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A technology of azithromycin and lactobionic acid, which is applied in the field of pharmaceuticals, can solve the problems of loss of antibacterial activity, uneven drug dosage, eye irritation, etc., and achieve the effect of reducing re-pollution, no appearance and good stability
Inactive Publication Date: 2007-11-28
SHENYANG XINGQI PHARM CO LTD
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Problems solved by technology
It shows that this patent fails to solve the stability problem of making a solution, and cannot make a kind of long-term stable eye drops
In addition, the preparation has obvious eye irritation, which is unbearable for most patients, which limits its application in ophthalmology
The combined preparation of "tablets + water" is more inconvenient to use: opening the bottle will cause re-contamination, differences in tablet weight and the size of the liquid medicine will cause uneven dosage, and foreign objects such as dust, Fine hair, etc. brought into eye drops, etc.
[0007] Studies have shown that both azithromycin and its acid salts have unstable factors, such as oxidation, hydrolysis, etc., which can lead to a decrease in their pote
Method used
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Embodiment 1
[0040] Example 1: Consists of the following components and mass percentages, which contain: azithromycin lactobionate 0.59% (as azithromycin 0.3%), sodium bisulfite 1.0%, povidone K 30 0.5%, hydrogenated castor oil 0.8%, medium chain glycerides 0.1%, Transcutol-p 0.4%, boric acid 1.0%, borax 0.2%, lactose 0.75%, ethyl paraben 0.03%, and the rest is water. The preparation process is the same as above.
Embodiment 2
[0041] Example 2: It is composed of the following components and mass percentages, which contains: 0.59% azithromycin lactobionate (0.3% as azithromycin), 0.6% vitamin C, and povidone K 30 0.5%, hydrogenated castor oil 0.8%, medium chain glycerides 0.1%, Transcutol-p 0.4%, boric acid 1.0%, borax 0.2%, lactose 0.75%, ethyl paraben 0.03%, and the rest is water. The preparation process is the same as above.
Embodiment 3
[0042] Example 3: Consists of the following components and mass percentages, which contain: azithromycin lactobionate 0.59% (0.3% as azithromycin), carbopol 0.5%, borax 1.4%, sodium bisulfite 1.0%, hydrogenated castor oil 1.5%, 0.3% medium chain glycerides, 0.6% Transcutol-p, 0.1% boric acid, 0.5% lactose, 0.03% ethyl paraben, and the rest is water. The preparation process is the same as above.
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Abstract
The present invention is one kind of composition for eye medicine preparation. The composition contains antibiotic azithromycin lactobionate as active component; at least one kind of surfactant and/or co-surfactant, such as hydrogenated castor oil and Transcutol-p, in such amount as to form micro emulsion; and medicinal supplementary material, such as boric acid, borax and sodium bisulfite. The composition is prepared into eye drop or eye gel, and when it is prepared into gel, carbomer is used as the gel matrix. Compared with similar products, the composition of the present invention has high stability, less irritation to eye, capacity of be used to child and other advantages.
Description
Technical field [0001] The invention belongs to the field of medicine technology. [0002] The invention relates to an ophthalmic preparation composition prepared by an antibiotic drug-azithromycin lactobionate-plus medicinal auxiliary materials according to a conventional method, such as eye drops, ophthalmic gel and other dosage forms. The composition of the present invention relates to azithromycin lactobionate eye drops and azithromycin lactobionate eye gel. Background technique [0003] Azithromycin Lactobionate (Azithromycin Lactobionate) is a semi-synthetic aza-fifteen-membered macrolide antibiotic, its chemical name is (2R, 3S, 4R, 5R, 8R, 10R, 11R, 12S, 13S, 14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-(-L-nucleo-hexapyranosyl)oxy)-2-ethyl-3, 4,10-Trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-tideoxy-3-(dimethylamino)-β-D- Wood-hexylpyranosyl)oxy]-1-oxa-6-azacyclopentadecan-15one 2 lactobionate, molecular formula C 38 H 72 N 2 O 12 ·2C 12 H 22 O 12 , Molecular weight...
Claims
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