic anhydride modified starch (OSA-S) by taking the OSA-S prepared by performing esterification on octenyl succinic anhydride and resistant starch as a base material and under the effects of hydrogen bond, electrostatic force and the like, thus constructing the nutritional carrier with a porous network structure. The nutritional carrier has favorable solution self-aggregation performance; by virtue of the great load quantity of the relatively single OSA-S and the metal-organic framework structured gamma-cyclodextrin, functional substances such as nutritional elements can be embedded in a solid state mode, so that the damage caused by light irradiation, oxygen as well as acid-base and the like is prevented effectively, and a certain slow-release effect is achieved; the resistant starch also has a good health protection effect, and thus the nutritional carrier is expected to be a safe functional food additive applied to the food processing field.

The preparation process of water soluble cyclodextrin-C60 supermolecular inclusion compound includes the first preparing C60 negative ion solution, the subsequent adding cyclodextrin for including reaction, and final oxidizing the obtained negative ion inclusion compound with iodine to obtain neutral cyclodextrin-C60 inclusion compound. The present invention makes it possible to form alpha-, beta- and gamma-cyclodextrin-C60 supermolecular inclusion compound with excellent water solubility, so as to promote the application of water soluble C60 in biology and medicine. By means of the increased polarity and charge density of C60 after forming negative ion and the strengthened force between C60 and the cyclodextrin, other alpha- and beta-cyclodextrin-C60 supermolecular inclusion compounds may be prepared. The present invention is significant in synthesis of supermolecules with other large cyclic molecule as main part.

The invention discloses a preparation method of sugammadex. The method comprises the steps of carrying out substitution by adopting fully halogenated gamma-cyclodextrin and 3-(chlorosulfonyl) propionate under the action of alkali to generate 2-ester ethyl sulfuryl-gamma-cyclodextrin; reducing under the action of a reducing agent metal and anhydrous alcohol to generate 2-ester ethyl sulfydryl-gamma-cyclodextrin; and finally adding sodium hydroxide to generate the sugammadex. The preparation method of the sugammadex is simple in operation, the reaction conditions are easy to control, the yield is relatively high and the preparation method has a wide application prospect.

The invention relates to a production process for producing gamma-cyclodextrin by a biological method and belongs to the technical field of cyclodextrin production. The production process solves the technical problems to provide the process for producing gamma-cyclodextrin by the biological method, and the production cost of the gamma-cyclodextrin is reduced. The production process has the technical scheme that the gamma-cyclodextrin glucosyltransferase from alkalophilic bacillus is adopted for producing the gamma-cyclodextrin, the starch pulp regulation is carried out according to the concentration being 10 percent, the materials are stirred for 5 to 15 minutes under the condition being 60 to 90 DEG C, the temperature is set to be 40 to 60 DEG C, the pH is regulated to be about 10.0, the gamma-cyclodextrin glucosyltransferase is added according to a quantity of 1 to 10 units for one gram of starch, after 2 to 5 percent (w / v) organic solvents are added, the sufficient reaction is carried out for 8 to 10 hours, the organic solvents are recovered, and the gamma-cyclodextrin is obtained by adopting a crystallization method.