10 results about "Percutaneous absorption" patented technology

The invention relates to the technical field of plant essential oil, in particular to a compound essential oil composition for improving vascular aging and a preparation method thereof.The essential oil composition comprises, by weight, 50-70 parts of core plant essential oil raw materials; 20-30 parts of an auxiliary plant essential oil raw material; and 5-10 parts of a stabilizer. According to the embodiment of the invention, through precise proportioning of the core and auxiliary plant essential oil, extraction of specific processes such as supercritical COextraction and the like and synergistic effect of the stabilizer, multi-target improvement of vascular aging is carried out, the percutaneous absorption efficiency and stability are improved, and the safety is guaranteed. Therefore, the problems of poor targeting property, volatile effective components, low percutaneous absorption efficiency, single effect and the like of a traditional blood vessel maintenance product are solved.

The present invention relates to atopical detergent composition comprising ascorbyl glucoside and ascorbyl palmitate, a washing and transcutaneous absorption-promoting base comprising at least one non-ionic surfactant, at least one anionic surfactant, glycerol, in combination with suitable excipients and / or diluents.

The invention belongs to the field of health-care physical therapy, and particularly relates to a transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide and a preparation method of the transdermal absorption type foot bath composition. The transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide is firstly provided, the transdermal absorption type foot bath composition comprises the following components: a CO2 generation system, a herbal active extract and a temperature-sensitive retardant, and through the synergistic interaction effect of CO2 and the herbal active extract, the transdermal absorption efficiency of active ingredients of traditional Chinese medicinal materials is promoted, so that the foot bath curative effect is improved; and better use experience is provided for the user. The invention further provides a preparation method of the transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide, and the preparation method is used for producing the foot bath composition and providing a new generation of foot bath products different from traditional foot bath bags for the market.

The invention provides an external application medicine for acute stage of subacute thyroiditis and a preparation method of the external application medicine. The external application medicine comprises an active component, a percutaneous absorption enhancer, an antioxidant and a gel matrix, the active ingredients comprise a traditional Chinese medicine compound extract, a non-steroidal anti-inflammatory drug and an immunomodulator in a specific weight ratio, the percutaneous absorption enhancer is a compound system of paeoniflorin oleate, camellia saponin and menthol, resveratrol and curcumin are added as antioxidants, and the gel matrix is a compound system of carboxymethyl chitosan and sodium alginate. The thyroid gland anti-inflammatory drug has the advantages of high transdermal efficiency and good biocompatibility, can act on thyroid lesions in a targeting manner, quickly relieves neck swelling and pain in the acute stage of subacute thyroiditis, reduces inflammation indexes, and is high in safety, and three-in-one synergistic treatment of anti-inflammatory, immunoregulation, stagnation eliminating and pain relieving is achieved.

The invention discloses a sponge microneedle mediated anti-hair-loss active component composition which can promote percutaneous absorption of hair growth active components. The composition comprises the following active components in percentage by weight: 0.1-6.0% of sponge microneedles subjected to scalp specificity screening, 0.6-10.0% of hair growth active matters (polygonum multiflorum extract, cacumen biotae extract, ginger root extract and the like), 0.2-6.0% of hair follicle metabolism promoting components (biotin, nicotinamide derivatives, hair growth promoting peptides and the like) and the balance of water-based components or excipient matrixes. The sponge microneedle is used as a core mediating carrier, a microchannel is formed through mechanical action, hair growth active ingredients are adsorbed and slowly released, a permeation path around hair follicles is opened, permeation and absorption of active matters to a hair follicle cell layer are enhanced, and various hair growth active ingredients are accurately delivered to a scalp dermis layer and hair follicle root cells, so that the hair follicles are activated, and the hair growth effect is improved. The hair growth is promoted.

The invention discloses a crisaborole nano-cream and a preparation method and application thereof, and the crisaborole nano-cream comprises the following substances in parts by weight: 1-100 parts of crisaborole, 4.5-450 parts of solid lipid, 0.5-50 parts of liquid lipid, 0.5-50 parts of a main emulsifier, 0-50 parts of an auxiliary emulsifier, and 10-1000 parts of deionized water. The preparation method comprises the following steps: heating and melting crisaborole, liquid lipid and solid lipid, heating and uniformly stirring in a water bath to obtain an oil phase, uniformly dispersing an emulsifier in deionized water, and heating and uniformly stirring in the water bath to obtain a water phase; under a constant-temperature stirring condition, transferring the oil phase into a water phase, and shearing to obtain primary emulsion; ultrasonically crushing the primary emulsion at constant temperature, and cooling; and carrying out high-pressure homogenization treatment on the obtained product to obtain primary emulsion, and cooling. The invention provides an application of crisaborole nano-cream in preparation of a medicine for treating dog atopic dermatitis. The crisaborole nano-cream prepared by the preparation method disclosed by the invention is good in characterization performance and stability and relatively good in percutaneous absorption effect.

A percutaneous absorption preparation for the treatment of dementia wherein the drug-containing layer contains donepezil or a pharmaceutically acceptable salt thereof as an active ingredient and a stabilizer that is either (i) a mixture of a thiocyanate salt and a compound selected from the group consisting of tea catechin, (+)-catechin, epigallocatechin gallate, ascorbic acid, and isoascorbic acid, or (ii) a mixture of monothioglycerol and a compound selected from the group consisting of tea catechin, (+)-catechin, epigallocatechin gallate, and ascorbic acid is disclosed. The percutaneous absorption preparation meets the criteria of Procedure 1 and Procedure 2 of the U.S. Pharmacopoeia in short-term stress test (70° C. 48 hours storage), long-term accelerated test 1 (40° C. relative humidity 75% 1 month storage), and long-term accelerated test 2 (40° C. relative humidity 75% 3 months storage), and exhibits improved stability for long-term preservation.

The present invention provides a transdermal absorption composition comprising 4-cyclopropylmethoxy-N-(3, 5-dichloro-1-oxo-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide (tivapram) and levulinic acid, in which the content of levulinic acid is in the range of 4-cyclopropylmethoxy-N-(3, 5-dichloro-1-oxo-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide (tivapram), and the content of levulinic acid is in the range of 4-cyclopropylmethoxy-N-(3, 5-dichloro-1-oxo-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide (tivapram). The ratio of the 2, 5-dichloro-1-oxide-4-pyridine-4-yl)-5-(methoxy) pyridine-2-formamide is 2 to 6 times that of the 2, 5-dichloro-1-oxide-4-pyridine-4-yl)-5-(methoxy) pyridine-2-formamide.