31 results about "Lactobionic acid" patented technology

The invention discloses a composition for improving the stability of oleuropein in a solution as well as a preparation method and application of the composition. The composition comprises oleuropein and at least one stabilizer, and the stabilizer is selected from the group consisting of anisic acid, lactobionic acid, glycyrrhizic acid, 3, 3-thiodipropionic acid, N-acetyl-L-glutamine, propyl-cysteine and lauramidopropyl betaine; and the pH value of the aqueous solution of the composition is 4.0-8.0. The preparation method comprises the following steps: dissolving oleuropein in water, adding the stabilizer, and uniformly mixing. Through simple physical mixing, by utilizing the synergistic effect of the specific stabilizer and the oleuropein, the degradation and discoloration of the oleuropein in the storage process are remarkably inhibited. Experiments show that after the preferable composition is preserved for 30 days in an open manner, the retention rate of the oleuropein still reaches up to 80% or above, and is far superior to that of blank control and a traditional liposome wrapping method. The composition is simple and convenient in preparation process and low in cost, and provides reliable technical support for wide application of oleuropein in liquid products such as food, medicine and cosmetics.

The invention discloses an oil-controlling and acne-removing synergistic composition which comprises the following components in percentage by weight: 0.8 to 2.0 percent of succinic acid, 0.3 to 1.0 percent of salicylic acid derivative and 0.5 to 1.5 percent of PCA (Principal Component Analysis) zinc. The invention also provides a sustained-release body. The sustained-release body is prepared from the following components in percentage by weight: 0.8 to 2.0 percent of succinic acid, 0.3 to 1.0 percent of salicylic acid derivative, 0.5 to 1.5 percent of PCA zinc, 1.0 to 2.5 percent of lactobionic acid, 1.0 to 3.0 percent of lactobacillus fermentation product, 2.0 to 4.0 percent of aminated modified diatomite and 0.1 to 0.3 percent of citric acid. The invention also provides a preparation method and application of the sustained release body. The acne-removing shampoo has low irritation, and can be used for controlling oil and removing acnes for a long time and efficiently dredging hair follicles.

The invention discloses a pore cleaning mud mask and a preparation method thereof, belongs to the technical field of cosmetics, and particularly relates to a pore cleaning mud mask. Comprising 14 to 18 parts of kaolin, 7 to 9 parts of Manny root ice river mud, 4.5 to 5.5 parts of Amazon white mud, 10 to 12 parts of wheat germ oil, 43 to 47 parts of tea water, 0.1 to 0.14 part of a phellinus linteus extract, 1 to 2 parts of swertia mileensis powder, 2 to 4 parts of lactobionic acid, 0.08 to 0.12 part of salicylic acid and 0.4 to 0.6 part of gluconolactone. The pore cleaning mud mask provided by the invention is uniform in particle size distribution, uniform in mixing and capable of keeping the state of the mud mask moist and not dry in the use process, the cleaning strength of controlling oil, dredging pores and resisting inflammation is improved, meanwhile, skin sensitivity caused by excessive cleaning is avoided, and the cleaning effect is good. The invention provides a novel cleaning mud mask formula for realizing the goal of cleaning pores and an efficient and stable preparation method of the novel cleaning mud mask formula.

The invention relates to a halogen-free heavy oil removal surfactant and a preparation method thereof, and belongs to the technical field of surfactants. The heavy oil removal surfactant is prepared from fatty alcohol-polyoxyethylene ether, hydrophilic alkyl quaternary ammonium salt, a glycosyl nonionic surfactant and an alcohol compound, the glycosyl nonionic surfactant is prepared by sequentially carrying out hydrophobic amidation and hydrophobic epoxy addition on lactobionic acid lactone; the heavy oil removal surfactant is good in oil removal effect, safe, free of halogen and small in corrosivity, and the use performance is improved through compound use of the fatty alcohol-polyoxyethylene ether, the hydrophilic alkyl quaternary ammonium salt and the glycosyl nonionic surfactant.

This invention relates to the field of cosmetic technology, specifically disclosing a synergistic exfoliating composition and a method for preparing a controlled-release carrier containing the composition. The synergistic exfoliating composition is a compound of adenosine, N-acetylneuraminic acid, and lactobionic acid. This invention has the advantage of maintaining good exfoliating efficacy while reducing skin irritation.

The invention discloses micro-molecular metastructured 4-butylresorcinol and a preparation method and application thereof, a skin external preparation and cosmetics, and belongs to the technical field of cosmetics. According to the technical scheme, the micro-molecular metastructured 4-butylresorcinol is obtained through hydrogen bond interaction of lactobionic acid and 4-butylresorcinol in water; according to the supramolecular complex provided by the invention, the lactobionic acid and the 4-butylresorcinol form the supramolecular complex, on one hand, both the lactobionic acid and the 4-butylresorcinol have certain whitening and antioxidant capacities, and on the other hand, due to a supramolecular complex structure formed by the lactobionic acid and the 4-butylresorcinol, the water solubility of the 4-butylresorcinol can be improved; hydroxyl on 4-butylresorcinol can be prevented from being oxidized, so that the 4-butylresorcinol can keep good oxidation resistance.

A biphasic product comprising lactobionic acid, lactic acid or corresponding salts thereof and / or gluconolactone.

The invention relates to the technical field of cosmetics, in particular to a blue copper peptide-containing composition and application thereof in cosmetics. The composition comprises the following components in parts by mass: 1 part of blue copper peptide; 0.5 to 5 parts of tetrahydromethylpyrimidine carboxylic acid; 0.05 to 0.5 part of sodium hyaluronate; and 0.05 to 0.5 part of beta-glucan. Preferably, the composition further comprises allantoin and lactobionic acid, based on 1 part by mass of the blue copper peptide, the content of the allantoin is 0.1-0.5 part, the content of the lactobionic acid is 0.2-1.0 part, and the mass ratio of the allantoin to the lactobionic acid is 1: (2-4). In-vitro efficacy experiments prove that the specific combination and proportion can generate a remarkable synergistic effect, and meanwhile, the capabilities of inhibiting the activity of elastinase and promoting epidermal cell repair are improved, so that the excellent dual effects of wrinkle resistance and skin barrier repair are realized. The composition can be used for preparing cosmetics such as essence, emulsion and face cream.

The invention discloses a pH self-adaptive private care lotion based on a composite biological antibacterial system. The pH self-adaptive private care lotion is prepared from 8 to 12 parts of cocamidopropyl betaine, 0.5 to 1.5 parts of polylysine hydrochloride, 0.3 to 0.8 part of tea tree essential oil, 1.2 to 2.0 parts of lactic acid-sodium lactate buffer agent, 0.1 to 0.3 part of dipotassium glycyrrhizinate, 0.5 to 1.2 parts of chamomile extract, 0.3 to 0.7 part of lactobionic acid, 1.0 to 2.0 parts of aloe polysaccharide and the balance of deionized water. During preparation, the tea tree essential oil and beta-cyclodextrin are subjected to clathration for 30 minutes at 35 DEG C to form a clathrate compound, so that the volatile loss is reduced by 80%; dissolving polylysine hydrochloride in deionized water at 4 DEG C, and adding a lactic acid-sodium lactate buffer solution; lactobionic acid and a chamomile extract are added; homogenizing for 3 minutes by using a homogenizer at the speed of 2000rpm; and carrying out vacuum defoaming under 0.08 MPa. Dynamic pH buffering is achieved, and a lactic acid-lactobionic acid double-buffering layer resists secreta impact; a preservative-free process is adopted, and vacuum defoaming and PES membrane filtration are used for replacing chemical preservatives; and gender differentiation adaptation: cranberry polyphenol, female adhesion prevention and succinic acid buffer male pH adaptation.

This application provides a skin-renewing composition containing an acid-enzyme peptide, comprising lactobionic acid, hexanoyl dipeptide-3-leucine, and papain; the mass ratio of lactobionic acid, hexanoyl dipeptide-3-leucine, and papain is 0.1~15:0.5~15:0.05~5. This application also provides a product comprising the above composition and its application. This application combines lactobionic acid, papain, and hexanoyl dipeptide-3-leucine for biological skin renewal, i.e., exfoliation. The three components interact synergistically, significantly increasing the content of exfoliated keratin proteins and providing excellent exfoliation effects. Furthermore, the composition provided in this application has low irritation.

A perfusion stock composition, for preserving a donor organ for transplantation, comprising: a source of 60 to 100 mM Na+; a source of 10 to 20 mM K+; a source of 5 to 10 mM Mg2+; a source of 0.25 to 0.75 mM Ca2+; 10 to 40 mM Tris(hydroxymethyl)aminomethane hydrochloride (Tris or THAM), 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), 3-(N-morpholino)propanesulfonic acid (MOPS), 2-(N-morpholino)ethanesulfonic acid (IviES), N,N-bis-(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), or N / -tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES); a source of 10 to 30 mM HCO3; 1 to 30 mM glucose; 1 to 20 U / L insulin; 1 to 10 mM fructose diphosphate or a salt thereof, 1 to 40 mM aspartate or glutamate; 1 to 10 mM adenosine, cAMP or cGMP; 1 to 10 mM reduced glutathione; and 30 to 100 mM lactobionate or mannitol; and, optionally, a diluent. The present disclosure also provides a perfusion composition, a kit, a method, and a perfusion apparatus, each related to the perfusion stock composition.

The present application relates to the technical field of nanomedicine delivery system, and particularly relates to a liver-targeting, long-circulating and acid-responsive nanomedicine delivery system loaded with oleuropein and a preparation method and application thereof. The nanomedicine delivery system comprises a drug-loaded core and a functional surface modification layer; the drug-loaded core is a zeolitic imidazolate framework loaded with oleuropein; and the functional surface modification layer is a lactobionic acid-polyethylene glycol conjugate. The present application realizes the precise delivery and efficient release of oleuropein at the site of sepsis liver injury by constructing a liver-targeting, long-circulating and acid-responsive three-level modular nanomedicine delivery system. The technical scheme can solve the technical problems of low bioavailability of oleuropein and unsatisfactory targeting delivery efficiency at the site of sepsis liver injury. The technical scheme comprehensively improves the pharmacokinetic characteristics and targeted treatment efficiency of OLE, and provides an efficient and safe nanomedicine delivery system for the precise treatment of sepsis liver injury.

The invention provides a skin care composition containing acid enzyme peptide. The skin care composition comprises lactobionic acid, hexanoyl dipeptide-3-n-leucine and papain, the mass ratio of the lactobionic acid to the hexanoyl dipeptide-3-n-leucine to the papain is (0.1 to 15) to (0.5 to 15) to (0.05 to 5). The invention further provides a product containing the composition and application of the product. According to the invention, lactobionic acid, papain and hexanoyl dipeptide-3-n-leucine are compounded for use, when the composition is used for biological skin renewal, namely exfoliating, the three components interact with each other and have a synergistic effect, the content of eluted keratin can be remarkably increased, and the composition has a good exfoliating effect. In addition, the composition provided by the invention is relatively low in irritation.

The invention discloses a preparation method of crocodile skin collagen peptide and application of a composition of the crocodile skin collagen peptide in antisepsis, anti-inflammation and skin repair. The crocodile skin collagen peptide provided by the invention is composed of 17 peptide fragments with the molecular weight of 700-1800 Da. The composition obtained by compounding crocodile skin collagen peptide, mandelic acid, lactobionic acid, asiaticoside and nicotinamide has multiple functions of antisepsis, anti-inflammation, skin repair and the like through multi-target point synergism, and the crocodile skin collagen peptide dominates oxidation resistance and skin repair and delays skin aging; mandelic acid is used for mildly conditioning cutin, effectively dredging pores and inhibiting growth and reproduction of acne-related flora; lactobionic acid promotes epidermis renewal, makes the skin moist and delicate, and reduces fine wrinkles; the asiaticoside is used for relieving, diminishing inflammation and relieving irritation reactions such as skin redness and swelling; nicotinamide can regulate sebum secretion, block melanin migration and brighten the skin color. The composition can effectively deal with acnes and complications, and solves the problems that an existing product is high in irritation, easy to leave marks and the like.

The invention belongs to the technical field of food chemistry and biological catalysis, and particularly relates to an enzymolysis reaction additive in low-sugar food and a preparation method of the enzymolysis reaction additive. According to the additive, tea polyphenol subjected to glycosylation-amidation synergistic modification and gluconic acid-acetamide are used as main components, sodium lactobionate, levulinic acid, 1-ethyl-3-methylimidazolium acetate, sodium citrate, polyethylene glycol-400 and ascorbic acid are used as auxiliary components, and through a synergistic modification and small molecule stabilization strategy, the tea polyphenol-gluconic acid-ascorbic acid composite additive is prepared. The hydrophilicity, the stability and the interaction capability with enzyme molecules of the tea polyphenol are improved. The prepared additive can significantly improve the reaction rate and thermal stability of amylase and protease in a low-sugar system, and improve the dispersity and uniformity of the system. The method has the advantages of scientific and reasonable formula, mild reaction conditions, high stability, excellent food compatibility and the like, and can be widely applied to the field of enzymatic processing of low-sugar foods, sugar substitutes and functional foods.

The invention relates to a hair care and / or scalp care composition comprising rhamnose, trehalose and lactobionic acid. Said composition moisturizes the scalp, protects the scalp from dehydration, promotes the growth of Staphylococcus epidermis and / or Cutibacterium acnes on the scalp and can be used for treating or preventing dandruff.

A perfusion stock composition, for preserving a donor organ for transplantation, comprising: a source of 60 to 100 mM Na+; a source of 10 to 20 mM K+; a source of 5 to 10 mM Mg2+; a source of 0.25 to 0.75 mM Ca2+; 10 to 40 mM Tris(hydroxymethyl)aminomethane hydrochloride (Tris or THAM), 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), 3-(N-morpholino)propanesulfonic acid (MOPS), 2-(N-morpholino)ethanesulfonic acid (IviES), N,N-bis-(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), or N / -tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES); a source of 10 to 30 mM HCO3; 1 to 30 mM glucose; 1 to 20 U / L insulin; 1 to 10 mM fructose diphosphate or a salt thereof; 1 to 40 mM aspartate or glutamate; 1 to 10 mM adenosine, cAMP or cGMP; 1 to 10 mM reduced glutathione; and 30 to 100 mM lactobionate or mannitol; and, optionally, a diluent. The present disclosure also provides a perfusion composition, a kit, a method, and a perfusion apparatus, each related to the perfusion stock composition.

The invention belongs to the field of drug delivery and oral preparations, and provides an 8-O-acetyl harpagide nano-composition and a preparation method thereof.The 8-O-acetyl harpagide-soybean lecithin compound is used as a nuclear phase, lactobionic acid and thioglycolic acid dual-modified chitosan and sodium tripolyphosphate are subjected to ionic crosslinking to form a shell layer, and the 8-O-acetyl harpagide nano-composition is prepared. Compared with the prior art, the freeze-dried powder has the advantages of high loading capacity, high solid content, low viscosity and wide processing window, small particle size, low polydispersity index and stable nano dispersion are obtained, ethanol residue and water content of the freeze-dried powder are reduced, freeze-dried storage stability, redissolution redispersibility and oral release and absorption performance are improved, and the freeze-dried powder is suitable for large-scale production. The method is suitable for the development of oral preparations for preventing the acetaminophen-induced liver injury.

The invention belongs to the technical field of feeds, and particularly relates to a special feed for low-cholesterol eggs and a preparation process of the special feed. The invention discloses a composition. The composition is prepared from the following components: plant polysaccharide, plant polypeptide, hesperidin, lactobionic acid, cordycepin and pubescent holly root saponin. The invention also discloses an application of the composition in preparation of a special feed for low-cholesterol eggs. A certain amount of the composition is added into the basal feed, the composition takes plant polysaccharide and plant polypeptide as main raw materials and takes hesperidin, lactobionic acid and other active molecules as auxiliary materials, and the combination of the components has a synergistic effect, so that the immunity and disease resistance of laying hens can be effectively improved, the laying rate is ensured, and the quality of laying hens is improved. Meanwhile, the content of cholesterol in eggs can be reduced, the color of the eggs is improved, the viscosity of egg white and the strength of eggshells are improved, the breakage rate is reduced, and the comprehensive quality of the eggs is comprehensively improved.

The present application relates to the technical field of disease diagnosis, and particularly relates to metabolic markers for early lung cancer diagnosis, and a screening method and application thereof. The metabolic markers for early lung cancer diagnosis of the present application comprise O-acetyl-L-carnitine, D-galactonic acid, fatty acid 20:3 and arachidonic acid. The metabolic markers of the present application are used for distinguishing healthy people and early lung cancer patients (including 0 stage and I stage early patients of LC), the metabolic markers can predict early onset of lung cancer, have higher potential clinical application value, and are expected to play an important role in lung cancer screening, early diagnosis and intervention of lung cancer.

The invention discloses a gland nutritional agent for improving fish scale skin and a preparation method thereof, and relates to the technical field of skin nutritional agent preparation. Comprising the following raw materials: an extract, modified seabuckthorn seed oil, modified lactobionic acid, nicotinamide, coenzyme Q10, a phytosterol compound, panthenol sodium phosphate, capryloyl salicylic acid, vitamin H, a ginseng extract, a humectant, oat beta-glucan, sodium hyaluronate, glycerol, propylene glycol, phosphatidylcholine, vitamin E, PEG-100 stearate, carbomer, triethanolamine, a preservative and allantoin. And the balance of deionized water. According to the invention, by adding the modified seabuckthorn seed oil, sebaceous gland can be nourished more efficiently, damaged skin barrier can be repaired, and percutaneous moisture loss can be reduced; meanwhile, the fish scale skin care product has an anti-oxidation effect, can protect skin cells from being damaged by free radicals, delays dryness and roughness aggravation of fish scale skin, and maintains normal physiological functions of glands.

An object of the present disclosure is to effectively suppress a decrease in body temperature and symptoms associated therewith, or to modify the intestinal flora so as to be effective in suppressing these symptoms.SOLUTION: The present disclosure provides a composition for suppressing a decrease in body temperature comprising lactobionic acid or a salt thereof, a composition for alleviating a symptom associated with an allergic reaction comprising lactobionic acid or a salt thereof, a composition for modifying a relative abundance of bacteria in intestinal flora comprising lactobionic acid or a salt thereof, and the like.SELECTED DRAWING: None

The invention discloses a preparation method and application of sesamin targeted carrying nanoparticles, and the preparation method comprises the following steps: reacting ketal thiol TK, 2-succinimido-1, 1, 3, 3-tetramethylurea tetrafluoroborate, N, N-diisopropylethylamine and iramitide SS-31 peptide to prepare an SS31 peptide-TK compound, then reacting with chitosan, and simultaneously preparing a sodium alginate-lactobionic acid compound, so as to obtain the sesamin targeted carrying nanoparticles. Finally, mixing the two solutions to obtain a covalent complex; the method comprises the following steps: baking pork slices, extracting with ethanol, filtering, carrying out rotary evaporation, extracting, dialyzing and purifying, and freeze-drying; and mixing the products of the first two steps, dissolving in ethanol, adding sesamin, and carrying out electrostatic self-assembly and freeze drying to obtain the visual sesamin targeted nanoparticles. According to the invention, specific positioning of liver mitochondria, ROS stimulation response intelligent drug release and real-time visualization of food-borne fluorescence labeling are realized, and the application prospect in prevention and treatment of liver diseases is wide.

The invention relates to the technical field of cosmetic raw materials, in particular to a preparation method and application of a lactoferrin composite spherical membrane body. The preparation method of the lactoferrin composite globular membrane body, provided by the invention, comprises the following steps of: wrapping lactoferrin by using milk fat globular membrane protein as a carrier to prepare a nano-scale composite globular membrane body, and specifically, reducing the iron saturation of the lactoferrin by adopting a chelate resin iron removal technology, and then preparing the lactoferrin composite globular membrane body by using the milk fat globular membrane protein as the carrier. Constructing a milk fat globule membrane protein / lactoferrin core-shell structure to form colostrum, and injecting the colostrum into a water phase containing 0.1 wt% of lactobionic acid to prepare a composite globule membrane body. The method not only can improve the stability and bacteriostatic activity of the lactoferrin, but also can significantly improve the transdermal rate of the milk iron eggs, enhance the ability of the lactoferrin to specifically bind to keratinocyte lectin receptors, and improve the uptake efficiency of keratinocytes, thereby achieving the effect of improving the bioavailability of the lactoferrin. The composition is an ideal functional cosmetic raw material.

The present invention discloses a lyophilized pharmaceutical composition of Sovateltide for parenteral administration. More specifically, the invention discloses a composition comprising Sovateltide stabilized with lactobionic acid 10 and polyvinyl pyrrolidone (Kollidon PF 12), as well as a process for its preparation, which offers improved stability and reduced impurities.

COSMETIC COMPOSITION FOR THE CARE OF KERATINIC MATERIALS The present invention relates to a composition for the care of keratinous materials, comprising (i) at least one hydroxyl-containing acid, selected from the group consisting of α-hydroxy acids, gluconic acid, lactobionic acid, salicylic acid, their precursors and mixtures thereof; (ii) at least one short-chain surfactant, each oleophilic chain containing 14 carbon atoms or fewer; (iii) at least two fatty alcohols having 20 carbon atoms or more; and (iv) at least one non-fatty alcoholic surfactant other than said short-chain surfactant. Figure for the abstract: none

The invention provides a composition with an anti-aging effect. The composition comprises fibroin and lactobionic acid, the mass ratio of the fibroin to the lactobionic acid is (0.02: 10)-(0.2: 1). The invention further provides application of the composition and a personal care product. In the composition provided by the invention, the fibroin and the lactobionic acid are compounded, so that a synergistic anti-aging effect is achieved. Experimental results show that the composition provided by the invention can promote the expression of at least one of type I collagen alpha1 chain, type I collagen alpha2 chain, type II collagen and elastin, has a synergistic effect and an anti-aging effect, and can be used for anti-aging cosmetics.

Methods and consumer products for detecting a metabolite, the method comprising: testing a urine sample from a subject for a metabolite selected from the group consisting of ascorbate, dehydroascorbate, CEHC-sulfate, CEHC-taurine, CEHC-glucronide, pantoate, 5-amino valerate, galactonate, phenylacetylalanine, methylcatecholsulfate, phenylacetylglutamine, carboxysuccinate, carboxyethylvaline, arabinose, threonate, methylcrotonylglycine, glucuronate, carboxyethylisoleucine, glycoursodeoxycholate, leucylalanine, lithocholatesulfate, alio-threonine, cholic, glucuronide and combinations thereof; and producing a metabolic profile for the metabolite.

The invention belongs to the technical field of food chemistry and biological catalysis, and relates to an efficient enzyme catalyst for low-sugar food and a preparation method of the efficient enzyme catalyst. The catalyst is prepared from a modified tea polyphenol-chitosan composite carrier, 2-hydroxy-4-methoxyacetophenone, a stabilizer, a complexing aid, a dispersing agent, a pH buffering agent and deionized water. The composite carrier takes chitosan as a matrix, realizes double-site grafting of a C-N bond and a C-O bond of a tea polyphenol molecule through laccase catalysis, and is prepared through synergistic modification of lactobionic acid lactone glycosylation and vitamin C reductive amination. The catalyst provided by the invention has a multi-site covalent binding and interface partition structure, and shows excellent enzyme immobilization efficiency and activity retention ability in a low-sugar environment. The activity retention rate of the catalyst in a 5% sugar degree system exceeds 95%, the enzyme activity of 90% or above is still kept after the catalyst is recycled for 10 times, the retention rate reaches 93% after the catalyst is stored for 12 months at 4 DEG C, and the catalyst is suitable for low-sugar food processing and enzymatic conversion systems.

To provide a selective nanostructure delivery system for targeting an inhibitor of the PKC signaling pathway into the liver for use in the treatment of septic cholestasis.SOLUTION: The selective nanostructure delivery system comprises a carbohydrate targeting moiety and a PKC signaling pathway, wherein the inhibitor of the PKC signaling pathway is covalently linked, directly or through a linker or spacer moiety, to the carbohydrate targeting moiety, wherein the carbohydrate targeting moiety is selected from the group consisting of N-acetylgalactosamine (GalNAc), galactose, lactose, mannose, glucosamine, asialofetuin, pullulan, arabinogalactan, arabinoglycan, fuconic acid, lactobionic acid, transferrin, sitosterol glycoside (sitoG), glycyrrhizin, and glycyrrhetinic acid.SELECTED DRAWING: Figure 1