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Bilayer tablet comprising telmisartan and amlodipine

A technology of telmisartan and amlodipine, which is applied in the direction of medical preparations containing active ingredients, pill delivery, metabolic diseases, etc., can solve problems such as incompatibility and stability, and achieve the goal of promoting dissolution and solving stability problems Effect

Inactive Publication Date: 2007-10-10
BOEHRINGER INGELHEIM INT GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The tablet structure also solves the stability problem caused by the incompatibility of the basic components of amlodipine and telmisartan

Method used

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  • Bilayer tablet comprising telmisartan and amlodipine
  • Bilayer tablet comprising telmisartan and amlodipine

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment

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[0117] * Volatile components do not remain in the final product

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PUM

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Abstract

A bilayer tablet comprises a first layer formulated for instant release of the angiotensin II receptor antagonist telmisartan from a dissolving tablet matrix and a second layer formulated for instant release of the calcium channel blocker amlodipine from a disintegrating or eroding tablet matrix.

Description

[0001] The present invention relates to a first layer comprising the angiotensin II receptor antagonist telmisartan in a dissolving tablet matrix and a second layer of the calcium ion channel blocker amlodipine in a disintegrating or eroding tablet matrix. Layers of medicine tablets. Background of the invention [0002] As disclosed in EP-A-502314, Telmisartan is an angiotensin II receptor antagonist developed for the treatment of hypertension and other medical indications. Its chemical name is 4'-[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-ylmethyl]- Biphenyl-2-carboxylic acid; [0003] [0004] Telmisartan is manufactured and supplied in the free acid form. It is characterized by very poor solubility in aqueous systems of the gastrointestinal tract in the physiological pH range between pH 1 and pH 7. As disclosed in WO 00 / 43370, crystalline telmisartan exists in two polymorphic forms with different melting points. Under the influence of heat and ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4184A61K31/4422A61P9/00A61P9/04A61P9/08A61P9/10A61P9/12A61P3/10A61P25/28
CPCA61K31/455A61K9/2009A61K9/2013A61K9/2018A61K9/2054A61K9/2059A61K9/2077A61K9/209A61K31/4184A61K31/4422A61P13/12A61P25/00A61P25/28A61P3/00A61P3/10A61P3/04A61P3/06A61P3/08A61P43/00A61P9/00A61P9/04A61P9/08A61P9/10A61P9/12A61K2300/00
Inventor 沃尔弗拉姆·艾森赖克
Owner BOEHRINGER INGELHEIM INT GMBH
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