6 results about "Donepezil" patented technology

The application discloses application of a drug composition of bacosol and donepezil in preparation of a drug for treating Alzheimer's disease. The application first discovers that bacosol has double-target point inhibitory activity on BACE1 and AChE. Through cell and animal model verification, the bacosol single drug and the composition can exert an anti-AD effect through a multi-target point mechanism, and the composition with a molar ratio of 1:1 to 1:10 has a significant synergistic effect, wherein the synergistic effect is the most significant when the molar ratio is 1:1. The application provides a new treatment method for Alzheimer's disease.

This invention discloses a traditional Chinese medicine composition for treating vascular cognitive impairment, its preparation method, and its application, belonging to the field of traditional Chinese medicine technology. It includes the following raw materials: stir-fried Atractylodes macrocephala, Fritillaria thunbergii, Ligusticum chuanxiong, Salvia miltiorrhiza, Curcuma longa, Acorus tatarinowii, Polygala tenuifolia, Cornus officinalis, Cistanche deserticola, Rehmannia glutinosa, Scrophularia ningpoensis, and borneol. Preparation method: First, the volatile oil is extracted by steam distillation and encapsulated with β-cyclodextrin; then, the lipid-soluble components in Salvia miltiorrhiza and Fritillaria thunbergii are extracted with ethanol; finally, the residue is combined with the remaining medicinal materials and decocted in water for extraction. Through the combination of Fritillaria thunbergii and borneol, the dual functions of "clearing inflammation + opening the blood-brain barrier" are achieved, increasing the brain concentration of lipid-soluble components such as tanshinone IIA. It significantly improves the learning and memory abilities of rats with vascular cognitive impairment, with efficacy superior to the Western medicine donepezil, and exhibits synergistic effects on multiple targets such as inhibiting NLRP3 inflammasomes and upregulating BDNF. This invention has a simple process, is suitable for industrial production, and has significant clinical application value.

The present application relates to the salt of donepezil derivative and its application in medicine, specifically, the present application relates to the salt of compound shown in formula (I), the salt of the compound can play the role of long-acting inhibition of acetylcholinesterase expression, thereby more long-acting prevention and / or treatment of Alzheimer's disease, wherein R 1 has the meaning described in the present application.

Provided herein are methods for promoting biostasis or preservation of a cell, tissue or organ during cancer treatment or for transplantation comprising contacting the cell, tissue or organ with an agonist of the δ-opioid receptor, SNC-80, an or Donepezil. Further provided herein is a method of treating a hematological neoplastic disease.

The invention provides compositions comprising a topical formulation of donepezil and methods of use thereof for intradermal applications.