53 results about "Percutaneous absorption" patented technology

The invention provides a traditional Chinese medicine gel patch for treating gouty arthritis and a preparation method thereof. The traditional Chinese medicine gel patch for treating gouty arthritis comprises at least a gel layer loaded with traditional Chinese medicine extracts; the traditional Chinese medicine extracts comprise the following raw materials: coix seed, phellodendron amurense, clematis root, radix scutellariae, atractylodes lancea, radix ophiopogonis, radix scutellariae, acer scutellariae, radix scutellariae, radix aconiti kusnezoffii, radix strychnii, frankincense, myrrh, angelica sinensis, safflower, cyathula root, radix paeoniae rubra, radix smilacis gracile, radix striatae, eucalyptus glomeratae, sophora flavescens, andrographis paniculatae, radix lobeliae, rhizoma coptidis, radix scutellariae, cassia twig, zanthoxylum bungeanum, and borneol; and a matrix of the gel layer comprises the following raw materials in parts by weight: silk fibroin, polyvinyl pyrrolidone, azido-polyethylene glycol-carboxylic acid, 1-ethynylcyclopropylcarboxylic acid, 2,5-dicarboxylic acid-3,4-ethylenedioxythiophene, and glycerol. The traditional Chinese medicine gel plaster of the present invention can achieve good therapeutic effects through percutaneous absorption.

The invention belongs to the technical field of cosmetics, and particularly relates to whitening and freckle-removing essence oil and a preparation method thereof. According to the invention, adamantane formyl is introduced into an alpha-arbutin benzene ring to obtain the adamantane formyl modified alpha-arbutin derivative, so that the compatibility of alpha-arbutin and base oil is enhanced; the alpha-arbutin is prevented from being converted into hydroquinone by utilizing the large steric effect of adamantane formyl, so that the safety of the whitening and freckle-removing essence oil is improved; the tranexamic acid is wrapped by the ceramide nano-emulsion, so that the skin allergy risk caused by ingestion of the tranexamic acid is reduced; the ceramide nano-emulsion and tranexamic acid act together to repair skin collagenous fibers, block melanin transfer and inhibit melanin synthesis; trilinolein and glabridin are catalyzed by lipase to form a compound, so that the molecular compatibility and photo-thermal stability of glabridin are enhanced; glycerin promotes transdermal absorption of glabridin and enhances the efficacy of the whitening and freckle-removing essence oil.

The invention relates to a preparation method of efficient transdermal regeneration polysaccharide cream ball skin care product emulsion. The preparation method of the efficient transdermal regeneration polysaccharide cream ball skin care product emulsion comprises the following steps: (1) peeling and pulping aloe leaves to obtain gel; (2) sequentially carrying out low-temperature stirring treatment and high-temperature film evaporation treatment on the gel to obtain an aloe primary extract; (3) treating the primary aloe extract and wheat germ oil in a double-cone rotary reactor for 24 hours, and then performing deoiling treatment to obtain oil-water amphiphilic aloe polysaccharide; (4) performing high-shear homogenization on the oil-water amphiphilic aloe polysaccharide and water, and homogenizing by a homogenizer to fully fuse the two to obtain a primary emulsion; and (5) adding vegetable oil into the primary emulsion, and continuously homogenizing by using the homogenizer to fully fuse all the components. According to the invention, the percutaneous absorption permeation rate can be accelerated, the wound regeneration and repair can be accelerated, and the application prospect of the obtained microemulsion in cosmetics, medical instruments and medicine scenes is verified.

To provide a lyotropic liquid crystal composition containing a polyglycerol surfactant.SOLUTION: A lyotropic liquid crystal composition is produced by adding, to a polyglycerol surfactant, a fatty acid or lipid combined with a monosaccharide or disaccharide, an oily component, and an aqueous component. The present disclosure allows for the provision of a lyotropic liquid crystal composition that exhibits high compatibility with the living organisms and the environment, and ensures high percutaneous absorption of active ingredients, thereby enabling the production of topical skin preparations and cosmetics containing the composition.SELECTED DRAWING: None

The microwave controlled-release corrosion type microneedle emplastrum comprises corrosion type microneedles, emplastrum, a microwave device, a power supply device, a regulation and control device and a fixing device, medicine is carried in the emplastrum, the corrosion type microneedles are arranged in a matrix mode and embedded in an emplastrum body layer, the emplastrum does not contain percutaneous absorption enhancer, and the microwave device is connected with the microwave device. The arrangement sequence of the corrosion type microneedle, the emplastrum and the microwave device is as follows: the corrosion type microneedle, the emplastrum and the microwave device. The microwave controlled-release corrosion type microneedle emplastrum is applied to the skin surface and organically combines a microwave mediation technology, an emplastrum, a corrosion type microneedle technology and an intelligent controlled-release technology to form a synergistic complementary effect; the problems that a traditional skin preparation is difficult to penetrate through a skin barrier, the drug release rate cannot be accurately controlled, and the dosage cannot be adjusted in time are solved, and transdermal drug absorption is facilitated to achieve the treatment effect to achieve safe and intelligent treatment.

Provided is an adhesive patch having excellent percutaneous absorption of selexipag. The adhesive patch of the present invention is characterized by including a backing and an adhesive layer that is integrally laminated on one surface of the backing and includes selexipag and an acrylic adhesive. In the adhesive layer, selexipag and an acrylic adhesive are used in combination to provide an adhesive patch having excellent percutaneous absorption of selexipag. The adhesive patch can percutaneously administer selexipag as a drug.

The present invention relates to a hyaluronate nanofabric sheet and a manufacturing method therefor and, more particularly, to a hyaluronate nanofabric sheet having excellent percutaneous absorption and physical properties and a manufacturing method therefor. A method for manufacturing a hyaluronate nanofabric sheet according to the present invention comprises the steps of: (a) mixing a hyaluronate having a weight average molecular weight of 5×103 - 5×104 Da and a hyaluronate having a weight average molecular weight of 1×105 - 1×106Da and dissolving same in water to prepare an aqueous hyaluronate solution; and (b) electrospinning the aqueous hyaluronate solution. The hyaluronate nanofabric sheet of the present invention has an excellent transdermal absorption rate due to the ultra-low molecular weight hyaluronic acid as a main component thereof and exhibits excellent physical properties due to a certain amount of medium-molecular weight hyaluronic acid mixed therewith, and as such, can be applied for various purposes, such as mask patches for topical uses, ophthalmic or mucosal drug delivery systems, etc.

The present invention relates to a percutaneous absorption preparation for relieving pain and, more specifically, to a percutaneous absorption preparation having enhanced drug absorption efficacy. Every ingredient in the percutaneous absorption preparation according to the present invention is uniformly dispersed and does not aggregate, and thus a sufficient anti-inflammatory and pain-relieving efficacy of the drug can be continuously exhibited over a long period of time. In addition, the drug is percutaneously delivered in an amount sufficient for exhibiting efficacy while minimizing skin irritation, which is a disadvantage of percutaneous absorption preparations, and thus a high level of pain-relieving efficacy is exhibited. Moreover, skin penetration promotion in which a consistent amount of percutaneous drug absorption is sustained over a long period of time can be achieved, and thus side effects such as the hepatic first-pass effect in the body can be prevented.

Provided are: lipid-containing nanoparticles that replace a reconstituted high-density lipoprotein (rHDL); and a composition comprising said lipid-containing nanoparticles. This complex comprises a complex lipid and an apolipoprotein A-I-derived helix 4 (H4) peptide, wherein the H4 peptide has an amino acid sequence of YLDDFQKKWQEEMELYRQKVE (SEQ NO. 1) and has a C-terminus that may be amidated. This composition comprises a complex according to the present invention. The composition can be for cosmetic use or percutaneous absorption drug use, or for the treatment of inflammatory diseases.

The invention relates to the technical field of masks, in particular to a citron extract sleeping mask and a preparation method of the citron extract sleeping mask. 15-25 parts of an intelligent moisturizing system; 3-8 parts of a brain wave synergistic sleep-aiding compound; 8-12 parts of a skin barrier repair system; 2-5 parts of a texture conditioning agent; 0.5 to 1.5 parts of an anticorrosion system; 0.1 to 0.5 part of a fragrance system; according to the present invention, the dual targeting delivery system is developed, the fat-soluble d-limonene is wrapped in the liposome, and the water-soluble naringin is delivered through the nano-micelle; the phospholipid bilayer structure of the liposome is similar to the skin cuticle, so that the transdermal absorption of d-limonene can be promoted. The nano-micelle realizes stable embedding and slow release of the water-soluble flavone through a hydrophilic shell and a hydrophobic core of the nano-micelle. By means of the design, the percutaneous absorption efficiency of the active ingredients is improved, and time-sequence-controllable release is achieved.

The invention discloses skin care essential oil as well as a preparation method and application thereof. The skin care essential oil is prepared from the following components in parts by mass: 20 to 40 parts of jasmine flower essential oil nano-liposome, 5 to 11 parts of sandalwood essential oil, 10 to 15 parts of cananga odorata essential oil, 55 to 75 parts of rose essential oil, 4 to 9 parts of beta-glucan, 3 to 12 parts of 1, 2-hexanediol and 3 to 7 parts of strawberry seed oil. The jasmine flower essential oil is loaded in the nano-liposome, so that the skin feeling of the jasmine flower essential oil is improved, the greasy and heavy feeling is reduced, the jasmine flower essential oil can be protected from being oxidized and deteriorated easily, the efficacy stability of the jasmine flower essential oil is improved, the permeability and bioavailability of the jasmine flower essential oil can be improved, and the jasmine flower essential oil can be absorbed and utilized by the skin more easily; meanwhile, the jasmine flower essential oil nano-liposome is compounded with sandalwood essential oil, cananga odorata essential oil, rose essential oil, beta-glucan and polyhydric alcohol, the beta-glucan can cooperate with the liposome to promote percutaneous absorption of the jasmine flower essential oil, and percutaneous absorption of other active components is further promoted.

The present disclosure relates to a high-drug-loading molecular state simvastatin skin ointment and a preparation process therefor. The ointment comprises simvastatin and a basic matrix composition. The basic matrix composition comprises a basic matrix, a solubilizer, a consistency regulator, a stabilizer, and the like. According to the ointment of the present disclosure, simvastatin is stably present in the basic matrix composition in the form of molecules. Phospholipid and cholesterol, as the solubilizer and the stabilizer, are self-assembled in a non-aqueous solution to form a reverse micelle structure, thereby enhancing the stability of a drug. Meanwhile, the solubility of a weak-polarity drug is increased by means of the reverse micelle system, so that the skin retention amount can be greatly increased when the reverse micelle system is used as a percutaneous administration carrier, thereby enhancing the percutaneous absorption of the drug. The formulation of the present disclosure is easy to prepare, good in storage stability, high in drug loading, high in drug accumulation amount in skin, easy to permeate, and quick to take effect, thereby avoiding side effects caused by oral simvastatin.

The invention relates to the technical field of plant essential oil, in particular to a compound essential oil composition for improving vascular aging and a preparation method thereof.The essential oil composition comprises, by weight, 50-70 parts of core plant essential oil raw materials; 20-30 parts of an auxiliary plant essential oil raw material; and 5-10 parts of a stabilizer. According to the embodiment of the invention, through precise proportioning of the core and auxiliary plant essential oil, extraction of specific processes such as supercritical COextraction and the like and synergistic effect of the stabilizer, multi-target improvement of vascular aging is carried out, the percutaneous absorption efficiency and stability are improved, and the safety is guaranteed. Therefore, the problems of poor targeting property, volatile effective components, low percutaneous absorption efficiency, single effect and the like of a traditional blood vessel maintenance product are solved.

The present invention relates to a transdermal absorption preparation for treating dementia, wherein the drug-containing layer contains donepezil or a pharmaceutically acceptable salt thereof as an active ingredient and a stabilizer, wherein the stabilizer is (i) a mixture of thiocyanate and a compound selected from the group consisting of tea catechins, (+)-catechins, epigallocatechin gallate, ascorbic acid and isoascorbic acid, or (ii) a mixture of thioglycerol and a compound selected from the group consisting of tea catechins, (+)-catechins, epigallocatechin gallate and ascorbic acid. The present invention provides a transdermal absorption preparation containing donepezil that meets the standards of the first method and the second method set forth in the United States Pharmacopoeia. The transdermal absorption preparation containing donepezil can reduce the generation of impurities by inhibiting the degradation of donepezil, thereby producing a transdermal absorption preparation containing donepezil with improved long-term storage stability.

The present invention relates to atopical detergent composition comprising ascorbyl glucoside and ascorbyl palmitate, a washing and transcutaneous absorption-promoting base comprising at least one non-ionic surfactant, at least one anionic surfactant, glycerol, in combination with suitable excipients and / or diluents.

The invention belongs to the field of health-care physical therapy, and particularly relates to a transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide and a preparation method of the transdermal absorption type foot bath composition. The transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide is firstly provided, the transdermal absorption type foot bath composition comprises the following components: a CO2 generation system, a herbal active extract and a temperature-sensitive retardant, and through the synergistic interaction effect of CO2 and the herbal active extract, the transdermal absorption efficiency of active ingredients of traditional Chinese medicinal materials is promoted, so that the foot bath curative effect is improved; and better use experience is provided for the user. The invention further provides a preparation method of the transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide, and the preparation method is used for producing the foot bath composition and providing a new generation of foot bath products different from traditional foot bath bags for the market.

The invention discloses an itching-relieving gel containing 3-hydroxydecanoic acid microemulsion and a preparation method thereof, the gel combines natural itching-relieving components 3-hydroxydecanoic acid and peppermint essential oil, the natural itching-relieving components 3-hydroxydecanoic acid and peppermint essential oil are prepared into a microemulsion form, nanoscale liquid drops are compounded with a skin-promoting absorbent, and the gel is slowly released, so that the itching-relieving effect is achieved. Therefore, the percutaneous absorption efficiency is improved, the residence time in the skin is prolonged, and a lasting itching relieving effect is realized; 3-hydroxydecanoic acid exerts an itching relieving effect through an anti-inflammatory effect, blocking of an itching signal channel and reduction of mast cell degranulation, and the itching relieving gel is stable at room temperature, convenient to use and suitable for relieving mosquito bites and skin itch problems caused by histamine or non-histamine substances and the like.

Disclosed is a percutaneous absorption preparation containing donepezil that is a pharmacologically active substance useful in treating Alzheimer's dementia symptoms. This percutaneous absorption preparation suppresses donepezil drug crystallization in the percutaneous absorption preparation even when left at room temperature for a long period of time, can improve a percutaneous permeability degree (cumulative permeation amount and skin permeation rate) of the drug, and in particular, can significantly increase the drug absorption of donepezil despite of a small drug loading amount compared to the currently commercially available Donerion patch.

The present invention provides an adhesive sheet for skin comprising a support and an adhesive layer formed on the support, wherein the adhesive layer comprises at least a thermoplastic elastomer, non-volatile hydrocarbon oil and polyisobutylene having a viscosity average molecular weight of more than 100,000 and not more than 500,000, and a tackifier is not contained.

The invention relates to the technical field of food additive preparation, in particular to a novel curcumin self-micellization solid dispersion and a preparation method thereof.The method comprises the steps that F127 and TPGS serve as composite carriers, the composite carriers and curcumin raw material medicine are dissolved in absolute ethyl alcohol, a solvent is removed through rotary evaporation, freeze drying, grinding and sieving are conducted, and the self-micellization solid dispersion is prepared. According to the process, the solubility and the stability of the curcumin are remarkably improved, the prepared solid dispersion has the characteristics of high drug loading capacity, good physical stability and rapid in-vitro dissolution, and in a simulated digestion experiment, the release rates of the curcumin in the oral cavity and gastric juice reach 9.9% and 4.6% respectively and are far superior to those of free curcumin, so that the curcumin solid dispersion can be applied to the oral cavity and the gastric juice of the oral cavity and the gastric juice of the oral cavity and the gastric juice of the oral cavity. Through the synergistic effect of micelle wrapping and the surfactant, drug aggregation is effectively reduced, gastrointestinal adsorption and permeation are enhanced, bioavailability is greatly improved, the curcumin dispersible tablet is suitable for development of various efficient preparations such as oral administration, inhalation and percutaneous absorption, and the key problems that curcumin is poor in dissolubility and low in bioavailability are solved.

The invention provides an external application medicine for acute stage of subacute thyroiditis and a preparation method of the external application medicine. The external application medicine comprises an active component, a percutaneous absorption enhancer, an antioxidant and a gel matrix, the active ingredients comprise a traditional Chinese medicine compound extract, a non-steroidal anti-inflammatory drug and an immunomodulator in a specific weight ratio, the percutaneous absorption enhancer is a compound system of paeoniflorin oleate, camellia saponin and menthol, resveratrol and curcumin are added as antioxidants, and the gel matrix is a compound system of carboxymethyl chitosan and sodium alginate. The thyroid gland anti-inflammatory drug has the advantages of high transdermal efficiency and good biocompatibility, can act on thyroid lesions in a targeting manner, quickly relieves neck swelling and pain in the acute stage of subacute thyroiditis, reduces inflammation indexes, and is high in safety, and three-in-one synergistic treatment of anti-inflammatory, immunoregulation, stagnation eliminating and pain relieving is achieved.

The invention discloses a percutaneous absorption preparation which comprises a release film, a medicine storage layer and a backing layer, the medicine storage layer at least comprises an active ingredient, a penetration enhancer and a pressure-sensitive adhesive; the active ingredients are tandospirone and pharmaceutically acceptable salts thereof. According to the invention, the specific active components are matched with the combined penetration enhancer, so that the permeation amount per unit area can be effectively increased, the problem of crystallization of the active components in the patch can be solved, the preparation process is simple, and the quality is stable and reliable; the medicine storage layer is in a semi-solid gel shape with good transdermal absorption, active ingredients are completely dissolved and dispersed in the medicine storage layer, the preparation process is simple, the preparation quality is stable and reliable, the limitation of medicine taking times and time is reduced through local external administration treatment, and a new administration approach is provided.

The invention discloses a sponge microneedle mediated anti-hair-loss active component composition which can promote percutaneous absorption of hair growth active components. The composition comprises the following active components in percentage by weight: 0.1-6.0% of sponge microneedles subjected to scalp specificity screening, 0.6-10.0% of hair growth active matters (polygonum multiflorum extract, cacumen biotae extract, ginger root extract and the like), 0.2-6.0% of hair follicle metabolism promoting components (biotin, nicotinamide derivatives, hair growth promoting peptides and the like) and the balance of water-based components or excipient matrixes. The sponge microneedle is used as a core mediating carrier, a microchannel is formed through mechanical action, hair growth active ingredients are adsorbed and slowly released, a permeation path around hair follicles is opened, permeation and absorption of active matters to a hair follicle cell layer are enhanced, and various hair growth active ingredients are accurately delivered to a scalp dermis layer and hair follicle root cells, so that the hair follicles are activated, and the hair growth effect is improved. The hair growth is promoted.

The present invention relates to a topical detergent composition comprising ascorbyl glucoside and ascorbyl palmitate, a matrix for washing and promoting transdermal absorption, said matrix comprising at least one nonionic surfactant, at least one anionic surfactant, and glycerol, in combination with suitable excipients and / or diluents.

The invention discloses a crisaborole nano-cream and a preparation method and application thereof, and the crisaborole nano-cream comprises the following substances in parts by weight: 1-100 parts of crisaborole, 4.5-450 parts of solid lipid, 0.5-50 parts of liquid lipid, 0.5-50 parts of a main emulsifier, 0-50 parts of an auxiliary emulsifier, and 10-1000 parts of deionized water. The preparation method comprises the following steps: heating and melting crisaborole, liquid lipid and solid lipid, heating and uniformly stirring in a water bath to obtain an oil phase, uniformly dispersing an emulsifier in deionized water, and heating and uniformly stirring in the water bath to obtain a water phase; under a constant-temperature stirring condition, transferring the oil phase into a water phase, and shearing to obtain primary emulsion; ultrasonically crushing the primary emulsion at constant temperature, and cooling; and carrying out high-pressure homogenization treatment on the obtained product to obtain primary emulsion, and cooling. The invention provides an application of crisaborole nano-cream in preparation of a medicine for treating dog atopic dermatitis. The crisaborole nano-cream prepared by the preparation method disclosed by the invention is good in characterization performance and stability and relatively good in percutaneous absorption effect.

The present disclosure relates to a method for manufacturing a spicule capable of promoting percutaneous absorption of skin improvement active ingredients and fine diamonds, a spicule manufactured thereby, and a cosmetic composition comprising the same. A spicule cosmetic composition prepared according to the present disclosure can be used in the preparation of a cosmetic composition that may have excellent percutaneous penetration efficacy and may be excellent in functionality.

The present disclosure relates to a high-drug-loading molecular state simvastatin skin ointment and a preparation process therefor. The ointment comprises simvastatin and a basic matrix composition. The basic matrix composition comprises a basic matrix, a solubilizer, a consistency regulator, a stabilizer, and the like. According to the ointment of the present disclosure, simvastatin is stably present in the basic matrix composition in the form of molecules. Phospholipid and cholesterol, as the solubilizer and the stabilizer, are self-assembled in a non-aqueous solution to form a reverse micelle structure, thereby enhancing the stability of a drug. Meanwhile, the solubility of a weak-polarity drug is increased by means of the reverse micelle system, so that the skin retention amount can be greatly increased when the reverse micelle system is used as a percutaneous administration carrier, thereby enhancing the percutaneous absorption of the drug. The formulation of the present disclosure is easy to prepare, good in storage stability, high in drug loading, high in drug accumulation amount in skin, easy to permeate, and quick to take effect, thereby avoiding side effects caused by oral simvastatin.

The invention relates to the field of medical auxiliary instruments, in particular to an intelligent regulation and control method and equipment for the transdermal absorption rate of a medicine, and the method comprises the following steps: S1, calculating the disease degree score of a patient according to the temperature data of a disease part of the patient and the temperature and humidity data of the environment where the patient is located; s2, the heating temperature is adjusted according to the disease degree score of the patient, and the percutaneous absorption rate of the medicine is dynamically adjusted by adjusting the heating temperature. According to internal data such as physiology and pathology of the patient and external data such as temperature and humidity of the environment, the disease degree of the patient is evaluated and predicted; the medicine percutaneous absorption rate is adjusted according to the disease degree of a patient; and the heating temperature is dynamically adjusted according to the transdermal absorption rate of the medicine. Therefore, the percutaneous absorption rate of the medicine is intelligently and dynamically regulated according to the disease degree change of a patient, namely the medicine dosage is regulated in real time, and the purpose of intelligent administration is achieved.