22 results about "Percutaneous absorption" patented technology

The invention provides a traditional Chinese medicine gel patch for treating gouty arthritis and a preparation method thereof. The traditional Chinese medicine gel patch for treating gouty arthritis comprises at least a gel layer loaded with traditional Chinese medicine extracts; the traditional Chinese medicine extracts comprise the following raw materials: coix seed, phellodendron amurense, clematis root, radix scutellariae, atractylodes lancea, radix ophiopogonis, radix scutellariae, acer scutellariae, radix scutellariae, radix aconiti kusnezoffii, radix strychnii, frankincense, myrrh, angelica sinensis, safflower, cyathula root, radix paeoniae rubra, radix smilacis gracile, radix striatae, eucalyptus glomeratae, sophora flavescens, andrographis paniculatae, radix lobeliae, rhizoma coptidis, radix scutellariae, cassia twig, zanthoxylum bungeanum, and borneol; and a matrix of the gel layer comprises the following raw materials in parts by weight: silk fibroin, polyvinyl pyrrolidone, azido-polyethylene glycol-carboxylic acid, 1-ethynylcyclopropylcarboxylic acid, 2,5-dicarboxylic acid-3,4-ethylenedioxythiophene, and glycerol. The traditional Chinese medicine gel plaster of the present invention can achieve good therapeutic effects through percutaneous absorption.

Provided are: lipid-containing nanoparticles that replace a reconstituted high-density lipoprotein (rHDL); and a composition comprising said lipid-containing nanoparticles. This complex comprises a complex lipid and an apolipoprotein A-I-derived helix 4 (H4) peptide, wherein the H4 peptide has an amino acid sequence of YLDDFQKKWQEEMELYRQKVE (SEQ NO. 1) and has a C-terminus that may be amidated. This composition comprises a complex according to the present invention. The composition can be for cosmetic use or percutaneous absorption drug use, or for the treatment of inflammatory diseases.

The invention discloses skin care essential oil as well as a preparation method and application thereof. The skin care essential oil is prepared from the following components in parts by mass: 20 to 40 parts of jasmine flower essential oil nano-liposome, 5 to 11 parts of sandalwood essential oil, 10 to 15 parts of cananga odorata essential oil, 55 to 75 parts of rose essential oil, 4 to 9 parts of beta-glucan, 3 to 12 parts of 1, 2-hexanediol and 3 to 7 parts of strawberry seed oil. The jasmine flower essential oil is loaded in the nano-liposome, so that the skin feeling of the jasmine flower essential oil is improved, the greasy and heavy feeling is reduced, the jasmine flower essential oil can be protected from being oxidized and deteriorated easily, the efficacy stability of the jasmine flower essential oil is improved, the permeability and bioavailability of the jasmine flower essential oil can be improved, and the jasmine flower essential oil can be absorbed and utilized by the skin more easily; meanwhile, the jasmine flower essential oil nano-liposome is compounded with sandalwood essential oil, cananga odorata essential oil, rose essential oil, beta-glucan and polyhydric alcohol, the beta-glucan can cooperate with the liposome to promote percutaneous absorption of the jasmine flower essential oil, and percutaneous absorption of other active components is further promoted.

The present disclosure relates to a high-drug-loading molecular state simvastatin skin ointment and a preparation process therefor. The ointment comprises simvastatin and a basic matrix composition. The basic matrix composition comprises a basic matrix, a solubilizer, a consistency regulator, a stabilizer, and the like. According to the ointment of the present disclosure, simvastatin is stably present in the basic matrix composition in the form of molecules. Phospholipid and cholesterol, as the solubilizer and the stabilizer, are self-assembled in a non-aqueous solution to form a reverse micelle structure, thereby enhancing the stability of a drug. Meanwhile, the solubility of a weak-polarity drug is increased by means of the reverse micelle system, so that the skin retention amount can be greatly increased when the reverse micelle system is used as a percutaneous administration carrier, thereby enhancing the percutaneous absorption of the drug. The formulation of the present disclosure is easy to prepare, good in storage stability, high in drug loading, high in drug accumulation amount in skin, easy to permeate, and quick to take effect, thereby avoiding side effects caused by oral simvastatin.

The invention relates to the technical field of plant essential oil, in particular to a compound essential oil composition for improving vascular aging and a preparation method thereof.The essential oil composition comprises, by weight, 50-70 parts of core plant essential oil raw materials; 20-30 parts of an auxiliary plant essential oil raw material; and 5-10 parts of a stabilizer. According to the embodiment of the invention, through precise proportioning of the core and auxiliary plant essential oil, extraction of specific processes such as supercritical COextraction and the like and synergistic effect of the stabilizer, multi-target improvement of vascular aging is carried out, the percutaneous absorption efficiency and stability are improved, and the safety is guaranteed. Therefore, the problems of poor targeting property, volatile effective components, low percutaneous absorption efficiency, single effect and the like of a traditional blood vessel maintenance product are solved.

The present invention relates to atopical detergent composition comprising ascorbyl glucoside and ascorbyl palmitate, a washing and transcutaneous absorption-promoting base comprising at least one non-ionic surfactant, at least one anionic surfactant, glycerol, in combination with suitable excipients and / or diluents.

The invention belongs to the field of health-care physical therapy, and particularly relates to a transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide and a preparation method of the transdermal absorption type foot bath composition. The transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide is firstly provided, the transdermal absorption type foot bath composition comprises the following components: a CO2 generation system, a herbal active extract and a temperature-sensitive retardant, and through the synergistic interaction effect of CO2 and the herbal active extract, the transdermal absorption efficiency of active ingredients of traditional Chinese medicinal materials is promoted, so that the foot bath curative effect is improved; and better use experience is provided for the user. The invention further provides a preparation method of the transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide, and the preparation method is used for producing the foot bath composition and providing a new generation of foot bath products different from traditional foot bath bags for the market.

The invention relates to the technical field of food additive preparation, in particular to a novel curcumin self-micellization solid dispersion and a preparation method thereof.The method comprises the steps that F127 and TPGS serve as composite carriers, the composite carriers and curcumin raw material medicine are dissolved in absolute ethyl alcohol, a solvent is removed through rotary evaporation, freeze drying, grinding and sieving are conducted, and the self-micellization solid dispersion is prepared. According to the process, the solubility and the stability of the curcumin are remarkably improved, the prepared solid dispersion has the characteristics of high drug loading capacity, good physical stability and rapid in-vitro dissolution, and in a simulated digestion experiment, the release rates of the curcumin in the oral cavity and gastric juice reach 9.9% and 4.6% respectively and are far superior to those of free curcumin, so that the curcumin solid dispersion can be applied to the oral cavity and the gastric juice of the oral cavity and the gastric juice of the oral cavity and the gastric juice of the oral cavity. Through the synergistic effect of micelle wrapping and the surfactant, drug aggregation is effectively reduced, gastrointestinal adsorption and permeation are enhanced, bioavailability is greatly improved, the curcumin dispersible tablet is suitable for development of various efficient preparations such as oral administration, inhalation and percutaneous absorption, and the key problems that curcumin is poor in dissolubility and low in bioavailability are solved.

The invention provides an external application medicine for acute stage of subacute thyroiditis and a preparation method of the external application medicine. The external application medicine comprises an active component, a percutaneous absorption enhancer, an antioxidant and a gel matrix, the active ingredients comprise a traditional Chinese medicine compound extract, a non-steroidal anti-inflammatory drug and an immunomodulator in a specific weight ratio, the percutaneous absorption enhancer is a compound system of paeoniflorin oleate, camellia saponin and menthol, resveratrol and curcumin are added as antioxidants, and the gel matrix is a compound system of carboxymethyl chitosan and sodium alginate. The thyroid gland anti-inflammatory drug has the advantages of high transdermal efficiency and good biocompatibility, can act on thyroid lesions in a targeting manner, quickly relieves neck swelling and pain in the acute stage of subacute thyroiditis, reduces inflammation indexes, and is high in safety, and three-in-one synergistic treatment of anti-inflammatory, immunoregulation, stagnation eliminating and pain relieving is achieved.

The invention discloses a sponge microneedle mediated anti-hair-loss active component composition which can promote percutaneous absorption of hair growth active components. The composition comprises the following active components in percentage by weight: 0.1-6.0% of sponge microneedles subjected to scalp specificity screening, 0.6-10.0% of hair growth active matters (polygonum multiflorum extract, cacumen biotae extract, ginger root extract and the like), 0.2-6.0% of hair follicle metabolism promoting components (biotin, nicotinamide derivatives, hair growth promoting peptides and the like) and the balance of water-based components or excipient matrixes. The sponge microneedle is used as a core mediating carrier, a microchannel is formed through mechanical action, hair growth active ingredients are adsorbed and slowly released, a permeation path around hair follicles is opened, permeation and absorption of active matters to a hair follicle cell layer are enhanced, and various hair growth active ingredients are accurately delivered to a scalp dermis layer and hair follicle root cells, so that the hair follicles are activated, and the hair growth effect is improved. The hair growth is promoted.

The invention discloses a crisaborole nano-cream and a preparation method and application thereof, and the crisaborole nano-cream comprises the following substances in parts by weight: 1-100 parts of crisaborole, 4.5-450 parts of solid lipid, 0.5-50 parts of liquid lipid, 0.5-50 parts of a main emulsifier, 0-50 parts of an auxiliary emulsifier, and 10-1000 parts of deionized water. The preparation method comprises the following steps: heating and melting crisaborole, liquid lipid and solid lipid, heating and uniformly stirring in a water bath to obtain an oil phase, uniformly dispersing an emulsifier in deionized water, and heating and uniformly stirring in the water bath to obtain a water phase; under a constant-temperature stirring condition, transferring the oil phase into a water phase, and shearing to obtain primary emulsion; ultrasonically crushing the primary emulsion at constant temperature, and cooling; and carrying out high-pressure homogenization treatment on the obtained product to obtain primary emulsion, and cooling. The invention provides an application of crisaborole nano-cream in preparation of a medicine for treating dog atopic dermatitis. The crisaborole nano-cream prepared by the preparation method disclosed by the invention is good in characterization performance and stability and relatively good in percutaneous absorption effect.

The present disclosure relates to a high-drug-loading molecular state simvastatin skin ointment and a preparation process therefor. The ointment comprises simvastatin and a basic matrix composition. The basic matrix composition comprises a basic matrix, a solubilizer, a consistency regulator, a stabilizer, and the like. According to the ointment of the present disclosure, simvastatin is stably present in the basic matrix composition in the form of molecules. Phospholipid and cholesterol, as the solubilizer and the stabilizer, are self-assembled in a non-aqueous solution to form a reverse micelle structure, thereby enhancing the stability of a drug. Meanwhile, the solubility of a weak-polarity drug is increased by means of the reverse micelle system, so that the skin retention amount can be greatly increased when the reverse micelle system is used as a percutaneous administration carrier, thereby enhancing the percutaneous absorption of the drug. The formulation of the present disclosure is easy to prepare, good in storage stability, high in drug loading, high in drug accumulation amount in skin, easy to permeate, and quick to take effect, thereby avoiding side effects caused by oral simvastatin.

The invention relates to the technical field of whitening and repairing, in particular to a preparation process of a nicotinamide whitening and repairing mask, which comprises the following steps: dissolving glycerol and 1, 3-propylene glycol in deionized water, adding disodium ethylene diamine tetraacetate, centella asiatica extract and purslane extract, uniformly stirring, and adjusting the pH value to obtain a phase A; adding a nicotinamide-beta-cyclodextrin-polyethylene glycol inclusion compound, a cross-linked hyaluronic acid microgel dispersion, a tranexamic acid liposome dispersion liquid, alpha-arbutin and panthenol, stirring, and adjusting the pH value to obtain essence; and finally, cooling, adding octyloxyglycerin, uniformly stirring, filtering, and dipping in membrane cloth to prepare the nicotinamide whitening and repairing mask. According to the nicotinamide-beta-cyclodextrin-polyethylene glycol inclusion compound, the stability of nicotinamide is effectively improved by utilizing a molecular inclusion technology, the stimulation risk caused by nicotinic acid produced by hydrolysis of the nicotinamide is avoided, and meanwhile, the percutaneous absorption rate of the nicotinamide is enhanced by virtue of the permeation enhancing effect of polyethylene glycol.

The invention discloses an asiatic acid nano-structure lipid carrier and a soluble microneedle drug delivery system, which are characterized in that the dosage form of asiatic acid is designed and optimized, and a drug is prepared into the nano-structure lipid carrier to improve the absorption of the drug, so that the drug effect of asiatic acid is maximized, and the drug delivery efficiency is improved. A soluble microneedle drug delivery system based on a soluble microneedle is designed, the microneedle is combined with an asiatic acid nano-structure lipid carrier, thickened scar tissue is punctured in a novel local percutaneous delivery mode, percutaneous absorption of insoluble traditional Chinese medicine ingredients can be promoted, and the curative effect is improved. According to the microneedle-nanostructure lipid carrier, the physical and chemical infiltration enhancing advantage of the microneedle-nanostructure lipid carrier is fully played, the percutaneous infiltration amount is increased, the problem of low drug absorption efficiency caused by scars is solved, and the adverse reaction of the drug is reduced by utilizing the slow release characteristic of the nanostructure lipid carrier, so that the effects of enhancing efficacy and reducing toxicity are achieved.

Provided is a method for promoting orbicularis oculi blood flow by causing percutaneous absorption of hydrogen from a periphery of an eye, a method for promoting other physiological effects, and an optimal configuration of goggles for supplying hydrogen carrying out these methods. Further, the goggles provided hereunder include a goggle body for integrally covering and sealing a periphery of both eyes including at least a lower eyelid part of a user, a temple member coupled with both side parts of the goggle body, to be hooked on both ears of the user, and a hydrogen releasing part arranged at positions near both lower eyelid parts of the user inside the goggle body, having a pair of hydrogen releasing openings directed to each of the both lower eyelid parts, which are fluidly coupled with a discharging side end part of a tubular tube member connected to an external hydrogen generating apparatus.

The invention provides a compound preparation for delaying and improving muscular atrophy, a preparation method and a collateral dredging and conditioning method. The compound preparation comprises Janus double-sided functional nano-particles, and amber extract and traditional Chinese medicine essential oil which are coated in the nano-particles, borneolum syntheticum is chemically connected to a PEG / lipid skeleton to modify Janus nano-particles, so that the nano-particles have good lipid solubility and are easily inserted into cuticle lipid, and the particles are easier to break through the cuticle; the traditional Chinese medicine essential oil can be loaded inside the particles as a hydrophobic oil phase, is easy to encapsulate and can enter hair follicles and cutin gaps along with the particles; meanwhile, the surface-modified borneol is cooperated with the amber extract, so that the percutaneous absorption rate of effective components of traditional Chinese medicines can be remarkably increased, blood flow is improved, nutrition supply is enhanced, inflammation and oxidation are resisted, muscle fiber regeneration is promoted, local circulation is improved by warming yang and dredging collaterals, and absorption is promoted in cooperation with the heat effect generated by massage and mechanical shearing; finally, the effect of delaying or even partially reversing amyotrophy is achieved.

A percutaneous absorption preparation for the treatment of dementia wherein the drug-containing layer contains donepezil or a pharmaceutically acceptable salt thereof as an active ingredient and a stabilizer that is either (i) a mixture of a thiocyanate salt and a compound selected from the group consisting of tea catechin, (+)-catechin, epigallocatechin gallate, ascorbic acid, and isoascorbic acid, or (ii) a mixture of monothioglycerol and a compound selected from the group consisting of tea catechin, (+)-catechin, epigallocatechin gallate, and ascorbic acid is disclosed. The percutaneous absorption preparation meets the criteria of Procedure 1 and Procedure 2 of the U.S. Pharmacopoeia in short-term stress test (70° C. 48 hours storage), long-term accelerated test 1 (40° C. relative humidity 75% 1 month storage), and long-term accelerated test 2 (40° C. relative humidity 75% 3 months storage), and exhibits improved stability for long-term preservation.

The present invention provides a transdermal absorption composition comprising 4-cyclopropylmethoxy-N-(3, 5-dichloro-1-oxo-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide (tivapram) and levulinic acid, in which the content of levulinic acid is in the range of 4-cyclopropylmethoxy-N-(3, 5-dichloro-1-oxo-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide (tivapram), and the content of levulinic acid is in the range of 4-cyclopropylmethoxy-N-(3, 5-dichloro-1-oxo-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide (tivapram). The ratio of the 2, 5-dichloro-1-oxide-4-pyridine-4-yl)-5-(methoxy) pyridine-2-formamide is 2 to 6 times that of the 2, 5-dichloro-1-oxide-4-pyridine-4-yl)-5-(methoxy) pyridine-2-formamide.

Provided is a drug delivery device capable of improving percutaneous absorption efficiency of a drug.　A drug delivery device (100) has: a drug-containing part (30) that contains a drug; a base material sheet (10); and a first electrode (21) and a second electrode (22) that are disposed on the base material sheet (10). The first electrode (21) and / or the second electrode (22) has a convex part (20) that is convex on the side opposite to the surface facing the base material sheet (10). The potential applied to the first electrode (21) differs from the potential applied to the second electrode (22).

The invention relates to Tibetan medicine bath granules prepared through dry granulation and a preparation method thereof, and belongs to the technical field of external medicine preparations. The particle system is composed of three structural particles of a quick release type, a slow release type and a delayed burst type, and is prepared by a dry pressing process to form a composite system with space release difference and time cooperative control. The quick-release particles contain aromatic Tibetan medicine components and are used for improving skin permeability in the initial bath stage; the sustained-release particles contain a polysaccharide matrix and a sterol Tibetan medicine extract, so that stable and persistent release is realized; the delayed burst particles expand in water and then break, and repair components are released in a concentrated mode. According to the system, the medicine concentration gradient is constructed in the medicated bath process, percutaneous absorption of effective components is enhanced through structural behavior triggering, and the system is suitable for external treatment of rheumatic joint discomfort and skin itch symptoms. The particle system has the synergistic effects of progressive drug effect release, improvement of absorption efficiency and enhancement of use comfort.