32 results about "Percutaneous absorption" patented technology

The invention provides a traditional Chinese medicine gel patch for treating gouty arthritis and a preparation method thereof. The traditional Chinese medicine gel patch for treating gouty arthritis comprises at least a gel layer loaded with traditional Chinese medicine extracts; the traditional Chinese medicine extracts comprise the following raw materials: coix seed, phellodendron amurense, clematis root, radix scutellariae, atractylodes lancea, radix ophiopogonis, radix scutellariae, acer scutellariae, radix scutellariae, radix aconiti kusnezoffii, radix strychnii, frankincense, myrrh, angelica sinensis, safflower, cyathula root, radix paeoniae rubra, radix smilacis gracile, radix striatae, eucalyptus glomeratae, sophora flavescens, andrographis paniculatae, radix lobeliae, rhizoma coptidis, radix scutellariae, cassia twig, zanthoxylum bungeanum, and borneol; and a matrix of the gel layer comprises the following raw materials in parts by weight: silk fibroin, polyvinyl pyrrolidone, azido-polyethylene glycol-carboxylic acid, 1-ethynylcyclopropylcarboxylic acid, 2,5-dicarboxylic acid-3,4-ethylenedioxythiophene, and glycerol. The traditional Chinese medicine gel plaster of the present invention can achieve good therapeutic effects through percutaneous absorption.

The invention belongs to the technical field of cosmetics, and particularly relates to whitening and freckle-removing essence oil and a preparation method thereof. According to the invention, adamantane formyl is introduced into an alpha-arbutin benzene ring to obtain the adamantane formyl modified alpha-arbutin derivative, so that the compatibility of alpha-arbutin and base oil is enhanced; the alpha-arbutin is prevented from being converted into hydroquinone by utilizing the large steric effect of adamantane formyl, so that the safety of the whitening and freckle-removing essence oil is improved; the tranexamic acid is wrapped by the ceramide nano-emulsion, so that the skin allergy risk caused by ingestion of the tranexamic acid is reduced; the ceramide nano-emulsion and tranexamic acid act together to repair skin collagenous fibers, block melanin transfer and inhibit melanin synthesis; trilinolein and glabridin are catalyzed by lipase to form a compound, so that the molecular compatibility and photo-thermal stability of glabridin are enhanced; glycerin promotes transdermal absorption of glabridin and enhances the efficacy of the whitening and freckle-removing essence oil.

The present invention relates to a percutaneous absorption preparation for relieving pain and, more specifically, to a percutaneous absorption preparation having enhanced drug absorption efficacy. Every ingredient in the percutaneous absorption preparation according to the present invention is uniformly dispersed and does not aggregate, and thus a sufficient anti-inflammatory and pain-relieving efficacy of the drug can be continuously exhibited over a long period of time. In addition, the drug is percutaneously delivered in an amount sufficient for exhibiting efficacy while minimizing skin irritation, which is a disadvantage of percutaneous absorption preparations, and thus a high level of pain-relieving efficacy is exhibited. Moreover, skin penetration promotion in which a consistent amount of percutaneous drug absorption is sustained over a long period of time can be achieved, and thus side effects such as the hepatic first-pass effect in the body can be prevented.

Provided are: lipid-containing nanoparticles that replace a reconstituted high-density lipoprotein (rHDL); and a composition comprising said lipid-containing nanoparticles. This complex comprises a complex lipid and an apolipoprotein A-I-derived helix 4 (H4) peptide, wherein the H4 peptide has an amino acid sequence of YLDDFQKKWQEEMELYRQKVE (SEQ NO. 1) and has a C-terminus that may be amidated. This composition comprises a complex according to the present invention. The composition can be for cosmetic use or percutaneous absorption drug use, or for the treatment of inflammatory diseases.

The invention relates to the technical field of masks, in particular to a citron extract sleeping mask and a preparation method of the citron extract sleeping mask. 15-25 parts of an intelligent moisturizing system; 3-8 parts of a brain wave synergistic sleep-aiding compound; 8-12 parts of a skin barrier repair system; 2-5 parts of a texture conditioning agent; 0.5 to 1.5 parts of an anticorrosion system; 0.1 to 0.5 part of a fragrance system; according to the present invention, the dual targeting delivery system is developed, the fat-soluble d-limonene is wrapped in the liposome, and the water-soluble naringin is delivered through the nano-micelle; the phospholipid bilayer structure of the liposome is similar to the skin cuticle, so that the transdermal absorption of d-limonene can be promoted. The nano-micelle realizes stable embedding and slow release of the water-soluble flavone through a hydrophilic shell and a hydrophobic core of the nano-micelle. By means of the design, the percutaneous absorption efficiency of the active ingredients is improved, and time-sequence-controllable release is achieved.

The invention discloses skin care essential oil as well as a preparation method and application thereof. The skin care essential oil is prepared from the following components in parts by mass: 20 to 40 parts of jasmine flower essential oil nano-liposome, 5 to 11 parts of sandalwood essential oil, 10 to 15 parts of cananga odorata essential oil, 55 to 75 parts of rose essential oil, 4 to 9 parts of beta-glucan, 3 to 12 parts of 1, 2-hexanediol and 3 to 7 parts of strawberry seed oil. The jasmine flower essential oil is loaded in the nano-liposome, so that the skin feeling of the jasmine flower essential oil is improved, the greasy and heavy feeling is reduced, the jasmine flower essential oil can be protected from being oxidized and deteriorated easily, the efficacy stability of the jasmine flower essential oil is improved, the permeability and bioavailability of the jasmine flower essential oil can be improved, and the jasmine flower essential oil can be absorbed and utilized by the skin more easily; meanwhile, the jasmine flower essential oil nano-liposome is compounded with sandalwood essential oil, cananga odorata essential oil, rose essential oil, beta-glucan and polyhydric alcohol, the beta-glucan can cooperate with the liposome to promote percutaneous absorption of the jasmine flower essential oil, and percutaneous absorption of other active components is further promoted.

The present disclosure relates to a high-drug-loading molecular state simvastatin skin ointment and a preparation process therefor. The ointment comprises simvastatin and a basic matrix composition. The basic matrix composition comprises a basic matrix, a solubilizer, a consistency regulator, a stabilizer, and the like. According to the ointment of the present disclosure, simvastatin is stably present in the basic matrix composition in the form of molecules. Phospholipid and cholesterol, as the solubilizer and the stabilizer, are self-assembled in a non-aqueous solution to form a reverse micelle structure, thereby enhancing the stability of a drug. Meanwhile, the solubility of a weak-polarity drug is increased by means of the reverse micelle system, so that the skin retention amount can be greatly increased when the reverse micelle system is used as a percutaneous administration carrier, thereby enhancing the percutaneous absorption of the drug. The formulation of the present disclosure is easy to prepare, good in storage stability, high in drug loading, high in drug accumulation amount in skin, easy to permeate, and quick to take effect, thereby avoiding side effects caused by oral simvastatin.

The invention relates to the technical field of plant essential oil, in particular to a compound essential oil composition for improving vascular aging and a preparation method thereof.The essential oil composition comprises, by weight, 50-70 parts of core plant essential oil raw materials; 20-30 parts of an auxiliary plant essential oil raw material; and 5-10 parts of a stabilizer. According to the embodiment of the invention, through precise proportioning of the core and auxiliary plant essential oil, extraction of specific processes such as supercritical COextraction and the like and synergistic effect of the stabilizer, multi-target improvement of vascular aging is carried out, the percutaneous absorption efficiency and stability are improved, and the safety is guaranteed. Therefore, the problems of poor targeting property, volatile effective components, low percutaneous absorption efficiency, single effect and the like of a traditional blood vessel maintenance product are solved.

The present invention relates to atopical detergent composition comprising ascorbyl glucoside and ascorbyl palmitate, a washing and transcutaneous absorption-promoting base comprising at least one non-ionic surfactant, at least one anionic surfactant, glycerol, in combination with suitable excipients and / or diluents.

The invention belongs to the field of health-care physical therapy, and particularly relates to a transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide and a preparation method of the transdermal absorption type foot bath composition. The transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide is firstly provided, the transdermal absorption type foot bath composition comprises the following components: a CO2 generation system, a herbal active extract and a temperature-sensitive retardant, and through the synergistic interaction effect of CO2 and the herbal active extract, the transdermal absorption efficiency of active ingredients of traditional Chinese medicinal materials is promoted, so that the foot bath curative effect is improved; and better use experience is provided for the user. The invention further provides a preparation method of the transdermal absorption type foot bath composition capable of continuously releasing carbon dioxide, and the preparation method is used for producing the foot bath composition and providing a new generation of foot bath products different from traditional foot bath bags for the market.

Disclosed is a percutaneous absorption preparation containing donepezil that is a pharmacologically active substance useful in treating Alzheimer's dementia symptoms. This percutaneous absorption preparation suppresses donepezil drug crystallization in the percutaneous absorption preparation even when left at room temperature for a long period of time, can improve a percutaneous permeability degree (cumulative permeation amount and skin permeation rate) of the drug, and in particular, can significantly increase the drug absorption of donepezil despite of a small drug loading amount compared to the currently commercially available Donerion patch.

The invention relates to the technical field of food additive preparation, in particular to a novel curcumin self-micellization solid dispersion and a preparation method thereof.The method comprises the steps that F127 and TPGS serve as composite carriers, the composite carriers and curcumin raw material medicine are dissolved in absolute ethyl alcohol, a solvent is removed through rotary evaporation, freeze drying, grinding and sieving are conducted, and the self-micellization solid dispersion is prepared. According to the process, the solubility and the stability of the curcumin are remarkably improved, the prepared solid dispersion has the characteristics of high drug loading capacity, good physical stability and rapid in-vitro dissolution, and in a simulated digestion experiment, the release rates of the curcumin in the oral cavity and gastric juice reach 9.9% and 4.6% respectively and are far superior to those of free curcumin, so that the curcumin solid dispersion can be applied to the oral cavity and the gastric juice of the oral cavity and the gastric juice of the oral cavity and the gastric juice of the oral cavity. Through the synergistic effect of micelle wrapping and the surfactant, drug aggregation is effectively reduced, gastrointestinal adsorption and permeation are enhanced, bioavailability is greatly improved, the curcumin dispersible tablet is suitable for development of various efficient preparations such as oral administration, inhalation and percutaneous absorption, and the key problems that curcumin is poor in dissolubility and low in bioavailability are solved.

The invention provides an external application medicine for acute stage of subacute thyroiditis and a preparation method of the external application medicine. The external application medicine comprises an active component, a percutaneous absorption enhancer, an antioxidant and a gel matrix, the active ingredients comprise a traditional Chinese medicine compound extract, a non-steroidal anti-inflammatory drug and an immunomodulator in a specific weight ratio, the percutaneous absorption enhancer is a compound system of paeoniflorin oleate, camellia saponin and menthol, resveratrol and curcumin are added as antioxidants, and the gel matrix is a compound system of carboxymethyl chitosan and sodium alginate. The thyroid gland anti-inflammatory drug has the advantages of high transdermal efficiency and good biocompatibility, can act on thyroid lesions in a targeting manner, quickly relieves neck swelling and pain in the acute stage of subacute thyroiditis, reduces inflammation indexes, and is high in safety, and three-in-one synergistic treatment of anti-inflammatory, immunoregulation, stagnation eliminating and pain relieving is achieved.

The invention discloses a sponge microneedle mediated anti-hair-loss active component composition which can promote percutaneous absorption of hair growth active components. The composition comprises the following active components in percentage by weight: 0.1-6.0% of sponge microneedles subjected to scalp specificity screening, 0.6-10.0% of hair growth active matters (polygonum multiflorum extract, cacumen biotae extract, ginger root extract and the like), 0.2-6.0% of hair follicle metabolism promoting components (biotin, nicotinamide derivatives, hair growth promoting peptides and the like) and the balance of water-based components or excipient matrixes. The sponge microneedle is used as a core mediating carrier, a microchannel is formed through mechanical action, hair growth active ingredients are adsorbed and slowly released, a permeation path around hair follicles is opened, permeation and absorption of active matters to a hair follicle cell layer are enhanced, and various hair growth active ingredients are accurately delivered to a scalp dermis layer and hair follicle root cells, so that the hair follicles are activated, and the hair growth effect is improved. The hair growth is promoted.

The present invention relates to a topical detergent composition comprising ascorbyl glucoside and ascorbyl palmitate, a matrix for washing and promoting transdermal absorption, said matrix comprising at least one nonionic surfactant, at least one anionic surfactant, and glycerol, in combination with suitable excipients and / or diluents.

The invention discloses a crisaborole nano-cream and a preparation method and application thereof, and the crisaborole nano-cream comprises the following substances in parts by weight: 1-100 parts of crisaborole, 4.5-450 parts of solid lipid, 0.5-50 parts of liquid lipid, 0.5-50 parts of a main emulsifier, 0-50 parts of an auxiliary emulsifier, and 10-1000 parts of deionized water. The preparation method comprises the following steps: heating and melting crisaborole, liquid lipid and solid lipid, heating and uniformly stirring in a water bath to obtain an oil phase, uniformly dispersing an emulsifier in deionized water, and heating and uniformly stirring in the water bath to obtain a water phase; under a constant-temperature stirring condition, transferring the oil phase into a water phase, and shearing to obtain primary emulsion; ultrasonically crushing the primary emulsion at constant temperature, and cooling; and carrying out high-pressure homogenization treatment on the obtained product to obtain primary emulsion, and cooling. The invention provides an application of crisaborole nano-cream in preparation of a medicine for treating dog atopic dermatitis. The crisaborole nano-cream prepared by the preparation method disclosed by the invention is good in characterization performance and stability and relatively good in percutaneous absorption effect.

The present disclosure relates to a method for manufacturing a spicule capable of promoting percutaneous absorption of skin improvement active ingredients and fine diamonds, a spicule manufactured thereby, and a cosmetic composition comprising the same. A spicule cosmetic composition prepared according to the present disclosure can be used in the preparation of a cosmetic composition that may have excellent percutaneous penetration efficacy and may be excellent in functionality.

The present disclosure relates to a high-drug-loading molecular state simvastatin skin ointment and a preparation process therefor. The ointment comprises simvastatin and a basic matrix composition. The basic matrix composition comprises a basic matrix, a solubilizer, a consistency regulator, a stabilizer, and the like. According to the ointment of the present disclosure, simvastatin is stably present in the basic matrix composition in the form of molecules. Phospholipid and cholesterol, as the solubilizer and the stabilizer, are self-assembled in a non-aqueous solution to form a reverse micelle structure, thereby enhancing the stability of a drug. Meanwhile, the solubility of a weak-polarity drug is increased by means of the reverse micelle system, so that the skin retention amount can be greatly increased when the reverse micelle system is used as a percutaneous administration carrier, thereby enhancing the percutaneous absorption of the drug. The formulation of the present disclosure is easy to prepare, good in storage stability, high in drug loading, high in drug accumulation amount in skin, easy to permeate, and quick to take effect, thereby avoiding side effects caused by oral simvastatin.

The invention relates to the field of medical auxiliary instruments, in particular to an intelligent regulation and control method and equipment for the transdermal absorption rate of a medicine, and the method comprises the following steps: S1, calculating the disease degree score of a patient according to the temperature data of a disease part of the patient and the temperature and humidity data of the environment where the patient is located; s2, the heating temperature is adjusted according to the disease degree score of the patient, and the percutaneous absorption rate of the medicine is dynamically adjusted by adjusting the heating temperature. According to internal data such as physiology and pathology of the patient and external data such as temperature and humidity of the environment, the disease degree of the patient is evaluated and predicted; the medicine percutaneous absorption rate is adjusted according to the disease degree of a patient; and the heating temperature is dynamically adjusted according to the transdermal absorption rate of the medicine. Therefore, the percutaneous absorption rate of the medicine is intelligently and dynamically regulated according to the disease degree change of a patient, namely the medicine dosage is regulated in real time, and the purpose of intelligent administration is achieved.

The invention relates to the technical field of whitening and repairing, in particular to a preparation process of a nicotinamide whitening and repairing mask, which comprises the following steps: dissolving glycerol and 1, 3-propylene glycol in deionized water, adding disodium ethylene diamine tetraacetate, centella asiatica extract and purslane extract, uniformly stirring, and adjusting the pH value to obtain a phase A; adding a nicotinamide-beta-cyclodextrin-polyethylene glycol inclusion compound, a cross-linked hyaluronic acid microgel dispersion, a tranexamic acid liposome dispersion liquid, alpha-arbutin and panthenol, stirring, and adjusting the pH value to obtain essence; and finally, cooling, adding octyloxyglycerin, uniformly stirring, filtering, and dipping in membrane cloth to prepare the nicotinamide whitening and repairing mask. According to the nicotinamide-beta-cyclodextrin-polyethylene glycol inclusion compound, the stability of nicotinamide is effectively improved by utilizing a molecular inclusion technology, the stimulation risk caused by nicotinic acid produced by hydrolysis of the nicotinamide is avoided, and meanwhile, the percutaneous absorption rate of the nicotinamide is enhanced by virtue of the permeation enhancing effect of polyethylene glycol.

The invention discloses an asiatic acid nano-structure lipid carrier and a soluble microneedle drug delivery system, which are characterized in that the dosage form of asiatic acid is designed and optimized, and a drug is prepared into the nano-structure lipid carrier to improve the absorption of the drug, so that the drug effect of asiatic acid is maximized, and the drug delivery efficiency is improved. A soluble microneedle drug delivery system based on a soluble microneedle is designed, the microneedle is combined with an asiatic acid nano-structure lipid carrier, thickened scar tissue is punctured in a novel local percutaneous delivery mode, percutaneous absorption of insoluble traditional Chinese medicine ingredients can be promoted, and the curative effect is improved. According to the microneedle-nanostructure lipid carrier, the physical and chemical infiltration enhancing advantage of the microneedle-nanostructure lipid carrier is fully played, the percutaneous infiltration amount is increased, the problem of low drug absorption efficiency caused by scars is solved, and the adverse reaction of the drug is reduced by utilizing the slow release characteristic of the nanostructure lipid carrier, so that the effects of enhancing efficacy and reducing toxicity are achieved.

Provided is a method for promoting orbicularis oculi blood flow by causing percutaneous absorption of hydrogen from a periphery of an eye, a method for promoting other physiological effects, and an optimal configuration of goggles for supplying hydrogen carrying out these methods. Further, the goggles provided hereunder include a goggle body for integrally covering and sealing a periphery of both eyes including at least a lower eyelid part of a user, a temple member coupled with both side parts of the goggle body, to be hooked on both ears of the user, and a hydrogen releasing part arranged at positions near both lower eyelid parts of the user inside the goggle body, having a pair of hydrogen releasing openings directed to each of the both lower eyelid parts, which are fluidly coupled with a discharging side end part of a tubular tube member connected to an external hydrogen generating apparatus.

The invention discloses a co-surfactant-free microemulsion entrapped with glycyrrhetinic acid as well as a preparation method and application of the co-surfactant-free microemulsion entrapped with glycyrrhetinic acid. The co-surfactant-free microemulsion entrapped with glycyrrhetinic acid comprises carvacrol / thymol, fatty acid, a nonionic surfactant and water, wherein the glycyrrhetinic acid accounts for 0.1-5% by mass of the raw materials, the carvacrol / thymol accounts for 0.1-5% by mass of the raw materials, the fatty acid accounts for 0.1-10% by mass of the raw materials, the nonionic surfactant accounts for 1-30% by mass of the raw materials, and the balance is water. The cosurfactant-free microemulsion loaded with glycyrrhetinic acid prepared by the invention contains glycyrrhetinic acid and carvacrol / thymol, the carvacrol / thymol not only increases the solubility of glycyrrhetinic acid, but also promotes percutaneous absorption of glycyrrhetinic acid, and the cosurfactant-free microemulsion loaded with glycyrrhetinic acid is a cosmetic composite efficacy composition with antioxidant, anti-inflammatory and antibacterial effects.

The invention discloses a traditional Chinese medicine external treatment medicine composition for treating children adenoid hypertrophy and a preparation method thereof. The traditional Chinese medicine external treatment medicine composition is prepared from the following components in parts by weight: 6 parts of flos magnoliae, 6 parts of rhizoma curcumae, 6 parts of rhizoma sparganii, 6 parts of rhizoma chuanxiong, 8 parts of radix cynanchi paniculati, 8 parts of bulbus fritillariae thunbergii, 8 parts of spica prunellae, 3 parts of raw herba ephedrae, 3 parts of herba asari and 3 parts of rhizoma cimicifugae. The traditional Chinese medicine is applied to acupuncture points such as Tianji, Dazhui and Shenque in a traditional Chinese medicine external treatment mode, effects are achieved through acupuncture point stimulation and medicine percutaneous absorption, the problems that children are difficult to orally take medicines and possibly stimulate gastrointestinal tracts and the like are avoided, operation is relatively simple and convenient, implementation is easy, the acceptability of child patients is relatively high, and the traditional Chinese medicine is worthy of popularization and application. The system is convenient to use at home and the like, and reduces the medical cost and burden to a certain extent.

The invention provides a compound preparation for delaying and improving muscular atrophy, a preparation method and a collateral dredging and conditioning method. The compound preparation comprises Janus double-sided functional nano-particles, and amber extract and traditional Chinese medicine essential oil which are coated in the nano-particles, borneolum syntheticum is chemically connected to a PEG / lipid skeleton to modify Janus nano-particles, so that the nano-particles have good lipid solubility and are easily inserted into cuticle lipid, and the particles are easier to break through the cuticle; the traditional Chinese medicine essential oil can be loaded inside the particles as a hydrophobic oil phase, is easy to encapsulate and can enter hair follicles and cutin gaps along with the particles; meanwhile, the surface-modified borneol is cooperated with the amber extract, so that the percutaneous absorption rate of effective components of traditional Chinese medicines can be remarkably increased, blood flow is improved, nutrition supply is enhanced, inflammation and oxidation are resisted, muscle fiber regeneration is promoted, local circulation is improved by warming yang and dredging collaterals, and absorption is promoted in cooperation with the heat effect generated by massage and mechanical shearing; finally, the effect of delaying or even partially reversing amyotrophy is achieved.

A percutaneous absorption preparation for the treatment of dementia wherein the drug-containing layer contains donepezil or a pharmaceutically acceptable salt thereof as an active ingredient and a stabilizer that is either (i) a mixture of a thiocyanate salt and a compound selected from the group consisting of tea catechin, (+)-catechin, epigallocatechin gallate, ascorbic acid, and isoascorbic acid, or (ii) a mixture of monothioglycerol and a compound selected from the group consisting of tea catechin, (+)-catechin, epigallocatechin gallate, and ascorbic acid is disclosed. The percutaneous absorption preparation meets the criteria of Procedure 1 and Procedure 2 of the U.S. Pharmacopoeia in short-term stress test (70° C. 48 hours storage), long-term accelerated test 1 (40° C. relative humidity 75% 1 month storage), and long-term accelerated test 2 (40° C. relative humidity 75% 3 months storage), and exhibits improved stability for long-term preservation.

The present invention provides a transdermal absorption composition comprising 4-cyclopropylmethoxy-N-(3, 5-dichloro-1-oxo-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide (tivapram) and levulinic acid, in which the content of levulinic acid is in the range of 4-cyclopropylmethoxy-N-(3, 5-dichloro-1-oxo-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide (tivapram), and the content of levulinic acid is in the range of 4-cyclopropylmethoxy-N-(3, 5-dichloro-1-oxo-4-pyridin-4-yl)-5-(methoxy) pyridine-2-carboxamide (tivapram). The ratio of the 2, 5-dichloro-1-oxide-4-pyridine-4-yl)-5-(methoxy) pyridine-2-formamide is 2 to 6 times that of the 2, 5-dichloro-1-oxide-4-pyridine-4-yl)-5-(methoxy) pyridine-2-formamide.

Provided is a drug delivery device capable of improving percutaneous absorption efficiency of a drug.　A drug delivery device (100) has: a drug-containing part (30) that contains a drug; a base material sheet (10); and a first electrode (21) and a second electrode (22) that are disposed on the base material sheet (10). The first electrode (21) and / or the second electrode (22) has a convex part (20) that is convex on the side opposite to the surface facing the base material sheet (10). The potential applied to the first electrode (21) differs from the potential applied to the second electrode (22).